Abstract:
:Comparative expression analysis of wild-typeETV6 in the disease state showed an absence of expression in ETV6-CBFA2 acute lymphoblastic leukaemia (ALL) when compared with non-ETV6-CBFA2 ALL and acute myeloid leukaemia. Fluorescent in-situ hybridization and loss of heterozygosity studies showed that 73% of the ETV6-CBFA2 samples had a fully or partially deleted second ETV6 allele, explaining the lack of wild-type expression in these patients. Although the second ETV6 allele was identified in the remaining patients, no ETV6 expression was detected. These observations support the hypothesis that loss of ETV6 expression is a critical secondary event for leukaemogenesis in ETV6-CBFA2 ALL.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Patel N,Goff LK,Clark T,Ford AM,Foot N,Lillington D,Hing S,Pritchard-Jones K,Jones LK,Saha Vdoi
10.1046/j.1365-2141.2003.04399.xsubject
Has Abstractpub_date
2003-07-01 00:00:00pages
94-8issue
1eissn
0007-1048issn
1365-2141pii
4399journal_volume
122pub_type
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