Abstract：
:We studied 13 patients with rheumatoid arthritis (RA) and gold-induced thrombocytopenia. Platelet-specific autoantibodies of the IgG and often also of the IgM class were detected by immunofluorescence on the patient's platelets and in ether eluates from these platelets. In nine patients we also detected autoantibodies in the serum. The antibodies were unreactive with platelets from patients with Glanzmann's disease in most cases, and were not EDTA dependent. Thus, they had the serological characteristics of true autoantibodies. The reaction of the antibodies with platelets was not influenced by the addition of extra gold. By atomic absorption spectrophotometry we found that the ether eluates, which were often strongly reactive with donor platelets, were free of gold. This indicated that the autoantibodies in the thrombocytopenic patients were not dependent on gold for their reaction. The possibility is raised that gold treatment of rheumatoid arthritis patients induces or enhances the formation of platelet-specific autoantibodies, and that gold-induced thrombocytopenia is a drug-induced autoimmune disease.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
von dem Borne AE,Pegels JG,van der Stadt RJ,van der Plas-van Dalen CM,Helmerhorst FMdoi
10.1111/j.1365-2141.1986.tb07528.xsubject
Has Abstractpub_date
1986-07-01 00:00:00pages
509-16issue
3eissn
0007-1048issn
1365-2141journal_volume
63pub_type
杂志文章abstract：:Studies during the last three decades have enabled the development of detailed molecular insights into the structural basis of altered function in various inherited red cell membrane disorders. This review highlights our current understanding of molecular and mechanistic insights into various inherited red cell membra...
journal_title：British journal of haematology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2141.2008.07091.x
更新日期：2008-05-01 00:00:00
abstract：:Much of the variability in the sensitivity to warfarin in anticoagulated patients is associated with the c.-1639G > A polymorphism of the vitamin K-epoxide reductase (VKORC1) gene. However, its association with the acenocoumarol dose in patients under anticoagulant therapy has not been studied. The c.-1639G > A genoty...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.2006.06007.x
更新日期：2006-04-01 00:00:00
abstract：:Although 5-fluorouracil (FUra) has been the drug of choice for the treatment of patients with advanced colorectal carcinoma, the response rates are in the range of 15% and the median survival times do not exceed 9 months. Interferon alpha (IFN alpha) has limited antitumour activity in this disease. Recent clinical tri...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1991.tb08120.x
更新日期：1991-10-01 00:00:00
abstract：:Assessment of chronic hepatitis C virus infection requires a liver biopsy in most circumstances. There is a reluctance to perform liver biopsy in haemophiliacs because of a perceived risk of haemorrhage, although with adequate factor concentrate replacement in patients without factor concentrate inhibitors it should b...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.1997.452691.x
更新日期：1997-05-01 00:00:00
abstract：:Bone disease in patients with thalassaemia major is a multifactorial and still poorly understood process. The present study evaluated 45 thalassaemic patients using dual X-ray absorptiometry at three sites (lumbar spine, head of femur and forearm) to assess bone mineral density, in parallel with a series of biochemica...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.2001.02549.x
更新日期：2001-01-01 00:00:00
abstract：:Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade B-cell lymphoproliferative disorder characterized by splenomegaly and circulating villous lymphocytes. The relationship between SLVL and splenic marginal zone lymphoma (SMZL), a disorder with identical splenic histology to SLVL, is not clear. Previous stu...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.1999.01209.x
更新日期：1999-03-01 00:00:00
abstract：:Phenotypic change of blood-type eosinophils to tissue-type eosinophils is induced by various cytokines. We examined the effect of nerve growth factor (NGF) as a candidate for a constitutive cytokine which is able to induce the phenotypic change of eosinophils. The viability of human peripheral blood eosinophils cultur...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.1996.5151055.x
更新日期：1996-05-01 00:00:00
abstract：:This work aimed to provide a means of assaying directly the effects of transient expression of introduced genes on the survival, proliferation, lineage commitment and differentiation of haemopoietic progenitor cells. For this purpose, we have developed a system that allows isolation of productively transfected, muliti...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.2000.02214.x
更新日期：2000-09-01 00:00:00
abstract：:We report two patients with acute leukaemia who received emetogenic cytotoxic drugs and were on therapeutic doses of sodium valproate for epilepsy. Neither patient reported significant nausea nor vomited at any time during the chemotherapy, at times requiring no anti-emetic treatment whatsoever. We suggest that this a...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1995.tb08433.x
更新日期：1995-04-01 00:00:00
abstract：:Antibodies (Abs) that block factor VIII (FVIII) activity occur in hemophilia A patients treated with FVIII replacement therapy and severely impair treatment. In this work, we designed and synthesized ten peptides whose sequences are found in putative epitopes at the surface of a1 and C2 domains of the FVIII molecule. ...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.2008.07043.x
更新日期：2008-05-01 00:00:00
abstract：:We describe two British families with similar, dominantly-inherited, temperature-related variants of hereditary stomatocytosis, consistent with the original description of 'cryohydrocytosis'. The cells show a 5-6-fold increase in passive permeability at 37 degrees C with abnormal intracellular Na and K levels at 15-20...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.1999.01444.x
更新日期：1999-06-01 00:00:00
abstract：:The proportion of T gamma and T mu lymphocytes was studied in 40 cases of B-chronic lymphocytic leukaemia (B-CLL) and six of B-prolymphocytic leukaemia (B-PLL). The significant increase in T gamma cells, previously reported in two small B-CLL series, was confirmed and shown to be directly correlated with the clinical ...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1981.tb02682.x
更新日期：1981-04-01 00:00:00
abstract：:Umbilical cord blood transplant (UCBT) is associated with impaired early immune reconstitution. This might be explained by a lower T-cell dose infused, the naivety of cord blood T-cells and the use of in vivo T-cell depletion. We studied the pattern of early immune reconstitution and the clinical outcome of children u...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.2011.08994.x
更新日期：2012-03-01 00:00:00
abstract：:We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resul...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.2002.03846.x
更新日期：2002-11-01 00:00:00
abstract：:This study was undertaken to evaluate the toxicity and pharmacokinetics of a dimethyl sulphoxide (DMSO)-based intravenous formulation of busulphan in the conditioning of 45 patients undergoing allogeneic or autologous stem cell transplantation (SCT). Busulphan was given as a single daily dose. In 15 patients a single ...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.2001.03044.x
更新日期：2001-09-01 00:00:00
abstract：:This study describes the largest series reported to date, of individuals belonging to unrelated families carrying a beta-thalassaemia-like phenotype in whom the beta-globin gene was found to be structurally intact by sequence analysis. This genetic determinant appears haematologically heterogeneous, displaying either ...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.2005.05915.x
更新日期：2006-03-01 00:00:00
abstract：:Previous studies have suggested that phorbol ester-activated neutrophils kill both antibody non-coated and antibody-coated K562 target cells. In this report the contribution of the receptors Fc gamma III (CD16) and CR3 (CD11b/CD18) in the lytic process was investigated. In neutrophils CD16 and CR3 are up-regulated by ...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1991.tb04518.x
更新日期：1991-10-01 00:00:00
abstract：:Intrinsic factor (IF) and cobalamin-R-binding protein (R-binder) linked to polyacrylamide beads were used to absorb cobalamins from solutions and serum extracts. Both binding agents were equally effective in removing [57Co]B12 from aqueous solution. IF was more effective than R-binder in removing [57Co]B12 added to a ...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1983.tb02141.x
更新日期：1983-08-01 00:00:00
abstract：:A patient presented with haemolytic anaemia and a negative direct antiglobulin test (DAT), and was found to have an IgG antibody with anti-Jka specificity in his serum. His red cells were typed as Jk(a-b+). Later he developed idiopathic thrombocytopenic purpura (ITP), and had a positive DAT due to anti-Jka bound to hi...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1988.tb02411.x
更新日期：1988-08-01 00:00:00
abstract：:Thrombocytopenia and neutropenia are common among neonates in intensive care units. Bone marrow aspirations are sometimes performed as part of their evaluation. However, marrow biopsies have not been reported from living neonates. Since architecture and cellularity cannot generally be accurately assessed from marrow a...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.1999.01712.x
更新日期：1999-11-01 00:00:00
abstract：:Erythrocyte sedimentation, viscosity, electrophroetic mobility, and osmotic fragility were measured in a study of the rheological behaviour of the erythrocyte in vitro. In comparison with physiological saline solution, a suspending medium containing a gamma2lambda2 monoclonal IgG from a patient with multiple myeloma c...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1979.tb05888.x
更新日期：1979-04-01 00:00:00
abstract：:The existence of two genetic variants (allotypes) of normal human factor IX is used for carrier detection in three families with severe and one with mild haemophilia B. By analysis of IX:Ag with two different monoclonal antibodies in 93 members of the families, allelic assignment is shown to be a complement in carrier...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1987.tb06164.x
更新日期：1987-12-01 00:00:00
abstract：:The very poor outcome of invasive fungal infections (IFI) in patients with haematological malignancies or recipients of haematopoietic stem cell transplantation is largely attributed to their compromised host defence mechanisms. The restoration or augmentation of immune responses in these patients is now considered as...
journal_title：British journal of haematology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2141.2005.05498.x
更新日期：2005-06-01 00:00:00
abstract：:Unfractionated heparin (UFH) and low-molecular weight heparin (LMWH) are well defined anticoagulant agents. Recent data suggest that both LMWH and UFH may also have potent anti-inflammatory properties; however, their mechanism of action responsible for the anti-inflammatory effect is not yet fully elucidated. This stu...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.2006.05959.x
更新日期：2006-04-01 00:00:00
abstract：:We have previously shown that polymorphonuclear leucocytes (PMN) harvested from children with cancer and exposed to chemotherapy exhibit defective bactericidal activities against both Gram-positive and Gram-negative microorganisms as well as accelerated apoptosis. In this study, PMN from children with cancer were eval...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.1999.01589.x
更新日期：1999-09-01 00:00:00
abstract：:In spite of several studies of immunoglobulin (Ig) gene rearrangements in whole Hodgkin's disease (HD) tissues and in isolated single Reed-Sternberg (RS) cells, the issue of clonality of the RS cell in HD remains incompletely resolved. Analysis of X-chromosome inactivation patterns (XCIPs) can be used to determine whe...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.1999.01727.x
更新日期：1999-12-01 00:00:00
abstract：:Phytosterolaemia (sitosterolaemia) is a recessively inherited metabolic condition in which the absorption of both cholesterol and plant-derived cholesterol-like molecules at the gut is unselective and unrestricted. In haematology, Mediterranean stomatocytosis or Mediterranean macrothrombocytopenia is a poorly understo...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.2005.05599.x
更新日期：2005-07-01 00:00:00
abstract：:Platelet function was investigated in three patients with the Lesch-Nyhan syndrome. Platelet count, morphology and size distribution was normal in all patients. Platelet turnover was normal. Electron microscopy did not reveal any ultrastructural abnormality. Template bleeding times were normal and prolonged after aspi...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1975.tb00854.x
更新日期：1975-10-01 00:00:00
abstract：:The aim of this study was to analyse the expression of NK-associated antigens in both peripheral blood and bone marrow lymphocytes from a large series of newly diagnosed multiple myeloma patients. 112 patients with untreated multiple myeloma (MM) were included in the study. 36 sex- and age-matched healthy volunteers w...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.1996.4651006.x
更新日期：1996-04-01 00:00:00
abstract：:Splanchnic vein thrombosis (SVT) is one of the most important complications of myeloproliferative neoplasms (MPN). Although MPN are common causes of SVT, the pathophysiological mechanisms underlying this predisposition, their epidemiology and natural history are not fully understood. Studies have concentrated on the g...
journal_title：British journal of haematology
pub_type： 杂志文章,评审
doi：10.1111/bjh.12461
更新日期：2013-09-01 00:00:00
