Bcl-2 rearrangements with breakpoints in both vcr and mbr in non-Hodgkin's lymphomas and chronic lymphocytic leukaemia.

abstract：:Any influence of G-CSF on eosinophils is mostly negative, although reports which have studied this relationship are few with varied results. The aim of this study was to investigate the influence of G-CSF administration to healthy subjects on eosinophils in peripheral blood. Blood eosinophil counts, serum levels of eo...

journal_title：British journal of haematology

authors： Karawajczyk M,Höglund M,Ericsson J,Venge P

更新日期：1997-02-01 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficient individuals are at increased risk of developing haemolysis following treatment with various antimalarial drugs. Reliable field tests for G6PD deficiency are thus needed in chemotherapy studies and their validity has to be assessed. In two phase II clinical trials on m...

journal_title：British journal of haematology

authors： Meissner PE,Coulibaly B,Mandi G,Mansmann U,Witte S,Schiek W,Müller O,Schirmer RH,Mockenhaupt FP,Bienzle U

更新日期：2005-11-01 00:00:00

abstract：:An unusual variant of congenital dyserythropoietic anaemia is described presenting as mild haemolytic anaemia with multinucleated erythroblasts in the marrow of the proband. The outcome of her non-consanguineous pregnancy was a third trimester, in utero, fetal demise. The hydropic fetus had dyserythropoiesis with circ...

journal_title：British journal of haematology

authors： Roberts DJ,Nadel A,Lage J,Rutherford CJ

更新日期：1993-07-01 00:00:00

abstract：:A double-blind, crossover, placebo-controlled study of the effect of vitamin E on platelet functions was performed on nine splenectomized and 16 non-splenectomized beta-thalassaemia/haemoglobin E (beta-thalassaemia/HbE) patients. The patients were supplemented with a daily dose of vitamin E (525 IU) for 3 months. The ...

journal_title：British journal of haematology

authors： Unchern S,Laoharuangpanya N,Phumala N,Sipankapracha P,Pootrakul P,Fucharoen S,Wanachivanawin W,Chantharaksri U

更新日期：2003-11-01 00:00:00

abstract：:Although the combination of tyrosine kinase inhibitors with chemotherapy is widely used for young adults with Philadelphia chromosome positive-acute lymphoblastic leukaemia (Ph+ ALL), the outcome and safety of this combination using intensive paediatric-based protocols has not been well described. The clinical course ...

journal_title：British journal of haematology

authors： Thyagu S,Minden MD,Gupta V,Yee KW,Schimmer AD,Schuh AC,Lipton JH,Messner HA,Xu W,Brandwein JM

更新日期：2012-08-01 00:00:00

abstract：:Hepatitis E virus (HEV) is increasingly found to cause hepatitis in allogeneic haematopoietic stem cell transplantation (HSCT) patients. However, little is known about HEV infection in patients receiving haploidentical HSCT (haplo-HSCT). Here, we retrospectively evaluate the incidence and clinical course of HEV infect...

journal_title：British journal of haematology

authors： Tang FF,Mo XD,Wang Y,Yan CH,Chen YH,Chen H,Han W,Chang YJ,Zhang HY,Xie YD,Ma H,Wei L,Xu LP,Huang XJ,Zhang XH

更新日期：2019-03-01 00:00:00

abstract：:Blood from five donors, previously shown to be positive for cytomegalovirus (CMV) DNA following polymerase chain reaction (PCR) amplification, was filtered through commercially available leucocyte filters. Analysis of pre- and post-filtration samples by PCR with ethidium bromide staining has shown that filtration was ...

journal_title：British journal of haematology

authors： Smith KL,Cobain T,Dunstan RA

更新日期：1993-04-01 00:00:00

abstract：:The sera of 14 patients with quinine/quinidine-dependent thrombocytopenia were studied in the platelet suspension immunofluorescence test (PSIFT), the 51Cr-lysis assay and the complement fixation test (CFT). When anti-Ig or anti-IgG reagents were used, the PSIFT proved to be a little more sensitive than the 51Cr-lysis...

journal_title：British journal of haematology

authors： van Leeuwen EF,Engelfriet CP,von dem Borne AE

更新日期：1982-08-01 00:00:00

abstract：:Twenty-one cases of acute promyelocytic leukaemia (FAB M3) demonstrating t(15,17) chromosomal translocation were studied in detail by immunocytochemical techniques using a panel of monoclonal antibodies. A characteristic myeloid phenotype of the leukaemic cells, co-expression of CD9 and CD68 antigens and absence of HL...

journal_title：British journal of haematology

authors： Erber WN,Asbahr H,Rule SA,Scott CS

更新日期：1994-09-01 00:00:00

abstract：:The translocation t(8;16) (p11;p13) was found as the sole deviation from the normal karyotype in three patients with acute monocytic leukaemia. The bone marrow morphology was strikingly similar in the two cases where smears were available for re-evaluation: the leukaemic cells showed signs of differentiation, and acti...

journal_title：British journal of haematology

authors： Heim S,Avanzi GC,Billström R,Kristoffersson U,Mandahl N,Bekassy AN,Garwicz S,Wiebe T,Pegoraro L,Falda M

更新日期：1987-07-01 00:00:00

abstract：:In myeloid malignancies, T-cell and NK function has been shown to deteriorate with transformation from pre-leukaemia to advanced disease. Immune dysfunction in solid tumours has been attributed to abnormal signal transduction, possibly through altered expression of intracellular components of the TCR/CD3 complex (e.g....

journal_title：British journal of haematology

authors： Buggins AG,Hirst WJ,Pagliuca A,Mufti GJ

更新日期：1998-03-01 00:00:00

abstract：:The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH ...

journal_title：British journal of haematology

authors： Muchtar E,Dispenzieri A,Lacy MQ,Buadi FK,Kapoor P,Hayman SR,Gonsalves W,Warsame R,Kourelis TV,Chakraborty R,Russell S,Lust JA,Lin Y,Go RS,Zeldenrust S,Dingli D,Leung N,Rajkumar SV,Kyle RA,Kumar SK,Gertz MA

更新日期：2017-09-01 00:00:00

abstract：:Increasing use of direct oral anticoagulants (DOACs) has made management of non-valvular atrial fibrillation and venous thromboembolism easier in most patients. But the presence of co-existing renal impairment could render the use of DOACs problematic because all of these drugs have varying degrees of renal excretion....

journal_title：British journal of haematology

authors： Parker K,Thachil J

更新日期：2018-10-01 00:00:00

abstract：:Abnormal adhesive interaction between bone marrow stroma and progenitors, one of the causes of unregulated proliferation in chronic myelocytic leukaemia (CML), may be caused by some alterations in adhesion molecules on CML progenitors. We investigated the expression of adhesion molecules (CD44, VLA-5, VLA-4, LFA-1, IC...

journal_title：British journal of haematology

authors： Kawaishi K,Kimura A,Katoh O,Sasaki A,Oguma N,Ihara A,Satow Y

更新日期：1996-05-01 00:00:00

abstract：:We determined the proportion of survival variability explained by the usual prognostic factors in childhood acute lymphoblastic leukaemia (ALL) during a prognostic study of 1552 patients enrolled in three consecutive Fralle group protocols (Fralle 83, Fralle 87 and Fralle 89). The event-free survival rates at 5 years ...

journal_title：British journal of haematology

authors： Donadieu J,Auclerc MF,Baruchel A,Leblanc T,Landman-Parker J,Perel Y,Michel G,Cornu G,Bordigoni P,Sommelet D,Leverger G,Hill C,Schaison G

更新日期：1998-08-01 00:00:00

abstract：:There is little information published comparing peripheral blood stem cells (PBSC) with bone marrow (BM) as the stem cell source in the long-term outcome in recipients of T-cell depleted (TCD) unrelated donor (UD) transplants. We present retrospective outcome data on 306 recipients of myeloablative, human leucocyte an...

journal_title：British journal of haematology

authors： Shaw BE,Apperley JF,Russell NH,Craddock C,Liakopoulou E,Potter MN,Wynn R,Gibson B,Pearce RM,Kirkland K,Lee J,Madrigal JA,Cook G,Byrne JL

更新日期：2011-04-01 00:00:00

abstract：:Restriction endonuclease analysis has been performed on the alpha and beta globin gene clusters of 57 Cypriots homozygous for beta thalassaemia, 30 with the transfusion dependent form of the condition (thalassaemia major) and 27 who are less severely affected (thalassaemia intermedia). There was a significant differen...

journal_title：British journal of haematology

authors： Wainscoat JS,Kanavakis E,Wood WG,Letsky EA,Huehns ER,Marsh GW,Higgs DR,Clegg JB,Weatherall DJ

更新日期：1983-03-01 00:00:00

abstract：:Of 125 patients aged 65 years or over, with atrial fibrillation taking warfarin for at least 12 months, with a standard deviation (SD) of prothrombin time, expressed as the International Normalized Ratio (INR) >0.5 over the previous 6 months, 40 were randomized to continue with usual clinic care and 85 to receive educ...

journal_title：British journal of haematology

authors： Khan TI,Kamali F,Kesteven P,Avery P,Wynne H

更新日期：2004-08-01 00:00:00

abstract：:The effect of parenteral administration of IL-11 on gastrointestinal iron absorption was evaluated. A significant increase in the absorption of 59Fe-tagged food iron fed to fasting rats was observed when two subcutaneous injections of IL-11 were given 48 and 24 h prior to testing. Relatively similar increases of 25% w...

journal_title：British journal of haematology

authors： Baynes RD,Cook JD,Keith J

更新日期：1995-09-01 00:00:00

abstract：:Survival outcome of patients with peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL) who experience disease progression/relapse remains very poor. A total of 321 patients, newly diagnosed with PTCL-NOS (n = 180) or AITL (n = 141) between 1999 and 2015, were anal...

journal_title：British journal of haematology

authors： Chihara D,Fanale MA,Miranda RN,Noorani M,Westin JR,Nastoupil LJ,Hagemeister FB,Fayad LE,Romaguera JE,Samaniego F,Turturro F,Lee HJ,Neelapu SS,Rodriguez MA,Wang M,Fowler NH,Davis RE,Medeiros LJ,Hosing C,Nieto YL,Ok

更新日期：2017-03-01 00:00:00

abstract：:Polycythaemia vera (PV) patients have an overall comparatively favourable prognosis, but disease progression is very heterogeneous and life-threatening thrombosis and bleedings are frequent complications in untreated disease. Moreover, transformation to more severe secondary myelofibrosis and acute myeloid leukaemia c...

journal_title：British journal of haematology

authors： Andréasson B,Pettersson H,Wasslavik C,Johansson P,Palmqvist L,Asp J

更新日期：2020-06-01 00:00:00

abstract：:A collaborative study on factor VIII related antigen (VIII R:Ag) has been carried out, involving 11 laboratories in the U.K. Samples of two different freeze-dried plasmas were assayed against participants' own local standards by the Laurell electroimmunoassay method. There was reasonably good agreement on the relative...

journal_title：British journal of haematology

authors： Kirkwood TB,Barrowcliffe TW

更新日期：1980-11-01 00:00:00

abstract：:We have investigated the control of lysozyme gene expression in HL-60 cells induced to differentiate into macrophage-like cells with phorbol myristate acetate (PMA). Differentiation, as evidenced by cellular adherence, and morphological changes corresponded temporally to an increase in nonspecific esterase activity. T...

journal_title：British journal of haematology

authors： Polansky DA,Yang A,Brader K,Miller DM

更新日期：1985-05-01 00:00:00

abstract：:Inhibition of apoptosis (genetically programmed active cell death) by p210 BCR-ABL expression is a mechanism that might contribute to clonal expansion in chronic myeloid leukaemia (CML). Since cell death following exposure to ionizing radiation and many chemotherapeutic agents can occur by the apoptotic pathway, inhib...

journal_title：British journal of haematology

authors： Amos TA,Lewis JL,Grand FH,Gooding RP,Goldman JM,Gordon MY

更新日期：1995-10-01 00:00:00

abstract：:Epistaxis is a common problem amongst anti-coagulated patients. Application of first-aid principles can control the majority of bleeds. In our sample of 60 patients attending the anticoagulant clinic, 40% were unable to think of a single measure that would be helpful in controlling a nose bleed. 6 weeks after being gi...

journal_title：British journal of haematology

authors： Lavy J

更新日期：1996-10-01 00:00:00

abstract：:Myeloma cells thrive in an environment of sustained inflammation, which impacts the development and evolution of the disease, as well as drug resistance. We evaluated the impact of genetic polymorphisms in the Toll-like receptor 4 (TLR4) pathway, which have been implicated in different inflammatory responses in the ou...

journal_title：British journal of haematology

authors： Bagratuni T,Terpos E,Eleutherakis-Papaiakovou E,Kalapanida D,Gavriatopoulou M,Migkou M,Liacos CI,Tasidou A,Matsouka C,Mparmparousi D,Dimopoulos MA,Kastritis E

更新日期：2016-01-01 00:00:00

abstract：:A prospective study was undertaken to determine the effectiveness of an empirical antibiotic therapy regimen in 34 neutropenic patients undergoing bone marrow transplantation or remission-induction chemotherapy for leukaemia. Throughout the study period a total of 90 pyrexial episodes were monitored in which organisms...

journal_title：British journal of haematology

authors： Barnes RA,Rogers TR

更新日期：1987-05-01 00:00:00

abstract：:Anaplastic large cell lymphomas (ALCLs) are rare CD30+ peripheral T-cell lymphomas (PTCLs) classified according to the expression of the anaplastic lymphoma kinase (ALK+) protein or not (ALK-). We have analysed the outcome and risk factors for survival in a population-based bi-national cohort of patients with systemic...

journal_title：British journal of haematology

authors： Cederleuf H,Bjerregård Pedersen M,Jerkeman M,Relander T,d'Amore F,Ellin F

更新日期：2017-09-01 00:00:00

abstract：:In a series of 306 cases of myeloproliferative disorders followed over a period of 21 years, 18 cases of well-documented acute leukaemia were encountered. Leukaemias were either acute myeloblastic or myelomonocytic and occurred from 6 months to 20 years after the initial diagnosis. Onset was relatively abrupt and the ...

journal_title：British journal of haematology

authors： Rosenthal DS,Moloney WC

更新日期：1977-07-01 00:00:00

abstract：:Transient myeloproliferative disorder (TMD) of the newborn and acute megakaryoblastic leukaemia (AMKL) in children with Down syndrome (DS) represent paradigmatic models of leukaemogenesis. Chromosome 21 gene dosage effects and truncating mutations of the X-chromosomal transcription factor GATA1 synergize to trigger TM...

journal_title：British journal of haematology

authors： Haemmerling S,Behnisch W,Doerks T,Korbel JO,Bork P,Moog U,Hentze S,Grasshoff U,Bonin M,Rieß O,Janssen JW,Jauch A,Bartram CR,Reinhardt D,Koch KA,Bandapalli OR,Kulozik AE

更新日期：2012-04-01 00:00:00