Hepatitis E virus infection after haploidentical haematopoietic stem cell transplantation: incidence and clinical course.

abstract：:Immunophenotypic studies, fluorescence in situ hybridization (FISH) and conventional karyotyping were used to define the clinicobiological significance of 14q32 translocations involving the immunoglobulin gene locus (14q32/IGH) in 252 chronic lymphocytic leukaemia (CLL) patients. The following regions were studied: 13...

journal_title：British journal of haematology

authors： Cavazzini F,Hernandez JA,Gozzetti A,Russo Rossi A,De Angeli C,Tiseo R,Bardi A,Tammiso E,Crupi R,Lenoci MP,Forconi F,Lauria F,Marasca R,Maffei R,Torelli G,Gonzalez M,Martin-Jimenez P,Maria Hernandez J,Rigolin GM,Cune

更新日期：2008-08-01 00:00:00

abstract：:Diamond-Blackfan anaemia (DBA) is a rare bone marrow failure syndrome characterised by anaemia, congenital anomalies and cancer predisposition. Although infections are the second leading cause of mortality in non-transplanted patients, immune function is largely unexplored. We identified quantitative deficits in serum...

journal_title：British journal of haematology

authors： Iskander D,Roberts I,Rees C,Szydlo R,Alikian M,Neale M,Harrington Y,Kelleher P,Karadimitris A,de la Fuente J

更新日期：2019-07-01 00:00:00

abstract：:We report on quantitative analyses of C5b-9 binding to target red blood cells (RBC) lysed through the action of drug (nomifensine)-dependent antibodies (ddab) and anti-RBC antibodies (warm plus cold agglutinins). Immunoradiometric assays showed that, at any given degree of haemolysis, more C5b-9 was bound to cells sen...

journal_title：British journal of haematology

authors： Salama A,Mueller-Eckhardt C,Boschek B,Bhakdi S

更新日期：1987-02-01 00:00:00

abstract：:Immunohistochemistry of acute leukaemias in bone-marrow paraffin sections is commonly thought to be useless because of the poor preservation of many lineage-related markers. The recent development of antibodies against fixative-resistant epitopes and of new antigen retrieval techniques, however, has expanded the possi...

journal_title：British journal of haematology

authors： Pileri SA,Ascani S,Milani M,Visani G,Piccioli M,Orcioni GF,Poggi S,Sabattini E,Santini D,Falini B

更新日期：1999-05-01 00:00:00

abstract：:Heterozygosity for a C8524T transition in the protein C gene converting Ser270(TCG) to Leu(TTG) in the protease domain was identified in a family with venous thrombosis. The mutation was associated with parallel reduction in plasma levels of protein C anticoagulant activity and protein C antigen, which is consistent w...

journal_title：British journal of haematology

authors： Lind B,Koefoed P,Thorsen S

更新日期：2001-06-01 00:00:00

abstract：:Recurrent large-scale somatic copy number alterations (SCNAs), and somatic point mutations can be analysed to stratify patients with chronic lymphocytic leukaemia (CLL) into distinct prognostic groups. To investigate the relationship between SCNAs and somatic mutations, we performed whole-exome sequencing and single n...

journal_title：British journal of haematology

authors： Zhou W,Goldin L,Wang M,McMaster ML,Jones K,Burdett L,Chanock SJ,Yeager M,Dean M,Caporaso NE

更新日期：2018-06-01 00:00:00

abstract：:The maintenance of physiological levels of haemoglobin is beneficial in the management of patients with thalassaemia major since it leads to better tissue oxygenation, reduction of blood volume, and reduced intestinal absorption of iron. We have studied 11 patients with thalassaemia major while treating them for 4-12 ...

journal_title：British journal of haematology

authors： Masera G,Terzoli S,Avanzini A,Fontanelli G,Mauri RA,Piacentini G,Ferrari M

更新日期：1982-09-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH), the most common histiocytic disorder, is characterized by the accumulation of CD1A(+) /CD207(+) mononuclear phagocytes within granulomatous lesions that can affect nearly all organ systems. Historically, LCH has been presumed to arise from transformed or pathologically activated ep...

journal_title：British journal of haematology

authors： Berres ML,Merad M,Allen CE

更新日期：2015-04-01 00:00:00

abstract：:The granulocytes of 23 patients with chronic granulocytic leukaemia were examined in the indirect immunofluorescence test and some also in the microleucoagglutination test, with specific alloantisera against the NA1, NA2, NB1 and ND1 antigens and a specific granulocyte xenoantiserum. In 10 cases a complete loss of all...

journal_title：British journal of haematology

authors： Reijden JH,von dem Borne AE,Verheugt FW,Floor-van Gent AB,Melief CJ,Engelfriet CP

更新日期：1979-12-01 00:00:00

abstract：:In a 2.5-month-old infant with beta-thalassaemia major, DNA analysis of the gamma-beta region revealed homozygosity for two large deletions removing the entire psi beta and beta regions including their 5' promoter regions but leaving the delta gene intact. The downstream deletion was predicted to be 7.6 kb in length e...

journal_title：British journal of haematology

authors： Oner C,Oner R,Gürgey A,Altay C

更新日期：1995-02-01 00:00:00

abstract：:Previously described platelet-aggregating antibodies associated with thrombosis and thrombocytopenia required heparin for their in vivo and in vitro expression. We have observed a patient with thrombosis who became thrombocytopenic during heparin treatment, but who suffered further thrombotic events and continued thro...

journal_title：British journal of haematology

authors： Pfueller SL,David R,Firkin BG,Bilston RA,Cortizo WF,Raines G

更新日期：1990-03-01 00:00:00

abstract：:Cooley's original description of beta-thalassaemia major included marked bone deformities as a characteristic feature. These were thought to be due to expansion of haemopoiesis attempting to compensate for the congenital anaemia. Regular blood transfusions from infancy prevents these skeletal problems. Nevertheless, s...

journal_title：British journal of haematology

authors： Jensen CE,Tuck SM,Agnew JE,Koneru S,Morris RW,Yardumian A,Prescott E,Hoffbrand AV,Wonke B

更新日期：1998-12-01 00:00:00

abstract：:We report a patient with CML in relapse after a sex-mismatch bone marrow transplant who was treated with donor lymphocyte infusions and developed severe marrow aplasia 3 months later. As cytogenetic analysis at this point was not possible because of the very low number of marrow cells available, we used in situ hybrid...

journal_title：British journal of haematology

authors： Garicochea B,van Rhee F,Spencer A,Chase A,Lin F,Cross NC,Goldman JM

更新日期：1994-10-01 00:00:00

abstract：:The very poor outcome of invasive fungal infections (IFI) in patients with haematological malignancies or recipients of haematopoietic stem cell transplantation is largely attributed to their compromised host defence mechanisms. The restoration or augmentation of immune responses in these patients is now considered as...

journal_title：British journal of haematology

authors： Antachopoulos C,Roilides E

更新日期：2005-06-01 00:00:00

abstract：:It is the capacity to generate thrombin, and the enzymatic work that thrombin does, that determines blood coagulability. Therefore, measurement of the enzymatic work potential of thrombin provides a method for quantifying the composite effect of the multiple factors that determine coagulation capacity. The application...

journal_title：British journal of haematology

authors： Baglin T

更新日期：2005-09-01 00:00:00

abstract：:The prognostic relevance of karyotype has been established in adult acute lymphoblastic leukaemia (ALL) patients treated with chemotherapy but not definitively evaluated in an allogeneic bone marrow transplantation (BMT) setting. To determine the factors affecting the outcome of allogeneic BMT for adults with precurso...

journal_title：British journal of haematology

authors： Lee S,Kim DW,Kim YJ,Park YH,Min CK,Lee JW,Min WS,Kim CC

更新日期：2002-04-01 00:00:00

abstract：:Our knowledge of the cellular and molecular mechanisms of platelet production has greatly expanded in recent years due to the opportunity to culture in vitro megakaryocytes and to create transgenic animals with specific genetic defects that interfere with platelet biogenesis. However, in vitro models do not reproduce ...

journal_title：British journal of haematology

authors： Pecci A,Balduini CL

更新日期：2014-04-01 00:00:00

abstract：:Paediatric B-cell non-Hodgkin lymphoma (B-NHL) compromises a heterogeneous group of histological entities of which Burkitt lymphoma is the most common. In resource-rich countries, the expected cure rate is in excess of 85% with application of risk-adapted short intensive chemotherapy. In recent years, large paediatric...

journal_title：British journal of haematology

authors： Giulino-Roth L,Goldman S

更新日期：2016-05-01 00:00:00

abstract：:To evaluate the clinical significance of CD21S expression of diffuse large B-cell lymphoma (DLBCL) tumour cells, we compared their clinical features, immunophenotype, response to therapy and outcome in relation to CD21S expression. Between 1987 and 1999, frozen sections from 240 DLBCL cases were examined for CD21S exp...

journal_title：British journal of haematology

authors： Ogawa S,Yamaguchi M,Oka K,Taniguchi M,Ito M,Nishii K,Nakase K,Ohno T,Kita K,Kobayashi T,Shiku H

更新日期：2004-04-01 00:00:00

abstract：:Primary infection with Epstein-Barr virus (EBV) in childhood is usually asymptomatic, whereas infection in adolescence may result in infectious mononucleosis (IM) often followed by a fatigue syndrome. EBV latent membrane protein 1 (LMP1) is expressed in latency and in many EBV-associated tumours, including non-Hodgkin...

journal_title：British journal of haematology

authors： Marshall NA,Culligan DJ,Johnston PW,Millar C,Barker RN,Vickers MA

更新日期：2007-10-01 00:00:00

abstract：:Peripheral blood stem cell autografts for the treatment of chronic myeloid leukaemia (CML) are currently under evaluation. A patient with CML received intensive chemotherapy followed by granulocyte colony-stimulating factor prior to the collection of peripheral blood derived stem cells. He developed unusually severe, ...

journal_title：British journal of haematology

authors： Clark RE,Lee ES

更新日期：1995-06-01 00:00:00

abstract：:The effects of donor T cells, or their CD8+ subset, on engraftment and tolerance induction in fetal transplantation were evaluated using an F1-into-parent mouse-model that does not permit a graft-versus-host effect. Gestational day 13 C57BL/6 (H-2Kb) fetuses were transplanted with B6D2F1 (H-2Kb/d) light density bone m...

journal_title：British journal of haematology

authors： Chen JC,Chang ML,Lee H,Muench MO

更新日期：2004-08-01 00:00:00

abstract：:Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells with a phenotype of ...

journal_title：British journal of haematology

authors： Rasmussen T,Kastrup J,Knudsen LM,Johnsen HE

更新日期：1999-04-01 00:00:00

abstract：:Cyclosporin A (CSA) exhibits greater multidrug resistance (MDR) modulating activity in vitro than other MDR modulators such as verapamil and quinidine. However, the immunosuppressive and nephrotoxic effects of CSA may limit its clinical use. PSC 833, a new cyclosporin D derivative, exerts a higher MDR reversal activit...

journal_title：British journal of haematology

authors： Jiang XR,Kelsey SM,Wu YL,Newland AC

更新日期：1995-06-01 00:00:00

abstract：:Cord blood (CB) has successfully been used as a stem cell source for haemopoietic reconstitution. However, a significant delay in platelet engraftment is consistently found in CB versus adult peripheral blood (PB) or bone marrow transplants. We sought to determine whether or not CB megakaryocytes have reached terminal...

journal_title：British journal of haematology

authors： Bornstein R,García-Vela J,Gilsanz F,Auray C,Calés C

更新日期：2001-08-01 00:00:00

abstract：:In a uniform series of 170 untreated myeloma patients (MM) we investigated the distribution of T cell subsets in peripheral blood (PB) and their relationship with the most relevant disease characteristics, including survival. CD4 cells were significantly decreased both in percentage and absolute numbers (P less than 0...

journal_title：British journal of haematology

authors： San Miguel JF,González M,Gascón A,Moro MJ,Hernández JM,Ortega F,Jiménez R,Guerras L,Romero M,Casanova F

更新日期：1992-03-01 00:00:00

abstract：:Virchow's triad describes three factors that contribute to the development of venous thrombosis: hypercoagulability, stasis and endothelial injury. Yet, extensive review of the historical literature casts doubt on the existence of a triad described by Virchow in the form it is currently quoted throughout contemporary ...

journal_title：British journal of haematology

authors： Bagot CN,Arya R

更新日期：2008-10-01 00:00:00

abstract：:A uniform system of classification and nomenclature of the acute leukaemias, at present lacking, should permit more accurate recording of the distribution of cases entered into clinical trials, and could provide a reference standard when newly developed cell-surface markers believed to characterize specific cell types...

journal_title：British journal of haematology

authors： Bennett JM,Catovsky D,Daniel MT,Flandrin G,Galton DA,Gralnick HR,Sultan C

更新日期：1976-08-01 00:00:00

abstract：:Since glycoprotein IV (GPIV) has been shown to play an important role in the interaction of platelets with collagen and thrombospondin, the aggregation and secretion of GPIV-deficient platelets were examined. Using a binding assay with monoclonal 125I-OKM5 antibody against CD36 antigen and crossed immunoelectrophoresi...

journal_title：British journal of haematology

authors： Yamamoto N,Akamatsu N,Yamazaki H,Tanoue K

更新日期：1992-05-01 00:00:00

abstract：:This case study provides evidence for clonal evolution in pre-B-cell leukaemia. At diagnosis, the lymphoblasts from a 3-year-old boy were morphologically subtyped as L1 (French-American-British classification). Their immunophenotype was CALLA+, CIgM+, SIg-, TdT+, and the karyotype was pseudodiploid with a 1;19 translo...

journal_title：British journal of haematology

authors： Abromowitch M,Williams DL,Melvin SL,Stass S

更新日期：1984-03-01 00:00:00