Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis.

abstract：:The incidence, characteristics and risk factors for the development of osteonecrosis of the jaw (ONJ) were evaluated among 303 myeloma patients. Only patients who received bisphosphonates developed ONJ (28/254; 11%). Zoledronic acid produced 9.5-fold greater risk for developing ONJ than pamidronate alone (P = 0.042) a...

journal_title：British journal of haematology

authors： Zervas K,Verrou E,Teleioudis Z,Vahtsevanos K,Banti A,Mihou D,Krikelis D,Terpos E

更新日期：2006-09-01 00:00:00

abstract：:The levels of soluble CD9 antigen released into spent medium from bone marrow (BM) cells were assayed using a unique enzyme-linked immunosorbent assay. We demonstrated that a considerable amount of soluble CD9 antigen was consistently detected in the spent medium from CD9+ leukaemic blasts, but little from normal or r...

journal_title：British journal of haematology

authors： Komada Y,Zhang SL,Zhou YW,Shibata T,Azuma E,Sakurai M

更新日期：1992-08-01 00:00:00

abstract：:We describe three patients with chronic granulocytic leukaemia who developed impaired visual acuity in association with high leucocyte counts. Two of the patients were in the chronic phase of their disease and the third developed visual symptoms at the time of blastic transformation. Fundoscopy showed retinal haemorrh...

journal_title：British journal of haematology

authors： Mehta AB,Goldman JM,Kohner E

更新日期：1984-04-01 00:00:00

abstract：:Whole exome sequencing and copy number aberration (CNA) analysis were performed on cells taken from peripheral blood (PB) and lymph nodes (LN) of patients with chronic lymphocytic leukaemia (CLL). Of 64 non-silent somatic mutations, 54 (84·4%) were clonal in both compartments, 3 (4·7%) were PB-specific and 7 (10·9%) w...

journal_title：British journal of haematology

authors： Del Giudice I,Marinelli M,Wang J,Bonina S,Messina M,Chiaretti S,Ilari C,Cafforio L,Raponi S,Mauro FR,Di Maio V,De Propris MS,Nanni M,Ciardullo C,Rossi D,Gaidano G,Guarini A,Rabadan R,Foà R

更新日期：2016-02-01 00:00:00

abstract：:Total knee replacement (TKR) is a safe treatment for alleviating pain and restoring physical function in end-stage arthropathy of the knee. First reports of TKR in haemophiliacs date back to the mid-1970s, however detailed information on long-term outcome is scarce. This study evaluated factors influencing the outcome...

journal_title：British journal of haematology

authors： Solimeno LP,Mancuso ME,Pasta G,Santagostino E,Perfetto S,Mannucci PM

更新日期：2009-04-01 00:00:00

abstract：:We have characterized the molecular defect in two families with severe factor VII (FVII) deficiency. In family I, the proband was found to be homozygous for a novel 18 bp deletion in exon 8 (g.10896-10913del) resulting in the in-frame deletion of six amino acids in the serine protease domain. Molecular modelling sugge...

journal_title：British journal of haematology

authors： Gomez K,Laffan MA,Kemball-Cook G,Pasi J,Layton M,Singer JD,Tuddenham EG,McVey JH

更新日期：2004-07-01 00:00:00

abstract：:Rearrangement of the immunoglobulin heavy chain (IgH) gene is widely exploited as a marker of B cell lineage and clonality in the pathology of lymphoproliferative disorders. We have developed a simple, polymerase chain reaction (PCR) based method for detecting IgH gene rearrangement which relies on the observation tha...

journal_title：British journal of haematology

authors： Deane M,Norton JD

更新日期：1991-03-01 00:00:00

abstract：:The combination of bortezomib and rituximab was evaluated in patients with mantle cell lymphoma (MCL), follicular lymphoma (FL) and Waldenström macroglobulinaemia (WM), in a Phase I and later, a randomized Phase II study. In the randomized study, 42 patients with recurrent/refractory disease received either: bortezomi...

journal_title：British journal of haematology

authors： Agathocleous A,Rohatiner A,Rule S,Hunter H,Kerr JP,Neeson SM,Matthews J,Strauss S,Montoto S,Johnson P,Radford J,Lister A

更新日期：2010-11-01 00:00:00

abstract：:The frequency and prognostic relevance of translocations t(11;14) and t(4;14), the most common translocations involving the immunoglobulin heavy chain (IgH) gene in multiple myeloma (MM), were investigated in 128 patients treated with intensive chemotherapy and autologous stem cell transplant. Myeloma cells were ident...

journal_title：British journal of haematology

authors： Chang H,Sloan S,Li D,Zhuang L,Yi QL,Chen CI,Reece D,Chun K,Keith Stewart A

更新日期：2004-04-01 00:00:00

abstract：:Immune-mediated pathways have been recognized to be of importance in the pathogenesis of chronic lymphocytic leukaemia (CLL). We assessed a broad variety of immune-related and inflammatory conditions and subsequent CLL development among 4 million adult male veterans admitted to VA hospitals. We identified 3,680 CLL ca...

journal_title：British journal of haematology

authors： Landgren O,Gridley G,Check D,Caporaso NE,Morris Brown L

更新日期：2007-12-01 00:00:00

abstract：:Venesection of 10% of whole blood volume or plateletpheresis was performed in nine patients with chronic myeloproliferative disorders and in five normal control subjects. Before venesection, the patients showed impaired platelet aggregation in 33% of tests, most often in response to stimulation with 9 mumol adrenaline...

journal_title：British journal of haematology

authors： Boughton BJ

更新日期：1978-08-01 00:00:00

abstract：:The safety and efficacy of the combination clofarabine/cyclophosphamide/etoposide were evaluated in children with advanced acute lymphoblastic leukaemia (ALL). The study enrolled 25 paediatric patients (median age 12.5 years) with either refractory (n = 17; 68%) or multiple relapsed (n = 8; 32%) ALL to receive clofara...

journal_title：British journal of haematology

authors： Locatelli F,Testi AM,Bernardo ME,Rizzari C,Bertaina A,Merli P,Pession A,Giraldi E,Parasole R,Barberi W,Zecca M

更新日期：2009-11-01 00:00:00

abstract：:The prognostic impact of bone marrow biopsy (BMB) histology and CD34 immunoreactivity was compared with that of the more conventional parameters (the FAB diagnosis, peripheral blood values, percentage of BM blasts and some common prognostic scores) in 100 MDS patients. Statistical correlations among the cytological, h...

journal_title：British journal of haematology

authors： Oriani A,Annaloro C,Soligo D,Pozzoli E,Cortelezzi A,Lambertenghi Deliliers G

更新日期：1996-02-01 00:00:00

abstract：:We evaluated the additional benefit of Technetium(99)-sestamibi (99mTc-MIBI) scanning in comparison with standard X-ray techniques for multiple myeloma patients either at diagnosis or during follow-up. Between February 2001 and January 2005, 397 whole body scans were acquired. On 229 scans performed at diagnosis, 146 ...

journal_title：British journal of haematology

authors： Mele A,Offidani M,Visani G,Marconi M,Cambioli F,Nonni M,Catarini M,Brianzoni E,Berbellini A,Ascoli G,Brunori M,Agostini V,Corvatta L,Isidori A,Spinelli A,Gradari M,Leoni P

更新日期：2007-03-01 00:00:00

abstract：:Haemophilia B Leyden is characterized by severe factor IX deficiency during childhood with partial resolution at puberty or following the administration of anabolic steroids. The disorder has recently been associated with point mutations in the putative factor IX promoter region, which contains an imperfect direct rep...

journal_title：British journal of haematology

authors： Royle G,Van de Water NS,Berry E,Ockelford PA,Browett PJ

更新日期：1991-02-01 00:00:00

abstract：:Sickle cell anaemia (SS) and sickle cell-haemoglobin C disease (SC) patients exhibit severe red blood cell (RBC) rheological alterations involved in the development of several complications. The contribution of oxidative stress in these haemorheological abnormalities is still unknown. We compared RBC reactive oxygen s...

journal_title：British journal of haematology

authors： Hierso R,Waltz X,Mora P,Romana M,Lemonne N,Connes P,Hardy-Dessources MD

更新日期：2014-08-01 00:00:00

abstract：:Marizomib (MRZ) is an irreversible, pan-subunit proteasome inhibitor (PI) in clinical development for relapsed/refractory multiple myeloma (RRMM) and glioma. This study analysed MRZ, pomalidomide (POM) and low-dose dexamethasone (Lo-DEX) [PMD] in RRMM to evaluate safety and determine the maximum tolerated dose (MTD) a...

journal_title：British journal of haematology

authors： Spencer A,Harrison S,Zonder J,Badros A,Laubach J,Bergin K,Khot A,Zimmerman T,Chauhan D,Levin N,MacLaren A,Reich SD,Trikha M,Richardson P

更新日期：2018-01-01 00:00:00

abstract：:The myelodysplastic syndromes (MDS) have a significant frequency of evolution into acute myeloid leukaemia (AML). Approximately 30% of MDS patients show activating mutations of the N-RAS proto-oncogene, and these patients are at increased risk of leukaemic evolution. Long-term survivors of aplastic anaemia (AA) and pa...

journal_title：British journal of haematology

authors： White JR,Josten KM,Chopra R,Tooze J,Saso R,Gordon-Smith EC,Rutherford TR

更新日期：1995-12-01 00:00:00

abstract：:Allogeneic sibling bone marrow transplantation (BMT) is the recommended treatment for relapsed childhood acute lymphoblastic leukaemia (ALL), but appropriate donors are only available in 30% of cases. Unfortunately, BMT from unrelated donors (UD) has been associated with high rates of severe graft-versus-host disease ...

journal_title：British journal of haematology

authors： Oakhill A,Pamphilon DH,Potter MN,Steward CG,Goodman S,Green A,Goulden P,Goulden NJ,Hale G,Waldmann H,Cornish JM

更新日期：1996-09-01 00:00:00

abstract：:The recent advent of an improved commercial serum enzyme-linked immunosorbent assay (ELISA) for the detection of circulating galactomannan (GM), a major constituent of Aspergillus cell walls, has contributed to the diagnosis of invasive aspergillosis (IA) in many haematology and transplant centres. However, the optima...

journal_title：British journal of haematology

authors： Maertens J,Theunissen K,Verbeken E,Lagrou K,Verhaegen J,Boogaerts M,Eldere JV

更新日期：2004-09-01 00:00:00

abstract：:The regulatory human immunodeficiency virus-1 (HIV-1) Tat protein shows pleiotropic effects on the survival and growth of both HIV-1-infected and uninfected CD4+ T lymphocytes. In this study, we have demonstrated that low concentrations (10 ng/ml) of extracellular Tat protein induce the expression of both c-fos mRNA a...

journal_title：British journal of haematology

authors： Gibellini D,Re MC,Ponti C,Celeghini C,Melloni E,La Placa M,Zauli G

更新日期：2001-03-01 00:00:00

abstract：:In 44 of 56 patients with malignant paraproteinaemia the relationship of serum viscosity, plasma volume (PV), estimated blood volume (BV) and clinical findings was investigated and in the remaining 12 patients one or more of these parameters was studied. There was a correlation between increased PV and serum viscosity...

journal_title：British journal of haematology

authors： Russell JA,Powles RL

更新日期：1978-06-01 00:00:00

abstract：:Recently developed ferrokinetic methods offer a tool to measure effective and ineffective erythropoiesis and mean red-cell lifespan (Ricketts et al, 1975). We have used this tool to investigate erythropoiesis in normal subjects and in patients with the anaemia of active rheumatoid arthritis. In normal subjects the res...

journal_title：British journal of haematology

authors： Dinant HJ,de Maat CE

更新日期：1978-07-01 00:00:00

abstract：:The inv(8)(p11q13) chromosomal abnormality, described in acute myeloid leukaemias (AML), fuses the histone acetyl-transferase (HAT) MYST3 (MOZ) gene with another HAT gene, NCOA2 (TIF2). We generated a transgenic zebrafish in which the MYST3/NCOA2 fusion gene was expressed under control of the spi1 promoter. An AML dev...

journal_title：British journal of haematology

authors： Zhuravleva J,Paggetti J,Martin L,Hammann A,Solary E,Bastie JN,Delva L

更新日期：2008-11-01 00:00:00

abstract：:Prospective studies in children with B-precursor acute lymphoblastic leukaemia (ALL) have shown that polymerase chain reaction (PCR)-based detection of minimal residual disease (MRD) using immunoglobin (Ig) and T-cell receptor (TCR) gene rearrangements as targets can be used to identify patients with a high relapse ri...

journal_title：British journal of haematology

authors： de Haas V,Breunis WB,Dee R,Verhagen OJ,Kroes W,van Wering ER,van Dongen JJ,van den Berg H,van der Schoot CE

更新日期：2002-01-01 00:00:00

abstract：:Employing an immunoblotting procedure, we have identified and characterized an autoantigen carried on glycoprotein (GP) IIb in a patient with chronic idiopathic thrombocytopenic purpura (ITP), and have compared the location of the autoantigen with that of the platelet-specific alloantigen Baka. Immunoblots, using the ...

journal_title：British journal of haematology

authors： Tomiyama Y,Kurata Y,Shibata Y,Honda S,Furubayashi T,Mizutani H,Tsubakio T,Yonezawa T,Tarui S

更新日期：1989-01-01 00:00:00

abstract：:Whether or not pregnant women with a previous episode of venous thromboembolism (VTE) should receive antithrombotic prophylaxis is a matter of debate. In order to estimate the rate of recurrent deep venous thrombosis (DVT) or pulmonary embolism (PE) during pregnancy and puerperium we retrospectively investigated a coh...

journal_title：British journal of haematology

authors： De Stefano V,Martinelli I,Rossi E,Battaglioli T,Za T,Mannuccio Mannucci P,Leone G

更新日期：2006-11-01 00:00:00

abstract：:During the administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) or granulocyte-macrophage CSF (rhGM-CSF) we studied the early and late changes of membrane antigen density on neutrophils. RhG-CSF and rhGM-CSF both caused an early transient reduction in blood neutrophilic granulocyte-conce...

journal_title：British journal of haematology

authors： Hansen PB,Kjaersgaard E,Johnsen HE,Gram J,Pedersen M,Nikolajsen K,Hansen NE

更新日期：1993-09-01 00:00:00

abstract：:Although many cases of multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are cytogenetically normal, interphase fluorescence in situ hybridization (FISH) analyses reveal aberrations in the majority of the cases. Most likely, non-neoplastic cells are more prone to divide in culture tha...

journal_title：British journal of haematology

authors： Nilsson T,Lenhoff S,Rylander L,Höglund M,Turesson I,Mitelman F,Westin J,Johansson B

更新日期：2004-08-01 00:00:00

abstract：:Given that donor T cells from a transplant contribute both the desired graft-versus-tumour (GVT) effect and detrimental graft-versus-host disease (GVHD), strategies to separate GVHD and GVT activity are a major clinical goal. We have previously demonstrated that in vivo administration of a recombinant (r)IL-7/HGFβ hyb...

journal_title：British journal of haematology

authors： Hu R,Liu Y,Song Y,Su M,Lu X,Rood D,Lai L

更新日期：2016-11-01 00:00:00