Sebestenoids A-D, BACE1 inhibitors from Cordia sebestena.

Abstract:

:Bioassay-guided fractionation of an extract prepared from the fruits of Cordia sebestena led to the isolation of sebestenoids A-D (1-4). Their structures were elucidated on the basis of extensive NMR experiments and mass spectroscopic measurements. Compounds 1-4 exhibited moderate inhibition of the aspartic protease BACE1.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Dai J,Sorribas A,Yoshida WY,Williams PG

doi

10.1016/j.phytochem.2010.09.008

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

2168-73

issue

17-18

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(10)00349-3

journal_volume

71

pub_type

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