Characterization of multiple molecular interactions between human cytomegalovirus (HCMV) and human immunodeficiency virus type 1 (HIV-1).

abstract：:Epstein-Barr virus (EBV) is known to infect B cells and epithelial cells. We and others have shown that EBV can also infect a subset of thymocytes. Infection of thymocytes was accompanied by the appearance of linear EBV genome within 8 hr of infection. Circularization of the EBV genome was not detected. This is in con...

journal_title：Virology

authors： Kelleher CA,Paterson RK,Dreyfus DH,Streib JE,Xu JW,Takase K,Jones JF,Gelfand EW

更新日期：1995-04-20 00:00:00

abstract：:The unordered N-termini of parvovirus capsid proteins (Nt) are translocated through a channel at the icosahedral five-fold axis to serve for virus traffick. Heterologous peptides were genetically inserted at the Nt of MVM to study their functional tolerance to manipulations. Insertion of a 5T4-single-chain antibody at...

journal_title：Virology

authors： Sánchez-Martínez C,Grueso E,Carroll M,Rommelaere J,Almendral JM

更新日期：2012-10-10 00:00:00

abstract：:Reactivation of latent herpes simplex virus 2 (HSV-2) infections can be characterized by episodic recurrent genital lesions and/or viral shedding. We hypothesize that infected (HSV-2(pos)) asymptomatic individuals have acquired T cell responses to specific HSV-2 antigen(s) that may be an important factor in controllin...

journal_title：Virology

authors： Long D,Skoberne M,Gierahn TM,Larson S,Price JA,Clemens V,Baccari AE,Cohane KP,Garvie D,Siber GR,Flechtner JB

更新日期：2014-09-01 00:00:00

abstract：:Studies attempting to identify reservoirs of HIV-1 latency have documented that the virus persists as both a latent and productive infection in subsets of CD4(+) cells. Reports regarding establishment of a stable HIV-1 infection in quiescent T cells in vitro, however, are controversial. In the present study, we invest...

journal_title：Virology

authors： Joshi A,Vahlenkamp TW,Garg H,Tompkins WA,Tompkins MB

更新日期：2004-04-10 00:00:00

abstract：:Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analy...

journal_title：Virology

authors： Na H,Huisman W,Ellestad KK,Phillips TR,Power C

更新日期：2010-09-01 00:00:00

abstract：:New sequences have been obtained by successive overlapping RT-PCR extensions from the pol region of a retroviral RNA (multiple sclerosis-associated retroviral element, MSRV) amplified in retrovirus-like particles from patients with multiple sclerosis. gag and pol sequences are related to type C oncoviruses, whereas th...

journal_title：Virology

authors： Komurian-Pradel F,Paranhos-Baccala G,Bedin F,Ounanian-Paraz A,Sodoyer M,Ott C,Rajoharison A,Garcia E,Mallet F,Mandrand B,Perron H

更新日期：1999-07-20 00:00:00

abstract：:The prevalence of hepatitis B virus vaccine escape mutants has increased as a consequence of the introduction of global vaccination programs. Furthermore and as a consequence of the organization of the genome of hepatitis B virus (HBV) into overlapping reading frames, the selection of polymerase mutants during long-te...

journal_title：Virology

authors： Torresi J,Earnest-Silveira L,Deliyannis G,Edgtton K,Zhuang H,Locarnini SA,Fyfe J,Sozzi T,Jackson DC

更新日期：2002-02-15 00:00:00

abstract：:PBMC and vaginal cell (VC) viruses were studied from 5 HIV-infected females for the presence of drug-resistance and non-drug resistance associated mutations. A 1318-bp fragment of polymerase gene was amplified from PBMC and VC proviral DNA. Four of the 5 PBMC viruses exhibited drug resistance-associated mutations in r...

journal_title：Virology

authors： Tirado G,Jove G,Reyes E,Sepulveda G,Yamamura Y,Singh DP,Kumar A

更新日期：2005-04-10 00:00:00

abstract：:Pseudorecombinants produced by exchanging genome components (DNAs A and B) of the geminiviruses African cassava mosaic virus (ACMV) and Indian cassava mosaic virus (ICMV), ACMV, and tomato golden mosaic virus (TGMV), and TGMV and abutilon mosaic virus (AbMV) are not infectious in their common host Nicotiana benthamian...

journal_title：Virology

authors： Frischmuth T,Roberts S,von Arnim A,Stanley J

更新日期：1993-10-01 00:00:00

abstract：:Hepatitis B virus synthesizes multiple spliced RNAs that can be reverse transcribed into viral DNA. We thoroughly characterized the contribution of spliced RNAs to DNA synthesis in transfected cultures of Huh7 and HepG2 cells. We found that up to 50% of DNA within intracellular capsids is derived from five spliced RNA...

journal_title：Virology

authors： Abraham TM,Lewellyn EB,Haines KM,Loeb DD

更新日期：2008-09-15 00:00:00

abstract：:Human herpesvirus-8 (HHV-8) variants have been found heterogeneously distributed among human populations living in diverse geographic regions, but their differential pathogenicity in Kaposi's sarcoma development remains controversial. In the present study, HHV-8 variant distribution has been analyzed in classic, iatro...

journal_title：Virology

authors： Tornesello ML,Biryahwaho B,Downing R,Hatzakis A,Alessi E,Cusini M,Ruocco V,Katongole-Mbidde E,Loquercio G,Buonaguro L,Buonaguro FM

更新日期：2010-03-15 00:00:00

abstract：:African Swine fever virus (ASFV) genome is a large (170-190 kb) double-stranded DNA molecule with structural features similar to those of Poxviruses. Prominent among those features are the presence of a hairpin loop structure at the end of the DNA molecule and terminal-inverted repeats (TIR). The TIRs have been previo...

journal_title：Virology

authors： de la Vega I,González A,Blasco R,Calvo V,Viñuela E

更新日期：1994-05-15 00:00:00

abstract：:LMP1 induces the expression of two members of the family of Id proteins, Id1 and Id3, and affects cell cycle regulation by decreasing the expression of the cyclin dependent kinase inhibitor, p27, and increasing levels and phosphorylation of cdk2 and Rb. In the present study, the contribution of the Id proteins to LMP1...

journal_title：Virology

authors： Everly DN Jr,Mainou BA,Raab-Traub N

更新日期：2008-07-05 00:00:00

abstract：:BS-1, a stroma cell line derived from normal human bone marrow, can support the growth of murine erythroid (BFU-E), granulocyte-macrophage (CFU-GM), and megakaryocyte (CFU-Meg) progenitor cells in a short-term in vitro coculture system. Exposure of BS-1 cell to the human immunodeficiency virus (HIV) prior to coculture...

journal_title：Virology

authors： Steinberg HN,Anderson J,Crumpacker CS,Chatis PA

更新日期：1993-03-01 00:00:00

abstract：:Because phosphorylation of the infectious bronchitis virus (IBV) nucleocapsid protein (N) may regulate its multiple roles in viral replication, the dynamics of N phosphorylation were examined. 32P-orthophosphate labeling and Western blot analyses confirmed that N was the only viral protein that was phosphorylated. Pul...

journal_title：Virology

authors： Jayaram J,Youn S,Collisson EW

更新日期：2005-08-15 00:00:00

abstract：:Hepatitis C virus (HCV) infection often leads to the development of hepatocellular carcinoma (HCC), but its molecular mechanism has not been clearly elucidated. Previously, transgenic mice constitutively expressing HCV core protein have been shown to develop HCC, suggesting a pivotal role of the core protein in hepato...

journal_title：Virology

authors： Tsutsumi T,Suzuki T,Moriya K,Yotsuyanagi H,Shintani Y,Fujie H,Matsuura Y,Kimura S,Koike K,Miyamura T

更新日期：2002-12-20 00:00:00

abstract：:We assess the genetic relationships between 49 HIV-1 group O strains from 24 and 25 patients living in Cameroon and France, respectively. Strains were sequenced in four genomic regions: gag (p24) and three env regions (C2-V3, gp41, and for 22 C2-gp41). In each of the genomic regions analyzed, the genetic diversity amo...

journal_title：Virology

authors： Roques P,Robertson DL,Souquière S,Damond F,Ayouba A,Farfara I,Depienne C,Nerrienet E,Dormont D,Brun-Vézinet F,Simon F,Mauclère P

更新日期：2002-10-25 00:00:00

abstract：:The purified genomic dsRNA of bluetongue virus type 1 (BTV 1) was separated into 10 size classes by polyacrylamide gel electrophoresis. These genome segments were recovered individually from the gel, denatured with methylmercuric hydroxide and translated in vitro in a rabbit reticulocyte lysate system. The virus-speci...

journal_title：Virology

authors： Mertens PP,Brown F,Sangar DV

更新日期：1984-05-01 00:00:00

abstract：:Priming of the viral glycoprotein (GP) by the cellular proteases cathepsin B and L (CatB, CatL) is believed to be essential for cell entry of filoviruses. However, pseudotyping systems that predominantly produce non-filamentous particles have frequently been used to prove this concept. Here, we report that GP-mediated...

journal_title：Virology

authors： González-Hernández M,Müller A,Hoenen T,Hoffmann M,Pöhlmann S

更新日期：2019-06-01 00:00:00

abstract：:Sulfation is a common post-translational modification of secreted and membrane proteins, with the sulfate attached to tyrosine residues or to glycan side-chains. I have shown that varicella-zoster virus (VZV) envelope glycoproteins gpI, gpII, and gpIII can be labeled with [35S]sulfate. The predominant VZV glycoprotein...

journal_title：Virology

authors： Edson CM

更新日期：1993-11-01 00:00:00

abstract：:The synthesis of linear duplex replicative structures (monomers, head-to-head, and tail-to-tail dimers) is an important hallmark of the productive phase of the adeno-associated virus (AAV) life cycle. These structures are generated by a strand-displacement replication mechanism and believed to be a reservoir for singl...

journal_title：Virology

authors： Musatov SA,Scully TA,Dudus L,Fisher KJ

更新日期：2000-09-30 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) gene of the Hitchner B1 strain of Newcastle disease virus (NDV) was cloned as a cDNA and inserted into a baculovirus expression vector. The recombinant HN (recHN) expressed in Spodoptera frugiperda cells had both hemagglutinating and neuraminidase activities both of which were inhi...

journal_title：Virology

authors： Nagy E,Derbyshire JB,Dobos P,Krell PJ

更新日期：1990-06-01 00:00:00

abstract：:CD8(+) T-lymphocytes from HIV-1 infected individuals express unidentified factors that suppress viral replication by inhibiting HIV-1 gene expression. We examined the role of epigenetics in modulating the HIV-1 suppressive factors expressed by primary CD8(+) T cells from subjects naturally controlling virus replicatio...

journal_title：Virology

authors： Saunders KO,Freel SA,Overman RG,Cunningham CK,Tomaras GD

更新日期：2010-09-15 00:00:00

abstract：:Several VV structural proteins are produced by the removal of amino-terminal peptides from their cognate precursors. In the experiments reported here, directed genetic approaches were used to investigate the possible role of these terminal peptides in protein processing. As a model system, the FLAG epitope-tagged P25K...

journal_title：Virology

authors： Lee P,Hruby DE

更新日期：1995-02-20 00:00:00

abstract：:HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed...

journal_title：Virology

authors： Reid W,Abdelwahab S,Sadowska M,Huso D,Neal A,Ahearn A,Bryant J,Gallo RC,Lewis GK,Reitz M

更新日期：2004-03-30 00:00:00

abstract：:Cells transformed with specific regions of the foot-and-mouth disease virus (FMDV) genome have been constructed and analyzed with respect to viability and susceptibility to FMDV infection. Constitutive expression of an active protease 3C under the control of the tk promoter has been documented by the ability of transf...

journal_title：Virology

authors： Martínez-Salas E,Domingo E

更新日期：1995-09-10 00:00:00

abstract：:Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding site (CD4bs). In new immunizations, we attempted to improve nAb response...

journal_title：Virology

authors： Crooks ET,Osawa K,Tong T,Grimley SL,Dai YD,Whalen RG,Kulp DW,Menis S,Schief WR,Binley JM

更新日期：2017-05-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) shows a remarkable antigenic variability. Like other RNA viruses, this virus has a high rate of mutation. It has been proposed that selection exerted by the host's antibodies could play a major role in the rapid evolution of FMDV. The present work reports the selection of FMDV antib...

journal_title：Virology

authors： Carrillo EC,Rojas ER,Cavallaro L,Schiappacassi M,Campos R

更新日期：1989-08-01 00:00:00

abstract：:Little is known about the neutralization properties of HIV-1 in India to optimally design and test vaccines. For this reason, a functional Env clone was obtained from each of ten newly acquired, heterosexually transmitted HIV-1 infections in Pune, Maharashtra. These clones formed a phylogenetically distinct genetic li...

journal_title：Virology

authors： Kulkarni SS,Lapedes A,Tang H,Gnanakaran S,Daniels MG,Zhang M,Bhattacharya T,Li M,Polonis VR,McCutchan FE,Morris L,Ellenberger D,Butera ST,Bollinger RC,Korber BT,Paranjape RS,Montefiori DC

更新日期：2009-03-15 00:00:00

abstract：:From two human brain tumors SV40 genomes were isolated by recombinant DNA techniques. The SV40 genome cloned from a human meningioma DNA was shown to be indistinguishable from wild-type SV40. In contrast, the SV40 genome cloned from a human astrocytoma proved to be a nonviable deletion mutant with a truncated early re...

journal_title：Virology

authors： Krieg P,Scherer G

更新日期：1984-10-30 00:00:00