Abstract:
:The accuracy in predicting different chemometric methods was compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS1) and two dependent variables (PLS2) were applied on spectral data of pharmaceutical formula containing pseudoephedrine (PDP) and guaifenesin (GFN). The ability to derivative in resolved overlapping spectra chloropheniramine maleate was evaluated when multivariate methods are adopted for analysis of two component mixtures without using any chemical pretreatment. The chemometrics models were tested on an external validation dataset and finally applied to the analysis of pharmaceuticals. Significant advantages were found in analysis of the real samples when the calibration models from derivative spectra were used. It should also be mentioned that the proposed method is a simple and rapid way requiring no preliminary separation steps and can be used easily for the analysis of these compounds, especially in quality control laboratories.
journal_name
Drug Test Analjournal_title
Drug testing and analysisauthors
Riahi S,Hadiloo F,Milani SM,Davarkhah N,Ganjali MR,Norouzi P,Seyfi Pdoi
10.1002/dta.235subject
Has Abstractpub_date
2011-05-01 00:00:00pages
319-24issue
5eissn
1942-7603issn
1942-7611journal_volume
3pub_type
杂志文章abstract::Bioactive peptides pose a great threat to sports integrity. The detection of these peptides is essential for enforcing their prohibition in sports. Identifying the catabolites of these peptides that are formed ex vivo in plasma may improve their detection. In the present study, the stability of 27 bioactive peptides w...
journal_title:Drug testing and analysis
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
abstract::Knowing that polyunsaturated fatty acids can lead to the formation of potentially toxic aldehydes as secondary oxidation products, an analytical method using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) detection was developed to measure the concentration of eight aldehydes in animal feed: malo...
journal_title:Drug testing and analysis
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abstract::Three legal highs; nitracaine (3-(diethylamino)-2,2-dimethylpropyl 4-nitrobenzoate), methoxypiperamide (MEOP, (4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone) and mephtetramine (MTTA, 2-((methylamino)methyl)-3,4-dihydronaphthalen-1(2H)-one) appeared in 2013 as new psychoactive substances (NPS) on Internet websites ...
journal_title:Drug testing and analysis
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journal_title:Drug testing and analysis
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abstract::To date, substances such as Mildronate (Meldonium) are not on the radar of anti-doping laboratories as the compound is not explicitly classified as prohibited. However, the anti-ischemic drug Mildronate demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection ag...
journal_title:Drug testing and analysis
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
abstract::Musk, the dried secretion of the musk pod (sac) of adult male musk deer, has been used as traditional Chinese Medicine (TCM) in China and south-east Asian countries for thousands of years. Due to the anabolic steroid component in this TCM, musk preparations have been included in the list of medical products containing...
journal_title:Drug testing and analysis
pub_type: 杂志文章
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abstract::New Psychoactive Substances are now a feature of Australia's recreational drug market. Little is known, however, about the prevalence of use, the characteristics of people who use them and the relationship between the NPS and ecstasy markets. This study examined the prevalence and correlates of NPS use amongst a group...
journal_title:Drug testing and analysis
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2769
更新日期:2020-06-01 00:00:00
abstract::Addiction is a complex disorder with interacting factors, including environmental factors, drug-induced neurobiological changes, comorbidity, personality traits and stress responsivity. Numerous genetic variants that affect these factors may work in concert to affect vulnerability and severity of addiction. Traditiona...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1401
更新日期:2013-01-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.74
更新日期:2009-07-01 00:00:00
abstract::Two primary animal models persist for assessing hallucinogenic potential of novel compounds and for examining the pharmacological and neurobiological substrates underlying the actions of classical hallucinogens, the two-lever drug discrimination procedure and the drug-induced head-twitch response (HTR) in rodents. The...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.1333
更新日期:2012-07-01 00:00:00
abstract::The use of corticosteroids, such as betamethasone, in performance horses is tightly regulated. The objective of the current study was to describe the plasma pharmacokinetics of betamethasone as well as time-related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve racin...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2170
更新日期:2017-09-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 信件
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.344
更新日期:2012-03-01 00:00:00
abstract::Oral fluid (OF) is an important matrix for monitoring drugs. Smoking cannabis is common, but vaporization and edible consumption also are popular. OF pharmacokinetics are available for controlled smoked cannabis, but few data exist for vaporized and oral routes. Frequent and occasional cannabis smokers were recruited ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2092
更新日期:2017-06-01 00:00:00
abstract::Anabolic-androgenic steroids (AAS) represent one of the most frequently detected classes of prohibited substances in doping controls. Due to their long-lasting beneficial effects on athletic performance, utmost retrospectivity via urine analysis is desirable and accomplished by targeting long-term metabolites of the r...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1516
更新日期:2013-11-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2010
更新日期:2016-05-01 00:00:00
abstract::The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration-based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2219
更新日期:2018-02-01 00:00:00
abstract::Cobalt is an essential mineral micronutrient and is regularly present in equine nutritional and feed supplements. Therefore, cobalt is naturally present at low concentrations in biological samples. The administration of cobalt chloride is considered to be blood doping and is thus prohibited. To control the misuse of c...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2191
更新日期:2017-09-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
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journal_title:Drug testing and analysis
pub_type: 杂志文章
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journal_title:Drug testing and analysis
pub_type: 杂志文章
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journal_title:Drug testing and analysis
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
abstract::The evolving nature of new psychoactive substances (NPS) - often referred to as 'legal highs', 'designer drugs' or 'bath salts' - presents an evolving challenge for toxicologists. Apart from the detection and identification of these compounds, further analytical challenges may arise from the presence of possible metab...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1576
更新日期:2014-07-01 00:00:00
abstract::The synthetic tryptamine 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT) has recently been abused as a hallucinogenic drug in Germany and Switzerland. This study presents a case of 5-MeO-MiPT intoxication and the structural elucidation of metabolites in pooled human liver microsomes (pHLM), blood, and urine. Mic...
journal_title:Drug testing and analysis
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
abstract::New bioanalytical assays were developed, validated, and applied in a clinical study for quantitative measurement of acetaminophen concentrations in blood and plasma samples. Furthermore, after validation, the bioanalytical assays were used for determination of pharmacokinetics within a group of six healthy male human ...
journal_title:Drug testing and analysis
pub_type: 临床试验,杂志文章
doi:10.1002/dta.1582
更新日期:2014-06-01 00:00:00
abstract::Prenylamine is a vasodilator of phenylalkylamine structure and was used for the treatment of angina pectoris, until reports of undesirable effects including ventricular tachycardia led to a decreasing use of the drug in the 1980s. Metabolic N-dealkylation of orally ingested prenylamine can liberate amphetamine in huma...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1388
更新日期:2012-09-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
abstract::The impact of dehydroepiandrosterone (DHEA) administration has been widely studied for anti-doping purposes in men, whereas only a few studies have been performed in women. In the present study, the impact of DHEA on the steroid profile parameters and their carbon isotopic ratios was explored. Eleven healthy young wom...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2519
更新日期:2018-11-01 00:00:00
abstract::The reactions involved in the metabolic pathways of SR9009 were characterized by liquid chromatography-mass spectrometry (LC-MS) to identify the most appropriate marker(s) of use. The effects of gender, genetic polymorphism, and drug-drug interaction on the metabolic profile of SR9009 were also evaluated. In vitro app...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2538
更新日期:2018-11-01 00:00:00