Abstract:
:The widespread use of antibiotics in animals is causing concerns about the growing risk for development and the spread of antibiotic-resistant bacteria. Antibiotic consumption is higher in animals than in humans as reported in a joint publication of EFSA (European Food Safety Agency), ECDC (European Centre for Disease Prevention and Control), and EMA (European Medicines Agency) using data from 2011 and 2012. Both in humans and animals, positive associations between the consumption of antibiotics and resistant bacteria are observed. Responsible use of antibiotics in humans and animals should therefore be promoted. In this paper some general aspects of antibiotic resistance such as microbiological versus clinical resistance, intrinsic versus acquired resistance, resistance mechanisms, and transfer of resistance are briefly introduced. In 2012, the Belgian Center of Expertise on Antimicrobial Consumption and Resistance in Animals (AMCRA) was founded. Its mission is to collect and analyze all data related to antibiotic use and resistance in animals in Belgium and to communicate these findings in a neutral and objective manner. One of AMCRA's 10 objectives is a 50% reduction in antibiotic consumption in veterinary medicine in Belgium by 2020. The aim of this paper is to report on the achievements of this national project. The Institute for Agricultural and Fisheries Research (ILVO, Merelbeke-Melle), in collaboration with Ghent University, is currently working on three nationally funded projects on antibiotic resistance in animal husbandry. In the first project, an in vitro model is used to study the influence of low antibiotic concentrations due to carry-over after production and usage of medicated feed on the development of resistance in the pig gut. Part of that project is to develop a quantitative risk assessment model. A second project focuses on tracking excreted antibiotics used in pig rearing and their influence on the development of antibiotic resistance in pig manure and the environment. In the last project, the relation between the use of biocides in animal husbandry and antibiotic resistance development are being studied. Copyright © 2016 John Wiley & Sons, Ltd.
journal_name
Drug Test Analjournal_title
Drug testing and analysisauthors
Daeseleire E,De Graef E,Rasschaert G,De Mulder T,Van den Meersche T,Van Coillie E,Dewulf J,Heyndrickx Mdoi
10.1002/dta.2010subject
Has Abstractpub_date
2016-05-01 00:00:00pages
549-55issue
5-6eissn
1942-7603issn
1942-7611journal_volume
8pub_type
杂志文章abstract::The present study demonstrates the applicability of a strategy involving use of liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) techniques for the identification and characterization of minute quantities of degradation products, without their isolation from the reaction matrix in pure fo...
journal_title:Drug testing and analysis
pub_type: 杂志文章
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journal_title:Drug testing and analysis
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journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
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abstract::Despite the implementation of a new blanket scheduling system in 2013, new psychoactive substance (NPS) abuse remains a serious social concern in Japan. We present a fatal intoxication case involving 5F-ADB (methyl 2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate) and diphenidine. Postmortem bloo...
journal_title:Drug testing and analysis
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journal_title:Drug testing and analysis
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2092
更新日期:2017-06-01 00:00:00
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journal_title:Drug testing and analysis
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journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00
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journal_title:Drug testing and analysis
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journal_title:Drug testing and analysis
pub_type: 历史文章,杂志文章
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1903
更新日期:2017-02-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1956
更新日期:2017-02-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2245
更新日期:2018-03-01 00:00:00
abstract::Doping with natural steroids can be detected by evaluating the urinary concentrations and ratios of several endogenous steroids. Since these biomarkers of steroid doping are known to present large inter-individual variations, monitoring of individual steroid profiles over time allows switching from population-based to...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.206
更新日期:2010-11-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1966
更新日期:2016-03-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1401
更新日期:2013-01-01 00:00:00
abstract::Fast and unequivocal drug detection is of considerable importance in numerous fields of analytical chemistry, and today mass spectrometry-based approaches are often the method of choice due to their sensitive and specific nature. Mass spectrometry is in constant flux with innovations and thus supports the development ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.344
更新日期:2012-03-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
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journal_title:Drug testing and analysis
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journal_title:Drug testing and analysis
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journal_title:Drug testing and analysis
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更新日期:2014-06-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2654
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abstract::The Ministry of Health in the Netherlands has made illicit drug testing for drug users possible since the 1990s, in order to prevent serious health hazards associated with unexpected dangerous substances. This system of illicit drug testing is called the Drug Information and Monitoring System (DIMS). In nearly two dec...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1326
更新日期:2012-02-01 00:00:00
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journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1749
更新日期:2015-01-01 00:00:00
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journal_title:Drug testing and analysis
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更新日期:2020-01-01 00:00:00
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journal_title:Drug testing and analysis
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abstract::The emerging new psychoactive substances made available for recreational drug use have recently started to include designer benzodiazepines. As a consequence, the routine immunoassay drug testing for benzodiazepines may become less effective, due to an increased occurrence of 'false negative' and 'false positive' resu...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2003
更新日期:2017-04-01 00:00:00