Mildronate (Meldonium) in professional sports - monitoring doping control urine samples using hydrophilic interaction liquid chromatography - high resolution/high accuracy mass spectrometry.

abstract：:Synthetic cannabinoids are a group of psychoactive drugs presently widespread among drug users in Europe. Analytical methods to measure these compounds in urine are in demand as urine is a preferred matrix for drug testing. For most synthetic cannabinoids, the parent compounds are rarely detected in urine. Therefore u...

journal_title：Drug testing and analysis

authors： Vikingsson S,Gréen H,Brinkhagen L,Mukhtar S,Josefsson M

更新日期：2016-09-01 00:00:00

abstract：:Higenamine was included in the World Anti-Doping Agency (WADA) Prohibited Substances and Methods List as a β2 -adrenoceptor agonist in 2017, thereby resulting in its prohibition both in and out of competition. The present mini review describes the physiology and pharmacology of adrenoceptors, summarizes the literature...

journal_title：Drug testing and analysis

authors： Hudzik TJ,Patel M,Brown A

更新日期：2020-12-26 00:00:00

abstract：:Evidence of the continuous rise of novel doping agents and novel doping strategies calls for the development of more accurate multi-target screening methods. Direct multi-target screening approaches are restricted to the targeted substances and their turnover. The development of effective "indirect" screening methods ...

journal_title：Drug testing and analysis

authors： Narduzzi L,Dervilly G,Audran M,Le Bizec B,Buisson C

更新日期：2020-06-01 00:00:00

abstract：:Drug and alcohol abuse is a concern for many European companies, especially those having safety-critical jobs. It is not uncommon for European companies to establish a drug policy with little or no provision for drug testing. The European Union (EU) has launched a number of initiatives in its fight against drugs. Ther...

journal_title：Drug testing and analysis

authors： Agius R,Kintz P,European Workplace Drug Testing Society.

更新日期：2010-08-01 00:00:00

abstract：:Two primary animal models persist for assessing hallucinogenic potential of novel compounds and for examining the pharmacological and neurobiological substrates underlying the actions of classical hallucinogens, the two-lever drug discrimination procedure and the drug-induced head-twitch response (HTR) in rodents. The...

journal_title：Drug testing and analysis

authors： Canal CE,Morgan D

更新日期：2012-07-01 00:00:00

abstract：:Driving under the influence of drugs (DUID) is a worldwide problem. Several countries have adopted DUID legislations which prove their deterrent effect and impact on road safety. However, the use of new psychoactive substances (NPS) and prescription drugs is not known, as the applied roadside screening tests have not ...

journal_title：Drug testing and analysis

authors： Wille SMR,Richeval C,Nachon-Phanithavong M,Gaulier JM,Di Fazio V,Humbert L,Samyn N,Allorge D

更新日期：2018-03-01 00:00:00

abstract：:The determination of protein- or peptide-based performance-enhancing pharmaceuticals has gained increasing attention in sports drug testing in recent decades. Proteases possess a high potential for use in the manipulation of regular urine specimens, interfering with established doping control procedures for proteins o...

journal_title：Drug testing and analysis

authors： Thomas A,Kohler M,Walpurgis K,Schänzer W,Thevis M

更新日期：2009-02-01 00:00:00

abstract：:5-(2-Aminopropyl)indole (5-IT) is a psychoactive compound that has recently been associated with several fatal and non-fatal intoxications in a number of European countries. There are indications that acute effects may include symptoms of monoaminergic (e.g. serotonin) toxicity and one mechanism involved in the increa...

journal_title：Drug testing and analysis

authors： Herraiz T,Brandt SD

更新日期：2014-07-01 00:00:00

abstract：:The accuracy in predicting different chemometric methods was compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS1) and two dependent variables (PLS2) were applied on spectral data of pharmaceuti...

journal_title：Drug testing and analysis

authors： Riahi S,Hadiloo F,Milani SM,Davarkhah N,Ganjali MR,Norouzi P,Seyfi P

更新日期：2011-05-01 00:00:00

abstract：:The impact of altitude training on haematological parameters and the Athlete Biological Passport (ABP) was evaluated in international-level elite athletes. One group of swimmers lived high and trained high (LHTH, n = 10) for three to four weeks at 2130 m or higher whereas a control group (n = 10) completed a three-wee...

journal_title：Drug testing and analysis

authors： Bonne TC,Lundby C,Lundby AK,Sander M,Bejder J,Nordsborg NB

更新日期：2015-08-01 00:00:00

abstract：:This work presents an analytical procedure for the identification and characterization of liposome-entrapped haemoglobins, based on flow cytofluorimetry. Flow cytofluorimetric detection is carried out following labelling by two distinct fluorescent reagents, an anti-haemoglobin antibody, fluorescein isothiocyanate con...

journal_title：Drug testing and analysis

authors： Esposito S,Colicchia S,de la Torre X,Donati F,Mazzarino M,Botrè F

更新日期：2017-02-01 00:00:00

abstract：:Sulfate metabolites have been described as long-term metabolites for some anabolic androgenic steroids (AAS). 4-chlorometandienone (4Cl-MTD) is one of the most frequently detected AAS in sports drug testing and it is commonly detected by monitoring metabolites excreted free or conjugated with glucuronic acid. Sulfatio...

journal_title：Drug testing and analysis

authors： Balcells G,Gómez C,Garrostas L,Pozo ÓJ,Ventura R

更新日期：2017-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-protein coding transcripts involved in many cellular and physiological mechanisms. Recently, a new class of miRNA called 'circulating miRNAs' was found in cell-free body fluids such as plasma and urine. Circulating miRNAs have been shown to be very stable, specific, and sensitive biom...

journal_title：Drug testing and analysis

authors： Leuenberger N,Jan N,Pradervand S,Robinson N,Saugy M

更新日期：2011-11-01 00:00:00

abstract：:Development of a mass spectrometric method for the unambiguous detection of doping with recombinant human erythropoietins (rhEPO) has been attempted for many years. Unfortunately, progress in this field was hampered by the unavailability of highly purified human endogenous EPOs (urinary[uhEPO], serum/plasma EPO)--a pr...

journal_title：Drug testing and analysis

authors： Reichel C

更新日期：2013-11-01 00:00:00

abstract：:Hemapolin (2α,3α-epithio-17α-methyl-5α-androstan-17β-ol) is a designer steroid that is an ingredient in several "dietary" and "nutritional" supplements available online. As an unusual chemical modification to the steroid A-ring could allow this compound to pass through antidoping screens undetected, the metabolism of ...

journal_title：Drug testing and analysis

authors： Waller CC,Weththasinghe SA,McClure L,Cawley AT,Suann C,Suann E,Sutherland E,Cooper E,Heather A,McLeod MD

更新日期：2020-06-01 00:00:00

abstract：:The quantitative structure-property relationship (QSPR) of drug molecules against the immobilized liposome chromatography partitioning (log K(s)) was studied. The genetic algorithm (GA) was employed to select the variables that resulted in the best-fitted models. After the variables were selected, the linear multivari...

journal_title：Drug testing and analysis

authors： Noorizadeh H,Farmany A

更新日期：2012-02-01 00:00:00

abstract：:A new and sensitive multi-residue method (MRM) with detection by LC-MS/MS was developed and validated for the screening, determination, and confirmation of residues of 7 nitroimidazoles and 3 of their metabolites in turkey muscle tissues at concentrations ≥ 0.05 ng/g. The compounds were extracted into a solvent with a...

journal_title：Drug testing and analysis

authors： Boison JO,Asea PA,Matus JL

更新日期：2012-08-01 00:00:00

abstract：:The widespread use of antibiotics in animals is causing concerns about the growing risk for development and the spread of antibiotic-resistant bacteria. Antibiotic consumption is higher in animals than in humans as reported in a joint publication of EFSA (European Food Safety Agency), ECDC (European Centre for Disease...

journal_title：Drug testing and analysis

authors： Daeseleire E,De Graef E,Rasschaert G,De Mulder T,Van den Meersche T,Van Coillie E,Dewulf J,Heyndrickx M

更新日期：2016-05-01 00:00:00

abstract：:1-Propanoyl-lysergic acid diethylamide (1P-LSD) appeared as a non-controlled alternative to LSD a few years ago. Although evidence is beginning to emerge from in vitro and animal studies that 1P-LSD might serve as a prodrug for LSD, an equivalent evaluation in humans is unavailable. Controlled oral and intravenous sel...

journal_title：Drug testing and analysis

authors： Grumann C,Henkel K,Brandt SD,Stratford A,Passie T,Auwärter V

更新日期：2020-08-01 00:00:00

abstract：:Testosterone and related compounds are the most recurrent doping substances. The steroid profile, consisting of the quantification of testosterone and its metabolites, has been described as the most significant biomarker to detect doping with pseudo-endogenous anabolic steroids. The steroidal module of the Athlete Bio...

journal_title：Drug testing and analysis

authors： Baume N,Geyer H,Vouillamoz M,Grisdale R,Earl M,Aguilera R,Cowan DA,Ericsson M,Gmeiner G,Kwiatkowska D,Kioukia-Fougia N,Molina A,Ruivo J,Segura J,Van Eenoo P,Jan N,Robinson N,Saugy M

更新日期：2016-07-01 00:00:00

abstract：:Selective androgen receptor modulators (SARMs) are a group of anabolic enhancer drugs posing threats to the integrity of animal sports and the safety of animal-derived foods. The current research describes for the first time the development of a semi-quantitative assay for the monitoring of SARM family compounds in bl...

journal_title：Drug testing and analysis

authors： Ventura E,Gadaj A,Buckley T,Mooney MH

更新日期：2020-09-01 00:00:00

abstract：:Meconium drug testing is a non-invasive method to detect prenatal drug exposure, which can cause severe problems for the infant, indicating the need for follow-up measures to ensure the welfare of the child. Meconium samples for drug testing were collected from 143 infants as part of routine clinical work among addict...

journal_title：Drug testing and analysis

authors： Launiainen T,Nupponen I,Halmesmäki E,Ojanperä I

更新日期：2013-07-01 00:00:00

abstract：:The tiletamine-zolazepam (TZ) combination is an anaesthetic drug commonly used in veterinary medicine. It is an equal amount combination of tiletamine, a dissociative anaesthetic pharmacologically classified as an N-methyl-D-aspartate (NMDA) receptor antagonist, and zolazepam, a benzodiazepine tranquilizer. There are ...

journal_title：Drug testing and analysis

authors： de la Peña JB,Cheong JH

更新日期：2016-08-01 00:00:00

abstract：:Zolpidem and zopiclone (Z-compounds) are non-benzodiazepine hypnotics of new generation that can be used in drug-facilitated sexual assault (DFSA). Their determination in biological fluids, mainly urine, is of primary importance; nevertheless, although they are excreted almost entirely as metabolites, available method...

journal_title：Drug testing and analysis

authors： Strano Rossi S,Anzillotti L,Castrignanò E,Frison G,Zancanaro F,Chiarotti M

更新日期：2014-03-01 00:00:00

abstract：:A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relativ...

journal_title：Drug testing and analysis

authors： Abounassif MA,Al-Omar MA,Amr AG,Mostafa GA

更新日期：2011-06-01 00:00:00

abstract：:Chemical warfare agents (CWA) are highly toxic compounds which have been produced to kill or hurt people during conflicts or terrorist attacks. Despite the fact that their use is strictly prohibited according to international convention, populations' exposure still recently occurred. Development of markers of exposure...

journal_title：Drug testing and analysis

authors： Spiandore M,Piram A,Lacoste A,Josse D,Doumenq P

更新日期：2014-06-01 00:00:00

abstract：:Dihydroartemisinin (DHA) and piperaquine (PPQ) are two drugs used in an artemisinin-based combination therapy (ACT). The circulation of counterfeit antimalarial drugs demands the development of simple, point-of-care (POC) tests for monitoring drug quality. Here we aimed to design an antibody-based lateral flow dipstic...

journal_title：Drug testing and analysis

authors： Ning X,Tan G,Chen X,Wang M,Wang B,Cui L

更新日期：2019-09-01 00:00:00

abstract：:The high frequency of the synthetic cannabinoid receptor agonists (SCRAs) emergence renders this group of new psychoactive compounds particularly demanding in terms of detection, identification, and responding. Without the available reference material, one of the specific problems is differentiation and structure eluc...

journal_title：Drug testing and analysis

authors： Martek BA,Mihelač M,Gazvoda M,Virant M,Urankar D,Krivec M,Gostič T,Nemec B,Koštrun B,Janežič M,Klemenc S,Košmrlj J

更新日期：2019-04-01 00:00:00

abstract：:Addiction is a complex disorder with interacting factors, including environmental factors, drug-induced neurobiological changes, comorbidity, personality traits and stress responsivity. Numerous genetic variants that affect these factors may work in concert to affect vulnerability and severity of addiction. Traditiona...

journal_title：Drug testing and analysis

authors： Fattore L

更新日期：2013-01-01 00:00:00

abstract：:The presence of erythropoiesis stimulating agents (ESAs) in the urine samples collected from athletes is detected using traditional Western blotting following either size-based separation (SDS/SAR-PAGE) or isoelectric focusing (IEF). Although there is an important testing effort, there is little doubt that ESAs are st...

journal_title：Drug testing and analysis

authors： Desharnais P,Naud JF,Ayotte C

更新日期：2018-11-01 00:00:00