解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Phosphatidylethanol 16:0/18:1 (PEth) is the most abundant homologue of the phosphatidylethanol group of phospholipids. Formed only in the presence of ethanol, PEth is used as a biomarker in whole blood to provide information about the consumption of alcohol. As information on the storage life of PEth is essential for ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2995
更新日期:2021-01-04 00:00:00
abstract::Higenamine was included in the World Anti-Doping Agency (WADA) Prohibited Substances and Methods List as a β2 -adrenoceptor agonist in 2017, thereby resulting in its prohibition both in and out of competition. The present mini review describes the physiology and pharmacology of adrenoceptors, summarizes the literature...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.2992
更新日期:2020-12-26 00:00:00
abstract::Selective androgen receptor modulators (SARMs) are a group of anabolic enhancer drugs posing threats to the integrity of animal sports and the safety of animal-derived foods. The current research describes for the first time the development of a semi-quantitative assay for the monitoring of SARM family compounds in bl...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2875
更新日期:2020-09-01 00:00:00
abstract::The amphetamine molecule contains a chiral center and its enantiomers exhibit differences in pharmacological effects, with the S-enantiomer mediating most of the central nervous system stimulating activity. The majority of prescribed amphetamine consists of the pure S-enantiomer, but therapeutic formulations containin...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2879
更新日期:2020-09-01 00:00:00
abstract::1-Propanoyl-lysergic acid diethylamide (1P-LSD) appeared as a non-controlled alternative to LSD a few years ago. Although evidence is beginning to emerge from in vitro and animal studies that 1P-LSD might serve as a prodrug for LSD, an equivalent evaluation in humans is unavailable. Controlled oral and intravenous sel...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2821
更新日期:2020-08-01 00:00:00
abstract::At present, there is a growing trend toward the intentional adulteration of dietary supplements (DS) with synthetic pharmaceuticals, which represents an alarming emerging risk to consumers and a serious problem for regulatory agencies. An amazing array of synthetic drugs and their analogues have been reported as adult...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.2806
更新日期:2020-07-01 00:00:00
abstract::Bioactive peptides pose a great threat to sports integrity. The detection of these peptides is essential for enforcing their prohibition in sports. Identifying the catabolites of these peptides that are formed ex vivo in plasma may improve their detection. In the present study, the stability of 27 bioactive peptides w...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2781
更新日期:2020-06-01 00:00:00
abstract::Hemapolin (2α,3α-epithio-17α-methyl-5α-androstan-17β-ol) is a designer steroid that is an ingredient in several "dietary" and "nutritional" supplements available online. As an unusual chemical modification to the steroid A-ring could allow this compound to pass through antidoping screens undetected, the metabolism of ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2769
更新日期:2020-06-01 00:00:00
abstract::The steroidal module of the Athlete Biological Passport (ABP) aims to detect doping with endogenous steroids, e.g. testosterone (T), by longitudinally monitoring several biomarkers. These biomarkers are ratios combined into urinary concentrations of testosterone and metabolically related steroids. However, it is evide...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2778
更新日期:2020-06-01 00:00:00
abstract::Evidence of the continuous rise of novel doping agents and novel doping strategies calls for the development of more accurate multi-target screening methods. Direct multi-target screening approaches are restricted to the targeted substances and their turnover. The development of effective "indirect" screening methods ...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.2788
更新日期:2020-06-01 00:00:00
abstract::Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1-acyl substituted lyserga...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2789
更新日期:2020-06-01 00:00:00
abstract::Current doping trends overshadow the traditional interpretation of using prohibited performance-enhancing drugs to improve training and/or sports results. Its definition has evolved due to several recent cases of unconventional manipulation in sports. In this article, we present a case study of an intentional intoxica...
journal_title:Drug testing and analysis
pub_type: 历史文章,杂志文章
doi:10.1002/dta.2753
更新日期:2020-05-01 00:00:00
abstract::The effectiveness of doping control in sport has been improved continuously during the past 50 years. One of the major steps forward was the introduction of unannounced and targeted out-of-competition testing in order to control the misuse of anabolic-androgenic steroids (AAS), mainly during the end of the 1980s. It a...
journal_title:Drug testing and analysis
pub_type: 信件
doi:10.1002/dta.2727
更新日期:2020-05-01 00:00:00
abstract::Hair analysis is useful for documenting long-term exposure to drugs. The potential of hair analysis for therapeutic drug monitoring within the forensic field has been studied, but reference values for some antidepressants and antipsychotics in the hair of individuals undergoing chronic therapy are still lacking. In th...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2754
更新日期:2020-04-01 00:00:00
abstract::Deschloroketamine (2-(methylamino)-2-phenyl-cyclohexanone) is a ketamine analog belonging to a group of dissociative anesthetics, which have been distributed within the illicit market since 2015. However, it was also being sold as 'ketamine' misleading people to believe that they were getting genuine ketamine. Dissoci...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2726
更新日期:2020-03-01 00:00:00
abstract::Vaping of synthetic cannabinoids via e-cigarettes is growing in popularity. In the present study, we tentatively identified 12 by-products found in a pure sample of the synthetic cannabinoid Cumyl-5F-PINACA (1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide), a prevalent new psychoactive substance (...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2673
更新日期:2020-01-01 00:00:00
abstract::The anabolic-androgenic steroid methylstenbolone (MSTEN; 2α,17α-dimethyl-17β-hydroxy-5α-androst-1-en-3-one) is available as a so-called designer steroid or nutritional supplement. It is occasionally detected in doping control samples, predominantly tested and confirmed as the glucuronic acid conjugate of methylstenbol...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2736
更新日期:2019-11-01 00:00:00
abstract::Tretoquinol (trimetoquinol), a β2-agonist, has been explicitly listed on the World Anti-Doping Agency Prohibited List 2019 since January 2019; however, it has been distributed as an antiasthmatic on the medical market. This study aimed to develop a liquid chromatography-tandem mass spectrometric method for the quantif...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2714
更新日期:2019-11-01 00:00:00
abstract::Synthetic cannabinoids (SCs), mimicking the psychoactive effects of cannabis, consist of a vast array of structurally diverse compounds. A novel compound belonging to the SC family, (1-(cyclohexylmethyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone (named TMCP-CHM in this article) contains a cyclopropane r...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2668
更新日期:2019-09-01 00:00:00
abstract::Urine samples were analyzed for lactose to investigate if elevated lactose concentrations indicate recent (< 48 hours) intravenous abuse of substances containing lactose as an excipient. Elevated lactose levels were found in samples given by patients who had recently injected substances intravenously, verified by fres...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2654
更新日期:2019-09-01 00:00:00
abstract::Recombinant human erythropoietin (rHuEPO) is used as doping a substance. Anti-doping efforts include urine and blood testing and monitoring the athlete biological passport (ABP). As data on the performance of these methods are incomplete, this study aimed to evaluate the performance of two common urine assays and the ...
journal_title:Drug testing and analysis
pub_type: 杂志文章,随机对照试验
doi:10.1002/dta.2665
更新日期:2019-09-01 00:00:00
abstract::Dihydroartemisinin (DHA) and piperaquine (PPQ) are two drugs used in an artemisinin-based combination therapy (ACT). The circulation of counterfeit antimalarial drugs demands the development of simple, point-of-care (POC) tests for monitoring drug quality. Here we aimed to design an antibody-based lateral flow dipstic...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2656
更新日期:2019-09-01 00:00:00
abstract::Anabolic-androgenic steroids are synthetic compounds prohibited due to their performance-enhancing characteristics. The use of these substances is known to cause health-related issues, which highlights the importance of being able to evaluate the scale of consumption by the general population. However, most available ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2591
更新日期:2019-07-01 00:00:00
abstract::According to French law, the roadside testing for drugs of abuse (DOA) should be performed in oral fluid (OF) using an immunological screening kit. If the screening is positive, confirmation has to be done in OF collected by a special swab, called the FLOQSwab™ (FS). Unlike other sampling kits, this device was not des...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2563
更新日期:2019-06-01 00:00:00
abstract::The high frequency of the synthetic cannabinoid receptor agonists (SCRAs) emergence renders this group of new psychoactive compounds particularly demanding in terms of detection, identification, and responding. Without the available reference material, one of the specific problems is differentiation and structure eluc...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2573
更新日期:2019-04-01 00:00:00
abstract::Synthetic cathinones continue to proliferate in clandestine drug markets worldwide. N-ethylnorpentylone (also known as N-ethylpentylone or ephylone) is a popular emergent cathinone, yet little information is available about its toxicology and pharmacology. Here we characterize the analytical quantification, clinical p...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2502
更新日期:2019-03-01 00:00:00
abstract::Eurycoma longifolia Jack (Tongkat Ali, Simaroubaceae) is a medicinal plant endemic to South-East Asia. For centuries, different parts of the plant have been used as a natural remedy to treat fever, hypertension, or sexual insufficiency. Today, Eurycoma longifolia preparations are commercially available and advertised ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2449
更新日期:2019-01-01 00:00:00
abstract::Clostebol is a synthetic anabolic androgenic steroid, with potential use as a performance-enhancing drug if taken for long periods in order to produce the desired effect. Recently, the use of medications containing clostebol acetate has led to the suspension of several athletes in various sports. Previous studies have...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2469
更新日期:2019-01-01 00:00:00
abstract::The impact of dehydroepiandrosterone (DHEA) administration has been widely studied for anti-doping purposes in men, whereas only a few studies have been performed in women. In the present study, the impact of DHEA on the steroid profile parameters and their carbon isotopic ratios was explored. Eleven healthy young wom...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2519
更新日期:2018-11-01 00:00:00
abstract::Zebrafish (Danio rerio) water tank (ZWT) approach was investigated as an alternative model for metabolism studies based on six different experiments with four model compounds. Sibutramine was applied for the multivariate optimization of ZWT conditions, also for the comparison of the metabolism among ZWT, humans and mi...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2523
更新日期:2018-11-01 00:00:00
abstract::We recently published two protocols for the detection of Sotatercept (ACE-011, ACVR2A-Fc) and Luspatercept (ACE-536, ACVR2B-Fc) in human serum. Both methods used covalently immobilized antibodies on agarose beads for immunoprecipitation and SAR-PAGE/Western blotting for detection. Disadvantages were the relatively hig...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2500
更新日期:2018-11-01 00:00:00
abstract::The presence of erythropoiesis stimulating agents (ESAs) in the urine samples collected from athletes is detected using traditional Western blotting following either size-based separation (SDS/SAR-PAGE) or isoelectric focusing (IEF). Although there is an important testing effort, there is little doubt that ESAs are st...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2528
更新日期:2018-11-01 00:00:00
abstract::The reactions involved in the metabolic pathways of SR9009 were characterized by liquid chromatography-mass spectrometry (LC-MS) to identify the most appropriate marker(s) of use. The effects of gender, genetic polymorphism, and drug-drug interaction on the metabolic profile of SR9009 were also evaluated. In vitro app...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2538
更新日期:2018-11-01 00:00:00
abstract::Urinalysis is well established for drug screening. Various methods of urine adulteration such as dilution, addition of oxidative/reductive chemicals or detergents, and handing over urine-like fluids are used to circumvent a positive screen. Validity parameters such as determination of pH, gravidity, urine temperature,...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2447
更新日期:2018-10-01 00:00:00
abstract::In the context of post-marketing surveillance supporting public-health authorities to take evidence-based decisions to fight the spread of poor-quality medicines, the quality of antimalarial artemether-lumefantrine (AL) medicines was assessed in the Democratic Republic of the Congo (DRC). A total of 150 samples of AL-...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2420
更新日期:2018-10-01 00:00:00
abstract::The availability of a real-time assay to experimentally investigate the release of encapsulated proteins would be beneficial given the interest in the use of liposomes as a drug delivery vehicle. Although simple assays for small molecular weight substances exist, assays to evaluate macromolecules do not. Here we descr...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2332
更新日期:2018-06-01 00:00:00
abstract::The steroid profile (SP) is a powerful tool to detect the misuse of endogenous anabolic androgenic steroids in sports, and it is included in the Athlete Biological Passport (ABP). Glucocorticoids (GCs), which are widely prescribed in sports and only prohibited in competition by systemic routes, inhibit the hypothalami...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2351
更新日期:2018-06-01 00:00:00
abstract::Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti-Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2343
更新日期:2018-05-01 00:00:00
abstract::Harm reduction services, including needle-exchange programmes, have been implemented in Switzerland for over 20 years. Their main aim is to lessen the negative social and/or physical consequences associated with illicit drug consumption and, therefore, improve prevention messages. To this end, knowledge of illicit dru...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2335
更新日期:2018-05-01 00:00:00
abstract::Indole-, indazole-, or azaindole-based synthetic cannabinoids (SCs), bearing a cumyl substituent are a widespread, recreationally used subgroup of new psychoactive substances (NPS). The latest cumyl-derivative, CUMYL-PEGACLONE, emerged in December 2016 on the German drug market. The substance features a novel γ-carbol...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2352
更新日期:2018-05-01 00:00:00