Development of an LC-MS/MS analytical method for the simultaneous measurement of aldehydes from polyunsaturated fatty acids degradation in animal feed.

abstract：:In Italy, Workplace Drug Testing (WDT) has been compulsory by law for specific categories of workers since 2008, offering the opportunity to compare studies conducted within a single regulatory framework. The aims of this paper are to estimate the overall prevalence of WDT positivity (at screening survey) among Italia...

journal_title：Drug testing and analysis

authors： Rosso GL,Montomoli C,Morini L,Candura SM

更新日期：2017-06-01 00:00:00

abstract：:Musk, the dried secretion of the musk pod (sac) of adult male musk deer, has been used as traditional Chinese Medicine (TCM) in China and south-east Asian countries for thousands of years. Due to the anabolic steroid component in this TCM, musk preparations have been included in the list of medical products containing...

journal_title：Drug testing and analysis

authors： Wang J,He Y,Liu X,Yang Z,Yang W

更新日期：2017-11-01 00:00:00

abstract：:1-Propanoyl-lysergic acid diethylamide (1P-LSD) appeared as a non-controlled alternative to LSD a few years ago. Although evidence is beginning to emerge from in vitro and animal studies that 1P-LSD might serve as a prodrug for LSD, an equivalent evaluation in humans is unavailable. Controlled oral and intravenous sel...

journal_title：Drug testing and analysis

authors： Grumann C,Henkel K,Brandt SD,Stratford A,Passie T,Auwärter V

更新日期：2020-08-01 00:00:00

abstract：:Indole-, indazole-, or azaindole-based synthetic cannabinoids (SCs), bearing a cumyl substituent are a widespread, recreationally used subgroup of new psychoactive substances (NPS). The latest cumyl-derivative, CUMYL-PEGACLONE, emerged in December 2016 on the German drug market. The substance features a novel γ-carbol...

journal_title：Drug testing and analysis

authors： Mogler L,Wilde M,Huppertz LM,Weinfurtner G,Franz F,Auwärter V

更新日期：2018-05-01 00:00:00

abstract：:Urine samples were analyzed for lactose to investigate if elevated lactose concentrations indicate recent (< 48 hours) intravenous abuse of substances containing lactose as an excipient. Elevated lactose levels were found in samples given by patients who had recently injected substances intravenously, verified by fres...

journal_title：Drug testing and analysis

authors： Keltanen TN,Heikman PK,Muhonen LH,Gunnar TO,Ojanperä IA

更新日期：2019-09-01 00:00:00

abstract：:The amphetamine molecule contains a chiral center and its enantiomers exhibit differences in pharmacological effects, with the S-enantiomer mediating most of the central nervous system stimulating activity. The majority of prescribed amphetamine consists of the pure S-enantiomer, but therapeutic formulations containin...

journal_title：Drug testing and analysis

authors： Havnen H,Hansen M,Spigset O,Hegstad S

更新日期：2020-09-01 00:00:00

abstract：:The advent of liquid chromatography-tandem mass spectrometry (LC-MS/MS), with the sensitivity it confers, permits the analysis of both phase I and II drug metabolites that in the past would have been difficult to target using other techniques. These metabolites may have relevance to current analytical toxicology emplo...

journal_title：Drug testing and analysis

authors： Turfus SC,Braithwaite RA,Cowan DA,Parkin MC,Smith NW,Kicman AT

更新日期：2011-10-01 00:00:00

abstract：:In doping control analysis, the characterization of urinary steroid metabolites is of high interest for a targeted and long-term detection of prohibited anabolic androgenic steroids (AAS). In this work, the structure of a long-term metabolite of dehydrochloromethyltestosterone (DHCMT) was elucidated. Altogether, 8 pos...

journal_title：Drug testing and analysis

authors： Forsdahl G,Geisendorfer T,Göschl L,Pfeffer S,Gärtner P,Thevis M,Gmeiner G

更新日期：2018-03-23 00:00:00

abstract：:Prenylamine is a vasodilator of phenylalkylamine structure and was used for the treatment of angina pectoris, until reports of undesirable effects including ventricular tachycardia led to a decreasing use of the drug in the 1980s. Metabolic N-dealkylation of orally ingested prenylamine can liberate amphetamine in huma...

journal_title：Drug testing and analysis

authors： Beuck S,Sigmund G,Koch A,Schänzer W,Pokrywka A,Kwiatkowska D,Thevis M

更新日期：2012-09-01 00:00:00

abstract：:Three legal highs; nitracaine (3-(diethylamino)-2,2-dimethylpropyl 4-nitrobenzoate), methoxypiperamide (MEOP, (4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone) and mephtetramine (MTTA, 2-((methylamino)methyl)-3,4-dihydronaphthalen-1(2H)-one) appeared in 2013 as new psychoactive substances (NPS) on Internet websites ...

journal_title：Drug testing and analysis

authors： Power JD,Scott KR,Gardner EA,Curran McAteer BM,O'Brien JE,Brehon M,Talbot B,Kavanagh PV

更新日期：2014-07-01 00:00:00

abstract：:Eurycoma longifolia Jack (Tongkat Ali, Simaroubaceae) is a medicinal plant endemic to South-East Asia. For centuries, different parts of the plant have been used as a natural remedy to treat fever, hypertension, or sexual insufficiency. Today, Eurycoma longifolia preparations are commercially available and advertised ...

journal_title：Drug testing and analysis

authors： Bräuer P,Anielski P,Schwaiger S,Stuppner H,Tran TVA,Vollmer G,Zierau O,Thieme D,Keiler AM

更新日期：2019-01-01 00:00:00

abstract：:In the context of post-marketing surveillance supporting public-health authorities to take evidence-based decisions to fight the spread of poor-quality medicines, the quality of antimalarial artemether-lumefantrine (AL) medicines was assessed in the Democratic Republic of the Congo (DRC). A total of 150 samples of AL-...

journal_title：Drug testing and analysis

authors： Mufusama JP,Ndjoko Ioset K,Feineis D,Hoellein L,Holzgrabe U,Bringmann G

更新日期：2018-10-01 00:00:00

abstract：:N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA) and N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) are carboxamide-type synthetic cannabinoids comprising indazole/indole-3-carboxylic acid and adamantan-1-amine moieties. However, in the case of compounds like APINACA or APICA, adamantyl positiona...

journal_title：Drug testing and analysis

authors： Asada A,Doi T,Tagami T,Takeda A,Sawabe Y

更新日期：2017-03-01 00:00:00

abstract：:The synthesis of positional isomers of designer drugs is a common way of bypassing legal restrictions. For forensic case work, and especially for the legal assessment of cases, there is a need for screening methods capable of the unequivocal identification of positional isomers. The presented liquid chromatography-ele...

journal_title：Drug testing and analysis

authors： Grumann C,Auwärter V

更新日期：2018-02-18 00:00:00

abstract：:5-(2-Aminopropyl)indole (5-IT) is a psychoactive compound that has recently been associated with several fatal and non-fatal intoxications in a number of European countries. There are indications that acute effects may include symptoms of monoaminergic (e.g. serotonin) toxicity and one mechanism involved in the increa...

journal_title：Drug testing and analysis

authors： Herraiz T,Brandt SD

更新日期：2014-07-01 00:00:00

abstract：:Meconium drug testing is a non-invasive method to detect prenatal drug exposure, which can cause severe problems for the infant, indicating the need for follow-up measures to ensure the welfare of the child. Meconium samples for drug testing were collected from 143 infants as part of routine clinical work among addict...

journal_title：Drug testing and analysis

authors： Launiainen T,Nupponen I,Halmesmäki E,Ojanperä I

更新日期：2013-07-01 00:00:00

abstract：:Oral fluid (OF) offers a simple, non-invasive, directly observable sample collection for clinical and forensic drug testing. Given that chronic cannabis smokers often engage in drug administration multiple times daily, evaluating OF cannabinoid pharmacokinetics during ad libitum smoking is important for practical deve...

journal_title：Drug testing and analysis

authors： Lee D,Vandrey R,Mendu DR,Murray JA,Barnes AJ,Huestis MA

更新日期：2015-06-01 00:00:00

abstract：:Several clinical-grade immunoassays exist for the specific measurement of hGH or its isoforms in blood but there is an urgent need to apply these same reliable assays to the measurement of hGH in urine as a preferred 'non-invasive' biofluid. Unfortunately, conventional hGH immunoassays cannot attain the sensitivity re...

journal_title：Drug testing and analysis

authors： Fredolini C,Tamburro D,Gambara G,Lepene BS,Espina V,Petricoin EF 3rd,Liotta LA,Luchini A

更新日期：2009-09-01 00:00:00

abstract：:Increasing numbers of new psychoactive substances (NPS) among them fentanyl derivatives has been reported by the European monitoring centre for drugs and drug addiction (EMCDDA). Butyrfentanyl is a new fentanyl derivative whose potency ratio was found to be seven compared to morphine and 0.13 compared to fentanyl. Sev...

journal_title：Drug testing and analysis

authors： Steuer AE,Williner E,Staeheli SN,Kraemer T

更新日期：2017-07-01 00:00:00

abstract：:Different extracts of Nigella sativa L. seed waste; aqueous (AE) 200 mg/kg, ethanol 70% (EE) 250 mg/kg and hexane (HE) 10 mg/kg, were evaluated for their hepatoprotective activities. They were administered orally, once daily, for 5 consecutive days. On day 5, liver injury was induced in animals by a single i.p. inject...

journal_title：Drug testing and analysis

authors： Michel CG,El-Sayed NS,Moustafa SF,Ezzat SM,Nesseem DI,El-Alfy TS

更新日期：2011-04-01 00:00:00

abstract：:Testosterone and related compounds are the most recurrent doping substances. The steroid profile, consisting of the quantification of testosterone and its metabolites, has been described as the most significant biomarker to detect doping with pseudo-endogenous anabolic steroids. The steroidal module of the Athlete Bio...

journal_title：Drug testing and analysis

authors： Baume N,Geyer H,Vouillamoz M,Grisdale R,Earl M,Aguilera R,Cowan DA,Ericsson M,Gmeiner G,Kwiatkowska D,Kioukia-Fougia N,Molina A,Ruivo J,Segura J,Van Eenoo P,Jan N,Robinson N,Saugy M

更新日期：2016-07-01 00:00:00

abstract：:N-Methyl-3-phenyl-norbornan-2-amine (N-methyl-3-phenylbicyclo[2.2.1]heptan-2-amine, Camfetamine(™) ) is available from a number of online legal highs/research chemicals' vendors. Although it was developed as an analeptic by Merck in the early 1960s, it was never commercialized. However, the Association of Independent ...

journal_title：Drug testing and analysis

authors： Kavanagh P,Angelov D,O'Brien J,Power JD,McDermott SD,Talbot B,Fox J,O'Donnell C,Christie R

更新日期：2013-04-01 00:00:00

abstract：:The abuse of stanozolol is quite widespread in Indian sport. Its analysis is challenging and this has led to the development of new methods to improve its detection. A method was developed and validated for the detection of the three main monohydroxylated metabolites of stanozolol. The excretion profile of these metab...

journal_title：Drug testing and analysis

authors： Ahi S,Beotra A,Jain S

更新日期：2009-11-01 00:00:00

abstract：:Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1-acyl substituted lyserga...

journal_title：Drug testing and analysis

authors： Brandt SD,Kavanagh PV,Westphal F,Stratford A,Odland AU,Klein AK,Dowling G,Dempster NM,Wallach J,Passie T,Halberstadt AL

更新日期：2020-06-01 00:00:00

abstract：:The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration-based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma...

journal_title：Drug testing and analysis

authors： Lobigs LM,Sottas PE,Bourdon PC,Nikolovski Z,El-Gingo M,Varamenti E,Peeling P,Dawson B,Schumacher YO

更新日期：2018-02-01 00:00:00

abstract：:The use of performance enhancing drugs is a widespread phenomenon in professional and leisure sports. A spectroscopic study was carried out on anabolic tablets labelled as 5 mg methandienone tablets provided by police departments. The analytical approach was based on a two-step methodology: a fast analysis of tablets ...

journal_title：Drug testing and analysis

authors： Rebiere H,Ghyselinck C,Lempereur L,Brenier C

更新日期：2016-03-01 00:00:00

abstract：:Dihydroartemisinin (DHA) and piperaquine (PPQ) are two drugs used in an artemisinin-based combination therapy (ACT). The circulation of counterfeit antimalarial drugs demands the development of simple, point-of-care (POC) tests for monitoring drug quality. Here we aimed to design an antibody-based lateral flow dipstic...

journal_title：Drug testing and analysis

authors： Ning X,Tan G,Chen X,Wang M,Wang B,Cui L

更新日期：2019-09-01 00:00:00

abstract：:Selective androgen receptor modulators (SARMs) are a group of anabolic enhancer drugs posing threats to the integrity of animal sports and the safety of animal-derived foods. The current research describes for the first time the development of a semi-quantitative assay for the monitoring of SARM family compounds in bl...

journal_title：Drug testing and analysis

authors： Ventura E,Gadaj A,Buckley T,Mooney MH

更新日期：2020-09-01 00:00:00

abstract：:Doping with natural steroids can be detected by evaluating the urinary concentrations and ratios of several endogenous steroids. Since these biomarkers of steroid doping are known to present large inter-individual variations, monitoring of individual steroid profiles over time allows switching from population-based to...

journal_title：Drug testing and analysis

authors： Van Renterghem P,Van Eenoo P,Sottas PE,Saugy M,Delbeke F

更新日期：2010-11-01 00:00:00

abstract：:The reactions involved in the metabolic pathways of SR9009 were characterized by liquid chromatography-mass spectrometry (LC-MS) to identify the most appropriate marker(s) of use. The effects of gender, genetic polymorphism, and drug-drug interaction on the metabolic profile of SR9009 were also evaluated. In vitro app...

journal_title：Drug testing and analysis

authors： Mazzarino M,Rizzato N,Stacchini C,de la Torre X,Botrè F

更新日期：2018-11-01 00:00:00