Abstract:
:The synthesis of positional isomers of designer drugs is a common way of bypassing legal restrictions. For forensic case work, and especially for the legal assessment of cases, there is a need for screening methods capable of the unequivocal identification of positional isomers. The presented liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method facilitates separation of positional isomers of 9 2-phenethylamine-derived designer drugs in different matrices including seized materials, hair, serum, and urine specimens. Chromatographic separation was achieved on a biphenyl phase using gradient elution with a total runtime of 26 minutes. The limit of detection was 25 pg/mg for hair samples and ranged from 0.1 ng/mL to 0.5 ng/mL for serum and from 0.2 ng/mL to 1.2 ng/mL for urine samples. The method proved to be selective and sensitive and showed good chromatographic resolution (R ≥ 1.2). The method was successfully applied to routine case samples.
journal_name
Drug Test Analjournal_title
Drug testing and analysisauthors
Grumann C,Auwärter Vdoi
10.1002/dta.2371subject
Has Abstractpub_date
2018-02-18 00:00:00eissn
1942-7603issn
1942-7611pub_type
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