Abstract:
:Phosphatidylethanol 16:0/18:1 (PEth) is the most abundant homologue of the phosphatidylethanol group of phospholipids. Formed only in the presence of ethanol, PEth is used as a biomarker in whole blood to provide information about the consumption of alcohol. As information on the storage life of PEth is essential for its beneficial use as a biomarker, this study investigated the stability of PEth in spiked and authentic whole blood samples stored at 4°C. Human whole blood samples (n = 23) and spiked whole blood samples (n = 7) with a concentration range between 5 and 2000 ng/ml were analysed at specific time intervals, up to 90 days. Differences were evident between the stability of authentic and spiked samples. PEth was stable at 4°C for 60 days (concentrations within 15% of initial concentration) in authentic samples, whereas spiked samples were stable for up to 30 days. This study emphasizes the importance of including authentic samples in stability experiments.
journal_name
Drug Test Analjournal_title
Drug testing and analysisauthors
Dumitrascu C,van de Lavoir MCA,Neels H,Covaci A,Jacobs W,D'Hondt D,van Nuijs ALNdoi
10.1002/dta.2995subject
Has Abstractpub_date
2021-01-04 00:00:00eissn
1942-7603issn
1942-7611pub_type
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