Abstract：
:At present, there is a growing trend toward the intentional adulteration of dietary supplements (DS) with synthetic pharmaceuticals, which represents an alarming emerging risk to consumers and a serious problem for regulatory agencies. An amazing array of synthetic drugs and their analogues have been reported as adulterants in DS. Mainly, the presence of analogues represents a serious health risk as their efficacy and toxic effects have not been clinically assessed yet and may result in unpredictable adverse effects. The purpose of this review is to provide an overview, over the period 2009-2019, of the most frequently reported adulterants in DS for the treatment of erectile dysfunction, obesity/overweight, diabetes mellitus, and hypertension and the analytical methods used for their detection.
journal_name
Drug Test Analjournal_title
Drug testing and analysisauthors
Muschietti L,Redko F,Ulloa Jdoi
10.1002/dta.2806subject
Has Abstractpub_date
2020-07-01 00:00:00pages
861-886issue
7eissn
1942-7603issn
1942-7611journal_volume
12pub_type
杂志文章,评审abstract：:5-(2-Aminopropyl)indole (5-IT) is a psychoactive compound that has recently been associated with several fatal and non-fatal intoxications in a number of European countries. There are indications that acute effects may include symptoms of monoaminergic (e.g. serotonin) toxicity and one mechanism involved in the increa...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.1530
更新日期：2014-07-01 00:00:00
abstract：:The tiletamine-zolazepam (TZ) combination is an anaesthetic drug commonly used in veterinary medicine. It is an equal amount combination of tiletamine, a dissociative anaesthetic pharmacologically classified as an N-methyl-D-aspartate (NMDA) receptor antagonist, and zolazepam, a benzodiazepine tranquilizer. There are ...
journal_title：Drug testing and analysis
pub_type： 杂志文章,评审
doi：10.1002/dta.1987
更新日期：2016-08-01 00:00:00
abstract：:A new, simple, rapid, accurate and precise high performance thin layer chromatography (HPTLC) method has been developed for the estimation of ondansetron hydrochloride in bulk and sublingual tablets. The mobile phase composition was chloroform : ethyl acetate : methanol : ammonia (9:5:4:0.1 v/v). Spectrodensitometric ...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.311
更新日期：2013-02-01 00:00:00
abstract：:In doping control analysis, the characterization of urinary steroid metabolites is of high interest for a targeted and long-term detection of prohibited anabolic androgenic steroids (AAS). In this work, the structure of a long-term metabolite of dehydrochloromethyltestosterone (DHCMT) was elucidated. Altogether, 8 pos...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2385
更新日期：2018-03-23 00:00:00
abstract：:Fast and unequivocal drug detection is of considerable importance in numerous fields of analytical chemistry, and today mass spectrometry-based approaches are often the method of choice due to their sensitive and specific nature. Mass spectrometry is in constant flux with innovations and thus supports the development ...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.344
更新日期：2012-03-01 00:00:00
abstract：:A simple and highly sensitive method that involves miniaturized hollow fibre assisted liquid-phase microextraction with gas chromatography-flame ionization detector was developed for the determination of trace concentration of sufentanil and alfentanil in biological samples. These drugs were extracted from 5 ml of aqu...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.1387
更新日期：2013-07-01 00:00:00
abstract：:Urinalysis is well established for drug screening. Various methods of urine adulteration such as dilution, addition of oxidative/reductive chemicals or detergents, and handing over urine-like fluids are used to circumvent a positive screen. Validity parameters such as determination of pH, gravidity, urine temperature,...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2447
更新日期：2018-10-01 00:00:00
abstract：:Anabolic-androgenic steroids (AAS) represent one of the most frequently detected classes of prohibited substances in doping controls. Due to their long-lasting beneficial effects on athletic performance, utmost retrospectivity via urine analysis is desirable and accomplished by targeting long-term metabolites of the r...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.1516
更新日期：2013-11-01 00:00:00
abstract：:Knowing that polyunsaturated fatty acids can lead to the formation of potentially toxic aldehydes as secondary oxidation products, an analytical method using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) detection was developed to measure the concentration of eight aldehydes in animal feed: malo...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2013
更新日期：2016-05-01 00:00:00
abstract：:Urine samples were analyzed for lactose to investigate if elevated lactose concentrations indicate recent (< 48 hours) intravenous abuse of substances containing lactose as an excipient. Elevated lactose levels were found in samples given by patients who had recently injected substances intravenously, verified by fres...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2654
更新日期：2019-09-01 00:00:00
abstract：:Synthetic cannabinoids are the psychotropic compounds frequently identified as active components of smoking mixtures easily available via the Internet in several countries. These herbal blends have become extremely popular as a legal alternative to cannabis-based products and are difficult to detect by regular drug te...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.1418
更新日期：2012-10-01 00:00:00
abstract：:In Australia, drug monitoring systems have been in place for more than a decade allowing for the measurement of ongoing trends in drug use and the detection of new drugs. The Drug Trends Unit at the National Drug and Alcohol Research Centre monitors drugs through four separate systems. The Illicit Drug Reporting Syste...
journal_title：Drug testing and analysis
pub_type： 杂志文章,评审
doi：10.1002/dta.1613
更新日期：2014-07-01 00:00:00
abstract：:Among the recently emerged synthetic cannabinoids, MDMB-CHMICA (methyl N-{[1-(cyclohexylmethyl)-1H-indol-3-yl]carbonyl}-3-methylvalinate) shows an extraordinarily high prevalence in intoxication cases, necessitating analytical methods capable of detecting drug uptake. In this study, the in vivo phase I metabolism of M...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2049
更新日期：2017-05-01 00:00:00
abstract：:MSforID represents a database of tandem mass spectral data obtained from (quasi-)molecular ions produced by atmospheric pressure ionization methods. At the current stage of development the library contains 12 122 spectra of 1208 small (bio-)organic molecules. The present work was aimed to evaluate the performance of t...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.341
更新日期：2012-03-01 00:00:00
abstract：:Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at present the only causal therapeutic approach. Being the key target of OP toxicity, AChE may serve as a valuable tool for diagnosis of OP exposure as well as for the invest...
journal_title：Drug testing and analysis
pub_type： 杂志文章,评审
doi：10.1002/dta.337
更新日期：2012-03-01 00:00:00
abstract：:Bioactive peptides pose a great threat to sports integrity. The detection of these peptides is essential for enforcing their prohibition in sports. Identifying the catabolites of these peptides that are formed ex vivo in plasma may improve their detection. In the present study, the stability of 27 bioactive peptides w...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2781
更新日期：2020-06-01 00:00:00
abstract：:New Psychoactive Substances are now a feature of Australia's recreational drug market. Little is known, however, about the prevalence of use, the characteristics of people who use them and the relationship between the NPS and ecstasy markets. This study examined the prevalence and correlates of NPS use amongst a group...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.1626
更新日期：2014-07-01 00:00:00
abstract：:Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti-Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit ...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2343
更新日期：2018-05-01 00:00:00
abstract：:Three sensitive, selective and precise stability-indicating methods for the determination of the anti-Alzheimer's drug, rivastigmine hydrogen tartrate (RIV) in the presence of its alkaline degradation product (major metabolite, NAP 226-90) and in pharmaceutical formulation were developed and validated. The first metho...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.121
更新日期：2010-05-01 00:00:00
abstract：:The availability of a real-time assay to experimentally investigate the release of encapsulated proteins would be beneficial given the interest in the use of liposomes as a drug delivery vehicle. Although simple assays for small molecular weight substances exist, assays to evaluate macromolecules do not. Here we descr...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2332
更新日期：2018-06-01 00:00:00
abstract：:A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relativ...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.231
更新日期：2011-06-01 00:00:00
abstract：:In 2005 and 2008, studies reported that cannabis in England had become dominated by the sinsemilla (unseeded female) form. The average potency (Δ9 -tetrahydrocannabinol [THC] content) of this material had doubled over the previous decade. Cannabis resin then circulating contained approximately equal ratios of THC and ...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2368
更新日期：2018-04-01 00:00:00
abstract：:Deschloroketamine (2-(methylamino)-2-phenyl-cyclohexanone) is a ketamine analog belonging to a group of dissociative anesthetics, which have been distributed within the illicit market since 2015. However, it was also being sold as 'ketamine' misleading people to believe that they were getting genuine ketamine. Dissoci...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2726
更新日期：2020-03-01 00:00:00
abstract：:Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1-acyl substituted lyserga...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2789
更新日期：2020-06-01 00:00:00
abstract：:The consumption of drugs is of great concern worldwide. Various drug tests for humans have been developed but there is no compact and easy-to-use test device available yet for direct semi-quantitative drug testing in the field. We suggest using attenuated total reflection (ATR) infrared spectroscopy as a sensing metho...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.346
更新日期：2012-06-01 00:00:00
abstract：:The amphetamine molecule contains a chiral center and its enantiomers exhibit differences in pharmacological effects, with the S-enantiomer mediating most of the central nervous system stimulating activity. The majority of prescribed amphetamine consists of the pure S-enantiomer, but therapeutic formulations containin...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2879
更新日期：2020-09-01 00:00:00
abstract：:Meconium drug testing is a non-invasive method to detect prenatal drug exposure, which can cause severe problems for the infant, indicating the need for follow-up measures to ensure the welfare of the child. Meconium samples for drug testing were collected from 143 infants as part of routine clinical work among addict...
journal_title：Drug testing and analysis
pub_type： 杂志文章,多中心研究
doi：10.1002/dta.1459
更新日期：2013-07-01 00:00:00
abstract：:The aim of this study was to investigate the effect of Morin on the pharmacokinetics of Piracetam in rats, in vitro enzyme kinetics and metabolic stability (high throughput) studies using human liver microsomes in UPLC. For pharmacokinetics studies, male Wistar rats were pretreated with Morin (10 mg/kg) for one week a...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.1382
更新日期：2013-07-01 00:00:00
abstract：:A rapid and sensitive method involving liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) coupled to an intracerebral microdialysis technique was developed for the determination and pharmacokinetic investigation of tramadol and its major active metabolite O-desmethyltramadol (ODT) in rat brain....
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.2157
更新日期：2017-08-01 00:00:00
abstract：:Iso-α-acids (IAAs) can be used as markers for the consumption of beer. Postmortem specimens from a range of coronial cases were analyzed for IAAs in order to determine the prevalence of beer consumption and any correlation to blood alcohol concentrations (BAC). A total of 130 cases were included in this study includin...
journal_title：Drug testing and analysis
pub_type： 杂志文章
doi：10.1002/dta.1749
更新日期：2015-01-01 00:00:00
