Abstract:
:A new, simple, rapid, accurate and precise high performance thin layer chromatography (HPTLC) method has been developed for the estimation of ondansetron hydrochloride in bulk and sublingual tablets. The mobile phase composition was chloroform : ethyl acetate : methanol : ammonia (9:5:4:0.1 v/v). Spectrodensitometric analysis of ondansetron was carried out at 254 nm and a symmetrical, well-resolved, well-defined peak was obtained at mean retardation factor (R(f) ) 0.52 ± 0.02. The calibration plot was linear in the range 200-1200 ng/spot and showed good linear relationship with coefficient of regression, R(2) = 0.9952 with respect to peak area. The method was validated according to the guidelines of the International Conference on Harmonization (ICH Q2(R1). The limit of detection and quantitation were 14.83 and 44.92 ng per spot, respectively. The recovery study was carried out by standard addition method and the percentage recovery was found to be 99.34 ± 1.08. Therefore it was concluded that the proposed developed HPTLC method can be applied for identification and quantitative determination of ondansetron in bulk drug and dosage forms.
journal_name
Drug Test Analjournal_title
Drug testing and analysisauthors
Mujtaba A,Kohli K,Ali J,Baboota Sdoi
10.1002/dta.311subject
Has Abstractpub_date
2013-02-01 00:00:00pages
122-5issue
2eissn
1942-7603issn
1942-7611journal_volume
5pub_type
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