Abstract:
:Designer drugs belong to a group of legally or illegally produced substances that are structurally and pharmacologically very similar to illicit drugs. In the past, designer drugs were often used during all-night dance parties, but they are now consumed in multiple settings from college bars to parks to private house parties. Most of these club drugs can be bought on legal websites and home-delivered for private parties. Recently, legal highs have once again become a burning media issue across the world. Our review will focus on GHB and synthetic cathinones. Literature searches were conducted for the period from 1975 to July 2010 using PubMed, EMBASE, PsycInfo, Internet underground and governmental websites using the following keywords alone or in combination: designer drugs, club drugs, party drugs, GHB, synthetic cathinones, mephedrone, methylone, flephedrone, MDAI, and MDVP. Available epidemiological, neurobiological, and clinical data for each compound are described. There is evidence that negative health and social consequences may occur in recreational and chronic users. The addictive potential of designer drugs is not weak. Non-fatal overdoses and deaths related to GHB/GBL or synthetic cathinones have been reported. Clinicians must be careful with GBL or synthetic cathinones, which are being sold and used as substitutes for GHB and MDMA, respectively. Interventions for drug prevention and harm reduction in response to the use of these drugs should be implemented on the Internet and in recreational settings. Prevention, Information, Action, and Treatment are the main goals that must be addressed for this new potentially addictive problem.
journal_name
Drug Test Analjournal_title
Drug testing and analysisauthors
Karila L,Reynaud Mdoi
10.1002/dta.210subject
Has Abstractpub_date
2011-09-01 00:00:00pages
552-9issue
9eissn
1942-7603issn
1942-7611journal_volume
3pub_type
杂志文章,评审abstract::1-Propanoyl-lysergic acid diethylamide (1P-LSD) appeared as a non-controlled alternative to LSD a few years ago. Although evidence is beginning to emerge from in vitro and animal studies that 1P-LSD might serve as a prodrug for LSD, an equivalent evaluation in humans is unavailable. Controlled oral and intravenous sel...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2821
更新日期:2020-08-01 00:00:00
abstract::A simple and sensitive method is described for voltammetric determination of promethazine hydrochloride (PMZ), a widely used phenothiazine drug, based on its electrochemical oxidation at a multi-wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE). Compared with bare GCE, the MWCNT-modified GCE exhibite...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.205
更新日期:2011-03-01 00:00:00
abstract::New Psychoactive Substances are now a feature of Australia's recreational drug market. Little is known, however, about the prevalence of use, the characteristics of people who use them and the relationship between the NPS and ecstasy markets. This study examined the prevalence and correlates of NPS use amongst a group...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1626
更新日期:2014-07-01 00:00:00
abstract::In the field of natural extracts, research generally focuses on the study of their biological activities for food, cosmetic, or pharmacological purposes. The evaluation of their adverse effects is often overlooked. In this study, the extracts of Thymus vulgaris L. were obtained by two different extraction methods. Int...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1606
更新日期:2014-10-01 00:00:00
abstract::Synthetic cannabinoids are a group of psychoactive drugs presently widespread among drug users in Europe. Analytical methods to measure these compounds in urine are in demand as urine is a preferred matrix for drug testing. For most synthetic cannabinoids, the parent compounds are rarely detected in urine. Therefore u...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1896
更新日期:2016-09-01 00:00:00
abstract::A simple and highly sensitive method that involves miniaturized hollow fibre assisted liquid-phase microextraction with gas chromatography-flame ionization detector was developed for the determination of trace concentration of sufentanil and alfentanil in biological samples. These drugs were extracted from 5 ml of aqu...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1387
更新日期:2013-07-01 00:00:00
abstract::The widespread use of antibiotics in animals is causing concerns about the growing risk for development and the spread of antibiotic-resistant bacteria. Antibiotic consumption is higher in animals than in humans as reported in a joint publication of EFSA (European Food Safety Agency), ECDC (European Centre for Disease...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2010
更新日期:2016-05-01 00:00:00
abstract::Formestane (4-hydroxy-androstenedione) is an aromatase inhibitor prohibited in sports and included, since 2004, in the list of prohibited substances updated yearly by the World Anti-Doping Agency (WADA). Since the endogenous production of formestane has been described, it is mandatory for the anti-doping laboratories ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1759
更新日期:2014-11-01 00:00:00
abstract::The aim of this study was to investigate the effect of Morin on the pharmacokinetics of Piracetam in rats, in vitro enzyme kinetics and metabolic stability (high throughput) studies using human liver microsomes in UPLC. For pharmacokinetics studies, male Wistar rats were pretreated with Morin (10 mg/kg) for one week a...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1382
更新日期:2013-07-01 00:00:00
abstract::The effectiveness of doping control in sport has been improved continuously during the past 50 years. One of the major steps forward was the introduction of unannounced and targeted out-of-competition testing in order to control the misuse of anabolic-androgenic steroids (AAS), mainly during the end of the 1980s. It a...
journal_title:Drug testing and analysis
pub_type: 信件
doi:10.1002/dta.2727
更新日期:2020-05-01 00:00:00
abstract::Workplace drug testing in Europe is governed by a patchwork of legislation--or lack of it. Other difficulties are caused by language, currency and a host of other factors, including the difficulty in defining 'safety critical'. The European Workplace Drug Testing Society's (EWDTS) history and objectives are briefly ou...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1326
更新日期:2012-02-01 00:00:00
abstract::Prenylamine is a vasodilator of phenylalkylamine structure and was used for the treatment of angina pectoris, until reports of undesirable effects including ventricular tachycardia led to a decreasing use of the drug in the 1980s. Metabolic N-dealkylation of orally ingested prenylamine can liberate amphetamine in huma...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1388
更新日期:2012-09-01 00:00:00
abstract::The synthetic tryptamine 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT) has recently been abused as a hallucinogenic drug in Germany and Switzerland. This study presents a case of 5-MeO-MiPT intoxication and the structural elucidation of metabolites in pooled human liver microsomes (pHLM), blood, and urine. Mic...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2245
更新日期:2018-03-01 00:00:00
abstract::Current doping trends overshadow the traditional interpretation of using prohibited performance-enhancing drugs to improve training and/or sports results. Its definition has evolved due to several recent cases of unconventional manipulation in sports. In this article, we present a case study of an intentional intoxica...
journal_title:Drug testing and analysis
pub_type: 历史文章,杂志文章
doi:10.1002/dta.2753
更新日期:2020-05-01 00:00:00
abstract::Detection of the abuse of synthetic steroids in food production is nowadays relatively straightforward using modern techniques such as gas or liquid chromatography coupled to mass spectrometry (GC-MS/MS or LC-MS/MS, respectively). However, proving the abuse of 'endogenous' (or naturally occurring) steroids is more dif...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.1354
更新日期:2012-08-01 00:00:00
abstract::The present study demonstrates the applicability of a strategy involving use of liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) techniques for the identification and characterization of minute quantities of degradation products, without their isolation from the reaction matrix in pure fo...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.116
更新日期:2010-02-01 00:00:00
abstract::Sulfate metabolites have been described as long-term metabolites for some anabolic androgenic steroids (AAS). 4-chlorometandienone (4Cl-MTD) is one of the most frequently detected AAS in sports drug testing and it is commonly detected by monitoring metabolites excreted free or conjugated with glucuronic acid. Sulfatio...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2101
更新日期:2017-07-01 00:00:00
abstract::Autologous blood transfusion is a powerful means of improving performance and remains one of the most challenging methods to detect. Recent investigations have identified 3 candidate reticulocytes genes whose expression was significantly influenced by blood transfusion. Using quantitative reverse transcription polymer...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2240
更新日期:2018-03-01 00:00:00
abstract::Cobalt is a well-established inducer of hypoxia-like responses, which can cause gene modulation at the hypoxia inducible factor pathway to induce erythropoietin transcription. Cobalt salts are orally active, inexpensive, and easily accessible. It is an attractive blood doping agent for enhancing aerobic performance. I...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1719
更新日期:2015-01-01 00:00:00
abstract::A new and sensitive multi-residue method (MRM) with detection by LC-MS/MS was developed and validated for the screening, determination, and confirmation of residues of 7 nitroimidazoles and 3 of their metabolites in turkey muscle tissues at concentrations ≥ 0.05 ng/g. The compounds were extracted into a solvent with a...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1356
更新日期:2012-08-01 00:00:00
abstract::Erythropoietin (EPO) has been misused in sports for many years due to its performance-enhancing effect. In the last decade, detection of abuse has been possible with isoelectric focusing (IEF) based on the different isoform profiles of endogenous and recombinant EPO. The release of new EPOs on the market, such as the ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.270
更新日期:2011-05-01 00:00:00
abstract::Tretoquinol (trimetoquinol), a β2-agonist, has been explicitly listed on the World Anti-Doping Agency Prohibited List 2019 since January 2019; however, it has been distributed as an antiasthmatic on the medical market. This study aimed to develop a liquid chromatography-tandem mass spectrometric method for the quantif...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2714
更新日期:2019-11-01 00:00:00
abstract::Zolpidem and zopiclone (Z-compounds) are non-benzodiazepine hypnotics of new generation that can be used in drug-facilitated sexual assault (DFSA). Their determination in biological fluids, mainly urine, is of primary importance; nevertheless, although they are excreted almost entirely as metabolites, available method...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1470
更新日期:2014-03-01 00:00:00
abstract::The advent of liquid chromatography-tandem mass spectrometry (LC-MS/MS), with the sensitivity it confers, permits the analysis of both phase I and II drug metabolites that in the past would have been difficult to target using other techniques. These metabolites may have relevance to current analytical toxicology emplo...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.305
更新日期:2011-10-01 00:00:00
abstract::Bioactive peptides pose a great threat to sports integrity. The detection of these peptides is essential for enforcing their prohibition in sports. Identifying the catabolites of these peptides that are formed ex vivo in plasma may improve their detection. In the present study, the stability of 27 bioactive peptides w...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2781
更新日期:2020-06-01 00:00:00
abstract::Fast and unequivocal drug detection is of considerable importance in numerous fields of analytical chemistry, and today mass spectrometry-based approaches are often the method of choice due to their sensitive and specific nature. Mass spectrometry is in constant flux with innovations and thus supports the development ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.344
更新日期:2012-03-01 00:00:00
abstract::Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1-acyl substituted lyserga...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2789
更新日期:2020-06-01 00:00:00
abstract::Two primary animal models persist for assessing hallucinogenic potential of novel compounds and for examining the pharmacological and neurobiological substrates underlying the actions of classical hallucinogens, the two-lever drug discrimination procedure and the drug-induced head-twitch response (HTR) in rodents. The...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.1333
更新日期:2012-07-01 00:00:00
abstract::The impact of altitude training on haematological parameters and the Athlete Biological Passport (ABP) was evaluated in international-level elite athletes. One group of swimmers lived high and trained high (LHTH, n = 10) for three to four weeks at 2130 m or higher whereas a control group (n = 10) completed a three-wee...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1757
更新日期:2015-08-01 00:00:00
abstract::Dihydroartemisinin (DHA) and piperaquine (PPQ) are two drugs used in an artemisinin-based combination therapy (ACT). The circulation of counterfeit antimalarial drugs demands the development of simple, point-of-care (POC) tests for monitoring drug quality. Here we aimed to design an antibody-based lateral flow dipstic...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2656
更新日期:2019-09-01 00:00:00