Abstract:
:Autologous blood transfusion is a powerful means of improving performance and remains one of the most challenging methods to detect. Recent investigations have identified 3 candidate reticulocytes genes whose expression was significantly influenced by blood transfusion. Using quantitative reverse transcription polymerase chain reaction as an alternative quantitative method, the present study supports that delta-aminolevulinate synthase 2 (ALAS2), carbonic anhydrase (CA1), and solute carrier family 4 member 1 (SLC4A1) genes are down-regulated post-transfusion. The expression of these genes exhibited stronger correlation with immature reticulocyte fraction than with reticulocytes percentage. Moreover, the repression of reticulocytes' gene expression was more pronounced than the diminution of immature reticulocyte fraction and reticulocyte percentage following blood transfusion. It suggests that the 3 candidate genes are reliable predictors of bone marrow's response to blood transfusion and that they represent potential biomarkers for the detection of this method prohibited in sports.
journal_name
Drug Test Analjournal_title
Drug testing and analysisauthors
Salamin O,Mignot J,Kuuranne T,Saugy M,Leuenberger Ndoi
10.1002/dta.2240subject
Has Abstractpub_date
2018-03-01 00:00:00pages
604-608issue
3eissn
1942-7603issn
1942-7611journal_volume
10pub_type
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