Effect of glucocorticoid administration on the steroid profile.

abstract：:The legally defensible proof of the abuse of endogenous steroids in sports is currently based on carbon isotope ratio mass spectrometry (IRMS), i.e. a comparison between (13)C/(12)C ratios of diagnostic precursors and metabolites of testosterone. The application of this technique requires a chromatographic baseline se...

journal_title：Drug testing and analysis

authors： Thieme D,Rautenberg C,Grosse J,Schoenfelder M

更新日期：2013-11-01 00:00:00

abstract：:A simple and sensitive method is described for voltammetric determination of promethazine hydrochloride (PMZ), a widely used phenothiazine drug, based on its electrochemical oxidation at a multi-wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE). Compared with bare GCE, the MWCNT-modified GCE exhibite...

journal_title：Drug testing and analysis

authors： Xi X,Ming L,Liu J

更新日期：2011-03-01 00:00:00

abstract：:The method of high sensitive gas chromatographic/time-of-flight mass-spectrometric (GC/TOF-MS) analysis of steroids was developed. Low-resolution TOF-MS instrument (with fast spectral acquisition rate) was used. This method is based on the formation of the silyl derivatives of steroids; exchange of the reagent mixture...

journal_title：Drug testing and analysis

authors： Revelsky AI,Samokhin AS,Virus ED,Rodchenkov GM,Revelsky IA

更新日期：2011-04-01 00:00:00

abstract：:Relaxin (RLX) has demonstrated diverse pharmacological effects in various scientific and clinical studies. The emergence of porcine relaxin (pRLX) has raised concerns on the doping potential of pRLX. There have also been speculations in the horseracing industry on its covert use. To control the abuse of pRLX in equine...

journal_title：Drug testing and analysis

authors： Wong ASY,Ho ENM,Kwok WH,Leung GNW,Shen Y,Qi RZ,Yue SK,Wan TSM

更新日期：2017-09-01 00:00:00

abstract：:Metal ion coordination ionspray (M(+) CIS) ionization is a powerful technique to enhance ionization efficiency and sensitivity. In this study, we developed and validated an analytical method for simultaneous ionization and analysis of 84 anabolic androgenic steroids (65 exogenous and 19 endogenous) using liquid chroma...

journal_title：Drug testing and analysis

authors： Kim SH,Cha EJ,Lee KM,Kim HJ,Kwon OS,Lee J

更新日期：2014-11-01 00:00:00

abstract：:Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alternative techniques, like dried blood spots (DBS), has consequently increased. A fast and easy to perform DBS method for...

journal_title：Drug testing and analysis

authors： Patteet L,Maudens KE,Stove CP,Lambert WE,Morrens M,Sabbe B,Neels H

更新日期：2015-06-01 00:00:00

abstract：:We recently published two protocols for the detection of Sotatercept (ACE-011, ACVR2A-Fc) and Luspatercept (ACE-536, ACVR2B-Fc) in human serum. Both methods used covalently immobilized antibodies on agarose beads for immunoprecipitation and SAR-PAGE/Western blotting for detection. Disadvantages were the relatively hig...

journal_title：Drug testing and analysis

authors： Reichel C,Gmeiner G,Walpurgis K,Thevis M

更新日期：2018-11-01 00:00:00

abstract：:Phosphatidylethanol 16:0/18:1 (PEth) is the most abundant homologue of the phosphatidylethanol group of phospholipids. Formed only in the presence of ethanol, PEth is used as a biomarker in whole blood to provide information about the consumption of alcohol. As information on the storage life of PEth is essential for ...

journal_title：Drug testing and analysis

authors： Dumitrascu C,van de Lavoir MCA,Neels H,Covaci A,Jacobs W,D'Hondt D,van Nuijs ALN

更新日期：2021-01-04 00:00:00

abstract：:Urine samples were analyzed for lactose to investigate if elevated lactose concentrations indicate recent (< 48 hours) intravenous abuse of substances containing lactose as an excipient. Elevated lactose levels were found in samples given by patients who had recently injected substances intravenously, verified by fres...

journal_title：Drug testing and analysis

authors： Keltanen TN,Heikman PK,Muhonen LH,Gunnar TO,Ojanperä IA

更新日期：2019-09-01 00:00:00

abstract：:To date, substances such as Mildronate (Meldonium) are not on the radar of anti-doping laboratories as the compound is not explicitly classified as prohibited. However, the anti-ischemic drug Mildronate demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection ag...

journal_title：Drug testing and analysis

authors： Görgens C,Guddat S,Dib J,Geyer H,Schänzer W,Thevis M

更新日期：2015-11-01 00:00:00

abstract：:The synthetic tryptamine 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT) has recently been abused as a hallucinogenic drug in Germany and Switzerland. This study presents a case of 5-MeO-MiPT intoxication and the structural elucidation of metabolites in pooled human liver microsomes (pHLM), blood, and urine. Mic...

journal_title：Drug testing and analysis

authors： Grafinger KE,Hädener M,König S,Weinmann W

更新日期：2018-03-01 00:00:00

abstract：:The Ministry of Health in the Netherlands has made illicit drug testing for drug users possible since the 1990s, in order to prevent serious health hazards associated with unexpected dangerous substances. This system of illicit drug testing is called the Drug Information and Monitoring System (DIMS). In nearly two dec...

journal_title：Drug testing and analysis

authors： Brunt TM,Niesink RJ

更新日期：2011-09-01 00:00:00

abstract：:Even though hair analysis often seems to be the best choice for retrospective monitoring of cocaine intake, differentiating between incorporated cocaine and external contamination is widely debated. In this study we report results obtained in 90 hair samples from addicts. All samples were analyzed for cocaine, benzoyl...

journal_title：Drug testing and analysis

authors： Gambelunghe C,Rossi R,Aroni K,Gili A,Bacci M,Pascali V,Fucci N

更新日期：2017-02-01 00:00:00

abstract：:The emerging new psychoactive substances made available for recreational drug use have recently started to include designer benzodiazepines. As a consequence, the routine immunoassay drug testing for benzodiazepines may become less effective, due to an increased occurrence of 'false negative' and 'false positive' resu...

journal_title：Drug testing and analysis

authors： Pettersson Bergstrand M,Helander A,Hansson T,Beck O

更新日期：2017-04-01 00:00:00

abstract：:Drug and alcohol abuse is a concern for many European companies, especially those having safety-critical jobs. It is not uncommon for European companies to establish a drug policy with little or no provision for drug testing. The European Union (EU) has launched a number of initiatives in its fight against drugs. Ther...

journal_title：Drug testing and analysis

authors： Agius R,Kintz P,European Workplace Drug Testing Society.

更新日期：2010-08-01 00:00:00

abstract：:Meconium drug testing is a non-invasive method to detect prenatal drug exposure, which can cause severe problems for the infant, indicating the need for follow-up measures to ensure the welfare of the child. Meconium samples for drug testing were collected from 143 infants as part of routine clinical work among addict...

journal_title：Drug testing and analysis

authors： Launiainen T,Nupponen I,Halmesmäki E,Ojanperä I

更新日期：2013-07-01 00:00:00

abstract：:An orthogonal signal correction-partial least squares (OSC-PLS) method was developed for the simultaneous spectrophotometric determination of orotic acid (OA), creatinine (CRE), and uric acid (UA) in spiked real samples. By multivariate calibration methods, such as PLS regression, it is possible to obtain a model adju...

journal_title：Drug testing and analysis

authors： Khajehsharifi H,Tavallali H,Shekoohi M,Sadeghi M

更新日期：2013-05-01 00:00:00

abstract：:The evolving nature of new psychoactive substances (NPS) - often referred to as 'legal highs', 'designer drugs' or 'bath salts' - presents an evolving challenge for toxicologists. Apart from the detection and identification of these compounds, further analytical challenges may arise from the presence of possible metab...

journal_title：Drug testing and analysis

authors： Soh YN,Elliott S

更新日期：2014-07-01 00:00:00

abstract：:Zolpidem and zopiclone (Z-compounds) are non-benzodiazepine hypnotics of new generation that can be used in drug-facilitated sexual assault (DFSA). Their determination in biological fluids, mainly urine, is of primary importance; nevertheless, although they are excreted almost entirely as metabolites, available method...

journal_title：Drug testing and analysis

authors： Strano Rossi S,Anzillotti L,Castrignanò E,Frison G,Zancanaro F,Chiarotti M

更新日期：2014-03-01 00:00:00

abstract：:Hemp nuts are mature cannabis seeds obtained after shelling and that are commonly used in traditional Chinese medicine for treating functional constipation. In this work, we screened hemp nut products, classified them, and verified the legality of consuming them. A total of 18 products were purchased from Taiwan, Chin...

journal_title：Drug testing and analysis

authors： Chang CW,Tung CW,Tsai CC,Wu YT,Hsu MC

更新日期：2017-06-01 00:00:00

abstract：:Anabolic-androgenic steroids are synthetic compounds prohibited due to their performance-enhancing characteristics. The use of these substances is known to cause health-related issues, which highlights the importance of being able to evaluate the scale of consumption by the general population. However, most available ...

journal_title：Drug testing and analysis

authors： Shimko KM,O'Brien JW,Barron L,Kayalar H,Mueller JF,Tscharke BJ,Choi PM,Jiang H,Eaglesham G,Thomas KV

更新日期：2019-07-01 00:00:00

abstract：:The study describes an LC-MS/MS method for simultaneous quantification of the cardiac glycosidic drugs digoxin and digitoxin and several of their metabolites. The assay represents a useful reference method for immunoassay-based tests, which are easily biased by the presence of metabolites of the target analytes or str...

journal_title：Drug testing and analysis

authors： Bylda C,Thiele R,Kobold U,Volmer DA

更新日期：2015-10-01 00:00:00

abstract：:A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relativ...

journal_title：Drug testing and analysis

authors： Abounassif MA,Al-Omar MA,Amr AG,Mostafa GA

更新日期：2011-06-01 00:00:00

abstract：:The detection of an intact ester of testosterone in plasma is leading towards unequivocal proof of the administration of exogenous testosterone. In the current study, a sensitive screening method for the detection of nine testosterone esters in human plasma was developed. By preparing oxime derivatives of intact testo...

journal_title：Drug testing and analysis

authors： Forsdahl G,Vatne HK,Geisendorfer T,Gmeiner G

更新日期：2013-11-01 00:00:00

abstract：:The annual update of the list of prohibited substances and doping methods as issued by the World Anti-Doping Agency (WADA) allows the implementation of most recent considerations of performance manipulation and emerging therapeutics into human sports doping control programmes. The annual banned-substance review for hu...

journal_title：Drug testing and analysis

authors： Thevis M,Kuuranne T,Geyer H,Schänzer W

更新日期：2010-04-01 00:00:00

abstract：:Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at present the only causal therapeutic approach. Being the key target of OP toxicity, AChE may serve as a valuable tool for diagnosis of OP exposure as well as for the invest...

journal_title：Drug testing and analysis

authors： Worek F,Eyer P,Thiermann H

更新日期：2012-03-01 00:00:00

abstract：:Clinical and forensic toxicology laboratories are continuously confronted by analytical challenges when dealing with the new psychoactive substances phenomenon. The number of synthetic cannabinoids, the chemical diversity, and the speed of emergence make this group of compounds particularly challenging in terms of det...

journal_title：Drug testing and analysis

authors： Liu C,Jia W,Hua Z,Qian Z

更新日期：2017-08-01 00:00:00

abstract：:New Psychoactive Substances are now a feature of Australia's recreational drug market. Little is known, however, about the prevalence of use, the characteristics of people who use them and the relationship between the NPS and ecstasy markets. This study examined the prevalence and correlates of NPS use amongst a group...

journal_title：Drug testing and analysis

authors： Burns L,Roxburgh A,Matthews A,Bruno R,Lenton S,Van Buskirk J

更新日期：2014-07-01 00:00:00

abstract：:Eurycoma longifolia Jack (Tongkat Ali, Simaroubaceae) is a medicinal plant endemic to South-East Asia. For centuries, different parts of the plant have been used as a natural remedy to treat fever, hypertension, or sexual insufficiency. Today, Eurycoma longifolia preparations are commercially available and advertised ...

journal_title：Drug testing and analysis

authors： Bräuer P,Anielski P,Schwaiger S,Stuppner H,Tran TVA,Vollmer G,Zierau O,Thieme D,Keiler AM

更新日期：2019-01-01 00:00:00

abstract：:Zebrafish (Danio rerio) water tank (ZWT) approach was investigated as an alternative model for metabolism studies based on six different experiments with four model compounds. Sibutramine was applied for the multivariate optimization of ZWT conditions, also for the comparison of the metabolism among ZWT, humans and mi...

journal_title：Drug testing and analysis

authors： Sardela VF,Anselmo CS,Nunes IKDC,Carneiro GRA,Dos Santos GRC,de Carvalho AR,Labanca BJ,Silva Oliveira D,Ribeiro WD,de Araujo ALD,Padilha MC,de Lima CKF,de Sousa VP,de Aquino Neto FR,Gualberto Pereira HM

更新日期：2018-11-01 00:00:00