Annual banned-substance review: analytical approaches in human sports drug testing.

abstract：:The quantitative structure-property relationship (QSPR) of drug molecules against the immobilized liposome chromatography partitioning (log K(s)) was studied. The genetic algorithm (GA) was employed to select the variables that resulted in the best-fitted models. After the variables were selected, the linear multivari...

journal_title：Drug testing and analysis

authors： Noorizadeh H,Farmany A

更新日期：2012-02-01 00:00:00

abstract：:Clinical and forensic toxicology laboratories are continuously confronted by analytical challenges when dealing with the new psychoactive substances phenomenon. The number of synthetic cannabinoids, the chemical diversity, and the speed of emergence make this group of compounds particularly challenging in terms of det...

journal_title：Drug testing and analysis

authors： Liu C,Jia W,Hua Z,Qian Z

更新日期：2017-08-01 00:00:00

abstract：:Deschloroketamine (2-(methylamino)-2-phenyl-cyclohexanone) is a ketamine analog belonging to a group of dissociative anesthetics, which have been distributed within the illicit market since 2015. However, it was also being sold as 'ketamine' misleading people to believe that they were getting genuine ketamine. Dissoci...

journal_title：Drug testing and analysis

authors： Hájková K,Jurásek B,Čejka J,Štefková K,Páleníček T,Sýkora D,Kuchař M

更新日期：2020-03-01 00:00:00

abstract：:This work presents an analytical procedure for the identification and characterization of liposome-entrapped haemoglobins, based on flow cytofluorimetry. Flow cytofluorimetric detection is carried out following labelling by two distinct fluorescent reagents, an anti-haemoglobin antibody, fluorescein isothiocyanate con...

journal_title：Drug testing and analysis

authors： Esposito S,Colicchia S,de la Torre X,Donati F,Mazzarino M,Botrè F

更新日期：2017-02-01 00:00:00

abstract：:Designer drugs belong to a group of legally or illegally produced substances that are structurally and pharmacologically very similar to illicit drugs. In the past, designer drugs were often used during all-night dance parties, but they are now consumed in multiple settings from college bars to parks to private house ...

journal_title：Drug testing and analysis

authors： Karila L,Reynaud M

更新日期：2011-09-01 00:00:00

abstract：:Sulfate metabolites have been described as long-term metabolites for some anabolic androgenic steroids (AAS). 4-chlorometandienone (4Cl-MTD) is one of the most frequently detected AAS in sports drug testing and it is commonly detected by monitoring metabolites excreted free or conjugated with glucuronic acid. Sulfatio...

journal_title：Drug testing and analysis

authors： Balcells G,Gómez C,Garrostas L,Pozo ÓJ,Ventura R

更新日期：2017-07-01 00:00:00

abstract：:The objective of the present work was (1) to develop an in situ gelling ophthalmic delivery system by combining pluronic F127 and pluronic F68, with sparfloxacin; and (2) to examine the influence of incorporating a mucoadhesive polysaccharide such as sodium hyaluronate on the healing property due to bacterial keratiti...

journal_title：Drug testing and analysis

authors： Nesseem DI

更新日期：2011-02-01 00:00:00

abstract：:The amphetamine molecule contains a chiral center and its enantiomers exhibit differences in pharmacological effects, with the S-enantiomer mediating most of the central nervous system stimulating activity. The majority of prescribed amphetamine consists of the pure S-enantiomer, but therapeutic formulations containin...

journal_title：Drug testing and analysis

authors： Havnen H,Hansen M,Spigset O,Hegstad S

更新日期：2020-09-01 00:00:00

abstract：:The reactions involved in the metabolic pathways of SR9009 were characterized by liquid chromatography-mass spectrometry (LC-MS) to identify the most appropriate marker(s) of use. The effects of gender, genetic polymorphism, and drug-drug interaction on the metabolic profile of SR9009 were also evaluated. In vitro app...

journal_title：Drug testing and analysis

authors： Mazzarino M,Rizzato N,Stacchini C,de la Torre X,Botrè F

更新日期：2018-11-01 00:00:00

abstract：:Addiction is a complex disorder with interacting factors, including environmental factors, drug-induced neurobiological changes, comorbidity, personality traits and stress responsivity. Numerous genetic variants that affect these factors may work in concert to affect vulnerability and severity of addiction. Traditiona...

journal_title：Drug testing and analysis

authors： Fattore L

更新日期：2013-01-01 00:00:00

abstract：:5-(2-Aminopropyl)indole (5-IT) is a psychoactive compound that has recently been associated with several fatal and non-fatal intoxications in a number of European countries. There are indications that acute effects may include symptoms of monoaminergic (e.g. serotonin) toxicity and one mechanism involved in the increa...

journal_title：Drug testing and analysis

authors： Herraiz T,Brandt SD

更新日期：2014-07-01 00:00:00

abstract：:To date, substances such as Mildronate (Meldonium) are not on the radar of anti-doping laboratories as the compound is not explicitly classified as prohibited. However, the anti-ischemic drug Mildronate demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection ag...

journal_title：Drug testing and analysis

authors： Görgens C,Guddat S,Dib J,Geyer H,Schänzer W,Thevis M

更新日期：2015-11-01 00:00:00

abstract：:The legally defensible proof of the abuse of endogenous steroids in sports is currently based on carbon isotope ratio mass spectrometry (IRMS), i.e. a comparison between (13)C/(12)C ratios of diagnostic precursors and metabolites of testosterone. The application of this technique requires a chromatographic baseline se...

journal_title：Drug testing and analysis

authors： Thieme D,Rautenberg C,Grosse J,Schoenfelder M

更新日期：2013-11-01 00:00:00

abstract：:Metal ion coordination ionspray (M(+) CIS) ionization is a powerful technique to enhance ionization efficiency and sensitivity. In this study, we developed and validated an analytical method for simultaneous ionization and analysis of 84 anabolic androgenic steroids (65 exogenous and 19 endogenous) using liquid chroma...

journal_title：Drug testing and analysis

authors： Kim SH,Cha EJ,Lee KM,Kim HJ,Kwon OS,Lee J

更新日期：2014-11-01 00:00:00

abstract：:Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1-acyl substituted lyserga...

journal_title：Drug testing and analysis

authors： Brandt SD,Kavanagh PV,Westphal F,Stratford A,Odland AU,Klein AK,Dowling G,Dempster NM,Wallach J,Passie T,Halberstadt AL

更新日期：2020-06-01 00:00:00

abstract：:The steroidal module of the Athlete Biological Passport (ABP) aims to detect doping with endogenous steroids, e.g. testosterone (T), by longitudinally monitoring several biomarkers. These biomarkers are ratios combined into urinary concentrations of testosterone and metabolically related steroids. However, it is evide...

journal_title：Drug testing and analysis

authors： Mullen J,Baekken LV,Törmäkangas T,Ekström L,Ericsson M,Hullstein IR,Schulze JJ

更新日期：2020-06-01 00:00:00

abstract：:Drug and alcohol abuse is a concern for many European companies, especially those having safety-critical jobs. It is not uncommon for European companies to establish a drug policy with little or no provision for drug testing. The European Union (EU) has launched a number of initiatives in its fight against drugs. Ther...

journal_title：Drug testing and analysis

authors： Agius R,Kintz P,European Workplace Drug Testing Society.

更新日期：2010-08-01 00:00:00

abstract：:The aim of this study was to investigate the effect of Morin on the pharmacokinetics of Piracetam in rats, in vitro enzyme kinetics and metabolic stability (high throughput) studies using human liver microsomes in UPLC. For pharmacokinetics studies, male Wistar rats were pretreated with Morin (10 mg/kg) for one week a...

journal_title：Drug testing and analysis

authors： Sahu K,Shaharyar M,Siddiqui AA

更新日期：2013-07-01 00:00:00

abstract：:Knowing that polyunsaturated fatty acids can lead to the formation of potentially toxic aldehydes as secondary oxidation products, an analytical method using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) detection was developed to measure the concentration of eight aldehydes in animal feed: malo...

journal_title：Drug testing and analysis

authors： Douny C,Bayram P,Brose F,Degand G,Scippo ML

更新日期：2016-05-01 00:00:00

abstract：:The use of corticosteroids, such as betamethasone, in performance horses is tightly regulated. The objective of the current study was to describe the plasma pharmacokinetics of betamethasone as well as time-related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve racin...

journal_title：Drug testing and analysis

authors： Knych HK,Stanley SD,Harrison LM,Mckemie DS

更新日期：2017-09-01 00:00:00

abstract：:Urine samples were analyzed for lactose to investigate if elevated lactose concentrations indicate recent (< 48 hours) intravenous abuse of substances containing lactose as an excipient. Elevated lactose levels were found in samples given by patients who had recently injected substances intravenously, verified by fres...

journal_title：Drug testing and analysis

authors： Keltanen TN,Heikman PK,Muhonen LH,Gunnar TO,Ojanperä IA

更新日期：2019-09-01 00:00:00

abstract：:The emerging new psychoactive substances made available for recreational drug use have recently started to include designer benzodiazepines. As a consequence, the routine immunoassay drug testing for benzodiazepines may become less effective, due to an increased occurrence of 'false negative' and 'false positive' resu...

journal_title：Drug testing and analysis

authors： Pettersson Bergstrand M,Helander A,Hansson T,Beck O

更新日期：2017-04-01 00:00:00

abstract：:Relaxin (RLX) has demonstrated diverse pharmacological effects in various scientific and clinical studies. The emergence of porcine relaxin (pRLX) has raised concerns on the doping potential of pRLX. There have also been speculations in the horseracing industry on its covert use. To control the abuse of pRLX in equine...

journal_title：Drug testing and analysis

authors： Wong ASY,Ho ENM,Kwok WH,Leung GNW,Shen Y,Qi RZ,Yue SK,Wan TSM

更新日期：2017-09-01 00:00:00

abstract：:Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti-Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit ...

journal_title：Drug testing and analysis

authors： Chen TT,Tseng YC,Huang TY,Chang-Chien GP,Hsu MC

更新日期：2018-05-01 00:00:00

abstract：:Different extracts of Nigella sativa L. seed waste; aqueous (AE) 200 mg/kg, ethanol 70% (EE) 250 mg/kg and hexane (HE) 10 mg/kg, were evaluated for their hepatoprotective activities. They were administered orally, once daily, for 5 consecutive days. On day 5, liver injury was induced in animals by a single i.p. inject...

journal_title：Drug testing and analysis

authors： Michel CG,El-Sayed NS,Moustafa SF,Ezzat SM,Nesseem DI,El-Alfy TS

更新日期：2011-04-01 00:00:00

abstract：:Even though hair analysis often seems to be the best choice for retrospective monitoring of cocaine intake, differentiating between incorporated cocaine and external contamination is widely debated. In this study we report results obtained in 90 hair samples from addicts. All samples were analyzed for cocaine, benzoyl...

journal_title：Drug testing and analysis

authors： Gambelunghe C,Rossi R,Aroni K,Gili A,Bacci M,Pascali V,Fucci N

更新日期：2017-02-01 00:00:00

abstract：:Standard treatment of poisoning by organophosphorus (OP) nerve agents with atropine and oximes lacks efficacy with some nerve agents. Promising in vitro and in vivo results were obtained with the bispyridinium compound SAD-128 which was partly attributed to its interaction with nicotinic acetylcholine receptors. Previ...

journal_title：Drug testing and analysis

authors： Niessen KV,Tattersall JE,Timperley CM,Bird M,Green C,Thiermann H,Worek F

更新日期：2012-03-01 00:00:00

abstract：:In doping control analysis, the characterization of urinary steroid metabolites is of high interest for a targeted and long-term detection of prohibited anabolic androgenic steroids (AAS). In this work, the structure of a long-term metabolite of dehydrochloromethyltestosterone (DHCMT) was elucidated. Altogether, 8 pos...

journal_title：Drug testing and analysis

authors： Forsdahl G,Geisendorfer T,Göschl L,Pfeffer S,Gärtner P,Thevis M,Gmeiner G

更新日期：2018-03-23 00:00:00

abstract：:Higenamine was included in the World Anti-Doping Agency (WADA) Prohibited Substances and Methods List as a β2 -adrenoceptor agonist in 2017, thereby resulting in its prohibition both in and out of competition. The present mini review describes the physiology and pharmacology of adrenoceptors, summarizes the literature...

journal_title：Drug testing and analysis

authors： Hudzik TJ,Patel M,Brown A

更新日期：2020-12-26 00:00:00

abstract：:Zebrafish (Danio rerio) water tank (ZWT) approach was investigated as an alternative model for metabolism studies based on six different experiments with four model compounds. Sibutramine was applied for the multivariate optimization of ZWT conditions, also for the comparison of the metabolism among ZWT, humans and mi...

journal_title：Drug testing and analysis

authors： Sardela VF,Anselmo CS,Nunes IKDC,Carneiro GRA,Dos Santos GRC,de Carvalho AR,Labanca BJ,Silva Oliveira D,Ribeiro WD,de Araujo ALD,Padilha MC,de Lima CKF,de Sousa VP,de Aquino Neto FR,Gualberto Pereira HM

更新日期：2018-11-01 00:00:00