Cocaine and benzoylecgonine oral fluid on-site screening and confirmation.

abstract：:Evidence of the continuous rise of novel doping agents and novel doping strategies calls for the development of more accurate multi-target screening methods. Direct multi-target screening approaches are restricted to the targeted substances and their turnover. The development of effective "indirect" screening methods ...

journal_title：Drug testing and analysis

authors： Narduzzi L,Dervilly G,Audran M,Le Bizec B,Buisson C

更新日期：2020-06-01 00:00:00

abstract：:The widespread use of antibiotics in animals is causing concerns about the growing risk for development and the spread of antibiotic-resistant bacteria. Antibiotic consumption is higher in animals than in humans as reported in a joint publication of EFSA (European Food Safety Agency), ECDC (European Centre for Disease...

journal_title：Drug testing and analysis

authors： Daeseleire E,De Graef E,Rasschaert G,De Mulder T,Van den Meersche T,Van Coillie E,Dewulf J,Heyndrickx M

更新日期：2016-05-01 00:00:00

abstract：:Metal ion coordination ionspray (M(+) CIS) ionization is a powerful technique to enhance ionization efficiency and sensitivity. In this study, we developed and validated an analytical method for simultaneous ionization and analysis of 84 anabolic androgenic steroids (65 exogenous and 19 endogenous) using liquid chroma...

journal_title：Drug testing and analysis

authors： Kim SH,Cha EJ,Lee KM,Kim HJ,Kwon OS,Lee J

更新日期：2014-11-01 00:00:00

abstract：:Since the appearance of recombinant human growth hormone (rhGH) in the 1980s, its expansion and acquisition through the black market has increased, so the detection of its abuse continues to be a challenge. New biomarkers that are more reliable and sensitive, allowing a larger detection window, are still needed. In th...

journal_title：Drug testing and analysis

authors： Ferro P,Ventura R,Pérez-Mañá C,Farré M,Segura J

更新日期：2017-07-01 00:00:00

abstract：:Doping with natural steroids can be detected by evaluating the urinary concentrations and ratios of several endogenous steroids. Since these biomarkers of steroid doping are known to present large inter-individual variations, monitoring of individual steroid profiles over time allows switching from population-based to...

journal_title：Drug testing and analysis

authors： Van Renterghem P,Van Eenoo P,Sottas PE,Saugy M,Delbeke F

更新日期：2010-11-01 00:00:00

abstract：:Driving under the influence of drugs (DUID) is a worldwide problem. Several countries have adopted DUID legislations which prove their deterrent effect and impact on road safety. However, the use of new psychoactive substances (NPS) and prescription drugs is not known, as the applied roadside screening tests have not ...

journal_title：Drug testing and analysis

authors： Wille SMR,Richeval C,Nachon-Phanithavong M,Gaulier JM,Di Fazio V,Humbert L,Samyn N,Allorge D

更新日期：2018-03-01 00:00:00

abstract：:Two primary animal models persist for assessing hallucinogenic potential of novel compounds and for examining the pharmacological and neurobiological substrates underlying the actions of classical hallucinogens, the two-lever drug discrimination procedure and the drug-induced head-twitch response (HTR) in rodents. The...

journal_title：Drug testing and analysis

authors： Canal CE,Morgan D

更新日期：2012-07-01 00:00:00

abstract：:Prenylamine is a vasodilator of phenylalkylamine structure and was used for the treatment of angina pectoris, until reports of undesirable effects including ventricular tachycardia led to a decreasing use of the drug in the 1980s. Metabolic N-dealkylation of orally ingested prenylamine can liberate amphetamine in huma...

journal_title：Drug testing and analysis

authors： Beuck S,Sigmund G,Koch A,Schänzer W,Pokrywka A,Kwiatkowska D,Thevis M

更新日期：2012-09-01 00:00:00

abstract：:Increasing numbers of new psychoactive substances (NPS) among them fentanyl derivatives has been reported by the European monitoring centre for drugs and drug addiction (EMCDDA). Butyrfentanyl is a new fentanyl derivative whose potency ratio was found to be seven compared to morphine and 0.13 compared to fentanyl. Sev...

journal_title：Drug testing and analysis

authors： Steuer AE,Williner E,Staeheli SN,Kraemer T

更新日期：2017-07-01 00:00:00

abstract：:In Australia, drug monitoring systems have been in place for more than a decade allowing for the measurement of ongoing trends in drug use and the detection of new drugs. The Drug Trends Unit at the National Drug and Alcohol Research Centre monitors drugs through four separate systems. The Illicit Drug Reporting Syste...

journal_title：Drug testing and analysis

authors： Burns L,Roxburgh A,Bruno R,Van Buskirk J

更新日期：2014-07-01 00:00:00

abstract：:Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alternative techniques, like dried blood spots (DBS), has consequently increased. A fast and easy to perform DBS method for...

journal_title：Drug testing and analysis

authors： Patteet L,Maudens KE,Stove CP,Lambert WE,Morrens M,Sabbe B,Neels H

更新日期：2015-06-01 00:00:00

abstract：:The quantitative structure-property relationship (QSPR) of drug molecules against the immobilized liposome chromatography partitioning (log K(s)) was studied. The genetic algorithm (GA) was employed to select the variables that resulted in the best-fitted models. After the variables were selected, the linear multivari...

journal_title：Drug testing and analysis

authors： Noorizadeh H,Farmany A

更新日期：2012-02-01 00:00:00

abstract：:The synthesis of positional isomers of designer drugs is a common way of bypassing legal restrictions. For forensic case work, and especially for the legal assessment of cases, there is a need for screening methods capable of the unequivocal identification of positional isomers. The presented liquid chromatography-ele...

journal_title：Drug testing and analysis

authors： Grumann C,Auwärter V

更新日期：2018-02-18 00:00:00

abstract：:Deschloroketamine (2-(methylamino)-2-phenyl-cyclohexanone) is a ketamine analog belonging to a group of dissociative anesthetics, which have been distributed within the illicit market since 2015. However, it was also being sold as 'ketamine' misleading people to believe that they were getting genuine ketamine. Dissoci...

journal_title：Drug testing and analysis

authors： Hájková K,Jurásek B,Čejka J,Štefková K,Páleníček T,Sýkora D,Kuchař M

更新日期：2020-03-01 00:00:00

abstract：:The detection of an intact ester of testosterone in plasma is leading towards unequivocal proof of the administration of exogenous testosterone. In the current study, a sensitive screening method for the detection of nine testosterone esters in human plasma was developed. By preparing oxime derivatives of intact testo...

journal_title：Drug testing and analysis

authors： Forsdahl G,Vatne HK,Geisendorfer T,Gmeiner G

更新日期：2013-11-01 00:00:00

abstract：:Current doping trends overshadow the traditional interpretation of using prohibited performance-enhancing drugs to improve training and/or sports results. Its definition has evolved due to several recent cases of unconventional manipulation in sports. In this article, we present a case study of an intentional intoxica...

journal_title：Drug testing and analysis

authors： Baltazar-Martins G,Del Mar Plata M,Muñoz-Guerra J,Argaya J,Del Coso J

更新日期：2020-05-01 00:00:00

abstract：:The impact of altitude training on haematological parameters and the Athlete Biological Passport (ABP) was evaluated in international-level elite athletes. One group of swimmers lived high and trained high (LHTH, n = 10) for three to four weeks at 2130 m or higher whereas a control group (n = 10) completed a three-wee...

journal_title：Drug testing and analysis

authors： Bonne TC,Lundby C,Lundby AK,Sander M,Bejder J,Nordsborg NB

更新日期：2015-08-01 00:00:00

abstract：:A new and sensitive multi-residue method (MRM) with detection by LC-MS/MS was developed and validated for the screening, determination, and confirmation of residues of 7 nitroimidazoles and 3 of their metabolites in turkey muscle tissues at concentrations ≥ 0.05 ng/g. The compounds were extracted into a solvent with a...

journal_title：Drug testing and analysis

authors： Boison JO,Asea PA,Matus JL

更新日期：2012-08-01 00:00:00

abstract：:Higenamine was included in the World Anti-Doping Agency (WADA) Prohibited Substances and Methods List as a β2 -adrenoceptor agonist in 2017, thereby resulting in its prohibition both in and out of competition. The present mini review describes the physiology and pharmacology of adrenoceptors, summarizes the literature...

journal_title：Drug testing and analysis

authors： Hudzik TJ,Patel M,Brown A

更新日期：2020-12-26 00:00:00

abstract：:Anabolic steroids are banned substances in equine sports. Gas chromatography-mass spectrometry (GC-MS) has been the traditional technique for doping control analysis of anabolic steroids in biological samples. Although liquid chromatography-mass spectrometry (LC/MS) has become an important technique in doping control,...

journal_title：Drug testing and analysis

authors： Wong ASY,Leung GNW,Leung DKK,Wan TSM

更新日期：2017-09-01 00:00:00

abstract：:5-(2-Aminopropyl)indole (5-IT) is a psychoactive compound that has recently been associated with several fatal and non-fatal intoxications in a number of European countries. There are indications that acute effects may include symptoms of monoaminergic (e.g. serotonin) toxicity and one mechanism involved in the increa...

journal_title：Drug testing and analysis

authors： Herraiz T,Brandt SD

更新日期：2014-07-01 00:00:00

abstract：:The impact of dehydroepiandrosterone (DHEA) administration has been widely studied for anti-doping purposes in men, whereas only a few studies have been performed in women. In the present study, the impact of DHEA on the steroid profile parameters and their carbon isotopic ratios was explored. Eleven healthy young wom...

journal_title：Drug testing and analysis

authors： Buisson C,Frelat C,Privat K,Martinat N,Audran M,Collomp K

更新日期：2018-11-01 00:00:00

abstract：:The evolving nature of new psychoactive substances (NPS) - often referred to as 'legal highs', 'designer drugs' or 'bath salts' - presents an evolving challenge for toxicologists. Apart from the detection and identification of these compounds, further analytical challenges may arise from the presence of possible metab...

journal_title：Drug testing and analysis

authors： Soh YN,Elliott S

更新日期：2014-07-01 00:00:00

abstract：:According to the World Anti-Doping Agency (WADA) technical document for erythropoiesis stimulating agents (ESA) analysis (TD2014EPO), double-blotting of serum/plasma samples is mandatory for all analysis by isoelectric focusing (IEF) and for the confirmation procedures (CP) performed by SDS-PAGE or SAR-PAGE. The goal ...

journal_title：Drug testing and analysis

authors： Desharnais P,Naud JF,Ayotte C

更新日期：2017-11-01 00:00:00

abstract：:Hemp nuts are mature cannabis seeds obtained after shelling and that are commonly used in traditional Chinese medicine for treating functional constipation. In this work, we screened hemp nut products, classified them, and verified the legality of consuming them. A total of 18 products were purchased from Taiwan, Chin...

journal_title：Drug testing and analysis

authors： Chang CW,Tung CW,Tsai CC,Wu YT,Hsu MC

更新日期：2017-06-01 00:00:00

abstract：:The study describes an LC-MS/MS method for simultaneous quantification of the cardiac glycosidic drugs digoxin and digitoxin and several of their metabolites. The assay represents a useful reference method for immunoassay-based tests, which are easily biased by the presence of metabolites of the target analytes or str...

journal_title：Drug testing and analysis

authors： Bylda C,Thiele R,Kobold U,Volmer DA

更新日期：2015-10-01 00:00:00

abstract：:The reactions involved in the metabolic pathways of SR9009 were characterized by liquid chromatography-mass spectrometry (LC-MS) to identify the most appropriate marker(s) of use. The effects of gender, genetic polymorphism, and drug-drug interaction on the metabolic profile of SR9009 were also evaluated. In vitro app...

journal_title：Drug testing and analysis

authors： Mazzarino M,Rizzato N,Stacchini C,de la Torre X,Botrè F

更新日期：2018-11-01 00:00:00

abstract：:The determination of protein- or peptide-based performance-enhancing pharmaceuticals has gained increasing attention in sports drug testing in recent decades. Proteases possess a high potential for use in the manipulation of regular urine specimens, interfering with established doping control procedures for proteins o...

journal_title：Drug testing and analysis

authors： Thomas A,Kohler M,Walpurgis K,Schänzer W,Thevis M

更新日期：2009-02-01 00:00:00

abstract：:The anabolic-androgenic steroid methylstenbolone (MSTEN; 2α,17α-dimethyl-17β-hydroxy-5α-androst-1-en-3-one) is available as a so-called designer steroid or nutritional supplement. It is occasionally detected in doping control samples, predominantly tested and confirmed as the glucuronic acid conjugate of methylstenbol...

journal_title：Drug testing and analysis

authors： Piper T,Fusshöller G,Schänzer W,Lagojda A,Kuehne D,Thevis M

更新日期：2019-11-01 00:00:00

abstract：:In this tutorial we describe the construction of chemiluminescence detectors for high performance liquid chromatography (HPLC), comprising the components required to deliver the chemiluminescence reagent, a coiled-tubing flow cell, photomultiplier tube and detector housing, and various options for data acquisition. We...

journal_title：Drug testing and analysis

authors： Adcock JL,Terry JM,Barrow CJ,Barnett NW,Olson DC,Francis PS

更新日期：2011-03-01 00:00:00