Drug residues in used syringes in Switzerland: A comparative study.

abstract：:In an earlier study, we developed two sensitive and reliable procedures for gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of methylhexaneamine (MHA) in P. graveolens plant materials and volatile oils. None of the analyzed plant materials or oils sho...

journal_title：Drug testing and analysis

authors： ElSohly MA,Gul W,Tolbert C,ElSohly KM,Murphy TP,Avula B,Chittiboyina AG,Wang M,Khan IA,Yang M,Guo D,Zhang WD,Su J

更新日期：2015-07-01 00:00:00

abstract：:Eurycoma longifolia Jack (Tongkat Ali, Simaroubaceae) is a medicinal plant endemic to South-East Asia. For centuries, different parts of the plant have been used as a natural remedy to treat fever, hypertension, or sexual insufficiency. Today, Eurycoma longifolia preparations are commercially available and advertised ...

journal_title：Drug testing and analysis

authors： Bräuer P,Anielski P,Schwaiger S,Stuppner H,Tran TVA,Vollmer G,Zierau O,Thieme D,Keiler AM

更新日期：2019-01-01 00:00:00

abstract：:Rocuronium bromide is a non-depolarizing neuromuscular blocking agent that causes rapid muscle relaxation after intravenous injection. Regulatory authorities for registration of pharmaceuticals for human use require the evaluation of the stability of active compounds under various stress conditions. Forced degradation...

journal_title：Drug testing and analysis

authors： Wegener O,Harms G,Volmer DA,Hayen H

更新日期：2015-09-01 00:00:00

abstract：:Classic examples of psychoactive arylcycloalkylamines include ketamine and 1-(1-phenylcyclohexyl)piperidine (PCP) and many others serve as important structural templates for neuropharmacological research. The recent emergence of PCP analogues that can be obtained from internet retailers requires the implementation of ...

journal_title：Drug testing and analysis

authors： Wallach J,De Paoli G,Adejare A,Brandt SD

更新日期：2014-07-01 00:00:00

abstract：:According to the World Anti-Doping Agency (WADA) technical document for erythropoiesis stimulating agents (ESA) analysis (TD2014EPO), double-blotting of serum/plasma samples is mandatory for all analysis by isoelectric focusing (IEF) and for the confirmation procedures (CP) performed by SDS-PAGE or SAR-PAGE. The goal ...

journal_title：Drug testing and analysis

authors： Desharnais P,Naud JF,Ayotte C

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to investigate the effect of Morin on the pharmacokinetics of Piracetam in rats, in vitro enzyme kinetics and metabolic stability (high throughput) studies using human liver microsomes in UPLC. For pharmacokinetics studies, male Wistar rats were pretreated with Morin (10 mg/kg) for one week a...

journal_title：Drug testing and analysis

authors： Sahu K,Shaharyar M,Siddiqui AA

更新日期：2013-07-01 00:00:00

abstract：:Selective androgen receptor modulators (SARMs) have great therapeutic potential in various diseases including cancer cachexia, sarcopenia, and osteoporosis, and the number of drug candidates has been growing over the last decade. The SARM drug candidates S-22 and S-23 belong to one of the most advanced groups of andro...

journal_title：Drug testing and analysis

authors： Thevis M,Gerace E,Thomas A,Beuck S,Geyer H,Schlörer N,Kearbey JD,Dalton JT,Schänzer W

更新日期：2010-11-01 00:00:00

abstract：:Phosphatidylethanol 16:0/18:1 (PEth) is the most abundant homologue of the phosphatidylethanol group of phospholipids. Formed only in the presence of ethanol, PEth is used as a biomarker in whole blood to provide information about the consumption of alcohol. As information on the storage life of PEth is essential for ...

journal_title：Drug testing and analysis

authors： Dumitrascu C,van de Lavoir MCA,Neels H,Covaci A,Jacobs W,D'Hondt D,van Nuijs ALN

更新日期：2021-01-04 00:00:00

abstract：:A new, simple, rapid, accurate and precise high performance thin layer chromatography (HPTLC) method has been developed for the estimation of ondansetron hydrochloride in bulk and sublingual tablets. The mobile phase composition was chloroform : ethyl acetate : methanol : ammonia (9:5:4:0.1 v/v). Spectrodensitometric ...

journal_title：Drug testing and analysis

authors： Mujtaba A,Kohli K,Ali J,Baboota S

更新日期：2013-02-01 00:00:00

abstract：:Iso-α-acids (IAAs) can be used as markers for the consumption of beer. Postmortem specimens from a range of coronial cases were analyzed for IAAs in order to determine the prevalence of beer consumption and any correlation to blood alcohol concentrations (BAC). A total of 130 cases were included in this study includin...

journal_title：Drug testing and analysis

authors： Rodda LN,Gerostamoulos D,Drummer OH

更新日期：2015-01-01 00:00:00

abstract：:Accurate on-site devices to screen for drug intake are critical for establishing whether an individual is driving under the influence of drugs (DUID); however, on-site oral fluid (OF) cocaine device performance is variable. We evaluated the performance of a newly developed benzoylecgonine (BE) test-strip for the Draeg...

journal_title：Drug testing and analysis

authors： Ellefsen KN,Concheiro M,Pirard S,Gorelick DA,Huestis MA

更新日期：2016-03-01 00:00:00

abstract：:Flubromazolam is a triazole benzodiazepine with high potency and long-lasting central nervous system depressant effects; however, limited data about its pharmacokinetics are available. Here, we report in vitro studies of the human flubromazolam metabolism analyzed by liquid chromatography high-resolution mass spectrom...

journal_title：Drug testing and analysis

authors： Noble C,Mardal M,Bjerre Holm N,Stybe Johansen S,Linnet K

更新日期：2017-08-01 00:00:00

abstract：:Anabolic-androgenic steroids are synthetic compounds prohibited due to their performance-enhancing characteristics. The use of these substances is known to cause health-related issues, which highlights the importance of being able to evaluate the scale of consumption by the general population. However, most available ...

journal_title：Drug testing and analysis

authors： Shimko KM,O'Brien JW,Barron L,Kayalar H,Mueller JF,Tscharke BJ,Choi PM,Jiang H,Eaglesham G,Thomas KV

更新日期：2019-07-01 00:00:00

abstract：:Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti-Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit ...

journal_title：Drug testing and analysis

authors： Chen TT,Tseng YC,Huang TY,Chang-Chien GP,Hsu MC

更新日期：2018-05-01 00:00:00

abstract：:New Psychoactive Substances are now a feature of Australia's recreational drug market. Little is known, however, about the prevalence of use, the characteristics of people who use them and the relationship between the NPS and ecstasy markets. This study examined the prevalence and correlates of NPS use amongst a group...

journal_title：Drug testing and analysis

authors： Burns L,Roxburgh A,Matthews A,Bruno R,Lenton S,Van Buskirk J

更新日期：2014-07-01 00:00:00

abstract：:Selective androgen receptor modulators (SARMs) are a group of anabolic enhancer drugs posing threats to the integrity of animal sports and the safety of animal-derived foods. The current research describes for the first time the development of a semi-quantitative assay for the monitoring of SARM family compounds in bl...

journal_title：Drug testing and analysis

authors： Ventura E,Gadaj A,Buckley T,Mooney MH

更新日期：2020-09-01 00:00:00

abstract：:The impact of altitude training on haematological parameters and the Athlete Biological Passport (ABP) was evaluated in international-level elite athletes. One group of swimmers lived high and trained high (LHTH, n = 10) for three to four weeks at 2130 m or higher whereas a control group (n = 10) completed a three-wee...

journal_title：Drug testing and analysis

authors： Bonne TC,Lundby C,Lundby AK,Sander M,Bejder J,Nordsborg NB

更新日期：2015-08-01 00:00:00

abstract：:Vaping of synthetic cannabinoids via e-cigarettes is growing in popularity. In the present study, we tentatively identified 12 by-products found in a pure sample of the synthetic cannabinoid Cumyl-5F-PINACA (1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide), a prevalent new psychoactive substance (...

journal_title：Drug testing and analysis

authors： Münster-Müller S,Matzenbach I,Knepper T,Zimmermann R,Pütz M

更新日期：2020-01-01 00:00:00

abstract：:The annual update of the list of prohibited substances and doping methods as issued by the World Anti-Doping Agency (WADA) allows the implementation of most recent considerations of performance manipulation and emerging therapeutics into human sports doping control programmes. The annual banned-substance review for hu...

journal_title：Drug testing and analysis

authors： Thevis M,Kuuranne T,Geyer H,Schänzer W

更新日期：2010-04-01 00:00:00

abstract：:Docetaxel (DTX) is an anti-cancer compound derived from 10-deacetyl baccatin III which is indicated for treatment of breast, lung, prostate, gastro-esophageal, and head and neck cancers. Epimerization of DTX at the C-7 hydroxyl position has intrigued chemists and has been implicated in loss of potency, as well as in t...

journal_title：Drug testing and analysis

authors： Mohsin S,Arellano IH,Choudhury NR,Garg S

更新日期：2014-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-protein coding transcripts involved in many cellular and physiological mechanisms. Recently, a new class of miRNA called 'circulating miRNAs' was found in cell-free body fluids such as plasma and urine. Circulating miRNAs have been shown to be very stable, specific, and sensitive biom...

journal_title：Drug testing and analysis

authors： Leuenberger N,Jan N,Pradervand S,Robinson N,Saugy M

更新日期：2011-11-01 00:00:00

abstract：:Chemical warfare agents (CWA) are highly toxic compounds which have been produced to kill or hurt people during conflicts or terrorist attacks. Despite the fact that their use is strictly prohibited according to international convention, populations' exposure still recently occurred. Development of markers of exposure...

journal_title：Drug testing and analysis

authors： Spiandore M,Piram A,Lacoste A,Josse D,Doumenq P

更新日期：2014-06-01 00:00:00

abstract：:Synthetic cannabinoids are the psychotropic compounds frequently identified as active components of smoking mixtures easily available via the Internet in several countries. These herbal blends have become extremely popular as a legal alternative to cannabis-based products and are difficult to detect by regular drug te...

journal_title：Drug testing and analysis

authors： Sobolevsky T,Prasolov I,Rodchenkov G

更新日期：2012-10-01 00:00:00

abstract：:Relaxin (RLX) has demonstrated diverse pharmacological effects in various scientific and clinical studies. The emergence of porcine relaxin (pRLX) has raised concerns on the doping potential of pRLX. There have also been speculations in the horseracing industry on its covert use. To control the abuse of pRLX in equine...

journal_title：Drug testing and analysis

authors： Wong ASY,Ho ENM,Kwok WH,Leung GNW,Shen Y,Qi RZ,Yue SK,Wan TSM

更新日期：2017-09-01 00:00:00

abstract：:Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alternative techniques, like dried blood spots (DBS), has consequently increased. A fast and easy to perform DBS method for...

journal_title：Drug testing and analysis

authors： Patteet L,Maudens KE,Stove CP,Lambert WE,Morrens M,Sabbe B,Neels H

更新日期：2015-06-01 00:00:00

abstract：:Bioactive peptides pose a great threat to sports integrity. The detection of these peptides is essential for enforcing their prohibition in sports. Identifying the catabolites of these peptides that are formed ex vivo in plasma may improve their detection. In the present study, the stability of 27 bioactive peptides w...

journal_title：Drug testing and analysis

authors： Guan F,Fay S,Li X,You Y,Robinson MA

更新日期：2020-06-01 00:00:00

abstract：:In vitro and in vivo experiments are widely used for studying the metabolism of new psychoactive substances (NPS). The availability of such data is required for toxicological risk assessments and development of urine screening approaches. This study investigated the in vitro metabolism of the 5 pyrrolidinophenone-deri...

journal_title：Drug testing and analysis

authors： Manier SK,Richter LHJ,Schäper J,Maurer HH,Meyer MR

更新日期：2018-01-04 00:00:00

abstract：:Indole-, indazole-, or azaindole-based synthetic cannabinoids (SCs), bearing a cumyl substituent are a widespread, recreationally used subgroup of new psychoactive substances (NPS). The latest cumyl-derivative, CUMYL-PEGACLONE, emerged in December 2016 on the German drug market. The substance features a novel γ-carbol...

journal_title：Drug testing and analysis

authors： Mogler L,Wilde M,Huppertz LM,Weinfurtner G,Franz F,Auwärter V

更新日期：2018-05-01 00:00:00

abstract：:Driving under the influence of drugs (DUID) is a worldwide problem. Several countries have adopted DUID legislations which prove their deterrent effect and impact on road safety. However, the use of new psychoactive substances (NPS) and prescription drugs is not known, as the applied roadside screening tests have not ...

journal_title：Drug testing and analysis

authors： Wille SMR,Richeval C,Nachon-Phanithavong M,Gaulier JM,Di Fazio V,Humbert L,Samyn N,Allorge D

更新日期：2018-03-01 00:00:00

abstract：:Sulfate metabolites have been described as long-term metabolites for some anabolic androgenic steroids (AAS). 4-chlorometandienone (4Cl-MTD) is one of the most frequently detected AAS in sports drug testing and it is commonly detected by monitoring metabolites excreted free or conjugated with glucuronic acid. Sulfatio...

journal_title：Drug testing and analysis

authors： Balcells G,Gómez C,Garrostas L,Pozo ÓJ,Ventura R

更新日期：2017-07-01 00:00:00