Profiling of synthesis-related impurities of the synthetic cannabinoid Cumyl-5F-PINACA in seized samples of e-liquids via multivariate analysis of UHPLC-MSn data.

abstract：:The synthetic tryptamine 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT) has recently been abused as a hallucinogenic drug in Germany and Switzerland. This study presents a case of 5-MeO-MiPT intoxication and the structural elucidation of metabolites in pooled human liver microsomes (pHLM), blood, and urine. Mic...

journal_title：Drug testing and analysis

authors： Grafinger KE,Hädener M,König S,Weinmann W

更新日期：2018-03-01 00:00:00

abstract：:Synthetic cannabinoids (SCs), mimicking the psychoactive effects of cannabis, consist of a vast array of structurally diverse compounds. A novel compound belonging to the SC family, (1-(cyclohexylmethyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone (named TMCP-CHM in this article) contains a cyclopropane r...

journal_title：Drug testing and analysis

authors： Grigoryev A,Kavanagh P,Labutin A,Pechnikov A,Dowling G,Shevyrin V,Krupina N

更新日期：2019-09-01 00:00:00

abstract：:The accuracy in predicting different chemometric methods was compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS1) and two dependent variables (PLS2) were applied on spectral data of pharmaceuti...

journal_title：Drug testing and analysis

authors： Riahi S,Hadiloo F,Milani SM,Davarkhah N,Ganjali MR,Norouzi P,Seyfi P

更新日期：2011-05-01 00:00:00

abstract：:Gamma-hydroxybutyrate (GHB) has been used as a recreational drug since the 1990s and over the last few years there has been increasing use of its analogues gamma-butyrolactone (GBL) and to a lesser extent 1,4-butanediol (1,4BD). This review will summarize the literature on the pharmacology of these compounds; the patt...

journal_title：Drug testing and analysis

authors： Wood DM,Brailsford AD,Dargan PI

更新日期：2011-07-01 00:00:00

abstract：:A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relativ...

journal_title：Drug testing and analysis

authors： Abounassif MA,Al-Omar MA,Amr AG,Mostafa GA

更新日期：2011-06-01 00:00:00

abstract：:The reactions involved in the metabolic pathways of SR9009 were characterized by liquid chromatography-mass spectrometry (LC-MS) to identify the most appropriate marker(s) of use. The effects of gender, genetic polymorphism, and drug-drug interaction on the metabolic profile of SR9009 were also evaluated. In vitro app...

journal_title：Drug testing and analysis

authors： Mazzarino M,Rizzato N,Stacchini C,de la Torre X,Botrè F

更新日期：2018-11-01 00:00:00

abstract：:The advent of liquid chromatography-tandem mass spectrometry (LC-MS/MS), with the sensitivity it confers, permits the analysis of both phase I and II drug metabolites that in the past would have been difficult to target using other techniques. These metabolites may have relevance to current analytical toxicology emplo...

journal_title：Drug testing and analysis

authors： Turfus SC,Braithwaite RA,Cowan DA,Parkin MC,Smith NW,Kicman AT

更新日期：2011-10-01 00:00:00

abstract：:The synthesis of positional isomers of designer drugs is a common way of bypassing legal restrictions. For forensic case work, and especially for the legal assessment of cases, there is a need for screening methods capable of the unequivocal identification of positional isomers. The presented liquid chromatography-ele...

journal_title：Drug testing and analysis

authors： Grumann C,Auwärter V

更新日期：2018-02-18 00:00:00

abstract：:Iso-α-acids (IAAs) can be used as markers for the consumption of beer. Postmortem specimens from a range of coronial cases were analyzed for IAAs in order to determine the prevalence of beer consumption and any correlation to blood alcohol concentrations (BAC). A total of 130 cases were included in this study includin...

journal_title：Drug testing and analysis

authors： Rodda LN,Gerostamoulos D,Drummer OH

更新日期：2015-01-01 00:00:00

abstract：:A quantitative structure-property relationship (QSPR) study based on an artificial neural network (ANN) was carried out for the prediction of the microemulsion liquid chromatography polar surface area (PSA) of a set of 32 drug compounds. The genetic algorithm-kernel partial least squares (GA-KPLS) method was used as a...

journal_title：Drug testing and analysis

authors： Noorizadeh H,Farmany A,Noorizadeh M,Kohzadi M

更新日期：2013-04-01 00:00:00

abstract：:The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration-based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma...

journal_title：Drug testing and analysis

authors： Lobigs LM,Sottas PE,Bourdon PC,Nikolovski Z,El-Gingo M,Varamenti E,Peeling P,Dawson B,Schumacher YO

更新日期：2018-02-01 00:00:00

abstract：:The aim of this study was to investigate the effect of Morin on the pharmacokinetics of Piracetam in rats, in vitro enzyme kinetics and metabolic stability (high throughput) studies using human liver microsomes in UPLC. For pharmacokinetics studies, male Wistar rats were pretreated with Morin (10 mg/kg) for one week a...

journal_title：Drug testing and analysis

authors： Sahu K,Shaharyar M,Siddiqui AA

更新日期：2013-07-01 00:00:00

abstract：:Musk, the dried secretion of the musk pod (sac) of adult male musk deer, has been used as traditional Chinese Medicine (TCM) in China and south-east Asian countries for thousands of years. Due to the anabolic steroid component in this TCM, musk preparations have been included in the list of medical products containing...

journal_title：Drug testing and analysis

authors： Wang J,He Y,Liu X,Yang Z,Yang W

更新日期：2017-11-01 00:00:00

abstract：:Formestane (4-hydroxy-androstenedione) is an aromatase inhibitor prohibited in sports and included, since 2004, in the list of prohibited substances updated yearly by the World Anti-Doping Agency (WADA). Since the endogenous production of formestane has been described, it is mandatory for the anti-doping laboratories ...

journal_title：Drug testing and analysis

authors： de la Torre X,Colamonici C,Curcio D,Jardines D,Molaioni F,Parr MK,Botrè F

更新日期：2014-11-01 00:00:00

abstract：:Three legal highs; nitracaine (3-(diethylamino)-2,2-dimethylpropyl 4-nitrobenzoate), methoxypiperamide (MEOP, (4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone) and mephtetramine (MTTA, 2-((methylamino)methyl)-3,4-dihydronaphthalen-1(2H)-one) appeared in 2013 as new psychoactive substances (NPS) on Internet websites ...

journal_title：Drug testing and analysis

authors： Power JD,Scott KR,Gardner EA,Curran McAteer BM,O'Brien JE,Brehon M,Talbot B,Kavanagh PV

更新日期：2014-07-01 00:00:00

abstract：:The annual update of the list of prohibited substances and doping methods as issued by the World Anti-Doping Agency (WADA) allows the implementation of most recent considerations of performance manipulation and emerging therapeutics into human sports doping control programmes. The annual banned-substance review for hu...

journal_title：Drug testing and analysis

authors： Thevis M,Kuuranne T,Geyer H,Schänzer W

更新日期：2010-04-01 00:00:00

abstract：:N-Methyl-3-phenyl-norbornan-2-amine (N-methyl-3-phenylbicyclo[2.2.1]heptan-2-amine, Camfetamine(™) ) is available from a number of online legal highs/research chemicals' vendors. Although it was developed as an analeptic by Merck in the early 1960s, it was never commercialized. However, the Association of Independent ...

journal_title：Drug testing and analysis

authors： Kavanagh P,Angelov D,O'Brien J,Power JD,McDermott SD,Talbot B,Fox J,O'Donnell C,Christie R

更新日期：2013-04-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) of immunosuppressive drugs (ISDs) with a narrow therapeutic index is an increasingly popular tool for minimizing drug toxicity while maximizing the prevention of graft loss and organ rejection. This review focuses on trends regarding analytical methods for the TDM of ISDs since 2011. ...

journal_title：Drug testing and analysis

authors： Zhang Y,Zhang R

更新日期：2018-01-01 00:00:00

abstract：:Bioactive peptides pose a great threat to sports integrity. The detection of these peptides is essential for enforcing their prohibition in sports. Identifying the catabolites of these peptides that are formed ex vivo in plasma may improve their detection. In the present study, the stability of 27 bioactive peptides w...

journal_title：Drug testing and analysis

authors： Guan F,Fay S,Li X,You Y,Robinson MA

更新日期：2020-06-01 00:00:00

abstract：:In a preliminary test, four single hairs of a drug abuser were analyzed for the presence of drugs by MALDI Fourier transform mass spectrometry (MALDI-FTMS). Washed hair strains were directly fixed on a sample plate using pressure stable, double-sided adhesive tape; α-cyano-4-hydroxycinnamic acid matrix was manually sp...

journal_title：Drug testing and analysis

authors： Musshoff F,Arrey T,Strupat K

更新日期：2013-05-01 00:00:00

abstract：:Metal ion coordination ionspray (M(+) CIS) ionization is a powerful technique to enhance ionization efficiency and sensitivity. In this study, we developed and validated an analytical method for simultaneous ionization and analysis of 84 anabolic androgenic steroids (65 exogenous and 19 endogenous) using liquid chroma...

journal_title：Drug testing and analysis

authors： Kim SH,Cha EJ,Lee KM,Kim HJ,Kwon OS,Lee J

更新日期：2014-11-01 00:00:00

abstract：:Selective androgen receptor modulators (SARMs) have great therapeutic potential in various diseases including cancer cachexia, sarcopenia, and osteoporosis, and the number of drug candidates has been growing over the last decade. The SARM drug candidates S-22 and S-23 belong to one of the most advanced groups of andro...

journal_title：Drug testing and analysis

authors： Thevis M,Gerace E,Thomas A,Beuck S,Geyer H,Schlörer N,Kearbey JD,Dalton JT,Schänzer W

更新日期：2010-11-01 00:00:00

abstract：:Classic examples of psychoactive arylcycloalkylamines include ketamine and 1-(1-phenylcyclohexyl)piperidine (PCP) and many others serve as important structural templates for neuropharmacological research. The recent emergence of PCP analogues that can be obtained from internet retailers requires the implementation of ...

journal_title：Drug testing and analysis

authors： Wallach J,De Paoli G,Adejare A,Brandt SD

更新日期：2014-07-01 00:00:00

abstract：:The legally defensible proof of the abuse of endogenous steroids in sports is currently based on carbon isotope ratio mass spectrometry (IRMS), i.e. a comparison between (13)C/(12)C ratios of diagnostic precursors and metabolites of testosterone. The application of this technique requires a chromatographic baseline se...

journal_title：Drug testing and analysis

authors： Thieme D,Rautenberg C,Grosse J,Schoenfelder M

更新日期：2013-11-01 00:00:00

abstract：:A new, simple, rapid, accurate and precise high performance thin layer chromatography (HPTLC) method has been developed for the estimation of ondansetron hydrochloride in bulk and sublingual tablets. The mobile phase composition was chloroform : ethyl acetate : methanol : ammonia (9:5:4:0.1 v/v). Spectrodensitometric ...

journal_title：Drug testing and analysis

authors： Mujtaba A,Kohli K,Ali J,Baboota S

更新日期：2013-02-01 00:00:00

abstract：:Eurycoma longifolia Jack (Tongkat Ali, Simaroubaceae) is a medicinal plant endemic to South-East Asia. For centuries, different parts of the plant have been used as a natural remedy to treat fever, hypertension, or sexual insufficiency. Today, Eurycoma longifolia preparations are commercially available and advertised ...

journal_title：Drug testing and analysis

authors： Bräuer P,Anielski P,Schwaiger S,Stuppner H,Tran TVA,Vollmer G,Zierau O,Thieme D,Keiler AM

更新日期：2019-01-01 00:00:00

abstract：:The method of high sensitive gas chromatographic/time-of-flight mass-spectrometric (GC/TOF-MS) analysis of steroids was developed. Low-resolution TOF-MS instrument (with fast spectral acquisition rate) was used. This method is based on the formation of the silyl derivatives of steroids; exchange of the reagent mixture...

journal_title：Drug testing and analysis

authors： Revelsky AI,Samokhin AS,Virus ED,Rodchenkov GM,Revelsky IA

更新日期：2011-04-01 00:00:00

abstract：:Tretoquinol (trimetoquinol), a β2-agonist, has been explicitly listed on the World Anti-Doping Agency Prohibited List 2019 since January 2019; however, it has been distributed as an antiasthmatic on the medical market. This study aimed to develop a liquid chromatography-tandem mass spectrometric method for the quantif...

journal_title：Drug testing and analysis

authors： Okano M,Miyamoto A,Sato M,Kageyama S

更新日期：2019-11-01 00:00:00

abstract：:The determination of protein- or peptide-based performance-enhancing pharmaceuticals has gained increasing attention in sports drug testing in recent decades. Proteases possess a high potential for use in the manipulation of regular urine specimens, interfering with established doping control procedures for proteins o...

journal_title：Drug testing and analysis

authors： Thomas A,Kohler M,Walpurgis K,Schänzer W,Thevis M

更新日期：2009-02-01 00:00:00

abstract：:In Australia, drug monitoring systems have been in place for more than a decade allowing for the measurement of ongoing trends in drug use and the detection of new drugs. The Drug Trends Unit at the National Drug and Alcohol Research Centre monitors drugs through four separate systems. The Illicit Drug Reporting Syste...

journal_title：Drug testing and analysis

authors： Burns L,Roxburgh A,Bruno R,Van Buskirk J

更新日期：2014-07-01 00:00:00