Abstract:
:Fast and unequivocal drug detection is of considerable importance in numerous fields of analytical chemistry, and today mass spectrometry-based approaches are often the method of choice due to their sensitive and specific nature. Mass spectrometry is in constant flux with innovations and thus supports the development of new, complementary assays for rapid determination of drugs and toxins as well as their metabolic products in clinical, forensic, and doping control laboratories. Examples of such innovations that have greatly aided the worldwide bioanalytical efforts are the modern improvements in ion trap, for example, Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometer--Orbitrap, and time-of-flight (TOF) mass analyzers when coupled with sensitive ionization techniques such as electrospray ionization. In this perspective, the utility of state-of-the-art mass spectrometers and recent instrumental developments such as new and/or improved hybrid analyzers are discussed and selected applications presented.
journal_name
Drug Test Analjournal_title
Drug testing and analysisauthors
Thevis M,Volmer DAdoi
10.1002/dta.344subject
Has Abstractpub_date
2012-03-01 00:00:00pages
242-5issue
3-4eissn
1942-7603issn
1942-7611journal_volume
4pub_type
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