GC-MS and GC-IRD studies on brominated dimethoxyamphetamines: regioisomers related to 4-Br-2,5-DMA (DOB).

abstract：:Buprenorphine and methadone are commonly used medications for opioid maintenance treatment (OMT), using sublingual and oral administration, respectively. Although beneficial for OMT, these drugs can also be abused by intravenous administration. In intravenous abuse cases, the adjuvants lactose and sucrose are excreted...

journal_title：Drug testing and analysis

authors： Keltanen T,Mariottini C,Walta AM,Rahikainen AL,Ojanperä I

更新日期：2017-06-01 00:00:00

abstract：:Relaxin (RLX) has demonstrated diverse pharmacological effects in various scientific and clinical studies. The emergence of porcine relaxin (pRLX) has raised concerns on the doping potential of pRLX. There have also been speculations in the horseracing industry on its covert use. To control the abuse of pRLX in equine...

journal_title：Drug testing and analysis

authors： Wong ASY,Ho ENM,Kwok WH,Leung GNW,Shen Y,Qi RZ,Yue SK,Wan TSM

更新日期：2017-09-01 00:00:00

abstract：:In Australia, drug monitoring systems have been in place for more than a decade allowing for the measurement of ongoing trends in drug use and the detection of new drugs. The Drug Trends Unit at the National Drug and Alcohol Research Centre monitors drugs through four separate systems. The Illicit Drug Reporting Syste...

journal_title：Drug testing and analysis

authors： Burns L,Roxburgh A,Bruno R,Van Buskirk J

更新日期：2014-07-01 00:00:00

abstract：:Hair analysis is useful for documenting long-term exposure to drugs. The potential of hair analysis for therapeutic drug monitoring within the forensic field has been studied, but reference values for some antidepressants and antipsychotics in the hair of individuals undergoing chronic therapy are still lacking. In th...

journal_title：Drug testing and analysis

authors： Wang X,Zhuo Y,Tang X,Qiang H,Liu W,Wu H,Xiang P,Duan G,Shen M

更新日期：2020-04-01 00:00:00

abstract：:Autologous blood transfusion is a powerful means of improving performance and remains one of the most challenging methods to detect. Recent investigations have identified 3 candidate reticulocytes genes whose expression was significantly influenced by blood transfusion. Using quantitative reverse transcription polymer...

journal_title：Drug testing and analysis

authors： Salamin O,Mignot J,Kuuranne T,Saugy M,Leuenberger N

更新日期：2018-03-01 00:00:00

abstract：:Amphetamine (AMP) is used as an illicit drug and also for the treatment of attention deficit hyperactivity disorder (ADHD). Respective drugs most often contain the enantiomer (S)-AMP as active compound or (S)-AMP is formed from the prodrug lisdexamfetamine (Elvanse®) whereas the illicit drug is usually traded as racem...

journal_title：Drug testing and analysis

authors： Binz TM,Williner E,Strajhar P,Dolder PC,Liechti ME,Baumgartner MR,Kraemer T,Steuer AE

更新日期：2018-02-01 00:00:00

abstract：:The reactions involved in the metabolic pathways of SR9009 were characterized by liquid chromatography-mass spectrometry (LC-MS) to identify the most appropriate marker(s) of use. The effects of gender, genetic polymorphism, and drug-drug interaction on the metabolic profile of SR9009 were also evaluated. In vitro app...

journal_title：Drug testing and analysis

authors： Mazzarino M,Rizzato N,Stacchini C,de la Torre X,Botrè F

更新日期：2018-11-01 00:00:00

abstract：:In vitro and in vivo experiments are widely used for studying the metabolism of new psychoactive substances (NPS). The availability of such data is required for toxicological risk assessments and development of urine screening approaches. This study investigated the in vitro metabolism of the 5 pyrrolidinophenone-deri...

journal_title：Drug testing and analysis

authors： Manier SK,Richter LHJ,Schäper J,Maurer HH,Meyer MR

更新日期：2018-01-04 00:00:00

abstract：:The effectiveness of doping control in sport has been improved continuously during the past 50 years. One of the major steps forward was the introduction of unannounced and targeted out-of-competition testing in order to control the misuse of anabolic-androgenic steroids (AAS), mainly during the end of the 1980s. It a...

journal_title：Drug testing and analysis

authors： Hemmersbach P

更新日期：2020-05-01 00:00:00

abstract：:New bioanalytical assays were developed, validated, and applied in a clinical study for quantitative measurement of acetaminophen concentrations in blood and plasma samples. Furthermore, after validation, the bioanalytical assays were used for determination of pharmacokinetics within a group of six healthy male human ...

journal_title：Drug testing and analysis

authors： Rincón JP,Meesters RJ

更新日期：2014-06-01 00:00:00

abstract：:Xenon is a modern inhalative anaesthetic with a very low solubility in tissues providing rapid elimination and weaning from anaesthesia. Besides its anaesthetic properties, Xenon promotes the endogenous erythropoietin biosynthesis and thus has been enlisted as prohibited substance by the World Anti-Doping Agency (WADA...

journal_title：Drug testing and analysis

authors： Schaefer MS,Piper T,Geyer H,Schneemann J,Neukirchen M,Thevis M,Kienbaum P

更新日期：2017-05-01 00:00:00

abstract：:Even though hair analysis often seems to be the best choice for retrospective monitoring of cocaine intake, differentiating between incorporated cocaine and external contamination is widely debated. In this study we report results obtained in 90 hair samples from addicts. All samples were analyzed for cocaine, benzoyl...

journal_title：Drug testing and analysis

authors： Gambelunghe C,Rossi R,Aroni K,Gili A,Bacci M,Pascali V,Fucci N

更新日期：2017-02-01 00:00:00

abstract：:A quantitative structure-property relationship (QSPR) study based on an artificial neural network (ANN) was carried out for the prediction of the microemulsion liquid chromatography polar surface area (PSA) of a set of 32 drug compounds. The genetic algorithm-kernel partial least squares (GA-KPLS) method was used as a...

journal_title：Drug testing and analysis

authors： Noorizadeh H,Farmany A,Noorizadeh M,Kohzadi M

更新日期：2013-04-01 00:00:00

abstract：:Trimethoprim (TMP) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Its use is associated with idiosyncratic reactions, including liver toxicity and agranulocytosis. I...

journal_title：Drug testing and analysis

authors： Rajith L,Kumar KG

更新日期：2010-09-01 00:00:00

abstract：:Several clinical-grade immunoassays exist for the specific measurement of hGH or its isoforms in blood but there is an urgent need to apply these same reliable assays to the measurement of hGH in urine as a preferred 'non-invasive' biofluid. Unfortunately, conventional hGH immunoassays cannot attain the sensitivity re...

journal_title：Drug testing and analysis

authors： Fredolini C,Tamburro D,Gambara G,Lepene BS,Espina V,Petricoin EF 3rd,Liotta LA,Luchini A

更新日期：2009-09-01 00:00:00

abstract：:Anabolic steroids are banned substances in equine sports. Gas chromatography-mass spectrometry (GC-MS) has been the traditional technique for doping control analysis of anabolic steroids in biological samples. Although liquid chromatography-mass spectrometry (LC/MS) has become an important technique in doping control,...

journal_title：Drug testing and analysis

authors： Wong ASY,Leung GNW,Leung DKK,Wan TSM

更新日期：2017-09-01 00:00:00

abstract：:The amphetamine molecule contains a chiral center and its enantiomers exhibit differences in pharmacological effects, with the S-enantiomer mediating most of the central nervous system stimulating activity. The majority of prescribed amphetamine consists of the pure S-enantiomer, but therapeutic formulations containin...

journal_title：Drug testing and analysis

authors： Havnen H,Hansen M,Spigset O,Hegstad S

更新日期：2020-09-01 00:00:00

abstract：:The purpose of this research is to validate the biomarker-based approach for the detection of doping with recombinant human growth hormone (rhGH) in sport. The GH-2000 project proposed an indirect method for the detection of exogenously administered growth hormone (GH) based on the measurement of the GH-dependent mark...

journal_title：Drug testing and analysis

authors： Jing J,Zhou X,He C,Zhang L,Yang S,Xu Y,Xie M,Yan Y,Su H,Wu M

更新日期：2012-10-01 00:00:00

abstract：:Higenamine was included in the World Anti-Doping Agency (WADA) Prohibited Substances and Methods List as a β2 -adrenoceptor agonist in 2017, thereby resulting in its prohibition both in and out of competition. The present mini review describes the physiology and pharmacology of adrenoceptors, summarizes the literature...

journal_title：Drug testing and analysis

authors： Hudzik TJ,Patel M,Brown A

更新日期：2020-12-26 00:00:00

abstract：:Synthetic cannabinoids (SCs), mimicking the psychoactive effects of cannabis, consist of a vast array of structurally diverse compounds. A novel compound belonging to the SC family, (1-(cyclohexylmethyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone (named TMCP-CHM in this article) contains a cyclopropane r...

journal_title：Drug testing and analysis

authors： Grigoryev A,Kavanagh P,Labutin A,Pechnikov A,Dowling G,Shevyrin V,Krupina N

更新日期：2019-09-01 00:00:00

abstract：:Flubromazolam is a triazole benzodiazepine with high potency and long-lasting central nervous system depressant effects; however, limited data about its pharmacokinetics are available. Here, we report in vitro studies of the human flubromazolam metabolism analyzed by liquid chromatography high-resolution mass spectrom...

journal_title：Drug testing and analysis

authors： Noble C,Mardal M,Bjerre Holm N,Stybe Johansen S,Linnet K

更新日期：2017-08-01 00:00:00

abstract：:Erythropoietin (EPO) has been misused in sports for many years due to its performance-enhancing effect. In the last decade, detection of abuse has been possible with isoelectric focusing (IEF) based on the different isoform profiles of endogenous and recombinant EPO. The release of new EPOs on the market, such as the ...

journal_title：Drug testing and analysis

authors： Dehnes Y,Hemmersbach P

更新日期：2011-05-01 00:00:00

abstract：:MSforID represents a database of tandem mass spectral data obtained from (quasi-)molecular ions produced by atmospheric pressure ionization methods. At the current stage of development the library contains 12 122 spectra of 1208 small (bio-)organic molecules. The present work was aimed to evaluate the performance of t...

journal_title：Drug testing and analysis

authors： Würtinger P,Oberacher H

更新日期：2012-03-01 00:00:00

abstract：:Two primary animal models persist for assessing hallucinogenic potential of novel compounds and for examining the pharmacological and neurobiological substrates underlying the actions of classical hallucinogens, the two-lever drug discrimination procedure and the drug-induced head-twitch response (HTR) in rodents. The...

journal_title：Drug testing and analysis

authors： Canal CE,Morgan D

更新日期：2012-07-01 00:00:00

abstract：:The impact of altitude training on haematological parameters and the Athlete Biological Passport (ABP) was evaluated in international-level elite athletes. One group of swimmers lived high and trained high (LHTH, n = 10) for three to four weeks at 2130 m or higher whereas a control group (n = 10) completed a three-wee...

journal_title：Drug testing and analysis

authors： Bonne TC,Lundby C,Lundby AK,Sander M,Bejder J,Nordsborg NB

更新日期：2015-08-01 00:00:00

abstract：:We recently published two protocols for the detection of Sotatercept (ACE-011, ACVR2A-Fc) and Luspatercept (ACE-536, ACVR2B-Fc) in human serum. Both methods used covalently immobilized antibodies on agarose beads for immunoprecipitation and SAR-PAGE/Western blotting for detection. Disadvantages were the relatively hig...

journal_title：Drug testing and analysis

authors： Reichel C,Gmeiner G,Walpurgis K,Thevis M

更新日期：2018-11-01 00:00:00

abstract：:Bioactive peptides pose a great threat to sports integrity. The detection of these peptides is essential for enforcing their prohibition in sports. Identifying the catabolites of these peptides that are formed ex vivo in plasma may improve their detection. In the present study, the stability of 27 bioactive peptides w...

journal_title：Drug testing and analysis

authors： Guan F,Fay S,Li X,You Y,Robinson MA

更新日期：2020-06-01 00:00:00

abstract：:Selective androgen receptor modulators (SARMs) are a group of anabolic enhancer drugs posing threats to the integrity of animal sports and the safety of animal-derived foods. The current research describes for the first time the development of a semi-quantitative assay for the monitoring of SARM family compounds in bl...

journal_title：Drug testing and analysis

authors： Ventura E,Gadaj A,Buckley T,Mooney MH

更新日期：2020-09-01 00:00:00

abstract：:The anabolic-androgenic steroid methylstenbolone (MSTEN; 2α,17α-dimethyl-17β-hydroxy-5α-androst-1-en-3-one) is available as a so-called designer steroid or nutritional supplement. It is occasionally detected in doping control samples, predominantly tested and confirmed as the glucuronic acid conjugate of methylstenbol...

journal_title：Drug testing and analysis

authors： Piper T,Fusshöller G,Schänzer W,Lagojda A,Kuehne D,Thevis M

更新日期：2019-11-01 00:00:00

abstract：:The use of corticosteroids, such as betamethasone, in performance horses is tightly regulated. The objective of the current study was to describe the plasma pharmacokinetics of betamethasone as well as time-related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve racin...

journal_title：Drug testing and analysis

authors： Knych HK,Stanley SD,Harrison LM,Mckemie DS

更新日期：2017-09-01 00:00:00