Xenon elimination kinetics following brief exposure.

abstract：:Relaxin (RLX) has demonstrated diverse pharmacological effects in various scientific and clinical studies. The emergence of porcine relaxin (pRLX) has raised concerns on the doping potential of pRLX. There have also been speculations in the horseracing industry on its covert use. To control the abuse of pRLX in equine...

journal_title：Drug testing and analysis

authors： Wong ASY,Ho ENM,Kwok WH,Leung GNW,Shen Y,Qi RZ,Yue SK,Wan TSM

更新日期：2017-09-01 00:00:00

abstract：:Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alternative techniques, like dried blood spots (DBS), has consequently increased. A fast and easy to perform DBS method for...

journal_title：Drug testing and analysis

authors： Patteet L,Maudens KE,Stove CP,Lambert WE,Morrens M,Sabbe B,Neels H

更新日期：2015-06-01 00:00:00

abstract：:According to the World Anti-Doping Agency (WADA) technical document for erythropoiesis stimulating agents (ESA) analysis (TD2014EPO), double-blotting of serum/plasma samples is mandatory for all analysis by isoelectric focusing (IEF) and for the confirmation procedures (CP) performed by SDS-PAGE or SAR-PAGE. The goal ...

journal_title：Drug testing and analysis

authors： Desharnais P,Naud JF,Ayotte C

更新日期：2017-11-01 00:00:00

abstract：:The method of high sensitive gas chromatographic/time-of-flight mass-spectrometric (GC/TOF-MS) analysis of steroids was developed. Low-resolution TOF-MS instrument (with fast spectral acquisition rate) was used. This method is based on the formation of the silyl derivatives of steroids; exchange of the reagent mixture...

journal_title：Drug testing and analysis

authors： Revelsky AI,Samokhin AS,Virus ED,Rodchenkov GM,Revelsky IA

更新日期：2011-04-01 00:00:00

abstract：:Vaping of synthetic cannabinoids via e-cigarettes is growing in popularity. In the present study, we tentatively identified 12 by-products found in a pure sample of the synthetic cannabinoid Cumyl-5F-PINACA (1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide), a prevalent new psychoactive substance (...

journal_title：Drug testing and analysis

authors： Münster-Müller S,Matzenbach I,Knepper T,Zimmermann R,Pütz M

更新日期：2020-01-01 00:00:00

abstract：:In this tutorial we describe the construction of chemiluminescence detectors for high performance liquid chromatography (HPLC), comprising the components required to deliver the chemiluminescence reagent, a coiled-tubing flow cell, photomultiplier tube and detector housing, and various options for data acquisition. We...

journal_title：Drug testing and analysis

authors： Adcock JL,Terry JM,Barrow CJ,Barnett NW,Olson DC,Francis PS

更新日期：2011-03-01 00:00:00

abstract：:The synthesis of positional isomers of designer drugs is a common way of bypassing legal restrictions. For forensic case work, and especially for the legal assessment of cases, there is a need for screening methods capable of the unequivocal identification of positional isomers. The presented liquid chromatography-ele...

journal_title：Drug testing and analysis

authors： Grumann C,Auwärter V

更新日期：2018-02-18 00:00:00

abstract：:Iso-α-acids (IAAs) can be used as markers for the consumption of beer. Postmortem specimens from a range of coronial cases were analyzed for IAAs in order to determine the prevalence of beer consumption and any correlation to blood alcohol concentrations (BAC). A total of 130 cases were included in this study includin...

journal_title：Drug testing and analysis

authors： Rodda LN,Gerostamoulos D,Drummer OH

更新日期：2015-01-01 00:00:00

abstract：:The abuse of stanozolol is quite widespread in Indian sport. Its analysis is challenging and this has led to the development of new methods to improve its detection. A method was developed and validated for the detection of the three main monohydroxylated metabolites of stanozolol. The excretion profile of these metab...

journal_title：Drug testing and analysis

authors： Ahi S,Beotra A,Jain S

更新日期：2009-11-01 00:00:00

abstract：:The impact of altitude training on haematological parameters and the Athlete Biological Passport (ABP) was evaluated in international-level elite athletes. One group of swimmers lived high and trained high (LHTH, n = 10) for three to four weeks at 2130 m or higher whereas a control group (n = 10) completed a three-wee...

journal_title：Drug testing and analysis

authors： Bonne TC,Lundby C,Lundby AK,Sander M,Bejder J,Nordsborg NB

更新日期：2015-08-01 00:00:00

abstract：:Cobalt is a well-established inducer of hypoxia-like responses, which can cause gene modulation at the hypoxia inducible factor pathway to induce erythropoietin transcription. Cobalt salts are orally active, inexpensive, and easily accessible. It is an attractive blood doping agent for enhancing aerobic performance. I...

journal_title：Drug testing and analysis

authors： Ho EN,Chan GH,Wan TS,Curl P,Riggs CM,Hurley MJ,Sykes D

更新日期：2015-01-01 00:00:00

abstract：:Zolpidem and zopiclone (Z-compounds) are non-benzodiazepine hypnotics of new generation that can be used in drug-facilitated sexual assault (DFSA). Their determination in biological fluids, mainly urine, is of primary importance; nevertheless, although they are excreted almost entirely as metabolites, available method...

journal_title：Drug testing and analysis

authors： Strano Rossi S,Anzillotti L,Castrignanò E,Frison G,Zancanaro F,Chiarotti M

更新日期：2014-03-01 00:00:00

abstract：:The absence of reference material is a commonly experienced difficulty among medical and forensic professionals tasked with identifying new psychoactive substances that are encountered for the first time. The identification of newly emerging substances lies at the heart of forensic and clinical analysis, and a proacti...

journal_title：Drug testing and analysis

authors： Brandt SD,Tearavarich R,Dempster N,Cozzi NV,Daley PF

更新日期：2012-01-01 00:00:00

abstract：:A simple and sensitive method is described for voltammetric determination of promethazine hydrochloride (PMZ), a widely used phenothiazine drug, based on its electrochemical oxidation at a multi-wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE). Compared with bare GCE, the MWCNT-modified GCE exhibite...

journal_title：Drug testing and analysis

authors： Xi X,Ming L,Liu J

更新日期：2011-03-01 00:00:00

abstract：:Standard treatment of poisoning by organophosphorus (OP) nerve agents with atropine and oximes lacks efficacy with some nerve agents. Promising in vitro and in vivo results were obtained with the bispyridinium compound SAD-128 which was partly attributed to its interaction with nicotinic acetylcholine receptors. Previ...

journal_title：Drug testing and analysis

authors： Niessen KV,Tattersall JE,Timperley CM,Bird M,Green C,Thiermann H,Worek F

更新日期：2012-03-01 00:00:00

abstract：:A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relativ...

journal_title：Drug testing and analysis

authors： Abounassif MA,Al-Omar MA,Amr AG,Mostafa GA

更新日期：2011-06-01 00:00:00

abstract：:Buprenorphine and methadone are commonly used medications for opioid maintenance treatment (OMT), using sublingual and oral administration, respectively. Although beneficial for OMT, these drugs can also be abused by intravenous administration. In intravenous abuse cases, the adjuvants lactose and sucrose are excreted...

journal_title：Drug testing and analysis

authors： Keltanen T,Mariottini C,Walta AM,Rahikainen AL,Ojanperä I

更新日期：2017-06-01 00:00:00

abstract：:1-Propanoyl-lysergic acid diethylamide (1P-LSD) appeared as a non-controlled alternative to LSD a few years ago. Although evidence is beginning to emerge from in vitro and animal studies that 1P-LSD might serve as a prodrug for LSD, an equivalent evaluation in humans is unavailable. Controlled oral and intravenous sel...

journal_title：Drug testing and analysis

authors： Grumann C,Henkel K,Brandt SD,Stratford A,Passie T,Auwärter V

更新日期：2020-08-01 00:00:00

abstract：:Oral fluid (OF) is an important matrix for monitoring drugs. Smoking cannabis is common, but vaporization and edible consumption also are popular. OF pharmacokinetics are available for controlled smoked cannabis, but few data exist for vaporized and oral routes. Frequent and occasional cannabis smokers were recruited ...

journal_title：Drug testing and analysis

authors： Swortwood MJ,Newmeyer MN,Andersson M,Abulseoud OA,Scheidweiler KB,Huestis MA

更新日期：2017-06-01 00:00:00

abstract：:Synthetic cathinones continue to proliferate in clandestine drug markets worldwide. N-ethylnorpentylone (also known as N-ethylpentylone or ephylone) is a popular emergent cathinone, yet little information is available about its toxicology and pharmacology. Here we characterize the analytical quantification, clinical p...

journal_title：Drug testing and analysis

authors： Costa JL,Cunha KF,Lanaro R,Cunha RL,Walther D,Baumann MH

更新日期：2019-03-01 00:00:00

abstract：:Two primary animal models persist for assessing hallucinogenic potential of novel compounds and for examining the pharmacological and neurobiological substrates underlying the actions of classical hallucinogens, the two-lever drug discrimination procedure and the drug-induced head-twitch response (HTR) in rodents. The...

journal_title：Drug testing and analysis

authors： Canal CE,Morgan D

更新日期：2012-07-01 00:00:00

abstract：:According to French law, the roadside testing for drugs of abuse (DOA) should be performed in oral fluid (OF) using an immunological screening kit. If the screening is positive, confirmation has to be done in OF collected by a special swab, called the FLOQSwab™ (FS). Unlike other sampling kits, this device was not des...

journal_title：Drug testing and analysis

authors： Fabresse N,Aouad H,Knapp A,Mayer C,Etting I,Larabi IA,Alvarez JC

更新日期：2019-06-01 00:00:00

abstract：:Even though hair analysis often seems to be the best choice for retrospective monitoring of cocaine intake, differentiating between incorporated cocaine and external contamination is widely debated. In this study we report results obtained in 90 hair samples from addicts. All samples were analyzed for cocaine, benzoyl...

journal_title：Drug testing and analysis

authors： Gambelunghe C,Rossi R,Aroni K,Gili A,Bacci M,Pascali V,Fucci N

更新日期：2017-02-01 00:00:00

abstract：:Anabolic steroids are banned substances in equine sports. Gas chromatography-mass spectrometry (GC-MS) has been the traditional technique for doping control analysis of anabolic steroids in biological samples. Although liquid chromatography-mass spectrometry (LC/MS) has become an important technique in doping control,...

journal_title：Drug testing and analysis

authors： Wong ASY,Leung GNW,Leung DKK,Wan TSM

更新日期：2017-09-01 00:00:00

abstract：:Three legal highs; nitracaine (3-(diethylamino)-2,2-dimethylpropyl 4-nitrobenzoate), methoxypiperamide (MEOP, (4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone) and mephtetramine (MTTA, 2-((methylamino)methyl)-3,4-dihydronaphthalen-1(2H)-one) appeared in 2013 as new psychoactive substances (NPS) on Internet websites ...

journal_title：Drug testing and analysis

authors： Power JD,Scott KR,Gardner EA,Curran McAteer BM,O'Brien JE,Brehon M,Talbot B,Kavanagh PV

更新日期：2014-07-01 00:00:00

abstract：:Sulfate metabolites have been described as long-term metabolites for some anabolic androgenic steroids (AAS). 4-chlorometandienone (4Cl-MTD) is one of the most frequently detected AAS in sports drug testing and it is commonly detected by monitoring metabolites excreted free or conjugated with glucuronic acid. Sulfatio...

journal_title：Drug testing and analysis

authors： Balcells G,Gómez C,Garrostas L,Pozo ÓJ,Ventura R

更新日期：2017-07-01 00:00:00

abstract：:In doping control analysis, the characterization of urinary steroid metabolites is of high interest for a targeted and long-term detection of prohibited anabolic androgenic steroids (AAS). In this work, the structure of a long-term metabolite of dehydrochloromethyltestosterone (DHCMT) was elucidated. Altogether, 8 pos...

journal_title：Drug testing and analysis

authors： Forsdahl G,Geisendorfer T,Göschl L,Pfeffer S,Gärtner P,Thevis M,Gmeiner G

更新日期：2018-03-23 00:00:00

abstract：:The steroidal module of the Athlete Biological Passport (ABP) aims to detect doping with endogenous steroids, e.g. testosterone (T), by longitudinally monitoring several biomarkers. These biomarkers are ratios combined into urinary concentrations of testosterone and metabolically related steroids. However, it is evide...

journal_title：Drug testing and analysis

authors： Mullen J,Baekken LV,Törmäkangas T,Ekström L,Ericsson M,Hullstein IR,Schulze JJ

更新日期：2020-06-01 00:00:00

abstract：:Despite the implementation of a new blanket scheduling system in 2013, new psychoactive substance (NPS) abuse remains a serious social concern in Japan. We present a fatal intoxication case involving 5F-ADB (methyl 2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate) and diphenidine. Postmortem bloo...

journal_title：Drug testing and analysis

authors： Kusano M,Zaitsu K,Taki K,Hisatsune K,Nakajima J,Moriyasu T,Asano T,Hayashi Y,Tsuchihashi H,Ishii A

更新日期：2018-02-01 00:00:00

abstract：:The amphetamine molecule contains a chiral center and its enantiomers exhibit differences in pharmacological effects, with the S-enantiomer mediating most of the central nervous system stimulating activity. The majority of prescribed amphetamine consists of the pure S-enantiomer, but therapeutic formulations containin...

journal_title：Drug testing and analysis

authors： Havnen H,Hansen M,Spigset O,Hegstad S

更新日期：2020-09-01 00:00:00