Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous detection of 10 illicit drugs in oral fluid collected with FLOQSwabs™ and application to real samples.

abstract：:Addiction is a complex disorder with interacting factors, including environmental factors, drug-induced neurobiological changes, comorbidity, personality traits and stress responsivity. Numerous genetic variants that affect these factors may work in concert to affect vulnerability and severity of addiction. Traditiona...

journal_title：Drug testing and analysis

authors： Fattore L

更新日期：2013-01-01 00:00:00

abstract：:Indole-, indazole-, or azaindole-based synthetic cannabinoids (SCs), bearing a cumyl substituent are a widespread, recreationally used subgroup of new psychoactive substances (NPS). The latest cumyl-derivative, CUMYL-PEGACLONE, emerged in December 2016 on the German drug market. The substance features a novel γ-carbol...

journal_title：Drug testing and analysis

authors： Mogler L,Wilde M,Huppertz LM,Weinfurtner G,Franz F,Auwärter V

更新日期：2018-05-01 00:00:00

abstract：:Erythropoietin (EPO) has been misused in sports for many years due to its performance-enhancing effect. In the last decade, detection of abuse has been possible with isoelectric focusing (IEF) based on the different isoform profiles of endogenous and recombinant EPO. The release of new EPOs on the market, such as the ...

journal_title：Drug testing and analysis

authors： Dehnes Y,Hemmersbach P

更新日期：2011-05-01 00:00:00

abstract：:Workplace drug testing in Europe is governed by a patchwork of legislation--or lack of it. Other difficulties are caused by language, currency and a host of other factors, including the difficulty in defining 'safety critical'. The European Workplace Drug Testing Society's (EWDTS) history and objectives are briefly ou...

journal_title：Drug testing and analysis

authors： Pierce A

更新日期：2012-02-01 00:00:00

abstract：:The impact of dehydroepiandrosterone (DHEA) administration has been widely studied for anti-doping purposes in men, whereas only a few studies have been performed in women. In the present study, the impact of DHEA on the steroid profile parameters and their carbon isotopic ratios was explored. Eleven healthy young wom...

journal_title：Drug testing and analysis

authors： Buisson C,Frelat C,Privat K,Martinat N,Audran M,Collomp K

更新日期：2018-11-01 00:00:00

abstract：:N-Methyl-3-phenyl-norbornan-2-amine (N-methyl-3-phenylbicyclo[2.2.1]heptan-2-amine, Camfetamine(™) ) is available from a number of online legal highs/research chemicals' vendors. Although it was developed as an analeptic by Merck in the early 1960s, it was never commercialized. However, the Association of Independent ...

journal_title：Drug testing and analysis

authors： Kavanagh P,Angelov D,O'Brien J,Power JD,McDermott SD,Talbot B,Fox J,O'Donnell C,Christie R

更新日期：2013-04-01 00:00:00

abstract：:Development of a mass spectrometric method for the unambiguous detection of doping with recombinant human erythropoietins (rhEPO) has been attempted for many years. Unfortunately, progress in this field was hampered by the unavailability of highly purified human endogenous EPOs (urinary[uhEPO], serum/plasma EPO)--a pr...

journal_title：Drug testing and analysis

authors： Reichel C

更新日期：2013-11-01 00:00:00

abstract：:The effectiveness of doping control in sport has been improved continuously during the past 50 years. One of the major steps forward was the introduction of unannounced and targeted out-of-competition testing in order to control the misuse of anabolic-androgenic steroids (AAS), mainly during the end of the 1980s. It a...

journal_title：Drug testing and analysis

authors： Hemmersbach P

更新日期：2020-05-01 00:00:00

abstract：:Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti-Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit ...

journal_title：Drug testing and analysis

authors： Chen TT,Tseng YC,Huang TY,Chang-Chien GP,Hsu MC

更新日期：2018-05-01 00:00:00

abstract：:Two primary animal models persist for assessing hallucinogenic potential of novel compounds and for examining the pharmacological and neurobiological substrates underlying the actions of classical hallucinogens, the two-lever drug discrimination procedure and the drug-induced head-twitch response (HTR) in rodents. The...

journal_title：Drug testing and analysis

authors： Canal CE,Morgan D

更新日期：2012-07-01 00:00:00

abstract：:Accurate on-site devices to screen for drug intake are critical for establishing whether an individual is driving under the influence of drugs (DUID); however, on-site oral fluid (OF) cocaine device performance is variable. We evaluated the performance of a newly developed benzoylecgonine (BE) test-strip for the Draeg...

journal_title：Drug testing and analysis

authors： Ellefsen KN,Concheiro M,Pirard S,Gorelick DA,Huestis MA

更新日期：2016-03-01 00:00:00

abstract：:The quantitative structure-property relationship (QSPR) of drug molecules against the immobilized liposome chromatography partitioning (log K(s)) was studied. The genetic algorithm (GA) was employed to select the variables that resulted in the best-fitted models. After the variables were selected, the linear multivari...

journal_title：Drug testing and analysis

authors： Noorizadeh H,Farmany A

更新日期：2012-02-01 00:00:00

abstract：:A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relativ...

journal_title：Drug testing and analysis

authors： Abounassif MA,Al-Omar MA,Amr AG,Mostafa GA

更新日期：2011-06-01 00:00:00

abstract：:The study describes an LC-MS/MS method for simultaneous quantification of the cardiac glycosidic drugs digoxin and digitoxin and several of their metabolites. The assay represents a useful reference method for immunoassay-based tests, which are easily biased by the presence of metabolites of the target analytes or str...

journal_title：Drug testing and analysis

authors： Bylda C,Thiele R,Kobold U,Volmer DA

更新日期：2015-10-01 00:00:00

abstract：:Dihydroartemisinin (DHA) and piperaquine (PPQ) are two drugs used in an artemisinin-based combination therapy (ACT). The circulation of counterfeit antimalarial drugs demands the development of simple, point-of-care (POC) tests for monitoring drug quality. Here we aimed to design an antibody-based lateral flow dipstic...

journal_title：Drug testing and analysis

authors： Ning X,Tan G,Chen X,Wang M,Wang B,Cui L

更新日期：2019-09-01 00:00:00

abstract：:Several clinical-grade immunoassays exist for the specific measurement of hGH or its isoforms in blood but there is an urgent need to apply these same reliable assays to the measurement of hGH in urine as a preferred 'non-invasive' biofluid. Unfortunately, conventional hGH immunoassays cannot attain the sensitivity re...

journal_title：Drug testing and analysis

authors： Fredolini C,Tamburro D,Gambara G,Lepene BS,Espina V,Petricoin EF 3rd,Liotta LA,Luchini A

更新日期：2009-09-01 00:00:00

abstract：:The legally defensible proof of the abuse of endogenous steroids in sports is currently based on carbon isotope ratio mass spectrometry (IRMS), i.e. a comparison between (13)C/(12)C ratios of diagnostic precursors and metabolites of testosterone. The application of this technique requires a chromatographic baseline se...

journal_title：Drug testing and analysis

authors： Thieme D,Rautenberg C,Grosse J,Schoenfelder M

更新日期：2013-11-01 00:00:00

abstract：:Zebrafish (Danio rerio) water tank (ZWT) approach was investigated as an alternative model for metabolism studies based on six different experiments with four model compounds. Sibutramine was applied for the multivariate optimization of ZWT conditions, also for the comparison of the metabolism among ZWT, humans and mi...

journal_title：Drug testing and analysis

authors： Sardela VF,Anselmo CS,Nunes IKDC,Carneiro GRA,Dos Santos GRC,de Carvalho AR,Labanca BJ,Silva Oliveira D,Ribeiro WD,de Araujo ALD,Padilha MC,de Lima CKF,de Sousa VP,de Aquino Neto FR,Gualberto Pereira HM

更新日期：2018-11-01 00:00:00

abstract：:A new and sensitive multi-residue method (MRM) with detection by LC-MS/MS was developed and validated for the screening, determination, and confirmation of residues of 7 nitroimidazoles and 3 of their metabolites in turkey muscle tissues at concentrations ≥ 0.05 ng/g. The compounds were extracted into a solvent with a...

journal_title：Drug testing and analysis

authors： Boison JO,Asea PA,Matus JL

更新日期：2012-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-protein coding transcripts involved in many cellular and physiological mechanisms. Recently, a new class of miRNA called 'circulating miRNAs' was found in cell-free body fluids such as plasma and urine. Circulating miRNAs have been shown to be very stable, specific, and sensitive biom...

journal_title：Drug testing and analysis

authors： Leuenberger N,Jan N,Pradervand S,Robinson N,Saugy M

更新日期：2011-11-01 00:00:00

abstract：:This work presents an analytical procedure for the identification and characterization of liposome-entrapped haemoglobins, based on flow cytofluorimetry. Flow cytofluorimetric detection is carried out following labelling by two distinct fluorescent reagents, an anti-haemoglobin antibody, fluorescein isothiocyanate con...

journal_title：Drug testing and analysis

authors： Esposito S,Colicchia S,de la Torre X,Donati F,Mazzarino M,Botrè F

更新日期：2017-02-01 00:00:00

abstract：:In the context of post-marketing surveillance supporting public-health authorities to take evidence-based decisions to fight the spread of poor-quality medicines, the quality of antimalarial artemether-lumefantrine (AL) medicines was assessed in the Democratic Republic of the Congo (DRC). A total of 150 samples of AL-...

journal_title：Drug testing and analysis

authors： Mufusama JP,Ndjoko Ioset K,Feineis D,Hoellein L,Holzgrabe U,Bringmann G

更新日期：2018-10-01 00:00:00

abstract：:Tretoquinol (trimetoquinol), a β2-agonist, has been explicitly listed on the World Anti-Doping Agency Prohibited List 2019 since January 2019; however, it has been distributed as an antiasthmatic on the medical market. This study aimed to develop a liquid chromatography-tandem mass spectrometric method for the quantif...

journal_title：Drug testing and analysis

authors： Okano M,Miyamoto A,Sato M,Kageyama S

更新日期：2019-11-01 00:00:00

abstract：:Abuse of gamma-hydroxybutyric acid (GHB) has been known since the early 1990's, but is not as widespread as the consumption of other illegal drugs. However, the number of severe intoxications with fatal outcomes is comparatively high; not the least of which is brought about by the consumption of the currently legal pr...

journal_title：Drug testing and analysis

authors： Andresen H,Aydin BE,Mueller A,Iwersen-Bergmann S

更新日期：2011-09-01 00:00:00

abstract：:'All scientific work is incomplete-whether it be observational or experimental. All scientific work is liable to be upset or modified by advancing knowledge. That does not confer upon us a freedom to ignore the knowledge we already have, or to postpone the action that it appears to demand at a given time.' ...

journal_title：Drug testing and analysis

authors： Evans-Brown M,Kimergård A,McVeigh J

更新日期：2009-07-01 00:00:00

abstract：:The steroid profile (SP) is a powerful tool to detect the misuse of endogenous anabolic androgenic steroids in sports, and it is included in the Athlete Biological Passport (ABP). Glucocorticoids (GCs), which are widely prescribed in sports and only prohibited in competition by systemic routes, inhibit the hypothalami...

journal_title：Drug testing and analysis

authors： Coll S,Matabosch X,Garrostas L,Perez-Maña C,Ventura R

更新日期：2018-06-01 00:00:00

abstract：:Autologous blood transfusion is a powerful means of improving performance and remains one of the most challenging methods to detect. Recent investigations have identified 3 candidate reticulocytes genes whose expression was significantly influenced by blood transfusion. Using quantitative reverse transcription polymer...

journal_title：Drug testing and analysis

authors： Salamin O,Mignot J,Kuuranne T,Saugy M,Leuenberger N

更新日期：2018-03-01 00:00:00

abstract：:Prenylamine is a vasodilator of phenylalkylamine structure and was used for the treatment of angina pectoris, until reports of undesirable effects including ventricular tachycardia led to a decreasing use of the drug in the 1980s. Metabolic N-dealkylation of orally ingested prenylamine can liberate amphetamine in huma...

journal_title：Drug testing and analysis

authors： Beuck S,Sigmund G,Koch A,Schänzer W,Pokrywka A,Kwiatkowska D,Thevis M

更新日期：2012-09-01 00:00:00

abstract：:Cobalt is an essential mineral micronutrient and is regularly present in equine nutritional and feed supplements. Therefore, cobalt is naturally present at low concentrations in biological samples. The administration of cobalt chloride is considered to be blood doping and is thus prohibited. To control the misuse of c...

journal_title：Drug testing and analysis

authors： Popot MA,Ho ENM,Stojiljkovic N,Bagilet F,Remy P,Maciejewski P,Loup B,Chan GHM,Hargrave S,Arthur RM,Russo C,White J,Hincks P,Pearce C,Ganio G,Zahra P,Batty D,Jarrett M,Brooks L,Prescott LA,Bailly-Chouriberry L,Bo

更新日期：2017-09-01 00:00:00

abstract：:MSforID represents a database of tandem mass spectral data obtained from (quasi-)molecular ions produced by atmospheric pressure ionization methods. At the current stage of development the library contains 12 122 spectra of 1208 small (bio-)organic molecules. The present work was aimed to evaluate the performance of t...

journal_title：Drug testing and analysis

authors： Würtinger P,Oberacher H

更新日期：2012-03-01 00:00:00