Abstract:
:'All scientific work is incomplete-whether it be observational or experimental. All scientific work is liable to be upset or modified by advancing knowledge. That does not confer upon us a freedom to ignore the knowledge we already have, or to postpone the action that it appears to demand at a given time.'
journal_name
Drug Test Analjournal_title
Drug testing and analysisauthors
Evans-Brown M,Kimergård A,McVeigh Jdoi
10.1002/dta.74subject
Has Abstractpub_date
2009-07-01 00:00:00pages
323-6issue
7eissn
1942-7603issn
1942-7611journal_volume
1pub_type
杂志文章abstract::In a preliminary test, four single hairs of a drug abuser were analyzed for the presence of drugs by MALDI Fourier transform mass spectrometry (MALDI-FTMS). Washed hair strains were directly fixed on a sample plate using pressure stable, double-sided adhesive tape; α-cyano-4-hydroxycinnamic acid matrix was manually sp...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1453
更新日期:2013-05-01 00:00:00
abstract::Three multivariate calibration methods, including classical least square with nonzero intercept (CLS), principal component regression (PCR) and partial least square (PLS), have been used for the determination of pyritinol dihydrochloride in the presence of its degradation product. The CLS, PCR and PLS techniques are u...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.37
更新日期:2009-05-01 00:00:00
abstract::Evidence of the continuous rise of novel doping agents and novel doping strategies calls for the development of more accurate multi-target screening methods. Direct multi-target screening approaches are restricted to the targeted substances and their turnover. The development of effective "indirect" screening methods ...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.2788
更新日期:2020-06-01 00:00:00
abstract::Indole-, indazole-, or azaindole-based synthetic cannabinoids (SCs), bearing a cumyl substituent are a widespread, recreationally used subgroup of new psychoactive substances (NPS). The latest cumyl-derivative, CUMYL-PEGACLONE, emerged in December 2016 on the German drug market. The substance features a novel γ-carbol...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2352
更新日期:2018-05-01 00:00:00
abstract::New bioanalytical assays were developed, validated, and applied in a clinical study for quantitative measurement of acetaminophen concentrations in blood and plasma samples. Furthermore, after validation, the bioanalytical assays were used for determination of pharmacokinetics within a group of six healthy male human ...
journal_title:Drug testing and analysis
pub_type: 临床试验,杂志文章
doi:10.1002/dta.1582
更新日期:2014-06-01 00:00:00
abstract::In Australia, drug monitoring systems have been in place for more than a decade allowing for the measurement of ongoing trends in drug use and the detection of new drugs. The Drug Trends Unit at the National Drug and Alcohol Research Centre monitors drugs through four separate systems. The Illicit Drug Reporting Syste...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.1613
更新日期:2014-07-01 00:00:00
abstract::Anabolic steroids are banned substances in equine sports. Gas chromatography-mass spectrometry (GC-MS) has been the traditional technique for doping control analysis of anabolic steroids in biological samples. Although liquid chromatography-mass spectrometry (LC/MS) has become an important technique in doping control,...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2090
更新日期:2017-09-01 00:00:00
abstract::In this tutorial we describe the construction of chemiluminescence detectors for high performance liquid chromatography (HPLC), comprising the components required to deliver the chemiluminescence reagent, a coiled-tubing flow cell, photomultiplier tube and detector housing, and various options for data acquisition. We...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.132
更新日期:2011-03-01 00:00:00
abstract::Relaxin (RLX) has demonstrated diverse pharmacological effects in various scientific and clinical studies. The emergence of porcine relaxin (pRLX) has raised concerns on the doping potential of pRLX. There have also been speculations in the horseracing industry on its covert use. To control the abuse of pRLX in equine...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2143
更新日期:2017-09-01 00:00:00
abstract::The absence of reference material is a commonly experienced difficulty among medical and forensic professionals tasked with identifying new psychoactive substances that are encountered for the first time. The identification of newly emerging substances lies at the heart of forensic and clinical analysis, and a proacti...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.398
更新日期:2012-01-01 00:00:00
abstract::A simple and sensitive method is described for voltammetric determination of promethazine hydrochloride (PMZ), a widely used phenothiazine drug, based on its electrochemical oxidation at a multi-wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE). Compared with bare GCE, the MWCNT-modified GCE exhibite...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.205
更新日期:2011-03-01 00:00:00
abstract::Hemp nuts are mature cannabis seeds obtained after shelling and that are commonly used in traditional Chinese medicine for treating functional constipation. In this work, we screened hemp nut products, classified them, and verified the legality of consuming them. A total of 18 products were purchased from Taiwan, Chin...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2062
更新日期:2017-06-01 00:00:00
abstract::Vaping of synthetic cannabinoids via e-cigarettes is growing in popularity. In the present study, we tentatively identified 12 by-products found in a pure sample of the synthetic cannabinoid Cumyl-5F-PINACA (1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide), a prevalent new psychoactive substance (...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2673
更新日期:2020-01-01 00:00:00
abstract::Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti-Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2343
更新日期:2018-05-01 00:00:00
abstract::Synthetic cannabinoids are a group of psychoactive drugs presently widespread among drug users in Europe. Analytical methods to measure these compounds in urine are in demand as urine is a preferred matrix for drug testing. For most synthetic cannabinoids, the parent compounds are rarely detected in urine. Therefore u...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1896
更新日期:2016-09-01 00:00:00
abstract::A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relativ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.231
更新日期:2011-06-01 00:00:00
abstract::According to French law, the roadside testing for drugs of abuse (DOA) should be performed in oral fluid (OF) using an immunological screening kit. If the screening is positive, confirmation has to be done in OF collected by a special swab, called the FLOQSwab™ (FS). Unlike other sampling kits, this device was not des...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2563
更新日期:2019-06-01 00:00:00
abstract::The advent of liquid chromatography-tandem mass spectrometry (LC-MS/MS), with the sensitivity it confers, permits the analysis of both phase I and II drug metabolites that in the past would have been difficult to target using other techniques. These metabolites may have relevance to current analytical toxicology emplo...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.305
更新日期:2011-10-01 00:00:00
abstract::The use of corticosteroids, such as betamethasone, in performance horses is tightly regulated. The objective of the current study was to describe the plasma pharmacokinetics of betamethasone as well as time-related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve racin...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2170
更新日期:2017-09-01 00:00:00
abstract::Current doping trends overshadow the traditional interpretation of using prohibited performance-enhancing drugs to improve training and/or sports results. Its definition has evolved due to several recent cases of unconventional manipulation in sports. In this article, we present a case study of an intentional intoxica...
journal_title:Drug testing and analysis
pub_type: 历史文章,杂志文章
doi:10.1002/dta.2753
更新日期:2020-05-01 00:00:00
abstract::Even though hair analysis often seems to be the best choice for retrospective monitoring of cocaine intake, differentiating between incorporated cocaine and external contamination is widely debated. In this study we report results obtained in 90 hair samples from addicts. All samples were analyzed for cocaine, benzoyl...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1903
更新日期:2017-02-01 00:00:00
abstract::Addiction is a complex disorder with interacting factors, including environmental factors, drug-induced neurobiological changes, comorbidity, personality traits and stress responsivity. Numerous genetic variants that affect these factors may work in concert to affect vulnerability and severity of addiction. Traditiona...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1401
更新日期:2013-01-01 00:00:00
abstract::Testosterone and related compounds are the most recurrent doping substances. The steroid profile, consisting of the quantification of testosterone and its metabolites, has been described as the most significant biomarker to detect doping with pseudo-endogenous anabolic steroids. The steroidal module of the Athlete Bio...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1851
更新日期:2016-07-01 00:00:00
abstract::Musk, the dried secretion of the musk pod (sac) of adult male musk deer, has been used as traditional Chinese Medicine (TCM) in China and south-east Asian countries for thousands of years. Due to the anabolic steroid component in this TCM, musk preparations have been included in the list of medical products containing...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2293
更新日期:2017-11-01 00:00:00
abstract::Xenon is a modern inhalative anaesthetic with a very low solubility in tissues providing rapid elimination and weaning from anaesthesia. Besides its anaesthetic properties, Xenon promotes the endogenous erythropoietin biosynthesis and thus has been enlisted as prohibited substance by the World Anti-Doping Agency (WADA...
journal_title:Drug testing and analysis
pub_type: 临床试验,杂志文章
doi:10.1002/dta.2001
更新日期:2017-05-01 00:00:00
abstract::Prenylamine is a vasodilator of phenylalkylamine structure and was used for the treatment of angina pectoris, until reports of undesirable effects including ventricular tachycardia led to a decreasing use of the drug in the 1980s. Metabolic N-dealkylation of orally ingested prenylamine can liberate amphetamine in huma...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1388
更新日期:2012-09-01 00:00:00
abstract::In an earlier study, we developed two sensitive and reliable procedures for gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of methylhexaneamine (MHA) in P. graveolens plant materials and volatile oils. None of the analyzed plant materials or oils sho...
journal_title:Drug testing and analysis
pub_type: 杂志文章,多中心研究
doi:10.1002/dta.1726
更新日期:2015-07-01 00:00:00
abstract::Different extracts of Nigella sativa L. seed waste; aqueous (AE) 200 mg/kg, ethanol 70% (EE) 250 mg/kg and hexane (HE) 10 mg/kg, were evaluated for their hepatoprotective activities. They were administered orally, once daily, for 5 consecutive days. On day 5, liver injury was induced in animals by a single i.p. inject...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.225
更新日期:2011-04-01 00:00:00
abstract::1-Propanoyl-lysergic acid diethylamide (1P-LSD) appeared as a non-controlled alternative to LSD a few years ago. Although evidence is beginning to emerge from in vitro and animal studies that 1P-LSD might serve as a prodrug for LSD, an equivalent evaluation in humans is unavailable. Controlled oral and intravenous sel...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.2821
更新日期:2020-08-01 00:00:00
abstract::The present study was designed to provide preliminary information on the potential impact of metabolic drug-drug interaction on the effectiveness of doping control strategies currently followed by the anti-doping laboratories to detect the intake of prohibited agents. In vitro assays based on the use of human liver mi...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1608
更新日期:2014-10-01 00:00:00