Electroanalysis of trimethoprim on metalloporphyrin incorporated glassy carbon electrode.

abstract：:Recombinant human erythropoietin (rHuEPO) is used as doping a substance. Anti-doping efforts include urine and blood testing and monitoring the athlete biological passport (ABP). As data on the performance of these methods are incomplete, this study aimed to evaluate the performance of two common urine assays and the ...

journal_title：Drug testing and analysis

authors： Heuberger JAAC,van Eenoo P,Rotmans JI,Gal P,Stuurman FE,Post TE,Daniels JMA,Ram H,de Hon O,Burggraaf J,Cohen AF

更新日期：2019-09-01 00:00:00

abstract：:Tretoquinol (trimetoquinol), a β2-agonist, has been explicitly listed on the World Anti-Doping Agency Prohibited List 2019 since January 2019; however, it has been distributed as an antiasthmatic on the medical market. This study aimed to develop a liquid chromatography-tandem mass spectrometric method for the quantif...

journal_title：Drug testing and analysis

authors： Okano M,Miyamoto A,Sato M,Kageyama S

更新日期：2019-11-01 00:00:00

abstract：:Three sensitive, selective and precise stability-indicating methods for the determination of the anti-Alzheimer's drug, rivastigmine hydrogen tartrate (RIV) in the presence of its alkaline degradation product (major metabolite, NAP 226-90) and in pharmaceutical formulation were developed and validated. The first metho...

journal_title：Drug testing and analysis

authors： Salem MY,El-Kosasy AM,El-Bardicy MG,Abd El-Rahman MK

更新日期：2010-05-01 00:00:00

abstract：:The evolving nature of new psychoactive substances (NPS) - often referred to as 'legal highs', 'designer drugs' or 'bath salts' - presents an evolving challenge for toxicologists. Apart from the detection and identification of these compounds, further analytical challenges may arise from the presence of possible metab...

journal_title：Drug testing and analysis

authors： Soh YN,Elliott S

更新日期：2014-07-01 00:00:00

abstract：:Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at present the only causal therapeutic approach. Being the key target of OP toxicity, AChE may serve as a valuable tool for diagnosis of OP exposure as well as for the invest...

journal_title：Drug testing and analysis

authors： Worek F,Eyer P,Thiermann H

更新日期：2012-03-01 00:00:00

abstract：:In this tutorial we describe the construction of chemiluminescence detectors for high performance liquid chromatography (HPLC), comprising the components required to deliver the chemiluminescence reagent, a coiled-tubing flow cell, photomultiplier tube and detector housing, and various options for data acquisition. We...

journal_title：Drug testing and analysis

authors： Adcock JL,Terry JM,Barrow CJ,Barnett NW,Olson DC,Francis PS

更新日期：2011-03-01 00:00:00

abstract：:Synthetic cannabinoids (SCs), mimicking the psychoactive effects of cannabis, consist of a vast array of structurally diverse compounds. A novel compound belonging to the SC family, (1-(cyclohexylmethyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone (named TMCP-CHM in this article) contains a cyclopropane r...

journal_title：Drug testing and analysis

authors： Grigoryev A,Kavanagh P,Labutin A,Pechnikov A,Dowling G,Shevyrin V,Krupina N

更新日期：2019-09-01 00:00:00

abstract：:Indole-, indazole-, or azaindole-based synthetic cannabinoids (SCs), bearing a cumyl substituent are a widespread, recreationally used subgroup of new psychoactive substances (NPS). The latest cumyl-derivative, CUMYL-PEGACLONE, emerged in December 2016 on the German drug market. The substance features a novel γ-carbol...

journal_title：Drug testing and analysis

authors： Mogler L,Wilde M,Huppertz LM,Weinfurtner G,Franz F,Auwärter V

更新日期：2018-05-01 00:00:00

abstract：:Δ(9) -Tetrahydrocannabinol (THC) is the most commonly analyzed cannabinoid in oral fluid (OF); however, its metabolite 11-nor-9-carboxy-THC (THCCOOH) offers the advantage of documenting active consumption, as it is not detected in cannabis smoke. Analytical challenges such as low (ng/L) THCCOOH OF concentrations hampe...

journal_title：Drug testing and analysis

authors： Desrosiers NA,Scheidweiler KB,Huestis MA

更新日期：2015-08-01 00:00:00

abstract：:The abuse of stanozolol is quite widespread in Indian sport. Its analysis is challenging and this has led to the development of new methods to improve its detection. A method was developed and validated for the detection of the three main monohydroxylated metabolites of stanozolol. The excretion profile of these metab...

journal_title：Drug testing and analysis

authors： Ahi S,Beotra A,Jain S

更新日期：2009-11-01 00:00:00

abstract：:Metal ion coordination ionspray (M(+) CIS) ionization is a powerful technique to enhance ionization efficiency and sensitivity. In this study, we developed and validated an analytical method for simultaneous ionization and analysis of 84 anabolic androgenic steroids (65 exogenous and 19 endogenous) using liquid chroma...

journal_title：Drug testing and analysis

authors： Kim SH,Cha EJ,Lee KM,Kim HJ,Kwon OS,Lee J

更新日期：2014-11-01 00:00:00

abstract：:Bioactive peptides pose a great threat to sports integrity. The detection of these peptides is essential for enforcing their prohibition in sports. Identifying the catabolites of these peptides that are formed ex vivo in plasma may improve their detection. In the present study, the stability of 27 bioactive peptides w...

journal_title：Drug testing and analysis

authors： Guan F,Fay S,Li X,You Y,Robinson MA

更新日期：2020-06-01 00:00:00

abstract：:N-Methyl-3-phenyl-norbornan-2-amine (N-methyl-3-phenylbicyclo[2.2.1]heptan-2-amine, Camfetamine(™) ) is available from a number of online legal highs/research chemicals' vendors. Although it was developed as an analeptic by Merck in the early 1960s, it was never commercialized. However, the Association of Independent ...

journal_title：Drug testing and analysis

authors： Kavanagh P,Angelov D,O'Brien J,Power JD,McDermott SD,Talbot B,Fox J,O'Donnell C,Christie R

更新日期：2013-04-01 00:00:00

abstract：:Three legal highs; nitracaine (3-(diethylamino)-2,2-dimethylpropyl 4-nitrobenzoate), methoxypiperamide (MEOP, (4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone) and mephtetramine (MTTA, 2-((methylamino)methyl)-3,4-dihydronaphthalen-1(2H)-one) appeared in 2013 as new psychoactive substances (NPS) on Internet websites ...

journal_title：Drug testing and analysis

authors： Power JD,Scott KR,Gardner EA,Curran McAteer BM,O'Brien JE,Brehon M,Talbot B,Kavanagh PV

更新日期：2014-07-01 00:00:00

abstract：:The detection of drug abuse in horseracing often requires knowledge of drug metabolism, especially if urine is the matrix of choice. In this study, equine liver/lung microsomes/S9 tissue fractions were used to study the phase I metabolism of eight drugs of relevance to equine drug surveillance (acepromazine, azaperone...

journal_title：Drug testing and analysis

authors： Scarth JP,Spencer HA,Timbers SE,Hudson SC,Hillyer LL

更新日期：2010-01-01 00:00:00

abstract：:Flubromazolam is a triazole benzodiazepine with high potency and long-lasting central nervous system depressant effects; however, limited data about its pharmacokinetics are available. Here, we report in vitro studies of the human flubromazolam metabolism analyzed by liquid chromatography high-resolution mass spectrom...

journal_title：Drug testing and analysis

authors： Noble C,Mardal M,Bjerre Holm N,Stybe Johansen S,Linnet K

更新日期：2017-08-01 00:00:00

abstract：:The laboratory anti-doping services during XXII Winter Olympic and XI Paralympic games in Sochi in 2014 were provided by a satellite laboratory facility located within the strictly secured Olympic Park. This laboratory, established and operated by the personnel of Antidoping Center, Moscow, has been authorized by the ...

journal_title：Drug testing and analysis

authors： Sobolevsky T,Krotov G,Dikunets M,Nikitina M,Mochalova E,Rodchenkov G

更新日期：2014-11-01 00:00:00

abstract：:The quantitative structure-property relationship (QSPR) of drug molecules against the immobilized liposome chromatography partitioning (log K(s)) was studied. The genetic algorithm (GA) was employed to select the variables that resulted in the best-fitted models. After the variables were selected, the linear multivari...

journal_title：Drug testing and analysis

authors： Noorizadeh H,Farmany A

更新日期：2012-02-01 00:00:00

abstract：:The annual update of the list of prohibited substances and doping methods as issued by the World Anti-Doping Agency (WADA) allows the implementation of most recent considerations of performance manipulation and emerging therapeutics into human sports doping control programmes. The annual banned-substance review for hu...

journal_title：Drug testing and analysis

authors： Thevis M,Kuuranne T,Geyer H,Schänzer W

更新日期：2010-04-01 00:00:00

abstract：:Even though hair analysis often seems to be the best choice for retrospective monitoring of cocaine intake, differentiating between incorporated cocaine and external contamination is widely debated. In this study we report results obtained in 90 hair samples from addicts. All samples were analyzed for cocaine, benzoyl...

journal_title：Drug testing and analysis

authors： Gambelunghe C,Rossi R,Aroni K,Gili A,Bacci M,Pascali V,Fucci N

更新日期：2017-02-01 00:00:00

abstract：:Increasing numbers of new psychoactive substances (NPS) among them fentanyl derivatives has been reported by the European monitoring centre for drugs and drug addiction (EMCDDA). Butyrfentanyl is a new fentanyl derivative whose potency ratio was found to be seven compared to morphine and 0.13 compared to fentanyl. Sev...

journal_title：Drug testing and analysis

authors： Steuer AE,Williner E,Staeheli SN,Kraemer T

更新日期：2017-07-01 00:00:00

abstract：:A quantitative structure-property relationship (QSPR) study based on an artificial neural network (ANN) was carried out for the prediction of the microemulsion liquid chromatography polar surface area (PSA) of a set of 32 drug compounds. The genetic algorithm-kernel partial least squares (GA-KPLS) method was used as a...

journal_title：Drug testing and analysis

authors： Noorizadeh H,Farmany A,Noorizadeh M,Kohzadi M

更新日期：2013-04-01 00:00:00

abstract：:Development of a mass spectrometric method for the unambiguous detection of doping with recombinant human erythropoietins (rhEPO) has been attempted for many years. Unfortunately, progress in this field was hampered by the unavailability of highly purified human endogenous EPOs (urinary[uhEPO], serum/plasma EPO)--a pr...

journal_title：Drug testing and analysis

authors： Reichel C

更新日期：2013-11-01 00:00:00

abstract：:The absence of reference material is a commonly experienced difficulty among medical and forensic professionals tasked with identifying new psychoactive substances that are encountered for the first time. The identification of newly emerging substances lies at the heart of forensic and clinical analysis, and a proacti...

journal_title：Drug testing and analysis

authors： Brandt SD,Tearavarich R,Dempster N,Cozzi NV,Daley PF

更新日期：2012-01-01 00:00:00

abstract：:A rapid and sensitive method involving liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) coupled to an intracerebral microdialysis technique was developed for the determination and pharmacokinetic investigation of tramadol and its major active metabolite O-desmethyltramadol (ODT) in rat brain....

journal_title：Drug testing and analysis

authors： Liu M,Wang P,Yu X,Dong G,Yue J

更新日期：2017-08-01 00:00:00

abstract：:The purpose of this research is to validate the biomarker-based approach for the detection of doping with recombinant human growth hormone (rhGH) in sport. The GH-2000 project proposed an indirect method for the detection of exogenously administered growth hormone (GH) based on the measurement of the GH-dependent mark...

journal_title：Drug testing and analysis

authors： Jing J,Zhou X,He C,Zhang L,Yang S,Xu Y,Xie M,Yan Y,Su H,Wu M

更新日期：2012-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-protein coding transcripts involved in many cellular and physiological mechanisms. Recently, a new class of miRNA called 'circulating miRNAs' was found in cell-free body fluids such as plasma and urine. Circulating miRNAs have been shown to be very stable, specific, and sensitive biom...

journal_title：Drug testing and analysis

authors： Leuenberger N,Jan N,Pradervand S,Robinson N,Saugy M

更新日期：2011-11-01 00:00:00

abstract：:Synthetic cathinones continue to proliferate in clandestine drug markets worldwide. N-ethylnorpentylone (also known as N-ethylpentylone or ephylone) is a popular emergent cathinone, yet little information is available about its toxicology and pharmacology. Here we characterize the analytical quantification, clinical p...

journal_title：Drug testing and analysis

authors： Costa JL,Cunha KF,Lanaro R,Cunha RL,Walther D,Baumann MH

更新日期：2019-03-01 00:00:00

abstract：:Classic examples of psychoactive arylcycloalkylamines include ketamine and 1-(1-phenylcyclohexyl)piperidine (PCP) and many others serve as important structural templates for neuropharmacological research. The recent emergence of PCP analogues that can be obtained from internet retailers requires the implementation of ...

journal_title：Drug testing and analysis

authors： Wallach J,De Paoli G,Adejare A,Brandt SD

更新日期：2014-07-01 00:00:00

abstract：:The effectiveness of doping control in sport has been improved continuously during the past 50 years. One of the major steps forward was the introduction of unannounced and targeted out-of-competition testing in order to control the misuse of anabolic-androgenic steroids (AAS), mainly during the end of the 1980s. It a...

journal_title：Drug testing and analysis

authors： Hemmersbach P

更新日期：2020-05-01 00:00:00