Miniaturized hollow fibre assisted liquid-phase microextraction and gas chromatography for determination of trace concentration of sufentanil and alfentanil in biological samples.

abstract：:Vaping of synthetic cannabinoids via e-cigarettes is growing in popularity. In the present study, we tentatively identified 12 by-products found in a pure sample of the synthetic cannabinoid Cumyl-5F-PINACA (1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide), a prevalent new psychoactive substance (...

journal_title：Drug testing and analysis

authors： Münster-Müller S,Matzenbach I,Knepper T,Zimmermann R,Pütz M

更新日期：2020-01-01 00:00:00

abstract：:Phosphatidylethanol 16:0/18:1 (PEth) is the most abundant homologue of the phosphatidylethanol group of phospholipids. Formed only in the presence of ethanol, PEth is used as a biomarker in whole blood to provide information about the consumption of alcohol. As information on the storage life of PEth is essential for ...

journal_title：Drug testing and analysis

authors： Dumitrascu C,van de Lavoir MCA,Neels H,Covaci A,Jacobs W,D'Hondt D,van Nuijs ALN

更新日期：2021-01-04 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-protein coding transcripts involved in many cellular and physiological mechanisms. Recently, a new class of miRNA called 'circulating miRNAs' was found in cell-free body fluids such as plasma and urine. Circulating miRNAs have been shown to be very stable, specific, and sensitive biom...

journal_title：Drug testing and analysis

authors： Leuenberger N,Jan N,Pradervand S,Robinson N,Saugy M

更新日期：2011-11-01 00:00:00

abstract：:Synthetic cannabinoids are a group of psychoactive drugs presently widespread among drug users in Europe. Analytical methods to measure these compounds in urine are in demand as urine is a preferred matrix for drug testing. For most synthetic cannabinoids, the parent compounds are rarely detected in urine. Therefore u...

journal_title：Drug testing and analysis

authors： Vikingsson S,Gréen H,Brinkhagen L,Mukhtar S,Josefsson M

更新日期：2016-09-01 00:00:00

abstract：:Development of a mass spectrometric method for the unambiguous detection of doping with recombinant human erythropoietins (rhEPO) has been attempted for many years. Unfortunately, progress in this field was hampered by the unavailability of highly purified human endogenous EPOs (urinary[uhEPO], serum/plasma EPO)--a pr...

journal_title：Drug testing and analysis

authors： Reichel C

更新日期：2013-11-01 00:00:00

abstract：:Oral fluid (OF) is an important matrix for monitoring drugs. Smoking cannabis is common, but vaporization and edible consumption also are popular. OF pharmacokinetics are available for controlled smoked cannabis, but few data exist for vaporized and oral routes. Frequent and occasional cannabis smokers were recruited ...

journal_title：Drug testing and analysis

authors： Swortwood MJ,Newmeyer MN,Andersson M,Abulseoud OA,Scheidweiler KB,Huestis MA

更新日期：2017-06-01 00:00:00

abstract：:To date, substances such as Mildronate (Meldonium) are not on the radar of anti-doping laboratories as the compound is not explicitly classified as prohibited. However, the anti-ischemic drug Mildronate demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection ag...

journal_title：Drug testing and analysis

authors： Görgens C,Guddat S,Dib J,Geyer H,Schänzer W,Thevis M

更新日期：2015-11-01 00:00:00

abstract：:The reactions involved in the metabolic pathways of SR9009 were characterized by liquid chromatography-mass spectrometry (LC-MS) to identify the most appropriate marker(s) of use. The effects of gender, genetic polymorphism, and drug-drug interaction on the metabolic profile of SR9009 were also evaluated. In vitro app...

journal_title：Drug testing and analysis

authors： Mazzarino M,Rizzato N,Stacchini C,de la Torre X,Botrè F

更新日期：2018-11-01 00:00:00

abstract：:N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA) and N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) are carboxamide-type synthetic cannabinoids comprising indazole/indole-3-carboxylic acid and adamantan-1-amine moieties. However, in the case of compounds like APINACA or APICA, adamantyl positiona...

journal_title：Drug testing and analysis

authors： Asada A,Doi T,Tagami T,Takeda A,Sawabe Y

更新日期：2017-03-01 00:00:00

abstract：:The use of performance enhancing drugs is a widespread phenomenon in professional and leisure sports. A spectroscopic study was carried out on anabolic tablets labelled as 5 mg methandienone tablets provided by police departments. The analytical approach was based on a two-step methodology: a fast analysis of tablets ...

journal_title：Drug testing and analysis

authors： Rebiere H,Ghyselinck C,Lempereur L,Brenier C

更新日期：2016-03-01 00:00:00

abstract：:The aim of this study was to investigate the effect of Morin on the pharmacokinetics of Piracetam in rats, in vitro enzyme kinetics and metabolic stability (high throughput) studies using human liver microsomes in UPLC. For pharmacokinetics studies, male Wistar rats were pretreated with Morin (10 mg/kg) for one week a...

journal_title：Drug testing and analysis

authors： Sahu K,Shaharyar M,Siddiqui AA

更新日期：2013-07-01 00:00:00

abstract：:Musk, the dried secretion of the musk pod (sac) of adult male musk deer, has been used as traditional Chinese Medicine (TCM) in China and south-east Asian countries for thousands of years. Due to the anabolic steroid component in this TCM, musk preparations have been included in the list of medical products containing...

journal_title：Drug testing and analysis

authors： Wang J,He Y,Liu X,Yang Z,Yang W

更新日期：2017-11-01 00:00:00

abstract：:A new and sensitive multi-residue method (MRM) with detection by LC-MS/MS was developed and validated for the screening, determination, and confirmation of residues of 7 nitroimidazoles and 3 of their metabolites in turkey muscle tissues at concentrations ≥ 0.05 ng/g. The compounds were extracted into a solvent with a...

journal_title：Drug testing and analysis

authors： Boison JO,Asea PA,Matus JL

更新日期：2012-08-01 00:00:00

abstract：:Autologous blood transfusion is a powerful means of improving performance and remains one of the most challenging methods to detect. Recent investigations have identified 3 candidate reticulocytes genes whose expression was significantly influenced by blood transfusion. Using quantitative reverse transcription polymer...

journal_title：Drug testing and analysis

authors： Salamin O,Mignot J,Kuuranne T,Saugy M,Leuenberger N

更新日期：2018-03-01 00:00:00

abstract：:Cobalt is a well-established inducer of hypoxia-like responses, which can cause gene modulation at the hypoxia inducible factor pathway to induce erythropoietin transcription. Cobalt salts are orally active, inexpensive, and easily accessible. It is an attractive blood doping agent for enhancing aerobic performance. I...

journal_title：Drug testing and analysis

authors： Ho EN,Chan GH,Wan TS,Curl P,Riggs CM,Hurley MJ,Sykes D

更新日期：2015-01-01 00:00:00

abstract：:Cobalt is an essential mineral micronutrient and is regularly present in equine nutritional and feed supplements. Therefore, cobalt is naturally present at low concentrations in biological samples. The administration of cobalt chloride is considered to be blood doping and is thus prohibited. To control the misuse of c...

journal_title：Drug testing and analysis

authors： Popot MA,Ho ENM,Stojiljkovic N,Bagilet F,Remy P,Maciejewski P,Loup B,Chan GHM,Hargrave S,Arthur RM,Russo C,White J,Hincks P,Pearce C,Ganio G,Zahra P,Batty D,Jarrett M,Brooks L,Prescott LA,Bailly-Chouriberry L,Bo

更新日期：2017-09-01 00:00:00

abstract：:In a preliminary test, four single hairs of a drug abuser were analyzed for the presence of drugs by MALDI Fourier transform mass spectrometry (MALDI-FTMS). Washed hair strains were directly fixed on a sample plate using pressure stable, double-sided adhesive tape; α-cyano-4-hydroxycinnamic acid matrix was manually sp...

journal_title：Drug testing and analysis

authors： Musshoff F,Arrey T,Strupat K

更新日期：2013-05-01 00:00:00

abstract：:The advent of liquid chromatography-tandem mass spectrometry (LC-MS/MS), with the sensitivity it confers, permits the analysis of both phase I and II drug metabolites that in the past would have been difficult to target using other techniques. These metabolites may have relevance to current analytical toxicology emplo...

journal_title：Drug testing and analysis

authors： Turfus SC,Braithwaite RA,Cowan DA,Parkin MC,Smith NW,Kicman AT

更新日期：2011-10-01 00:00:00

abstract：:The synthesis of positional isomers of designer drugs is a common way of bypassing legal restrictions. For forensic case work, and especially for the legal assessment of cases, there is a need for screening methods capable of the unequivocal identification of positional isomers. The presented liquid chromatography-ele...

journal_title：Drug testing and analysis

authors： Grumann C,Auwärter V

更新日期：2018-02-18 00:00:00

abstract：:The anabolic-androgenic steroid methylstenbolone (MSTEN; 2α,17α-dimethyl-17β-hydroxy-5α-androst-1-en-3-one) is available as a so-called designer steroid or nutritional supplement. It is occasionally detected in doping control samples, predominantly tested and confirmed as the glucuronic acid conjugate of methylstenbol...

journal_title：Drug testing and analysis

authors： Piper T,Fusshöller G,Schänzer W,Lagojda A,Kuehne D,Thevis M

更新日期：2019-11-01 00:00:00

abstract：:Trimethoprim (TMP) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Its use is associated with idiosyncratic reactions, including liver toxicity and agranulocytosis. I...

journal_title：Drug testing and analysis

authors： Rajith L,Kumar KG

更新日期：2010-09-01 00:00:00

abstract：:Xenon is a modern inhalative anaesthetic with a very low solubility in tissues providing rapid elimination and weaning from anaesthesia. Besides its anaesthetic properties, Xenon promotes the endogenous erythropoietin biosynthesis and thus has been enlisted as prohibited substance by the World Anti-Doping Agency (WADA...

journal_title：Drug testing and analysis

authors： Schaefer MS,Piper T,Geyer H,Schneemann J,Neukirchen M,Thevis M,Kienbaum P

更新日期：2017-05-01 00:00:00

abstract：:Selective androgen receptor modulators (SARMs) are a group of anabolic enhancer drugs posing threats to the integrity of animal sports and the safety of animal-derived foods. The current research describes for the first time the development of a semi-quantitative assay for the monitoring of SARM family compounds in bl...

journal_title：Drug testing and analysis

authors： Ventura E,Gadaj A,Buckley T,Mooney MH

更新日期：2020-09-01 00:00:00

abstract：:Designer drugs belong to a group of legally or illegally produced substances that are structurally and pharmacologically very similar to illicit drugs. In the past, designer drugs were often used during all-night dance parties, but they are now consumed in multiple settings from college bars to parks to private house ...

journal_title：Drug testing and analysis

authors： Karila L,Reynaud M

更新日期：2011-09-01 00:00:00

abstract：:At present, there is a growing trend toward the intentional adulteration of dietary supplements (DS) with synthetic pharmaceuticals, which represents an alarming emerging risk to consumers and a serious problem for regulatory agencies. An amazing array of synthetic drugs and their analogues have been reported as adult...

journal_title：Drug testing and analysis

authors： Muschietti L,Redko F,Ulloa J

更新日期：2020-07-01 00:00:00

abstract：:Sulfate metabolites have been described as long-term metabolites for some anabolic androgenic steroids (AAS). 4-chlorometandienone (4Cl-MTD) is one of the most frequently detected AAS in sports drug testing and it is commonly detected by monitoring metabolites excreted free or conjugated with glucuronic acid. Sulfatio...

journal_title：Drug testing and analysis

authors： Balcells G,Gómez C,Garrostas L,Pozo ÓJ,Ventura R

更新日期：2017-07-01 00:00:00

abstract：:A new, simple, rapid, accurate and precise high performance thin layer chromatography (HPTLC) method has been developed for the estimation of ondansetron hydrochloride in bulk and sublingual tablets. The mobile phase composition was chloroform : ethyl acetate : methanol : ammonia (9:5:4:0.1 v/v). Spectrodensitometric ...

journal_title：Drug testing and analysis

authors： Mujtaba A,Kohli K,Ali J,Baboota S

更新日期：2013-02-01 00:00:00

abstract：:Amphetamine (AMP) is used as an illicit drug and also for the treatment of attention deficit hyperactivity disorder (ADHD). Respective drugs most often contain the enantiomer (S)-AMP as active compound or (S)-AMP is formed from the prodrug lisdexamfetamine (Elvanse®) whereas the illicit drug is usually traded as racem...

journal_title：Drug testing and analysis

authors： Binz TM,Williner E,Strajhar P,Dolder PC,Liechti ME,Baumgartner MR,Kraemer T,Steuer AE

更新日期：2018-02-01 00:00:00

abstract：:The absence of reference material is a commonly experienced difficulty among medical and forensic professionals tasked with identifying new psychoactive substances that are encountered for the first time. The identification of newly emerging substances lies at the heart of forensic and clinical analysis, and a proacti...

journal_title：Drug testing and analysis

authors： Brandt SD,Tearavarich R,Dempster N,Cozzi NV,Daley PF

更新日期：2012-01-01 00:00:00

abstract：:Rocuronium bromide is a non-depolarizing neuromuscular blocking agent that causes rapid muscle relaxation after intravenous injection. Regulatory authorities for registration of pharmaceuticals for human use require the evaluation of the stability of active compounds under various stress conditions. Forced degradation...

journal_title：Drug testing and analysis

authors： Wegener O,Harms G,Volmer DA,Hayen H

更新日期：2015-09-01 00:00:00