Decrease of ethyl glucuronide concentrations in hair after exposure to chlorinated swimming pool water.

abstract：:Despite the implementation of a new blanket scheduling system in 2013, new psychoactive substance (NPS) abuse remains a serious social concern in Japan. We present a fatal intoxication case involving 5F-ADB (methyl 2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate) and diphenidine. Postmortem bloo...

journal_title：Drug testing and analysis

authors： Kusano M,Zaitsu K,Taki K,Hisatsune K,Nakajima J,Moriyasu T,Asano T,Hayashi Y,Tsuchihashi H,Ishii A

更新日期：2018-02-01 00:00:00

abstract：:A new, simple, rapid, accurate and precise high performance thin layer chromatography (HPTLC) method has been developed for the estimation of ondansetron hydrochloride in bulk and sublingual tablets. The mobile phase composition was chloroform : ethyl acetate : methanol : ammonia (9:5:4:0.1 v/v). Spectrodensitometric ...

journal_title：Drug testing and analysis

authors： Mujtaba A,Kohli K,Ali J,Baboota S

更新日期：2013-02-01 00:00:00

abstract：:Zolpidem and zopiclone (Z-compounds) are non-benzodiazepine hypnotics of new generation that can be used in drug-facilitated sexual assault (DFSA). Their determination in biological fluids, mainly urine, is of primary importance; nevertheless, although they are excreted almost entirely as metabolites, available method...

journal_title：Drug testing and analysis

authors： Strano Rossi S,Anzillotti L,Castrignanò E,Frison G,Zancanaro F,Chiarotti M

更新日期：2014-03-01 00:00:00

abstract：:Different extracts of Nigella sativa L. seed waste; aqueous (AE) 200 mg/kg, ethanol 70% (EE) 250 mg/kg and hexane (HE) 10 mg/kg, were evaluated for their hepatoprotective activities. They were administered orally, once daily, for 5 consecutive days. On day 5, liver injury was induced in animals by a single i.p. inject...

journal_title：Drug testing and analysis

authors： Michel CG,El-Sayed NS,Moustafa SF,Ezzat SM,Nesseem DI,El-Alfy TS

更新日期：2011-04-01 00:00:00

abstract：:The absence of reference material is a commonly experienced difficulty among medical and forensic professionals tasked with identifying new psychoactive substances that are encountered for the first time. The identification of newly emerging substances lies at the heart of forensic and clinical analysis, and a proacti...

journal_title：Drug testing and analysis

authors： Brandt SD,Tearavarich R,Dempster N,Cozzi NV,Daley PF

更新日期：2012-01-01 00:00:00

abstract：:Selective androgen receptor modulators (SARMs) are a group of anabolic enhancer drugs posing threats to the integrity of animal sports and the safety of animal-derived foods. The current research describes for the first time the development of a semi-quantitative assay for the monitoring of SARM family compounds in bl...

journal_title：Drug testing and analysis

authors： Ventura E,Gadaj A,Buckley T,Mooney MH

更新日期：2020-09-01 00:00:00

abstract：:The availability of a real-time assay to experimentally investigate the release of encapsulated proteins would be beneficial given the interest in the use of liposomes as a drug delivery vehicle. Although simple assays for small molecular weight substances exist, assays to evaluate macromolecules do not. Here we descr...

journal_title：Drug testing and analysis

authors： Mujoo H,Reynolds JNJ,Tucker IG

更新日期：2018-06-01 00:00:00

abstract：:The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration-based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma...

journal_title：Drug testing and analysis

authors： Lobigs LM,Sottas PE,Bourdon PC,Nikolovski Z,El-Gingo M,Varamenti E,Peeling P,Dawson B,Schumacher YO

更新日期：2018-02-01 00:00:00

abstract：:The impact of dehydroepiandrosterone (DHEA) administration has been widely studied for anti-doping purposes in men, whereas only a few studies have been performed in women. In the present study, the impact of DHEA on the steroid profile parameters and their carbon isotopic ratios was explored. Eleven healthy young wom...

journal_title：Drug testing and analysis

authors： Buisson C,Frelat C,Privat K,Martinat N,Audran M,Collomp K

更新日期：2018-11-01 00:00:00

abstract：:Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti-Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit ...

journal_title：Drug testing and analysis

authors： Chen TT,Tseng YC,Huang TY,Chang-Chien GP,Hsu MC

更新日期：2018-05-01 00:00:00

abstract：:Xenon is a modern inhalative anaesthetic with a very low solubility in tissues providing rapid elimination and weaning from anaesthesia. Besides its anaesthetic properties, Xenon promotes the endogenous erythropoietin biosynthesis and thus has been enlisted as prohibited substance by the World Anti-Doping Agency (WADA...

journal_title：Drug testing and analysis

authors： Schaefer MS,Piper T,Geyer H,Schneemann J,Neukirchen M,Thevis M,Kienbaum P

更新日期：2017-05-01 00:00:00

abstract：:The determination of protein- or peptide-based performance-enhancing pharmaceuticals has gained increasing attention in sports drug testing in recent decades. Proteases possess a high potential for use in the manipulation of regular urine specimens, interfering with established doping control procedures for proteins o...

journal_title：Drug testing and analysis

authors： Thomas A,Kohler M,Walpurgis K,Schänzer W,Thevis M

更新日期：2009-02-01 00:00:00

abstract：:Synthetic cannabinoids are the psychotropic compounds frequently identified as active components of smoking mixtures easily available via the Internet in several countries. These herbal blends have become extremely popular as a legal alternative to cannabis-based products and are difficult to detect by regular drug te...

journal_title：Drug testing and analysis

authors： Sobolevsky T,Prasolov I,Rodchenkov G

更新日期：2012-10-01 00:00:00

abstract：:Δ(9) -Tetrahydrocannabinol (THC) is the most commonly analyzed cannabinoid in oral fluid (OF); however, its metabolite 11-nor-9-carboxy-THC (THCCOOH) offers the advantage of documenting active consumption, as it is not detected in cannabis smoke. Analytical challenges such as low (ng/L) THCCOOH OF concentrations hampe...

journal_title：Drug testing and analysis

authors： Desrosiers NA,Scheidweiler KB,Huestis MA

更新日期：2015-08-01 00:00:00

abstract：:The synthesis of positional isomers of designer drugs is a common way of bypassing legal restrictions. For forensic case work, and especially for the legal assessment of cases, there is a need for screening methods capable of the unequivocal identification of positional isomers. The presented liquid chromatography-ele...

journal_title：Drug testing and analysis

authors： Grumann C,Auwärter V

更新日期：2018-02-18 00:00:00

abstract：:The study describes an LC-MS/MS method for simultaneous quantification of the cardiac glycosidic drugs digoxin and digitoxin and several of their metabolites. The assay represents a useful reference method for immunoassay-based tests, which are easily biased by the presence of metabolites of the target analytes or str...

journal_title：Drug testing and analysis

authors： Bylda C,Thiele R,Kobold U,Volmer DA

更新日期：2015-10-01 00:00:00

abstract：:Buprenorphine and methadone are commonly used medications for opioid maintenance treatment (OMT), using sublingual and oral administration, respectively. Although beneficial for OMT, these drugs can also be abused by intravenous administration. In intravenous abuse cases, the adjuvants lactose and sucrose are excreted...

journal_title：Drug testing and analysis

authors： Keltanen T,Mariottini C,Walta AM,Rahikainen AL,Ojanperä I

更新日期：2017-06-01 00:00:00

abstract：:A simple and sensitive method is described for voltammetric determination of promethazine hydrochloride (PMZ), a widely used phenothiazine drug, based on its electrochemical oxidation at a multi-wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE). Compared with bare GCE, the MWCNT-modified GCE exhibite...

journal_title：Drug testing and analysis

authors： Xi X,Ming L,Liu J

更新日期：2011-03-01 00:00:00

abstract：:The use of corticosteroids, such as betamethasone, in performance horses is tightly regulated. The objective of the current study was to describe the plasma pharmacokinetics of betamethasone as well as time-related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve racin...

journal_title：Drug testing and analysis

authors： Knych HK,Stanley SD,Harrison LM,Mckemie DS

更新日期：2017-09-01 00:00:00

abstract：:N-Methyl-3-phenyl-norbornan-2-amine (N-methyl-3-phenylbicyclo[2.2.1]heptan-2-amine, Camfetamine(™) ) is available from a number of online legal highs/research chemicals' vendors. Although it was developed as an analeptic by Merck in the early 1960s, it was never commercialized. However, the Association of Independent ...

journal_title：Drug testing and analysis

authors： Kavanagh P,Angelov D,O'Brien J,Power JD,McDermott SD,Talbot B,Fox J,O'Donnell C,Christie R

更新日期：2013-04-01 00:00:00

abstract：:In Australia, drug monitoring systems have been in place for more than a decade allowing for the measurement of ongoing trends in drug use and the detection of new drugs. The Drug Trends Unit at the National Drug and Alcohol Research Centre monitors drugs through four separate systems. The Illicit Drug Reporting Syste...

journal_title：Drug testing and analysis

authors： Burns L,Roxburgh A,Bruno R,Van Buskirk J

更新日期：2014-07-01 00:00:00

abstract：:The steroidal module of the Athlete Biological Passport (ABP) aims to detect doping with endogenous steroids, e.g. testosterone (T), by longitudinally monitoring several biomarkers. These biomarkers are ratios combined into urinary concentrations of testosterone and metabolically related steroids. However, it is evide...

journal_title：Drug testing and analysis

authors： Mullen J,Baekken LV,Törmäkangas T,Ekström L,Ericsson M,Hullstein IR,Schulze JJ

更新日期：2020-06-01 00:00:00

abstract：:In the field of natural extracts, research generally focuses on the study of their biological activities for food, cosmetic, or pharmacological purposes. The evaluation of their adverse effects is often overlooked. In this study, the extracts of Thymus vulgaris L. were obtained by two different extraction methods. Int...

journal_title：Drug testing and analysis

authors： Benourad F,Kahvecioglu Z,Youcef-Benkada M,Colet JM

更新日期：2014-10-01 00:00:00

abstract：:A quantitative structure-property relationship (QSPR) study based on an artificial neural network (ANN) was carried out for the prediction of the microemulsion liquid chromatography polar surface area (PSA) of a set of 32 drug compounds. The genetic algorithm-kernel partial least squares (GA-KPLS) method was used as a...

journal_title：Drug testing and analysis

authors： Noorizadeh H,Farmany A,Noorizadeh M,Kohzadi M

更新日期：2013-04-01 00:00:00

abstract：:Anabolic-androgenic steroids are synthetic compounds prohibited due to their performance-enhancing characteristics. The use of these substances is known to cause health-related issues, which highlights the importance of being able to evaluate the scale of consumption by the general population. However, most available ...

journal_title：Drug testing and analysis

authors： Shimko KM,O'Brien JW,Barron L,Kayalar H,Mueller JF,Tscharke BJ,Choi PM,Jiang H,Eaglesham G,Thomas KV

更新日期：2019-07-01 00:00:00

abstract：:Three legal highs; nitracaine (3-(diethylamino)-2,2-dimethylpropyl 4-nitrobenzoate), methoxypiperamide (MEOP, (4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone) and mephtetramine (MTTA, 2-((methylamino)methyl)-3,4-dihydronaphthalen-1(2H)-one) appeared in 2013 as new psychoactive substances (NPS) on Internet websites ...

journal_title：Drug testing and analysis

authors： Power JD,Scott KR,Gardner EA,Curran McAteer BM,O'Brien JE,Brehon M,Talbot B,Kavanagh PV

更新日期：2014-07-01 00:00:00

abstract：:We recently published two protocols for the detection of Sotatercept (ACE-011, ACVR2A-Fc) and Luspatercept (ACE-536, ACVR2B-Fc) in human serum. Both methods used covalently immobilized antibodies on agarose beads for immunoprecipitation and SAR-PAGE/Western blotting for detection. Disadvantages were the relatively hig...

journal_title：Drug testing and analysis

authors： Reichel C,Gmeiner G,Walpurgis K,Thevis M

更新日期：2018-11-01 00:00:00

abstract：:The use of performance enhancing drugs is a widespread phenomenon in professional and leisure sports. A spectroscopic study was carried out on anabolic tablets labelled as 5 mg methandienone tablets provided by police departments. The analytical approach was based on a two-step methodology: a fast analysis of tablets ...

journal_title：Drug testing and analysis

authors： Rebiere H,Ghyselinck C,Lempereur L,Brenier C

更新日期：2016-03-01 00:00:00

abstract：:The tiletamine-zolazepam (TZ) combination is an anaesthetic drug commonly used in veterinary medicine. It is an equal amount combination of tiletamine, a dissociative anaesthetic pharmacologically classified as an N-methyl-D-aspartate (NMDA) receptor antagonist, and zolazepam, a benzodiazepine tranquilizer. There are ...

journal_title：Drug testing and analysis

authors： de la Peña JB,Cheong JH

更新日期：2016-08-01 00:00:00

abstract：:At present, there is a growing trend toward the intentional adulteration of dietary supplements (DS) with synthetic pharmaceuticals, which represents an alarming emerging risk to consumers and a serious problem for regulatory agencies. An amazing array of synthetic drugs and their analogues have been reported as adult...

journal_title：Drug testing and analysis

authors： Muschietti L,Redko F,Ulloa J

更新日期：2020-07-01 00:00:00