Abstract：
:Inhalation is a potentially viable route of administration for numerous agents. In diabetes mellitus, the need for frequent injections to achieve ideal glycemic control remains a significant limitation for initiating and complying with insulin therapy in a large number of patients. To overcome this barrier, inhaled insulin was developed. The inhalation form of regular human insulin has been tested and administered in a large number of trials. Respiratory capacity was evaluated in patients with normal lung parenchyma in whom inhaled insulin was administered without complications. However, issues like cost, bulky device, fear for lung safety, and the small number of studies in subjects with underlying respiratory disease prevented widespread use of this new mode of delivery. In the present review, we will suggest a number of methods that could be applied in this form of administration to maximize drug absorption and fully exploit the advantages of this route of administration.
journal_name
J Aerosol Med Pulm Drug Delivjournal_title
Journal of aerosol medicine and pulmonary drug deliveryauthors
Zarogoulidis P,Papanas N,Kouliatsis G,Spyratos D,Zarogoulidis K,Maltezos Edoi
10.1089/jamp.2011.0876subject
Has Abstractpub_date
2011-10-01 00:00:00pages
213-23issue
5eissn
1941-2711issn
1941-2703journal_volume
24pub_type
杂志文章,评审abstract：BACKGROUND:Computer modeling is used to predict inhaled aerosol deposition in the lung based on definition of the aerosol characteristics and the breathing pattern and airway anatomy of the subject. Validation of the models is limited by the lack of detailed experimental data. Three-dimensional imaging provides an oppo...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2014.1191
更新日期：2015-12-01 00:00:00
abstract：: Background: Inhalation of medications is the cornerstone in the treatment of patients with lung diseases. A variety of inhalation devices exists and each device has specific requirements to achieve optimum inhalation of the drug. The goal of this study was to establish a c...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1376
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Inhaled corticosteroid (ICS) therapy has improved the quality of life (QOL) for many asthmatics and reduced mortality rates associated with asthma. However, some patients do not obtain therapeutic benefit despite satisfactory adherence. OBJECTIVES:To determine whether asthmatic patients were using ICS devic...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2010.0868
更新日期：2011-12-01 00:00:00
abstract：: Background: The photo reflection method (PRM) is used to measure light reflected from particles released from dry powder inhalers (DPIs). This simple method depicts time trajectories of released drugs; however, it underestimates the number of particles at high peak inhalat...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2020.1610
更新日期：2020-11-04 00:00:00
abstract：BACKGROUND:The Respimat Soft Mist Inhaler is reported to generate an aerosol with low spray momentum and a small droplet size. However, the transport characteristics of the Respimat aerosol are not well understood. The objective of this study was to characterize the transport and deposition of an aerosol emitted from t...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2008.0708
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Use of a valved holding chamber (VHC) in conjunction with a pressurized metered dose inhaler (pMDI) can reduce issues relating to poor actuation-inhalation coordination and potentially improve the lung deposition of aerosol, compared with use of a pMDI alone. However, the performance of a VHC is influenced b...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2013.1067
更新日期：2014-08-01 00:00:00
abstract：:Flexhaler is a multiple-dose, inspiratory flow-driven dry powder inhaler that is a newer version of Turbuhaler, and is identical to the Symbicort Turbuhaler. Sustained performance is of the utmost importance to ensure consistent drug delivery throughout the lifespan of the inhaler. We report functionality testing resu...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2008.0700
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:To validate the 'Test of Adherence to Inhalers' (TAI), a 12-item questionnaire designed to assess the adherence to inhalers in patients with COPD or asthma. METHODS:A total of 1009 patients with asthma or COPD participated in a cross-sectional multicenter study. Patients with electronic adherence ≥80% were ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,多中心研究
doi：10.1089/jamp.2015.1212
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Predicting local lung tissue pharmacodynamic (PD) responses of inhaled drugs is a longstanding challenge related to the lack of experimental techniques to determine local free drug concentrations. This has prompted the use of physiologically based pharmacokinetic (PBPK) modeling to potentially predict local ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1436
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:The effectiveness of metered-dose inhalers (MDIs) in delivering medication to the lungs highly depends on its correct usage technique. Current guidelines state optimal technique for high lung deposition should include a slow inhalation (>5 seconds) at an inspiratory flow rate of 30 L/min and inhaler actuatio...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2015.1278
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Preclinical evaluation of new chemical entities (NCEs) designed to be administered by inhalation route requires lung administration to rodents, especially in the discovery phase. Different administration methods have been used until now, but more efforts are required to obtain controlled and reproducible lun...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1369
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Currently bronchial provocation testing (BPT) using mannitol powder cannot be performed in children under 6 years. A primary reason is it is challenging for children at this age to generate a consistent inspiratory effort to inhale mannitol efficiently from a dry powder inhaler. A prototype system, which doe...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2015.1208
更新日期：2015-12-01 00:00:00
abstract：:Upper respiratory tract infections (URTIs), primarily acute rhinopharyngitis, tonsillitis, adenoiditis, and rhinosinusitis (RS), are major causes of morbidity in both children and adults of any age. In addition to the frequent occurrence of related medical problems and the associated socioeconomic costs, URTIs have a ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
doi：10.1089/jamp.2016.1300
更新日期：2017-02-01 00:00:00
abstract：:Exhaled breath condensate (EBC) consists mainly of water, but also contains semivolatile and nonvolatile compounds. The aim of this study was to develop a system in which two condensers are simultaneously used in series to clarify the mechanisms of EBC condensation. Two aliquots of EBC (EBC1 and EBC2) were collected f...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2007.0644
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Model predictions of regional deposition in the respiratory tract are useful in assessing factors that influence the effectiveness of aerosol delivery. Regional deposition models have previously been coupled with models of mucous production and clearance to estimate initial concentrations of drug deposited i...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1377
更新日期：2018-02-01 00:00:00
abstract：:Since the early 1960s, there has been a continuous evolution in scientific understanding regarding bioequivalence (BE) of oral dosage forms, intermittently punctuated by some breakthrough research findings and conceptual advances. The accumulated knowledge from this body of research has been translated into a sophisti...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
doi：10.1089/jamp.2014.1144
更新日期：2014-12-01 00:00:00
abstract：:Antibiotic-resistant bacterial infections have renewed interest in finding substitute methods of treatment. The purpose of the present in vitro study was to investigate the possibility of respiratory delivery of a Burkholderia cepacia complex (BCC) bacteriophage by nebulized aerosol administration. Bacteriophages in i...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2008.0701
更新日期：2008-12-01 00:00:00
abstract：: Background: Salvia miltiorrhiza polyphenolic acid (SMPA) is effective in the treatment of cardiovascular diseases and currently it is administered orally or intravenously. However, SMPA is poorly absorbed orally and quickly eliminated in vivo. A long-term frequent intraveno...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2019.1538
更新日期：2020-04-01 00:00:00
abstract：:The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. Similarly, the toxicity of environmental and industrial particulate matter is affected not only by the nature of the dust but also by the am...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2020.29029.cd
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Understanding the regional partition of deposition of inhaled particles within the lung is important for improving targeted delivery of inhaled aerosolized drugs. One factor affecting regional deposition is gravity. As the lung deforms under its own weight, changes in lung volume, in airway geometries, and i...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2014.1189
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Particle size and velocity are two of the most significant factors that impact the deposition of pressurized metered-dose inhaler (pMDI) sprays in the mouth cavity. pMDIs are prominently used around the world in the treatment of patients suffering from a variety of lung diseases such as asthma and chronic ob...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2015.1264
更新日期：2016-12-01 00:00:00
abstract：:The present study aimed at assessing the pharmacokinetics (PK) and safety pharmacodynamics (PD) of 24 microg formoterol delivered via a Novolizer and via an Aerolizer in healthy subjects. This was a randomized, open-label, crossover study. Beside PK, serum potassium, and glucose profiles, vital signs, and ECG were rec...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,随机对照试验
doi：10.1089/jamp.2008.0690
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Inhaled alpha1-antitrypsin (AAT) is being developed for treatment of cystic fibrosis to protect the lungs from excessive free elastase. High drug costs mandate a very efficient aerosol system to deliver a high payload to the airways. The I-neb Adaptive Aerosol Delivery (AAD) System is a portable, electronic,...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2009.0793
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:The site of deposition in the respiratory tract for aerosolized, inhaled therapeutic drugs depends on both the particles' aerodynamic size and the patient's breathing pattern. METHODS:In 21 healthy subjects with normal lung function, we evaluated an extremely slow inhalation of a large 9.5-μm MMAD particle ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2008.0711
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Vitamin A (VA) is crucial for lung growth and development. In premature infants, inadequate VA levels are associated with an increased risk of bronchopulmonary dysplasia (BPD). Intramuscular VA supplementation has been shown to decrease the incidence of BPD, but is not widely used in the clinical setting due...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1438
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:The Abbreviated Impactor Measurement (AIM) concept simplifies determination of aerodynamic size metrics for inhaler quality control testing. A similar approach is needed to compare in vitro particle size distribution metrics with human respiratory tract (HRT) deposition. METHODS:An abbreviated impactor base...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2011.0925
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:The unit dose dry powder inhaler (UD-DPI) is being considered as an alternative inhaler platform that, if developed, has the potential to improve access to inhaled respiratory medicines in developing countries. AIM:This study compared the systemic exposure of fluticasone furoate after delivery from the UD-D...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,随机对照试验
doi：10.1089/jamp.2016.1322
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:To our knowledge, quantification of intranasal deposition of aerosol generated by Accuspray(™) (AS) in children has never been published. We hypothesized that deposition would vary significantly with age and with placement of the device within, or outside, of the nostril. METHODS:We tested these hypotheses ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2014.1174
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Remote inhaler monitoring is an emerging technology that enables the healthcare team to monitor the time and location of a patient's inhaler use. We assessed the feasibility of remote inhaler monitoring for chronic obstructive pulmonary disease (COPD) patients and the pattern of albuterol inhaler use associa...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1383
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Secondary lung infections are the primary cause of morbidity associated with cystic fibrosis lung disease. Aerosolized antibiotic inhalation is potentially advantageous but has limited effectiveness due to altered airway aerodynamics and deposition patterns that limit drug access to infected regions. One pot...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1412
更新日期：2018-08-01 00:00:00
