Abstract：
BACKGROUND:New therapeutic options have led to substantial increases in survival expectations of patients with non-Hodgkin lymphoma (NHL) in recent years. In contrast to many malignancies, survival in older patients has improved in NHL at a rate similar to that in younger patients. In the past, the impact of innovations on long-term survival of NHL patients on the population level has been disclosed only with substantial delay. METHODS:We employ a novel model-based projection method to estimate survival expectations of NHL patients age 60+ diagnosed in 2008-2012. Preliminary empirical evaluation of the method using historical data indicates excellent performance in projection of age specific and overall 5- and 10-year relative survival. RESULTS:Overall 5- and 10-year survival projections for 2008-2012 were 67.5% and 56.9%, respectively, 8.2 percentage units (% units) and 15.2% units, respectively, higher than the most recent survival estimates available from traditional cohort analysis. Projected survival decreased with age, ranging from 79.1% for patients age 60-64 to 54.3% for patients age 80+. Projected survival estimates for diffuse large B-cell lymphoma and follicular lymphoma were 59% and 84.9%, respectively. Survival estimates by model-based projection were substantially higher than available cohort estimates for all age groups including 80+, each specific morphology examined, nodal and extranodal disease, and both genders. CONCLUSIONS:Patients over 60 diagnosed with NHL in 2008-2012 have much higher long-term survival expectations than suggested by previously available survival statistics.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Pulte D,Gondos A,Brenner Hdoi
10.1016/j.canep.2011.08.006subject
Has Abstractpub_date
2012-02-01 00:00:00pages
e19-25issue
1eissn
1877-7821issn
1877-783Xpii
S1877-7821(11)00128-7journal_volume
36pub_type
杂志文章abstract：:Lung cancer is the leading cause of cancer death in the United States, but a large fraction of cases is preventable. We use a spatial smoothing algorithm to identify a geographic pattern of high lung cancer mortality, primarily in the Southeast, which we call a lung cancer belt. Disease belts are an effective mode for...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2012.05.015
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVES:This study aimed to investigate the association between physical activity and site-specific cancer incidence. METHODS:UK Biobank is a prospective population-based cohort study. 364,899 adults (51.6 % females, mean age 56.0 years) were included. The exposure variable was physical activity level derived from ...
journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.07.013
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abstract：BACKGROUND:Barrett's Esophagus (BE), particularly long-segment Barrett's Esophagus, and the age of onset of Barrett's Esophagus are risk factors for esophageal adenocarcinoma. However, it is unknown if lifestyle factors such as alcohol abuse, tobacco use, weight gains that increase the risk of developing BE and esophag...
journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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abstract：BACKGROUND:Cow's milk contain phytoestrogens especially equol depending on the composition of the feed ration. However, it is unknown whether milk differing in equol exhibits different estrogenicity in model systems and thereby potentially in humans as milk consumers. METHODS:The estrogenicity of high and low equol mi...
journal_title：Cancer epidemiology
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更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Previous studies have reported inconsistent results regarding the effect of epidermal growth factor receptor (EGFR) mutations on overall survival in patients with non-squamous non-small-cell lung cancer (NSCLC). This study assesses the effect of EGFR mutation on overall survival, and how the effects of other...
journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.04.013
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abstract：BACKGROUND:The French national screening programme for colorectal cancer (CRC) was rolled out nationwide from 2008. It targets men and women aged 50-74 who are invited every 2 years to perform a guaiac faecal occult blood test, followed, if positive, by a colonoscopy. This paper presents the evaluation of the programme...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.07.008
更新日期：2013-12-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2009.10.009
更新日期：2009-11-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101827
更新日期：2020-12-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.04.017
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:Social inequalities in survival after cancer diagnosis have been described in several high-income countries, all cancer sites combined and for several specific cancer sites. The objective of this study was to analyze 5-year net survival after cancer diagnosis in a middle-income country (Costa Rica), accordin...
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doi：10.1016/j.canep.2020.101695
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:This study aimed to provide information on timing, anatomical location, and predictors for metachronous metastases of colorectal cancer based on a large consecutive series of non-selected patients. METHODS:All patients operated on with curative intent for colorectal cancer (TanyNanyM0) between 2003 and 2008...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.04.004
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:We developed a novel method of methylation-specific PCR (MSP) using immunoprecipitation with anti-histone antibody (IP-MSP) to efficiently detect serum methylated DNA tightly bound to de-acetylated histones. MATERIALS AND METHODS:The detection limit of IP-MSP for p16 methylation was determined with a standa...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.01.004
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the prognostic role of diagnostic delay and clinical presentation (regarding pain, jaundice, and weight loss) in pancreatic carcinoma. METHODS:One hundred and seventy patients with pancreatic cancer were diagnosed and treated in the decade 2001-2010 (100 males and 70...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2012.12.002
更新日期：2013-04-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.12.010
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Leukaemia is a heterogeneous disease in which haematopoietic progenitor cells acquire genetic lesions that lead to a block in differentiation, increased self-renewal, and unregulated proliferation. The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), involved in folate metabolism, plays a crucial rol...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2012.02.008
更新日期：2012-08-01 00:00:00
abstract：INTRODUCTION:This paper presents race-specific prostate cancer mortality rates and the corresponding disparities for the largest cities in the US over two decades. METHODS:The 50 largest cities in the US were the units of analysis. Data from two 5-year periods were analyzed: 1990-1994 and 2005-2009. Numerator data wer...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.07.019
更新日期：2016-10-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.11.009
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:We aimed to report, for the first time, the results of the Iranian National Population-based Cancer Registry (INPCR) for the year 2014. METHODS:Total population of Iran in 2014 was 76,639,000. The INPCR covered 30 out of 31 provinces (98% of total population). It registered only cases diagnosed with maligna...
journal_title：Cancer epidemiology
pub_type： 历史文章,杂志文章
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更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the contribution of the BRCA1 and BRCA2 promoter methylation in the pathogenesis of sporadic breast cancer in Tunisian patients. METHODS:Breast carcinoma tissues (n=117) and available paired normal breast tissues (n=65) from Tunisian women who had no family history were ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.09.001
更新日期：2012-04-01 00:00:00
abstract：INTRODUCTION:It is unknown whether a normal range, diagnostic serum prostate specific antigen (PSA) level's influence on prostate cancer specific mortality (PCSM) is dependent upon digital rectal examination (DRE) findings. METHODS:Between 2004 and 2007, 9081 men diagnosed with non-palpable (T1c, N=1710) or palpable (...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.07.007
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:During the last 20 years, relevant diagnostic procedures and advanced treatments have been progressively introduced in the management of hepatocellular carcinoma (HCC). The aim of the present study was to assess up-to-date survival trends for HCC in southern Switzerland, a region with one of the highest inci...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.09.008
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:The aim of this nationwide follow-up study was to examine whether neighborhood linking social capital is associated with lung cancer, including incident and mortality cases, after adjustment for individual- and familial-level factors. METHODS:This follow-up study comprised 2,123,707 men and 2,046,174 women ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.05.005
更新日期：2019-08-01 00:00:00
