Abstract:
BACKGROUND:This study aimed to provide information on timing, anatomical location, and predictors for metachronous metastases of colorectal cancer based on a large consecutive series of non-selected patients. METHODS:All patients operated on with curative intent for colorectal cancer (TanyNanyM0) between 2003 and 2008 in the Dutch Eindhoven Cancer Registry were included (N=5671). By means of active follow-up by the Cancer Registry staff within ten hospitals, data on development of metastatic disease were collected. Median follow-up was 5.0 years. RESULTS:Of the 5671 colorectal cancer patients, 1042 (18%) were diagnosed with metachronous metastases. Most common affected sites were the liver (60%), lungs (39%), extra-regional lymph nodes (22%), and peritoneum (19%). 86% of all metastases was diagnosed within three years and the median time to diagnosis was 17 months (interquartile range 10-29 months). Male gender (HR=1.2, 95%CI 1.03-1.32), an advanced primary T-stage (T4 vs. T3 HR=1.6, 95%CI 1.32-1.90) and N-stage (N1 vs. N0 HR=2.8, 95%CI 2.42-3.30 and N2 vs. N0 HR=4.5, 95%CI 3.72-5.42), high-grade tumour differentiation (HR=1.4, 95%CI 1.17-1.62), and a positive (HR=2.1, 95%CI 1.68-2.71) and unknown (HR=1.7, 95%CI 1.34-2.22) resection margin were predictors for metachronous metastases. CONCLUSIONS:Different patterns of metastatic spread were observed for colon and rectal cancer patients and differences in time to diagnosis were found. Knowledge on these patterns and predictors for metachronous metastases may enhance tailor-made follow-up schemes leading to earlier detection of metastasized disease and increased curative treatment options.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
van Gestel YR,de Hingh IH,van Herk-Sukel MP,van Erning FN,Beerepoot LV,Wijsman JH,Slooter GD,Rutten HJ,Creemers GJ,Lemmens VEdoi
10.1016/j.canep.2014.04.004subject
Has Abstractpub_date
2014-08-01 00:00:00pages
448-54issue
4eissn
1877-7821issn
1877-783Xpii
S1877-7821(14)00086-1journal_volume
38pub_type
杂志文章abstract:BACKGROUND:The aim of this study was to describe survival of lymphoid neoplasms (LNs) in the Girona province (Spain) during 1996-2015. METHODS:Data were extracted from the Girona cancer registry. LN incident cases were registered using the ICD-O-3, following the 2008 WHO classification scheme and HAEMACARE grouping. F...
journal_title:Cancer epidemiology
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
abstract:AIM:We studied whether incidence of all cancer sites combined was associated with the radiation exposure due to fallout from the Chernobyl accident in Finland. An emphasis was on the first decade after the accident to assess the suggested "promotion effect". METHODS:The segment of Finnish population with a stable resi...
journal_title:Cancer epidemiology
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更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Partial nephrectomy (PN) is technically feasible in patients with metastatic renal cell carcinoma (mRCC). We tested the contemporary effect of PN on cancer-specific mortality (CSM), other-cause mortality (OCM) and early postoperative outcomes compared to radical nephrectomy (RN) in mRCC patients. MATERIALS A...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.08.006
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Despite evidence of a decline in both incidence and prevalence of colorectal cancer nationwide, it remains the second most commonly diagnosed cancer and the third highest cause of mortality among Asian Americans, including Korean Americans. This community-based and theoretically guided study evaluated a cult...
journal_title:Cancer epidemiology
pub_type: 临床试验,杂志文章
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abstract:INTRODUCTION:Basal cell carcinoma (BCC) is the most common malignancy in the US. Body mass index (BMI) and height have been associated with a variety of cancer types, yet the evidence regarding BCC is limited. Therefore, we evaluated BMI and height in relation to early-onset BCC (under age 40) and explored the potentia...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2016.12.007
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:We aimed to assess oncological outcomes in colorectal cancer patients with type 2 diabetes mellitus (T2DM) using metformin. METHODS:Patients with colorectal cancer and T2DM during 2000-2012 period were identified form Lithuanian Cancer Registry and the National Health Insurance Fund database. Colorectal cancer...
journal_title:Cancer epidemiology
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doi:10.1016/j.canep.2019.101587
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abstract:INTRODUCTION:Despite the continuous efforts made with the TNM system, the issue of heterogeneity of prognosis within the stages of non-small cell lung cancer (NSCLC) could not be resolved. Our aim was to identify prognostic factors and develop an index to predict NSCLC survival with greater accuracy. METHODS:We conduc...
journal_title:Cancer epidemiology
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abstract:BACKGROUND:Based the important role of patient-reported outcome in measuring patients' QoL, a general PRO instrument was designed for Chinese patients with cancer. METHODS:The instrument was administered in eight hospitals. Based on PRO guidelines, a conceptual framework and item pool were generated after literature r...
journal_title:Cancer epidemiology
pub_type: 杂志文章
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pub_type: 历史文章,杂志文章
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abstract:BACKGROUND:Asian studies on soft tissue sarcoma (STS) incidence, irrespective of the primary site, are scant. METHODS:STS data were acquired from the population-based 2007-2013 Taiwan Cancer Registry of the Health and Welfare Data Science Center, Taiwan. Histological subtype-, site-, sex-, and age-specific STS inciden...
journal_title:Cancer epidemiology
pub_type: 历史文章,杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2014.07.007
更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.canep.2010.08.008
更新日期:2011-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Both small and large body size at birth are now known to predict a range of chronic disorders in adult life, including certain cancers. These associations are thought to reflect "fetal programming." This may lead to impairment of a small number of key systems including the immune system. Hodgkin's lymphoma i...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2013.01.004
更新日期:2013-06-01 00:00:00
abstract:INTRODUCTION:In the last ten to twenty years, a stabilization or decline in colorectal cancer (CRC) incidence has been observed in some countries across the world but not in Spain. Our objective here is to assess the gender-specific CRC spatio-temporal pattern in the health areas of Navarre, a Spanish province, during ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.10.004
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Previous studies have reported inconsistent results regarding the effect of epidermal growth factor receptor (EGFR) mutations on overall survival in patients with non-squamous non-small-cell lung cancer (NSCLC). This study assesses the effect of EGFR mutation on overall survival, and how the effects of other...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101847
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:A quantifiable and reliable technique for the determination of body circadian phase applicable to non-laboratory studies would allow the evaluation of circadian dysregulation. In this study we evaluated feasible methodologies to individualize whole body circadian phase in lung cancer patients. METHODS:Corti...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.06.005
更新日期:2012-02-01 00:00:00
abstract:AIM:Our study aim was to investigate the degree of adherence to international recommendations for cutaneous melanoma pathology reports at the population level by a EUROCARE high resolution study. METHODS:The availability of nine characteristics - predominant cell type, tumour-infiltrating lymphocytes, mitotic index, h...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2015.01.016
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abstract::Lung cancer is the leading cause of cancer death in the United States, but a large fraction of cases is preventable. We use a spatial smoothing algorithm to identify a geographic pattern of high lung cancer mortality, primarily in the Southeast, which we call a lung cancer belt. Disease belts are an effective mode for...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2012.05.015
更新日期:2012-10-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.11.004
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Cancer epidemiology
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更新日期:2020-10-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2009.08.009
更新日期:2009-10-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.04.006
更新日期:2018-06-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.05.001
更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:Obesity is a well-established risk factor for postmenopausal breast cancer, but mechanisms underlying the association are unclear. Adipocyte-derived, cytokine-like adipokines have been suggested as contributory factors. To evaluate their association with breast cancer risk factors and breast cancer risk, w...
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更新日期:2010-10-01 00:00:00