Abstract：
BACKGROUND:We developed a novel method of methylation-specific PCR (MSP) using immunoprecipitation with anti-histone antibody (IP-MSP) to efficiently detect serum methylated DNA tightly bound to de-acetylated histones. MATERIALS AND METHODS:The detection limit of IP-MSP for p16 methylation was determined with a standard made by cell line (SKCO-1) lysate. p16 methylation of tumor and/or serum of 51 colorectal cancers and 10 adenoma patients, and 10 healthy volunteers was detected with conventional MSP or IP-MSP. RESULTS:IP-MSP detected p16 methylation from 0.5pg/mul of the cell lysate. The sensitivity of IP-MSP for detecting serum p16 methylation in 27 patients with tumors characterized by p16 methylation was significantly higher than that with conventional method (81% versus 59%), particularly in Stage II patients (91% versus 45%). IP-MSP detected no p16 hypermethylation in sera of adenoma patients and volunteers. CONCLUSIONS:IP-MSP is thus considered to be a promising procedure to detect serum methylated DNA in colorectal cancer patients.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Sakamoto J,Fujiya M,Okamoto K,Nata T,Inaba Y,Moriichi K,Tanabe H,Mizukami Y,Watari J,Ashida T,Kohgo Ydoi
10.1016/j.canep.2010.01.004subject
Has Abstractpub_date
2010-04-01 00:00:00pages
194-9issue
2eissn
1877-7821issn
1877-783Xpii
S1877-7821(10)00007-Xjournal_volume
34pub_type
杂志文章abstract：BACKGROUND:The disparity in breast cancer mortality rates among white and black US women is widening, with higher mortality rates among black women. We apply functional time series models on age-specific breast cancer mortality rates for each group of women, and forecast their mortality curves using exponential smoothi...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.05.001
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVES:To compare the trends in prostate cancer incidence, treatment with curative intent and mortality across regions and counties in Norway, and to consider changes in incidence (an indicator for early diagnosis) and treatment with curative intent as explanatory factors for the decreasing prostate cancer mortalit...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.04.017
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:In cancer care, the cure proportion (P) and time-to-cure (TTC) are important indicators for practitioners, patients, and healthcare policy makers. The recent definition of TTC as the time at which the probability of belonging to the cured group reaches 95% was used for the first time. METHODS:The data stem ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.02.006
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:We aimed to assess oncological outcomes in colorectal cancer patients with type 2 diabetes mellitus (T2DM) using metformin. METHODS:Patients with colorectal cancer and T2DM during 2000-2012 period were identified form Lithuanian Cancer Registry and the National Health Insurance Fund database. Colorectal cancer...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.101587
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Uruguay, a country with one of the highest lung cancer rates worldwide, initiated a series of comprehensive anti-smoking measures in 2005. We assess the tobacco control policies in the context of cohort-driven lung cancer incidence trends over a 25-year period, providing baseline predictions to 2035. METHOD...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.04.012
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Recent research suggests that the Bayesian paradigm may be useful for modeling biases in epidemiological studies, such as those due to misclassification and missing data. We used Bayesian methods to perform sensitivity analyses for assessing the robustness of study findings to the potential effect of these t...
journal_title：Cancer epidemiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.canep.2012.11.006
更新日期：2013-04-01 00:00:00
abstract：:Nibrin and DNA repair protein XRCC3 are involved in DNA double-strand break repair. We genotyped seven tagging SNPs in these genes (rs1805794, rs709816; rs1063054; rs7141928, rs1799794, rs861530, rs861539) with the aim to analyse their association with acute lymphoblastic leukaemia (ALL), a disease, that is characteri...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.08.002
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:New therapeutic options have led to substantial increases in survival expectations of patients with non-Hodgkin lymphoma (NHL) in recent years. In contrast to many malignancies, survival in older patients has improved in NHL at a rate similar to that in younger patients. In the past, the impact of innovation...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.08.006
更新日期：2012-02-01 00:00:00
abstract：AIM:The prevalence of hysterectomy is decreasing worldwide. It is not clear whether changes in the population at risk (women with intact uteruses) have contributed to an increased uterine cancer incidence. This study aims to assess the effect of changing trends in hysterectomy prevalence on uterine cancer incidence in ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.02.008
更新日期：2019-04-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101827
更新日期：2020-12-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.12.007
更新日期：2017-02-01 00:00:00
abstract：:Recent studies have identified the important role of cancer stem cells (CSCs) in carcinogenesis and relapse. However, with respect to multistage cancer metastasis, the role of CSCs has not been well-defined. In several human cancers, data showed that some phenotypic subsets of CSCs were responsible for cancer metastas...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2012.07.007
更新日期：2013-02-01 00:00:00
abstract：INTRODUCTION:In Lebanon, annual national breast awareness campaigns were started in 2002 during the international breast month of October to promote the utilization of mammography for women aged ≥ 40. The impact of the campaigns has been assessed periodically since 2003. Results of 2003-2005 campaigns have been publish...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.09.015
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Implementation of mammography screening and advances in breast cancer treatment are considered as main reasons for the decline in breast cancer mortality observed in many industrialized countries during the past two decades. The purpose of this study was to provide a comprehensive assessment of trends in bre...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.01.008
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Chronic myelomonocytic leukemia (CMML) is a rare hematopoietic malignancy. Treatment with hypomethylating agents (HMA) was introduced between 2004 and 2006 but its impact on population-based survival remains controversial. The aim of this study was to investigate epidemiological characteristics and survival ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.01.003
更新日期：2019-04-01 00:00:00
abstract：INTRODUCTION:Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL. OBJECTIVES:Investigate the association of caesarean sections, pre- and po...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101851
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited number of studies have investigated SES differences in tumour stage at...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.canep.2016.01.012
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the prognostic role of diagnostic delay and clinical presentation (regarding pain, jaundice, and weight loss) in pancreatic carcinoma. METHODS:One hundred and seventy patients with pancreatic cancer were diagnosed and treated in the decade 2001-2010 (100 males and 70...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2012.12.002
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:Although the risk of oxaliplatin-induced neuropathy depends on cumulative oxaliplatin dose, susceptibility to this adverse event differs greatly among patients. In this study, we investigated the associations between oxaliplatin-induced neuropathy and the following polymorphisms: glutathione S-transferase pi (G...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.02.008
更新日期：2010-04-01 00:00:00
abstract：INTRODUCTION:This paper presents race-specific breast cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for each of the 5-year intervals between 2005 and 2014. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.07.018
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Polymorphisms in sex hormone receptor-encoding genes may alter the activity of sex hormone receptors and thereby affect susceptibility to breast cancer and related outcomes. METHODS:In a case-control study of women from Shanghai, China, we examined the risk of breast cancer and fibrocystic breast conditions...
journal_title：Cancer epidemiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.canep.2010.08.005
更新日期：2011-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.canep.2020.101767
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:A large proportion of patients with cutaneous malignant melanoma (CMM) do not experience excess mortality due to their disease. This group of patients is referred to as the cure proportion. Few studies have examined the possibility of cure for CMM. The aim of this study was to estimate the cure proportion of...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.12.006
更新日期：2014-02-01 00:00:00
abstract：:DNA repair plays a pivotal role in maintaining genomic integrity with over 130 genes involved in various repair pathways that include base excision repair, nucleotide excision repair, double strand break repair and DNA mismatch repair. Polymorphisms within genes that are involved in these processes have been widely re...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.09.003
更新日期：2012-04-01 00:00:00
abstract：:We examined the prevalence of HR- and LR-HPV by Linear Array genotyping test in 299 women aged 18-63 years who consecutively visited Molise Region main hospitals for routine Pap smear between February and August 2008. Ninety women were positive for any HPV (30.1%), and 66 for any HR-HPV (22.1%). The most prevalent HR-...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.12.010
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:American Community Survey (ACS) estimates are said to be uncertain for small areas and small population groups. The Surveillance, Epidemiology and End Results (SEER) database uses a decennial census extrapolation methodology to yield population estimates used by cancer researchers across the country. We comp...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.06.014
更新日期：2016-08-01 00:00:00
abstract：INTRODUCTION:This paper presents race-specific lung cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for the 5-year intervals 1990-1994 and 2005-2009. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death files wh...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.10.003
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:While differences in CPM use between White and Black patients are well known, it is not clear whether CPM use differs by estrogen/progesterone receptor (ER/PR) status of tumors and whether racial/ethnic differences in the use are affected by ER/PR status, which varies between racial groups. The purpose of th...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.02.011
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:The distinctive racial/ethnic and geographic distribution of multiple myeloma (MM) suggests that both family history and environmental factors may contribute to its development. METHODS:A hospital-based case-control study consisting of 220 confirmed MM cases and 220 individually matched patient controls, by...
journal_title：Cancer epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.canep.2012.05.002
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:One of the potential strategies for preventing cancers is using food-based natural products to induce cytoprotective enzymes including phase II and antioxidative enzymes that act in concert to detoxify and eliminate harmful reactive intermediates formed from carcinogens. The antioxidant response element (ARE...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2010.06.012
更新日期：2010-10-01 00:00:00
