Abstract:
PURPOSE:Although the risk of oxaliplatin-induced neuropathy depends on cumulative oxaliplatin dose, susceptibility to this adverse event differs greatly among patients. In this study, we investigated the associations between oxaliplatin-induced neuropathy and the following polymorphisms: glutathione S-transferase pi (GSTP1) Ile(105)Val, and glyoxylate aminotransferase (AGXT) Pro(11)Leu and AGXT Ile(340)Met. EXPERIMENTAL DESIGN:Eighty-two Japanese patients with histologically confirmed colorectal cancer who received at least six cycles of the modified FOLFOX6 (m-FOLFOX6) regimen were enrolled. To minimize differences in cumulative oxaliplatin dose between patients, oxaliplatin-induced neuropathy was evaluated using an oxaliplatin-specific scale during the 2-week period after completion of the sixth cycle of treatment. RESULTS:Forty-four patients developed grade 2/3 oxaliplatin-induced neuropathy. There were more patients carrying at least one GSTP1(105)Val allele among the group with grade 2/3 neuropathy (18/44, 41%) than among the group with grade 1 neuropathy (9/38, 24%), although the difference was not statistically significant (P=0.098). There were similar numbers of patients carrying at least one AGXT(105)Met allele in the grade 2/3 neuropathy (7/44, 16%) and grade 1 neuropathy groups (5/38, 13%; P=0.725). The AGXT(11)Leu allele was not found in any of our patients or controls. CONCLUSIONS:We found no significant association between oxaliplatin-induced neuropathy and the GSTP1 Ile(105)Val and AGXT Ile(340)Met polymorphisms. Given that no AGXT(11)Leu allele was found among our study population (n=177), evaluating this polymorphism in Japanese patients in future studies is likely to be uninformative.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Kanai M,Yoshioka A,Tanaka S,Nagayama S,Matsumoto S,Nishimura T,Niimi M,Teramukai S,Takahashi R,Mori Y,Kitano T,Ishiguro H,Yanagihara K,Chiba T,Fukushima M,Matsuda Fdoi
10.1016/j.canep.2010.02.008subject
Has Abstractpub_date
2010-04-01 00:00:00pages
189-93issue
2eissn
1877-7821issn
1877-783Xpii
S1877-7821(10)00027-5journal_volume
34pub_type
杂志文章abstract:BACKGROUND:The relative 5-year survival rate of salivary gland cancer is moderate at best. This study was set up to evaluate whether the improvements in diagnosis and treatment in the last decades impacted the incidence, mortality and survival of salivary gland cancer. METHODS:Data on patients with salivary gland canc...
journal_title:Cancer epidemiology
pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Diabetes and metabolic syndrome have been found to increase the risk of various cancers. Previous studies indicated that diabetes may increase the risk of head and neck squamous cell carcinoma (HNSCC). Metabolic syndrome has not been investigated as a risk factor. We tested whether type II diabetes or metabo...
journal_title:Cancer epidemiology
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journal_title:Cancer epidemiology
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abstract::The complement system is an important immunosurveillance mechanism against tumors, and complement factor H (CFH) is a key regulator for activation of the complement system. Expression of complement factor H has been demonstrated in cell lines from several malignancies. In this study we examined the contribution of the...
journal_title:Cancer epidemiology
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journal_title:Cancer epidemiology
pub_type: 杂志文章,meta分析,评审
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:Cancer epidemiology
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pub_type: 杂志文章
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journal_title:Cancer epidemiology
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更新日期:2009-12-01 00:00:00
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journal_title:Cancer epidemiology
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更新日期:2019-04-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2015.11.004
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Incidence of childhood cancer increased in most countries worldwide, but reasons are unclear. This study investigates trends of childhood cancer incidence in Switzerland from 1985 to 2014. METHODS:We extracted data on all childhood cancer cases diagnosed at ages 0-14 years in Switzerland from the Swiss Chil...
journal_title:Cancer epidemiology
pub_type: 历史文章,杂志文章
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更新日期:2019-08-01 00:00:00
abstract::CDKN2A is the most common, most penetrant gene whom germline mutations predisposing to cutaneous familial melanoma (FAM). Multiple primary melanoma (MPM), early age at onset, >2 affected members and pancreatic cancer are consistent features predicting positive test. However, the impact that cumulative clinical feature...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.07.007
更新日期:2011-12-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.07.013
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journal_title:Cancer epidemiology
pub_type: 历史文章,杂志文章
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2013.02.010
更新日期:2013-08-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.10.011
更新日期:2012-04-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2014.09.008
更新日期:2014-12-01 00:00:00
abstract::French uterine cancer recordings in death certificates include 60% of "uterine cancer, Not Otherwise Specified (NOS)"; this hampers the estimation of mortalities from cervix and corpus uteri cancers. The aims of this work were to study the reliability of uterine cancer recordings in death certificates using a case mat...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.10.008
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Asian studies on soft tissue sarcoma (STS) incidence, irrespective of the primary site, are scant. METHODS:STS data were acquired from the population-based 2007-2013 Taiwan Cancer Registry of the Health and Welfare Data Science Center, Taiwan. Histological subtype-, site-, sex-, and age-specific STS inciden...
journal_title:Cancer epidemiology
pub_type: 历史文章,杂志文章
doi:10.1016/j.canep.2019.04.007
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Few studies have examined the association of common genetic variants related to vitamin D metabolism and signaling to esophageal squamous cell carcinoma (ESCC). METHODS:We evaluated the association between 12 single nucleotide polymorphisms (SNPs) in four genes related to vitamin D levels and ESCC risk usin...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2014.12.013
更新日期:2015-04-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Peritoneal malignant mesothelioma is a rare disease for which few population-based studies are available. The aim of this study was to describe the evolution of the incidence and survival of peritoneal malignant mesothelioma in France between 1989 and 2015, using data derived from the French network of cance...
journal_title:Cancer epidemiology
pub_type: 历史文章,杂志文章
doi:10.1016/j.canep.2019.03.014
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abstract::Lung cancer is the leading cause of cancer death in the United States, but a large fraction of cases is preventable. We use a spatial smoothing algorithm to identify a geographic pattern of high lung cancer mortality, primarily in the Southeast, which we call a lung cancer belt. Disease belts are an effective mode for...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2012.05.015
更新日期:2012-10-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章,多中心研究
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更新日期:2020-04-01 00:00:00