Abstract：
BACKGROUND:One of the potential strategies for preventing cancers is using food-based natural products to induce cytoprotective enzymes including phase II and antioxidative enzymes that act in concert to detoxify and eliminate harmful reactive intermediates formed from carcinogens. The antioxidant response element (ARE), which is activated upon binding of the nuclear factor E2-related protein 2 (Nrf2) transcription factor protein, has been identified in the regulatory regions of numerous genes encoding cytoprotective enzymes. Herein, we summarized the current body of knowledge regarding Nrf2 regulation as well as highlighted the Nrf2/ARE activators from natural products, which will potentially be used as chemopreventive agents for cancer patients. METHODS:Via reviewing Pubmed, we summarized the current progress in the molecular mechanisms of Nrf2 regulation and the major classes of dietary components that act as promising chemopreventive agents through evoking Nrf2-ARE core signaling pathway. RESULTS:Under basal condition, Nrf2 is at low level, sequestered in the cytoplasm by being tethered to an actin binding Kelch-like ECH associating protein 1 (Keap1). Pharmacological and putative chemopreventive agents trigger the release of Nrf2 from Keap1, allowing it to translocate into the nucleus and drive the gene expression of detoxifying enzymes to perform cancer chemopreventive effect. CONCLUSION:Augmenting both expression and activity of phase II detoxification and antioxidant enzymes via Nrf2-ARE core signaling pathway would be a rational approach for cancer chemoprevention and the number of novel Nrf2/ARE activators from dietary sources is growing.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Zhao CR,Gao ZH,Qu XJdoi
10.1016/j.canep.2010.06.012subject
Has Abstractpub_date
2010-10-01 00:00:00pages
523-33issue
5eissn
1877-7821issn
1877-783Xpii
S1877-7821(10)00118-9journal_volume
34pub_type
杂志文章,评审abstract：:Pancreatic cancer is a leading cause of cancer-related deaths worldwide. Methylation of DNA may influence risk or be a marker of early disease. The aim of this study was to measure the association between methylation of three DNA repetitive elements in white blood cell (WBC) DNA and pancreatic cancer. DNA from WBCs of...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.08.006
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abstract：:Several risk factors for colorectal cancer (CRC) have been identified. If individuals with risk factors are more likely to harbor cancer or it precursors screening programs should be targeted toward this population. We evaluated the predictive value of colorectal cancer risk factors for the detection of advanced color...
journal_title：Cancer epidemiology
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abstract：INTRODUCTION:In the Netherlands, breast cancer patients are treated and followed at least 5 years after diagnosis. Furthermore, all women aged 50-74 are invited biennially for mammography by the nationwide screening programme. The relation between the outpatient follow-up (follow-up visits in the outpatient clinic for ...
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abstract：BACKGROUND:Time to treatment of cancer is becoming a serious political and social issue. A greater understanding of the timeframes involved in cancer care is needed to reduce inequalities in access to care caused by delays. OBJECTIVE:To describe indicators of time to first treatment after colonoscopy in colon cancer (...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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journal_title：Cancer epidemiology
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更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:To describe the thyroid cancer incidence trends and geographical patterns in the Latina Province of Lazio, Italy using the population-based cancer registry. METHODS:We extracted from the Latina cancer registry all cases of thyroid cancer from 1997 to 2006. Cases were classified according to morphological typ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2014.07.006
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abstract：BACKGROUND:The 'Two Week Wait' policy aims to ensure patients with suspected cancer are seen within two weeks of referral. However, patient non-attendance can result in this target being missed. This study aimed to identify predictors of non-attendance; and analyse the relationship between attendance and outcomes inclu...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析
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更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:The French national screening programme for colorectal cancer (CRC) was rolled out nationwide from 2008. It targets men and women aged 50-74 who are invited every 2 years to perform a guaiac faecal occult blood test, followed, if positive, by a colonoscopy. This paper presents the evaluation of the programme...
journal_title：Cancer epidemiology
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pub_type： 杂志文章
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journal_title：Cancer epidemiology
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更新日期：2015-12-01 00:00:00
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journal_title：Cancer epidemiology
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更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Although tobacco involuntary smoking is an established risk factor for lung cancer, the association with head and neck cancer (HNC) is not established. We aimed to investigate this potential association in an East Asian population. METHODS:We conducted a multicenter case-control study in East Asia including...
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章,meta分析,评审
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更新日期：2015-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.canep.2015.07.003
更新日期：2015-10-01 00:00:00
abstract：AIM:To review and summarize evidence from longitudinal studies on the association between serum 25-hydroxyvitamin D (25(OH)D) and the risk of prostate cancer (PC). METHODS:Relevant prospective cohort studies and nested case-control studies published until July 2009 were identified by systematically searching Ovid Medl...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.canep.2009.10.014
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abstract：BACKGROUND:Chromosome 19q13.3 has been identified as one of the regions that associate with cancer risk in previous studies. METHODS:We systematically examined the 70.772kb region comprising four genes on chromosome 19q13.3 among Chinese using the haplotype-tagging SNP (htSNP) approach and the HapMap platform. The stu...
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abstract：BACKGROUND:The incidence trends of biliary tract cancer need to be established. This study investigated the incidence and mortality of biliary tract cancer in Sweden in 1970-2010. METHODS:Sex-specific biliary tract cancer incidence and mortality rates were evaluated using data from the Swedish Cancer Register, Patient...
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pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Consumption of fruit and vegetables has been inversely related to gastric cancer. Two studies found that dietary antioxidant capacity has some role in explaining this association. We investigated the overall antioxidant effect from diet on gastric cancer using three measures of non-enzymatic antioxidant capa...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Little is known about the epidemiology and etiology of Waldenstrom macroglobulinemia (WM). Despite several studies of the relation between family history and B-cell disorders and WM, family history of non-hematologic cancers has not been systematically investigated. We thus examined associations of family hi...
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