Abstract：
INTRODUCTION:It is unknown whether a normal range, diagnostic serum prostate specific antigen (PSA) level's influence on prostate cancer specific mortality (PCSM) is dependent upon digital rectal examination (DRE) findings. METHODS:Between 2004 and 2007, 9081 men diagnosed with non-palpable (T1c, N=1710) or palpable (T2-T4, N=7371) and non-metastatic prostate cancer (PC) were identified from surveillance, epidemiology, and end results data, selected based on pre-treatment PSA<2.5 ng/ml. A multivariable competing risks regression model evaluated whether DRE findings interacted with PSA level in predicting risk of PCSM. RESULTS:After median follow-up of 2.83 years, 118 of 548 deaths (21.5%) were due to PC. Increasing diagnostic PSA was associated with increased risk of PCSM (AHR=3.52; 95% CI: 1.25-9.89; P=.017) in men with T1c, Gleason score 7-10 PC, but decreased PCSM risk (AHR=0.66; 95% CI: 0.52-0.83; P<.001) for men with T2-T4 PC and any Gleason score. DISCUSSION:For men with diagnostic PSA level <2.5 ng/ml and palpable PC, risk of early PCSM increases by 34% for a 1 point decrease in PSA from 2. This suggests the existence of clinically detectable, low PSA secreting disease with an elevated risk of early PCSM, highlighting the importance of the DRE in men with PC and normal range, diagnostic PSA.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Pashtan I,Chen MH,D'Amico AVdoi
10.1016/j.canep.2014.07.007subject
Has Abstractpub_date
2014-10-01 00:00:00pages
613-8issue
5eissn
1877-7821issn
1877-783Xpii
S1877-7821(14)00133-7journal_volume
38pub_type
杂志文章abstract：:Several risk factors for colorectal cancer (CRC) have been identified. If individuals with risk factors are more likely to harbor cancer or it precursors screening programs should be targeted toward this population. We evaluated the predictive value of colorectal cancer risk factors for the detection of advanced color...
journal_title：Cancer epidemiology
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abstract：BACKGROUND:Implementation of mammography screening and advances in breast cancer treatment are considered as main reasons for the decline in breast cancer mortality observed in many industrialized countries during the past two decades. The purpose of this study was to provide a comprehensive assessment of trends in bre...
journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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更新日期：2016-06-01 00:00:00
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.12.001
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Despite being a well-documented phenomenon, seasonal variation in the incidence of cutaneous melanoma is poorly understood, and data on the seasonality of melanoma survival are scarce. We sought to explore the seasonal variation in melanoma incidence and survival in Belgium and to assess the characteristics ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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journal_title：Cancer epidemiology
pub_type： 杂志文章
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abstract：:Pancreatic cancer is a leading cause of cancer-related deaths worldwide. Methylation of DNA may influence risk or be a marker of early disease. The aim of this study was to measure the association between methylation of three DNA repetitive elements in white blood cell (WBC) DNA and pancreatic cancer. DNA from WBCs of...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章,多中心研究
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abstract：INTRODUCTION:This paper presents race-specific breast cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for each of the 5-year intervals between 2005 and 2014. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.07.018
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journal_title：Cancer epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.canep.2010.06.017
更新日期：2010-10-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2012.07.007
更新日期：2013-02-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.02.002
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:This article reports on the methods and framework we have developed to guide economic evaluation of noncommunicable disease registries. METHODS:We developed a cost data collection instrument, the Centers for Disease Control and Prevention's (CDC's) International Registry Costing Tool (IntRegCosting Tool), b...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.10.003
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:We investigated cancer incidence and all-cause mortality among 21,582 Norwegian male military peacekeepers deployed to Lebanon during 1978-1998. We also looked at cancer risk according to duration of service in Lebanon, in the occupational groups of cooks and mechanics, and the risk of alcohol- and smoking-re...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.04.011
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Recent research suggests that the Bayesian paradigm may be useful for modeling biases in epidemiological studies, such as those due to misclassification and missing data. We used Bayesian methods to perform sensitivity analyses for assessing the robustness of study findings to the potential effect of these t...
journal_title：Cancer epidemiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.canep.2012.11.006
更新日期：2013-04-01 00:00:00
abstract：INTRODUCTION:Basal cell carcinoma (BCC) is the most common malignancy in the US. Body mass index (BMI) and height have been associated with a variety of cancer types, yet the evidence regarding BCC is limited. Therefore, we evaluated BMI and height in relation to early-onset BCC (under age 40) and explored the potentia...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.12.007
更新日期：2017-02-01 00:00:00
abstract：:DNA repair plays a pivotal role in maintaining genomic integrity with over 130 genes involved in various repair pathways that include base excision repair, nucleotide excision repair, double strand break repair and DNA mismatch repair. Polymorphisms within genes that are involved in these processes have been widely re...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.09.003
更新日期：2012-04-01 00:00:00
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journal_title：Cancer epidemiology
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更新日期：2013-02-01 00:00:00
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journal_title：Cancer epidemiology
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更新日期：2009-08-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2012.12.010
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journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2012.03.002
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