Abstract：
BACKGROUND:Global variations in the frequency of the major sub-types of lymphoma have been reported. However, studies on different sub-types of adult malignant lymphoma had never been conducted in Mashhad, Iran. In this paper, we aimed to identify the major sub-types of malignant lymphoma in our area and compare the distribution with other published studies. METHODS:During a retrospective study we evaluate 391 adult patients with lymphoid malignancy from "Omid Hospital" - a cancer research center and an outpatient hematologic clinic in Mashhad - were evaluated from 2000 to 2009. Patients were reclassified using the World Health Organization (WHO) classification. RESULTS:The frequency of non-Hodgkin lymphomas (NHL) was 92% (n=359) and Hodgkin lymphoma (HL) was 8% (n=32). The most frequent NHL sub-type using WHO classification was diffuse large B cell lymphoma (DLBCL) and the second most common NHL was chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The most common sub-type of HL was mixed cellularity. In this study the frequency of primary extranodal NHL in our study was 11.5%, which slightly less common than other eastern countries. CONCLUSION:Our findings add to the body of knowledge concerning geographic variations in the descriptive epidemiology of the major lymphoma sub-types. Such observations are extremely important since they potentially point to underling etiological variations.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Mozaheb Z,Aledavood A,Farzad Fdoi
10.1016/j.canep.2010.09.009subject
Has Abstractpub_date
2011-02-01 00:00:00pages
26-9issue
1eissn
1877-7821issn
1877-783Xpii
S1877-7821(10)00178-5journal_volume
35pub_type
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