Abstract：
AIM:We have reported the in vitro and in vivo anticancer activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) derived from a Japanese spice, wasabi. In order to obtain some clues about the mechanism of the anticancer activity, we have studied the effect of alkyl isothiocyanates (MITCs) on protein kinase activities. METHODS:The anti-autophosphorylation activity of MITCs with respect to the epidermal growth factor (EGF)-stimulated receptor kinase of A431 epidermoid carcinoma cells was examined by incorporation of radioactive ATP into an acid-insoluble fraction. Their anti-phosphorylation activity with respect to the non-receptor protein kinase was analyzed by a standard SDS-PAGE method. RESULTS:All the tested MITCs interfered with the EGF-stimulated receptor kinase activity in a dose-dependent manner, although their effects were less than 1/10 of that of erbstatin in microg/ml. On the other hand, the MITCs did not interfere with non-receptor kinases (kinase A, kinase C, tyrosine kinase and calmodulin dependent kinase III), but enhanced non-receptor tyrosine kinase. DISCUSSION:A possible anticancer mechanism of MITCs may involve the suppression of EGF receptor kinase activity and augmentation of non-receptor PTK.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Nomura T,Uehara Y,Kawajiri H,Ryoyama K,Yamori T,Fuke Ydoi
10.1016/j.canep.2009.08.009subject
Has Abstractpub_date
2009-10-01 00:00:00pages
288-92issue
3-4eissn
1877-7821issn
1877-783Xpii
S1877-7821(09)00108-8journal_volume
33pub_type
杂志文章abstract：BACKGROUND:The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the h...
journal_title：Cancer epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.canep.2019.101643
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:We developed a novel method of methylation-specific PCR (MSP) using immunoprecipitation with anti-histone antibody (IP-MSP) to efficiently detect serum methylated DNA tightly bound to de-acetylated histones. MATERIALS AND METHODS:The detection limit of IP-MSP for p16 methylation was determined with a standa...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.01.004
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Immigrant women often have lower cervical cancer screening (CCS) rates, tend to have a higher body mass index (BMI) and may be more vulnerable to BMI-related stigmatization. Our aim was to assess the role of BMI in differences in CCS rates by migration history. METHODS:Analyses were based on the 2012-2015 i...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.11.009
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:Matrix metalloproteinase-7 (MMP-7) is a member of the family of matrix metalloproteinases (MMPs); it is associated with invasive tumor growth and distant metastasis in colorectal cancer (CRC). However, the prognostic value of MMP-7 in CRC remains controversial. Thus, we conducted a meta-analysis to investigat...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.canep.2015.01.009
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:rs11801299 and rs1380576, two novel polymorphisms in MDM4 gene, have been investigated in several different cancer types. However, the role of these two polymorphisms in retinoblastoma (RB) remains unclear. METHODS:A total of 126 patients with primary RB and 148 age-/gender-matched controls were included in...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.12.010
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Recent research suggests that the Bayesian paradigm may be useful for modeling biases in epidemiological studies, such as those due to misclassification and missing data. We used Bayesian methods to perform sensitivity analyses for assessing the robustness of study findings to the potential effect of these t...
journal_title：Cancer epidemiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.canep.2012.11.006
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Age-standardization is vital in international comparison studies of cancer patient survival, but standard approaches can fail to produce estimates in the case of sparsity. METHODS:The purpose of this paper is to demonstrate that using a standardization pre-weighting approach is a viable alternative approach...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101745
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Chronic myelomonocytic leukemia (CMML) is a rare hematopoietic malignancy. Treatment with hypomethylating agents (HMA) was introduced between 2004 and 2006 but its impact on population-based survival remains controversial. The aim of this study was to investigate epidemiological characteristics and survival ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.01.003
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Incidence of childhood cancer increased in most countries worldwide, but reasons are unclear. This study investigates trends of childhood cancer incidence in Switzerland from 1985 to 2014. METHODS:We extracted data on all childhood cancer cases diagnosed at ages 0-14 years in Switzerland from the Swiss Chil...
journal_title：Cancer epidemiology
pub_type： 历史文章,杂志文章
doi：10.1016/j.canep.2019.06.002
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND/AIM:This study tested the utility of retrospectively staging cancer registry data for comparing stage and stage-specific survivals of Aboriginal and non-Aboriginal people. Differences by area level factors were also explored. METHODS:This test dataset comprised 950 Aboriginal cases and all other cases recor...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.04.013
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Although tobacco involuntary smoking is an established risk factor for lung cancer, the association with head and neck cancer (HNC) is not established. We aimed to investigate this potential association in an East Asian population. METHODS:We conducted a multicenter case-control study in East Asia including...
journal_title：Cancer epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.canep.2019.01.020
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Androgen deprivation therapy (ADT) remains the mainstay treatment for locally advanced or metastatic prostate cancer (PC). However, potential effects of ADT treatment on neurocognitive dysfunction remain unclear. The present study was conducted to assess the relation between ADT treatment and risk of cogniti...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.101657
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:This paper aims to determine whether racial disparities exist in hospitalization outcomes among African-American and White hospitalized prostate cancer patients in the United States. We evaluated racial differences among matched groups of patients in post-operative complications, hospital length of stay and ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.12.001
更新日期：2017-02-01 00:00:00
abstract：:Nibrin and DNA repair protein XRCC3 are involved in DNA double-strand break repair. We genotyped seven tagging SNPs in these genes (rs1805794, rs709816; rs1063054; rs7141928, rs1799794, rs861530, rs861539) with the aim to analyse their association with acute lymphoblastic leukaemia (ALL), a disease, that is characteri...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.08.002
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Although, biologically plausible evidence has implicated coffee, tea and caffeine with carcinogenesis, there is a paucity of data on their associations with risk of cancer among Canadian women. Hence, we assessed their associations with risk of breast, endometrial and ovarian cancers within this population. ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.07.013
更新日期：2018-10-01 00:00:00
abstract：:French uterine cancer recordings in death certificates include 60% of "uterine cancer, Not Otherwise Specified (NOS)"; this hampers the estimation of mortalities from cervix and corpus uteri cancers. The aims of this work were to study the reliability of uterine cancer recordings in death certificates using a case mat...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.10.008
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Survival of children with cancer in resource-limited regions is very poor compared to better-resourced regions. Retinoblastoma (RB) is a childhood cancer that is commonly reported in many regions of Africa. RB may be safely and effectively treated by non-specialists, which could facilitate more widespread av...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101777
更新日期：2020-07-10 00:00:00
abstract：OBJECTIVE:To describe the thyroid cancer incidence trends and geographical patterns in the Latina Province of Lazio, Italy using the population-based cancer registry. METHODS:We extracted from the Latina cancer registry all cases of thyroid cancer from 1997 to 2006. Cases were classified according to morphological typ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.02.007
更新日期：2013-06-01 00:00:00
abstract：AIM:The prevalence of hysterectomy is decreasing worldwide. It is not clear whether changes in the population at risk (women with intact uteruses) have contributed to an increased uterine cancer incidence. This study aims to assess the effect of changing trends in hysterectomy prevalence on uterine cancer incidence in ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.02.008
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:This report describes the resources required to support the integrated approach of the Barbados National Registry for Chronic Non-communicable Diseases (BNR) to non-communicable disease (NCD) case registration, and to identify differences in cost for collecting and maintaining information on cancer and cardi...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.10.020
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Chromosome 19q13.3 has been identified as one of the regions that associate with cancer risk in previous studies. METHODS:We systematically examined the 70.772kb region comprising four genes on chromosome 19q13.3 among Chinese using the haplotype-tagging SNP (htSNP) approach and the HapMap platform. The stu...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.09.016
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Upper-tract urothelial cancer (UTUC), which includes renal pelvic cancer and ureter cancer, is a rare cancer and its prognosis is poor. Smoking and high-risk occupations (e.g., printing and dyestuff working which involves exposure to aniline dyes) are well-known risk factors for UTUC. However, the risk of al...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：INTRODUCTION:This paper presents race-specific prostate cancer mortality rates and the corresponding disparities for the largest cities in the US over two decades. METHODS:The 50 largest cities in the US were the units of analysis. Data from two 5-year periods were analyzed: 1990-1994 and 2005-2009. Numerator data wer...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.07.019
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:This paper presents race-specific lung cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for the 5-year intervals 1990-1994 and 2005-2009. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death files wh...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.10.003
更新日期：2015-12-01 00:00:00
abstract：:The complement system is an important immunosurveillance mechanism against tumors, and complement factor H (CFH) is a key regulator for activation of the complement system. Expression of complement factor H has been demonstrated in cell lines from several malignancies. In this study we examined the contribution of the...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.11.004
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Infection is hypothesised as a contributory cause of childhood immune cell malignancies. Although some have reported associations between individual infections and immune cell malignancies, some could be spurious due to infections caused by malignancies that were already active prior to diagnosis. METHODS:I...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101767
更新日期：2020-08-01 00:00:00
abstract：:Squamous cell carcinoma of the conjunctiva (SCCC) is a relatively common cancer in Africa, although its precise incidence and geographic distribution have not been previously systematically studied. METHODS:Using the methods employed to produce national estimates of cancer incidence for the "Globocan" series of the I...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.06.007
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Cow's milk contain phytoestrogens especially equol depending on the composition of the feed ration. However, it is unknown whether milk differing in equol exhibits different estrogenicity in model systems and thereby potentially in humans as milk consumers. METHODS:The estrogenicity of high and low equol mi...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.04.003
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:To investigate whether health insurance affiliation and socioeconomic deprivation is associated with overall cause survival from gastric cancer in a middle-income country. METHODS:All patients resident in the Bucaramanga metropolitan area (Colombia) diagnosed with gastric cancer between 2003 and 2009 (n=1039...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.10.012
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited number of studies have investigated SES differences in tumour stage at...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.canep.2016.01.012
更新日期：2016-04-01 00:00:00
