Abstract：
OBJECTIVE:Matrix metalloproteinase-7 (MMP-7) is a member of the family of matrix metalloproteinases (MMPs); it is associated with invasive tumor growth and distant metastasis in colorectal cancer (CRC). However, the prognostic value of MMP-7 in CRC remains controversial. Thus, we conducted a meta-analysis to investigate the prognostic value of MMP-7 expression in CRC. METHODS:We systematically searched for studies evaluating the relationship between MMP-7 expression and the outcome of CRC patients in PubMed, the Cochrane library, Embase, Google Scholar, and Wanfang databases updated to August 2014. Studies were assessed for quality using REMARK (REporting recommendations for tumor MARKer prognostic studies). Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were pooled to estimate the hazard for overall survival (OS) and disease-free survival (DFS), and odds ratios (ORs) with 95%CIs were pooled to estimate the impact of MMP-7 on the 5-year survival rate. RESULTS:In total, 2985 patients from 17 studies were included in this meta-analysis. Our results showed that MMP-7 over-expression predicted poor OS (HR=3.57, 95%CI 2.21-5.75, P=0.000, random-effect model), poor DFS (HR=2.49, 95%CI 1.73-3.57, P=0.000, fixed-effect model), and decreased 5-year survival rate (OR=0.26, 95%CI 0.19-0.37, P=0.000, fixed-effect model). Therefore, MMP-7 is an indicator of poor survival and high recurrence rate in CRC patients. CONCLUSION:MMP-7 can serve as a prognostic indicator and a potential novel target for treatment in CRC patients. More well-designed prospective studies with better methodology for MMP-7 assessment are required to clarify the prognostic significance of MMP-7 expression in CRC patients.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Sun DW,Zhang YY,Qi Y,Zhou XT,Lv GYdoi
10.1016/j.canep.2015.01.009subject
Has Abstractpub_date
2015-04-01 00:00:00pages
135-42issue
2eissn
1877-7821issn
1877-783Xpii
S1877-7821(15)00028-4journal_volume
39pub_type
杂志文章,meta分析,评审abstract：INTRODUCTION:This paper presents race-specific lung cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for the 5-year intervals 1990-1994 and 2005-2009. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death files wh...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.10.003
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:This paper presents race-specific breast cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for each of the 5-year intervals between 2005 and 2014. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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abstract：BACKGROUND:Despite being a well-documented phenomenon, seasonal variation in the incidence of cutaneous melanoma is poorly understood, and data on the seasonality of melanoma survival are scarce. We sought to explore the seasonal variation in melanoma incidence and survival in Belgium and to assess the characteristics ...
journal_title：Cancer epidemiology
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abstract：:DNA repair plays a pivotal role in maintaining genomic integrity with over 130 genes involved in various repair pathways that include base excision repair, nucleotide excision repair, double strand break repair and DNA mismatch repair. Polymorphisms within genes that are involved in these processes have been widely re...
journal_title：Cancer epidemiology
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abstract：BACKGROUND:Breast cancer has the highest incidence in women of all cancers and its burden is expected to continue to increase worldwide, especially in middle-income countries such as Thailand. The southern region of Thailand is unique in that it is comprised of 30% Muslims, whereas the rest of Thailand is 95% Buddhist....
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
pub_type： 杂志文章,多中心研究
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更新日期：2010-10-01 00:00:00
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journal_title：Cancer epidemiology
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.04.012
更新日期：2017-08-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2012.07.007
更新日期：2013-02-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.08.006
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Cow's milk contain phytoestrogens especially equol depending on the composition of the feed ration. However, it is unknown whether milk differing in equol exhibits different estrogenicity in model systems and thereby potentially in humans as milk consumers. METHODS:The estrogenicity of high and low equol mi...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.04.003
更新日期：2009-07-01 00:00:00
abstract：:Tobacco smoking continues to be the leading preventable cause of morbidity and mortality worldwide. Each year more than 5 million smokers die prematurely because of their habit wreaking havoc on the welfare of families and communities worldwide. While cigarettes remain the main tobacco killer worldwide, for many youth...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2012.10.013
更新日期：2013-02-01 00:00:00
abstract：INTRODUCTION:Antigenic stimulation is a proposed aetiologic mechanism for many haematological malignancies. Limited evidence suggests that community-acquired infections may increase the risk of acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). However, associations with other myeloid malignancies includ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.10.009
更新日期：2014-02-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.04.009
更新日期：2016-06-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101762
更新日期：2020-08-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.01.016
更新日期：2015-06-01 00:00:00
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更新日期：2020-08-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.08.003
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Despite the progress made in recent years, multiple myeloma is still considered an incurable disease. Most survival data come from clinical trials. Little is known about the outcome in unselected real-life patients. METHODS:Overall survival was analyzed in a cohort of newly diagnosed symptomatic multiple my...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Data from the Surveillance, Epidemiology, and End Results (SEER) revealed that the incidence of pediatric cancer in Nebraska exceeded the national average during 2009-2013. Further investigation could help understand these patterns. METHODS:This retrospective cohort study investigated pediatric cancer (0-19...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.12.006
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:The publication of the Women's Health Initiative Study in 2002 spurred reductions in hormone replacement therapy (HRT) use worldwide. Subsequent drops in breast cancer incidence have since been reported. We used person-level data from a large Israeli health plan to study the relationship between HRT use and ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Esophageal cancer is one of the most commonly diagnosed malignant tumors in China. The aim of this study was to provide the representative and comprehensive informations about the long-term mortality trends of this disease in China between 1987 and 2009, using joinpoint regression and generalized additive mo...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Global variations in the frequency of the major sub-types of lymphoma have been reported. However, studies on different sub-types of adult malignant lymphoma had never been conducted in Mashhad, Iran. In this paper, we aimed to identify the major sub-types of malignant lymphoma in our area and compare the di...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.09.009
更新日期：2011-02-01 00:00:00
