Abstract：
BACKGROUND:The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. METHODS:This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. RESULTS:Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. CONCLUSION:Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Boekstegers F,Marcelain K,Barahona Ponce C,Baez Benavides PF,Müller B,de Toro G,Retamales J,Barajas O,Ahumada M,Morales E,Rojas A,Sanhueza V,Loader D,Rivera MT,Gutiérrez L,Bernal G,Ortega A,Montalvo D,Portiño S,Bertdoi
10.1016/j.canep.2019.101643subject
Has Abstractpub_date
2020-04-01 00:00:00pages
101643eissn
1877-7821issn
1877-783Xpii
S1877-7821(19)30153-5journal_volume
65pub_type
杂志文章,多中心研究abstract：:South Asian countries are facing a hidden breast cancer epidemic. A significant proportion of the breast cancer cases occur in premenopausal women. Knowledge of the various aspects of breast cancer in different geographical regions is limited in South Asia. In this article, we review the Bangladeshi perspective of the...
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