Abstract：
BACKGROUND:Few studies have examined the association of common genetic variants related to vitamin D metabolism and signaling to esophageal squamous cell carcinoma (ESCC). METHODS:We evaluated the association between 12 single nucleotide polymorphisms (SNPs) in four genes related to vitamin D levels and ESCC risk using data from a genome-wide association study. Participants were recruited from the Shanxi Upper Gastrointestinal Cancer Genetics Project and the Linxian Nutrition Intervention Trials, and included 1942 ESCC cases and 2111 controls. We used logistic models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the SNP associations, after controlling for age and gender. RESULTS:None of the 12 evaluated SNPs in the four vitamin D-related genes were significantly associated with risk of ESCC. The strongest associations were for rs3794060 (P=0.07) and rs12800438 (P=0.08) in the DHCR7/NADSYN1 gene. No association between vitamin D-related SNPs and risk of ESCC was observed in a genotype score analysis that included all 12 SNPs. ORs for quartiles 2, 3 and 4 of the genotype scores were 0.83 (95% CI: 0.68, 1.01), 1.02 (0.85, 1.21), and 1.08 (0.89, 1.30), respectively, with no evidence for a significant monotonic trend (P=0.120). CONCLUSIONS:Our results suggested that common genetic variants related to vitamin D levels are not associated with risk of ESCC in this Chinese population.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Wang JB,Dawsey SM,Fan JH,Freedman ND,Tang ZZ,Ding T,Hu N,Wang LM,Wang CY,Su H,Qiao YL,Goldstein AM,Taylor PR,Abnet CCdoi
10.1016/j.canep.2014.12.013subject
Has Abstractpub_date
2015-04-01 00:00:00pages
157-9issue
2eissn
1877-7821issn
1877-783Xpii
S1877-7821(14)00232-Xjournal_volume
39pub_type
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