Abstract:
INTRODUCTION:Folic acid fortification and supplementation to prevent neural tube defects has led to concerns regarding increased risk of colorectal cancer. The results of existing studies have been inconclusive. The purpose was to examine the relationship between level of folate intake and the incidence of colorectal cancer. METHODS:A systematic review and meta analysis were conducted. MEDLINE, Embase, and SCOPUS were searched from inception to October 2009 with the following search terms "folic acid," "folate", "colorectal cancer," "colon neoplasms," rectal neoplasms." Observational studies in adult populations were included that defined levels of folate intake and incidence of colorectal cancer. RESULT:Out of 6427 references, 27 studies met our inclusion criteria. The summary risk estimate for case control studies comparing high versus low total folate intake was 0.85 (CI 95% 0.74-0.99) with no significant heterogeneity among studies. Similarly, for cohort studies, the resulting summary risk estimate for high versus low dietary folate intake was 0.92 (CI 95% 0.81-1.05) with no significant heterogeneity. However, defining what represents a higher intake of folic acid is difficult as there is variability in the upper limit of folic acid intake used in the studies. DISCUSSION:These results suggest that higher folate intake levels offer a reduction in one of the perceived risks associated with developing colorectal cancer. These data can serve to help reassure women planning a pregnancy to increase folic intake during the preconception period to levels sufficient to prevent neural tube defects.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Kennedy DA,Stern SJ,Moretti M,Matok I,Sarkar M,Nickel C,Koren Gdoi
10.1016/j.canep.2010.11.004subject
Has Abstractpub_date
2011-02-01 00:00:00pages
2-10issue
1eissn
1877-7821issn
1877-783Xpii
S1877-7821(10)00204-3journal_volume
35pub_type
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.07.013
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.10.007
更新日期:2018-12-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章,评审
doi:10.1016/j.canep.2012.08.012
更新日期:2013-02-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2015.06.003
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Esophageal cancer is one of the most commonly diagnosed malignant tumors in China. The aim of this study was to provide the representative and comprehensive informations about the long-term mortality trends of this disease in China between 1987 and 2009, using joinpoint regression and generalized additive mo...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.12.003
更新日期:2012-04-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.10.004
更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.canep.2015.09.008
更新日期:2015-12-01 00:00:00
abstract:AIM:To test the effect of African-American race on cancer specific mortality (CSM) in clear cell metastatic renal cell carcinoma (ccmRCC) and non-ccmRCC. PATIENTS AND METHODS:Within Surveillance, Epidemiology and End Results registry (2001-2014), we identified patients with ccmRCC and non-ccmRCC. We relied on propensi...
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pub_type: 杂志文章
doi:10.1016/j.canep.2018.04.006
更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 历史文章,杂志文章
doi:10.1016/j.canep.2019.06.002
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.05.014
更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.canep.2013.12.005
更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-10 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.canep.2019.101566
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2019.06.007
更新日期:2019-08-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.11.004
更新日期:2012-04-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.11.006
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Breast cancer has the highest incidence in women of all cancers and its burden is expected to continue to increase worldwide, especially in middle-income countries such as Thailand. The southern region of Thailand is unique in that it is comprised of 30% Muslims, whereas the rest of Thailand is 95% Buddhist....
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.02.007
更新日期:2018-06-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2009.09.002
更新日期:2009-12-01 00:00:00