Abstract：
:Association of epigenetic modifications with cancer has been widely studied. Gene-specific hypermethylation and global DNA hypomethylation are the most frequently observed patterns in great number of tumors. The methionine synthase (MTR) gene plays key role in maintaining adequate intracellular folate, methionine and normal homocysteine concentrations and, its polymorphism have been associated with the risk of retinoblastoma and other neoplasms. We evaluated the association of MTR A2756G polymorphism with the risk of retinoblastoma in an Iranian population. Totally, 150 retinoblastoma patients and 300 individuals with no family history of cancer as control were included in this study. Genotyping of the A2756G polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) using the restriction enzymes HaeIII. Our results showed that the "G" was the minor allele with a frequency of 31.7% and 20.3% in both retinoblastoma and control groups, respectively. The frequency of the 2756GG genotype (P=0.023) and 2756G allele (P=0.0001) were significantly higher in the patients than control group, respectively. Individual with the 2756GG genotype had a 2.99 fold increased risk for retinoblastoma. According to our results, the MTR A2756G polymorphism was associated with the risk of retinoblastoma in Iranian patients.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Akbari MT,Naderi A,Saremi L,Sayad A,Irani S,Ahani Adoi
10.1016/j.canep.2015.11.002subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1023-5issue
6eissn
1877-7821issn
1877-783Xpii
S1877-7821(15)00253-2journal_volume
39pub_type
杂志文章abstract：OBJECTIVE:To investigate the clinical value in detecting occult primary tumors with (18)F-FDG PET-CT whole body imaging. METHODS:120 patients with unknown primary origin were referred for (18)F-FDG PET-CT whole body imaging. All patients were performed (18)F-FDG PET-CT whole body scan. PET-CT images were interpreted b...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2012.03.002
更新日期：2012-10-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
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journal_title：Cancer epidemiology
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更新日期：2018-10-01 00:00:00
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更新日期：2016-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.12.010
更新日期：2019-02-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.10.008
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Diabetes and metabolic syndrome have been found to increase the risk of various cancers. Previous studies indicated that diabetes may increase the risk of head and neck squamous cell carcinoma (HNSCC). Metabolic syndrome has not been investigated as a risk factor. We tested whether type II diabetes or metabo...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.03.006
更新日期：2013-08-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.04.009
更新日期：2016-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.04.003
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Upper-tract urothelial cancer (UTUC), which includes renal pelvic cancer and ureter cancer, is a rare cancer and its prognosis is poor. Smoking and high-risk occupations (e.g., printing and dyestuff working which involves exposure to aniline dyes) are well-known risk factors for UTUC. However, the risk of al...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.03.002
更新日期：2017-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-07-10 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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更新日期：2016-04-01 00:00:00
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更新日期：2020-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-04-01 00:00:00
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更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.canep.2014.12.013
更新日期：2015-04-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
abstract：PURPOSE:We assessed the association between diabetes and breast cancer and whether physical activity modified the effect of diabetes on breast cancer in Hispanic women. METHODS:We used data from a case-control study of breast cancer among Hispanic women aged 30-79 conducted between 2003 and 2008 on the Texas-Mexico bo...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.06.001
更新日期：2010-10-01 00:00:00
