Abstract:
BACKGROUND:Cutaneous malignant melanoma is a major public health issue in Australia and other nations. A greater understanding of the genetic determinants and their interactions with environmental factors may lead to better interventions and control of the disease. The Western Australian Melanoma Health Study (WAMHS) is a population-based case-collection and biospecimen resource established to investigate the genetic epidemiology of melanoma. This manuscript discusses the design of the WAMHS and the characteristics of the participants. METHODS:Participants were recruited through the Western Australian Cancer Registry, which is notified of all incident cancers in the state of Western Australia by law. Once the diagnosing doctor's consent was obtained, all eligible, resident Western Australian, adult cases of melanoma diagnosed between January 2006 and September 2009, were contacted by mail and invited to participate. Clinical, questionnaire-based phenotypic and blood samples for extraction of DNA, RNA and serum were collected from consenting cases. Clinical data consisted of all pathological data recorded by the cancer registry and the questionnaire, administered by telephone interview, covered major risk factors for melanoma, such as sun exposure history and skin type. RESULTS:The final sample consisted of 1643 consenting cases out of 3420 cancer notifications (48.04%), of which 1455 cases completed one or more components of the study and 1157 completed all components. The WAMHS sample differed to all melanoma notifications only in age, with a bias towards older individuals (P<0.0001). No significant differences were observed in sex, melanoma site, Breslow thickness or Clark's level. CONCLUSIONS:The WAMHS study is novel in its non-family based approach and focus on common (low penetrance) genetic determinants. This comprehensive resource will enable further steps to be taken towards understanding the complex pathways involved in melanoma.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Ward SV,Cadby G,Lee A,Cole JM,Heyworth JS,Millward MJ,Wood FM,Palmer LJdoi
10.1016/j.canep.2011.02.010subject
Has Abstractpub_date
2011-10-01 00:00:00pages
423-31issue
5eissn
1877-7821issn
1877-783Xpii
S1877-7821(11)00035-Xjournal_volume
35pub_type
杂志文章abstract::Recent studies have identified the important role of cancer stem cells (CSCs) in carcinogenesis and relapse. However, with respect to multistage cancer metastasis, the role of CSCs has not been well-defined. In several human cancers, data showed that some phenotypic subsets of CSCs were responsible for cancer metastas...
journal_title:Cancer epidemiology
pub_type: 杂志文章,评审
doi:10.1016/j.canep.2012.07.007
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the association between physical activity and site-specific cancer incidence. METHODS:UK Biobank is a prospective population-based cohort study. 364,899 adults (51.6 % females, mean age 56.0 years) were included. The exposure variable was physical activity level derived from ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101780
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The distinctive racial/ethnic and geographic distribution of multiple myeloma (MM) suggests that both family history and environmental factors may contribute to its development. METHODS:A hospital-based case-control study consisting of 220 confirmed MM cases and 220 individually matched patient controls, by...
journal_title:Cancer epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.canep.2012.05.002
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Consumption of fruit and vegetables has been inversely related to gastric cancer. Two studies found that dietary antioxidant capacity has some role in explaining this association. We investigated the overall antioxidant effect from diet on gastric cancer using three measures of non-enzymatic antioxidant capa...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2015.04.003
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:This paper presents race-specific lung cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for the 5-year intervals 1990-1994 and 2005-2009. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death files wh...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2015.10.003
更新日期:2015-12-01 00:00:00
abstract::Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.10.007
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:To compare the trends in prostate cancer incidence, treatment with curative intent and mortality across regions and counties in Norway, and to consider changes in incidence (an indicator for early diagnosis) and treatment with curative intent as explanatory factors for the decreasing prostate cancer mortalit...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.04.017
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Survival of children with cancer in resource-limited regions is very poor compared to better-resourced regions. Retinoblastoma (RB) is a childhood cancer that is commonly reported in many regions of Africa. RB may be safely and effectively treated by non-specialists, which could facilitate more widespread av...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101777
更新日期:2020-07-10 00:00:00
abstract:BACKGROUND:The potentially functional polymorphism, rs909253 (+252 G>A), in the intron region of the LT-α (TNF-β) gene has been implicated in the risk of gastric cancer (GC) in some individually published studies, but others have shown inconsistent and inconclusive results. METHODS:We conducted a meta-analysis to asse...
journal_title:Cancer epidemiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.canep.2012.05.014
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:We aimed to report, for the first time, the results of the Iranian National Population-based Cancer Registry (INPCR) for the year 2014. METHODS:Total population of Iran in 2014 was 76,639,000. The INPCR covered 30 out of 31 provinces (98% of total population). It registered only cases diagnosed with maligna...
journal_title:Cancer epidemiology
pub_type: 历史文章,杂志文章
doi:10.1016/j.canep.2019.05.009
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:A prospective study to estimate benefits due to fecal occult blood tests for colorectal cancer are carried out for both males and females, under different screening frequencies. METHODS:We apply the statistical method developed by Wu et al. (2007) [1] using the Minnesota colorectal cancer study group data, ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2009.08.001
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:The disparity in breast cancer mortality rates among white and black US women is widening, with higher mortality rates among black women. We apply functional time series models on age-specific breast cancer mortality rates for each group of women, and forecast their mortality curves using exponential smoothi...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.05.001
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:Obesity and diabetes have been associated with liver cancer. However, recent US-based studies have suggested a lack of association between obesity and liver cancer among blacks and women. METHODS:We conducted a nested case-control study within the Multiphasic Health Checkup (MHC) cohort of Kaiser Permanente ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2016.04.009
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Telomeres help maintain chromosomal structure and may influence tumorigenesis. We examined the association between telomere length and skin cancer in a clinic-based case-control study of 198 melanoma cases, 136 squamous cell carcinoma (SCC) cases, 185 basal cell carcinoma (BCC) cases, and 372 healthy control...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2013.02.010
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Prostate cancer is the leading type of cancer among men in more developed countries. Incidence trends and survival rates could differ by age groups considering potential differences in the frequency of PSA testing, types of cancers and medical management. Our objective was to compare incidence trends and sur...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.07.007
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:ARID1A gene encodes BAF250a which is a member of the ARID family of DNA-binding proteins and a subunit of human SWI/SNF-related complexes. Low expression of ARID1A has been correlated with specific tumor cell lines or specific pathological types of cancer tissue. The purpose of this study was to investigate ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.07.006
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:To examine the overall and stage-specific age-adjusted incidence, 5-year survival and mortality rates of bladder cancer (BCa) in the United States, between 1973 and 2009. MATERIALS AND METHODS:A total of 148,315 BCa patients were identified in the Surveillance, Epidemiology and End Results database, between ye...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2013.02.002
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:The 'Two Week Wait' policy aims to ensure patients with suspected cancer are seen within two weeks of referral. However, patient non-attendance can result in this target being missed. This study aimed to identify predictors of non-attendance; and analyse the relationship between attendance and outcomes inclu...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2019.101588
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:One of the potential strategies for preventing cancers is using food-based natural products to induce cytoprotective enzymes including phase II and antioxidative enzymes that act in concert to detoxify and eliminate harmful reactive intermediates formed from carcinogens. The antioxidant response element (ARE...
journal_title:Cancer epidemiology
pub_type: 杂志文章,评审
doi:10.1016/j.canep.2010.06.012
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Implementation of mammography screening and advances in breast cancer treatment are considered as main reasons for the decline in breast cancer mortality observed in many industrialized countries during the past two decades. The purpose of this study was to provide a comprehensive assessment of trends in bre...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.01.008
更新日期:2011-10-01 00:00:00
abstract::Down syndrome (DS) is a common congenital anomaly, and children with DS have a substantially higher risk of leukemia. Although understanding of genetic and epigenetic changes of childhood leukemia has improved, the causes of childhood leukemia and the potential role of environmental exposures in leukemogenesis remain ...
journal_title:Cancer epidemiology
pub_type: 杂志文章,评审
doi:10.1016/j.canep.2014.07.006
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether health insurance affiliation and socioeconomic deprivation is associated with overall cause survival from gastric cancer in a middle-income country. METHODS:All patients resident in the Bucaramanga metropolitan area (Colombia) diagnosed with gastric cancer between 2003 and 2009 (n=1039...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2014.10.012
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:Antigenic stimulation is a proposed aetiologic mechanism for many haematological malignancies. Limited evidence suggests that community-acquired infections may increase the risk of acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). However, associations with other myeloid malignancies includ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2013.10.009
更新日期:2014-02-01 00:00:00
abstract:INTRODUCTION:Folic acid fortification and supplementation to prevent neural tube defects has led to concerns regarding increased risk of colorectal cancer. The results of existing studies have been inconclusive. The purpose was to examine the relationship between level of folate intake and the incidence of colorectal c...
journal_title:Cancer epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.canep.2010.11.004
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:The burden of renal cell carcinoma (RCC) in young adults received marginal attention. We assessed contemporary gender, race and stage-specific incidence and trends of RCC among young adults (20-39 years-old) in the United States. METHODS:Within Surveillance, Epidemiology, and End Results database (2000-2016...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101762
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Data from the Surveillance, Epidemiology, and End Results (SEER) revealed that the incidence of pediatric cancer in Nebraska exceeded the national average during 2009-2013. Further investigation could help understand these patterns. METHODS:This retrospective cohort study investigated pediatric cancer (0-19...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2017.12.006
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:During the last 20 years, relevant diagnostic procedures and advanced treatments have been progressively introduced in the management of hepatocellular carcinoma (HCC). The aim of the present study was to assess up-to-date survival trends for HCC in southern Switzerland, a region with one of the highest inci...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2014.09.008
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The anatomic distribution of advanced colorectal neoplasia is increasingly important for choosing screening strategies and treatment options. We sought to evaluate the impact of repeated screening on the positive predictive value (PPV) for advanced colorectal neoplasia (advanced adenoma, AA, and colorectal c...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2015.09.008
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) metastasis occurs in various organs, most frequently in liver. Serological examination including tumor and biochemical markers for liver function evaluation is routinely performed, though its accuracy is not high. MicroRNAs (miRNAs) have been implicated in a variety of human diseases ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.05.002
更新日期:2012-02-01 00:00:00
abstract::High thyroid hormone values have been associated with an increased risk of incident cancers, especially breast cancer but also lung cancer and any solid cancers. We explored whether there is an increased risk of overall and cause-specific cancers in those receiving levothyroxine treatment. We included all individuals ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101707
更新日期:2020-06-01 00:00:00