Abstract：
BACKGROUND:Telomeres help maintain chromosomal structure and may influence tumorigenesis. We examined the association between telomere length and skin cancer in a clinic-based case-control study of 198 melanoma cases, 136 squamous cell carcinoma (SCC) cases, 185 basal cell carcinoma (BCC) cases, and 372 healthy controls. METHODS:Cases were histologically confirmed patients treated at the Moffitt Cancer Center and University of South Florida Dermatology Clinic in Tampa, FL. Controls self-reported no history of cancer and underwent a skin cancer screening exam at study enrollment to rule out the presence of skin cancer. Quantitative real time PCR was used to measure telomere length in peripheral blood samples. RESULTS:Melanoma patients had longer telomeres than controls (odds ratio (OR)=3.75; 95% confidence interval (CI): 2.02-6.94 for highest versus lowest tertile) (P for trend=<0.0001). In contrast, longer telomere length was significantly inversely associated with SCC (OR=0.01; 95% CI: 0.00-0.05 for highest versus lowest tertile) (P for trend=<0.0001) and BCC (OR=0.10; 95% CI: 0.06-0.19 for highest versus lowest tertile) (P for trend=<0.0001). CONCLUSION:Telomere length may be involved in the development of skin cancer, although the effect on cancer risk differs for melanoma and non-melanoma carcinomas. Our findings suggest that long telomere length is positively associated with melanoma while inversely associated with SCC and BCC.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Anic GM,Sondak VK,Messina JL,Fenske NA,Zager JS,Cherpelis BS,Lee JH,Fulp WJ,Epling-Burnette PK,Park JY,Rollison DEdoi
10.1016/j.canep.2013.02.010subject
Has Abstractpub_date
2013-08-01 00:00:00pages
434-9issue
4eissn
1877-7821issn
1877-783Xpii
S1877-7821(13)00033-7journal_volume
37pub_type
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