Abstract：
BACKGROUND:Melanoma is one of the highest metastatic cancers and its incidence is rapidly increasing. A great effort has been devoted to determine gene mutations and expression profiles in melanoma cells, but less attention has been given to the possible influence of melanin synthesis in melanocytes on melanomagenesis. SLC7A11 encodes the cystine/glutamate antiporter xCT and its expression increases the antioxidant capacity of cells by providing cysteine that may be used for glutathione (GSH) synthesis. Melanocytes, however, can also use cysteine for pheomelanin synthesis and pigmentation. Therefore, pheomelanin synthesis may lead to chronic oxidative stress. Possible consequences of this for melanomagenesis have never been explored. METHODS:We quantified the expression of SLC7A11 and other genes that are involved in the synthesis of pheomelanin but do not regulate the transport of cysteine from the extracellular medium to the cytosol (CTNS, MC1R, ASIP and SLC45A2) in non-tumorous skin of 45 patients of cutaneous melanoma and 50 healthy individuals. We controlled for the effects of Fitzpatrick skin type, age, gender, body mass, frequency of sun exposure and sunburns and number of melanocytic nevi, as well as for the intrinsic antioxidant capacity as given by the expression of the gene NFE2L2. RESULTS:The expression of SLC7A11, but not of the other genes, was significantly higher in melanoma patients than in healthy individuals. This was independent of phenotypic factors and antioxidant capacity, thus supporting an effect of pheomelanin-induced oxidative stress on melanomagenesis. CONCLUSION:Our findings indicate that SLC7A11 downregulation in normal epidermal melanocytes may represent a preventive treatment against melanoma.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Galván I,Inácio Â,Dañino M,Corbí-Llopis R,Monserrat MT,Bernabeu-Wittel Jdoi
10.1016/j.canep.2019.101582subject
Has Abstractpub_date
2019-10-01 00:00:00pages
101582eissn
1877-7821issn
1877-783Xpii
S1877-7821(19)30093-1journal_volume
62pub_type
杂志文章abstract：BACKGROUND:Global variations in the frequency of the major sub-types of lymphoma have been reported. However, studies on different sub-types of adult malignant lymphoma had never been conducted in Mashhad, Iran. In this paper, we aimed to identify the major sub-types of malignant lymphoma in our area and compare the di...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.09.009
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:While differences in CPM use between White and Black patients are well known, it is not clear whether CPM use differs by estrogen/progesterone receptor (ER/PR) status of tumors and whether racial/ethnic differences in the use are affected by ER/PR status, which varies between racial groups. The purpose of th...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.02.011
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:The objective of this study is to estimate the gap between smoking prevalence and lung cancer mortality and provide predictions of lung cancer mortality based on previous smoking prevalence. MATERIALS AND METHODS:We used data from the Spanish National Health Surveys (2003, 2006 and 2011) to obtain informati...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.04.012
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Consumption of fruit and vegetables has been inversely related to gastric cancer. Two studies found that dietary antioxidant capacity has some role in explaining this association. We investigated the overall antioxidant effect from diet on gastric cancer using three measures of non-enzymatic antioxidant capa...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.04.003
更新日期：2015-06-01 00:00:00
abstract：:Tobacco smoking continues to be the leading preventable cause of morbidity and mortality worldwide. Each year more than 5 million smokers die prematurely because of their habit wreaking havoc on the welfare of families and communities worldwide. While cigarettes remain the main tobacco killer worldwide, for many youth...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2012.10.013
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:With linked register and cause of death data becoming more accessible than ever, competing risks methodology is being increasingly used as a way of obtaining "real world" probabilities of death broken down by specific causes. It is important, in terms of the validity of these studies, to have accurate cause ...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2012.08.012
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Corpus uteri cancer has become the fourth most common female cancer in Europe. In Estonia, the prevalence of obesity is increasing, and corpus uteri cancer survival has been relatively low. The aim of the study was to evaluate incidence, mortality and survival trends of corpus uteri cancer in Estonia by age,...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.101566
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:rs11801299 and rs1380576, two novel polymorphisms in MDM4 gene, have been investigated in several different cancer types. However, the role of these two polymorphisms in retinoblastoma (RB) remains unclear. METHODS:A total of 126 patients with primary RB and 148 age-/gender-matched controls were included in...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.12.010
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVES:A large proportion of patients with cutaneous malignant melanoma (CMM) do not experience excess mortality due to their disease. This group of patients is referred to as the cure proportion. Few studies have examined the possibility of cure for CMM. The aim of this study was to estimate the cure proportion of...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.12.006
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Survival has steadily improved for major cancer types in most parts of the world. We compared all-cause mortality between foreign-born and Sweden-born residents of Sweden who were diagnosed with cancer of the colon, lung, stomach, prostate, breast, cervix, and all site. METHODS:We used Swedish national vita...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.06.003
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Data from the Surveillance, Epidemiology, and End Results (SEER) revealed that the incidence of pediatric cancer in Nebraska exceeded the national average during 2009-2013. Further investigation could help understand these patterns. METHODS:This retrospective cohort study investigated pediatric cancer (0-19...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.12.006
更新日期：2018-02-01 00:00:00
abstract：INTRODUCTION:This paper presents race-specific breast cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for each of the 5-year intervals between 2005 and 2014. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.07.018
更新日期：2016-12-01 00:00:00
abstract：AIM:We studied whether incidence of all cancer sites combined was associated with the radiation exposure due to fallout from the Chernobyl accident in Finland. An emphasis was on the first decade after the accident to assess the suggested "promotion effect". METHODS:The segment of Finnish population with a stable resi...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.05.006
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Infection is hypothesised as a contributory cause of childhood immune cell malignancies. Although some have reported associations between individual infections and immune cell malignancies, some could be spurious due to infections caused by malignancies that were already active prior to diagnosis. METHODS:I...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101767
更新日期：2020-08-01 00:00:00
abstract：INTRODUCTION:Folic acid fortification and supplementation to prevent neural tube defects has led to concerns regarding increased risk of colorectal cancer. The results of existing studies have been inconclusive. The purpose was to examine the relationship between level of folate intake and the incidence of colorectal c...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.canep.2010.11.004
更新日期：2011-02-01 00:00:00
abstract：:Recent studies have identified the important role of cancer stem cells (CSCs) in carcinogenesis and relapse. However, with respect to multistage cancer metastasis, the role of CSCs has not been well-defined. In several human cancers, data showed that some phenotypic subsets of CSCs were responsible for cancer metastas...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2012.07.007
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVES:To compare the trends in prostate cancer incidence, treatment with curative intent and mortality across regions and counties in Norway, and to consider changes in incidence (an indicator for early diagnosis) and treatment with curative intent as explanatory factors for the decreasing prostate cancer mortalit...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.04.017
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:The aim of this study was to describe incidence patterns of lymphoid neoplasms in the Girona province (Spain) (1996-2015), and to predict the number of cases in Spain during 2020. METHODS:Data were extracted from the Girona cancer registry. Incident cases were classified using the ICD-O-3, third revision, a...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.11.001
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:An increase in immunoglobulin (Ig) A isotype directed against benzo(a)pyrene (BP) structure has previously been described in sera of cancer patients. In this study, new polycyclic aromatic hydrocarbon (PAH) conjugates were synthesized in order to more closely mimic the endogenous ligands of the cytosolic ary...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.04.013
更新日期：2009-07-01 00:00:00
abstract：:Lung cancer is the leading cause of cancer death in the United States, but a large fraction of cases is preventable. We use a spatial smoothing algorithm to identify a geographic pattern of high lung cancer mortality, primarily in the Southeast, which we call a lung cancer belt. Disease belts are an effective mode for...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2012.05.015
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited number of studies have investigated SES differences in tumour stage at...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.canep.2016.01.012
更新日期：2016-04-01 00:00:00
abstract：INTRODUCTION:This paper presents race-specific lung cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for the 5-year intervals 1990-1994 and 2005-2009. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death files wh...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.10.003
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:Obesity is a well-established risk factor for postmenopausal breast cancer, but mechanisms underlying the association are unclear. Adipocyte-derived, cytokine-like adipokines have been suggested as contributory factors. To evaluate their association with breast cancer risk factors and breast cancer risk, w...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.05.014
更新日期：2010-10-01 00:00:00
abstract：:This study was aimed to analyze the spectrum of time intervals, from the onset of symptoms to the commencement of treatment in esophagogastric cancers. Factors influencing these time delays and correlation between these time points with variables including socioeconomic strata, educational level, histopathology, locat...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101770
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVE:We investigated cancer incidence and all-cause mortality among 21,582 Norwegian male military peacekeepers deployed to Lebanon during 1978-1998. We also looked at cancer risk according to duration of service in Lebanon, in the occupational groups of cooks and mechanics, and the risk of alcohol- and smoking-re...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.04.011
更新日期：2015-08-01 00:00:00
abstract：:South Asian countries are facing a hidden breast cancer epidemic. A significant proportion of the breast cancer cases occur in premenopausal women. Knowledge of the various aspects of breast cancer in different geographical regions is limited in South Asia. In this article, we review the Bangladeshi perspective of the...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2014.08.004
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Survival of children with cancer in resource-limited regions is very poor compared to better-resourced regions. Retinoblastoma (RB) is a childhood cancer that is commonly reported in many regions of Africa. RB may be safely and effectively treated by non-specialists, which could facilitate more widespread av...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101777
更新日期：2020-07-10 00:00:00
abstract：BACKGROUND:Chewing areca (betel) nut has been deemed carcinogenic. The practice has become a public health concern in Micronesia. The Children's Healthy Living (CHL) Program included an areca (betel) nut questionnaire in a survey of household characteristics in the Freely Associated States (FAS). This paper describes a...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.07.009
更新日期：2017-10-01 00:00:00
abstract：:Cadmium, a human carcinogenic heavy metal, has been reported to be associated with breast cancer risk; however, the results from the epidemiological studies are not always consistent. The objective of this study was to quantitatively summarize the current evidence for the relationship between cadmium exposure and brea...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.canep.2016.04.002
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:The burden of renal cell carcinoma (RCC) in young adults received marginal attention. We assessed contemporary gender, race and stage-specific incidence and trends of RCC among young adults (20-39 years-old) in the United States. METHODS:Within Surveillance, Epidemiology, and End Results database (2000-2016...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101762
更新日期：2020-08-01 00:00:00
