Abstract:
OBJECTIVES:A prospective study to estimate benefits due to fecal occult blood tests for colorectal cancer are carried out for both males and females, under different screening frequencies. METHODS:We apply the statistical method developed by Wu et al. (2007) [1] using the Minnesota colorectal cancer study group data, to make Bayesian inference for the lead time, the time of diagnosis advanced by screening for both male and female participants in a periodic screening program. The lead time is distributed as a mixture of a point mass at zero and a piecewise continuous distribution. The two parts of the mixture correspond to two aspects of the screening: the probability of no benefit, or the percentage of interval cases; and the probability distribution of the early diagnosis time. We present estimates of these two measures for males and females by simulation studies using the Minnesota study group data. We also provide the mean, mode, variance, and density curve of the program's lead time by gender. This may provide policy makers important information on the effectiveness of the FOBT screening in colorectal cancer early detection. RESULTS:The mean lead time increases as the screening time interval decreases for both males and females. The standard error of the lead time also increases as the screening time interval decreases for both genders. Females seem get more benefit than males, in that females usually have a longer lead time than males if both take the test at the same time interval and the lead time mode for females is greater than that of males in the same screening time interval. CONCLUSION:According to the predictive estimation of the lead time distribution, to guarantee a 90% chance of early detection, it seems necessary for the males to take the fecal occult blood test every 9 months, while the females can take it annually.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Wu D,Erwin D,Rosner GLdoi
10.1016/j.canep.2009.08.001subject
Has Abstractpub_date
2009-10-01 00:00:00pages
212-5issue
3-4eissn
1877-7821issn
1877-783Xpii
S1877-7821(09)00100-3journal_volume
33pub_type
杂志文章abstract:PURPOSE:To examine the overall and stage-specific age-adjusted incidence, 5-year survival and mortality rates of bladder cancer (BCa) in the United States, between 1973 and 2009. MATERIALS AND METHODS:A total of 148,315 BCa patients were identified in the Surveillance, Epidemiology and End Results database, between ye...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2013.02.002
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Although tobacco involuntary smoking is an established risk factor for lung cancer, the association with head and neck cancer (HNC) is not established. We aimed to investigate this potential association in an East Asian population. METHODS:We conducted a multicenter case-control study in East Asia including...
journal_title:Cancer epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.canep.2019.01.020
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:In cancer care, the cure proportion (P) and time-to-cure (TTC) are important indicators for practitioners, patients, and healthcare policy makers. The recent definition of TTC as the time at which the probability of belonging to the cured group reaches 95% was used for the first time. METHODS:The data stem ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2019.02.006
更新日期:2019-06-01 00:00:00
abstract::Here we discuss the impact of Beral et al's 1990 paper "Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection?" Not only did this paper galvanise research into the underlying infectious cause of Kaposi's sarcoma, it also demonstrated the power of observational epidemiology in pointing the way towa...
journal_title:Cancer epidemiology
pub_type: 杂志文章,评审
doi:10.1016/j.canep.2016.07.014
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The relative 5-year survival rate of salivary gland cancer is moderate at best. This study was set up to evaluate whether the improvements in diagnosis and treatment in the last decades impacted the incidence, mortality and survival of salivary gland cancer. METHODS:Data on patients with salivary gland canc...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2014.10.007
更新日期:2015-02-01 00:00:00
abstract::Several risk factors for colorectal cancer (CRC) have been identified. If individuals with risk factors are more likely to harbor cancer or it precursors screening programs should be targeted toward this population. We evaluated the predictive value of colorectal cancer risk factors for the detection of advanced color...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2013.02.004
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Although the incidence of small intestinal adenocarcinoma (SIA) is low, rates are increasing and little information regarding modifiable lifestyle risk factors is available. AIM:To provide a systematic review of lifestyle factors and SIA risk. METHODS:Ovid MEDLINE, EMBASE and Web of science were searched f...
journal_title:Cancer epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.canep.2015.02.001
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Accumulated exposure to hormones and growth factors during early life may influence the future risk of breast cancer (BC). This study examines the influence of childhood-related, socio-demographic and anthropometric variables on BC risk, overall and by specific pathologic subtypes. METHODS:This is a case-co...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2015.11.004
更新日期:2016-02-01 00:00:00
abstract::High thyroid hormone values have been associated with an increased risk of incident cancers, especially breast cancer but also lung cancer and any solid cancers. We explored whether there is an increased risk of overall and cause-specific cancers in those receiving levothyroxine treatment. We included all individuals ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101707
更新日期:2020-06-01 00:00:00
abstract::Tobacco smoking continues to be the leading preventable cause of morbidity and mortality worldwide. Each year more than 5 million smokers die prematurely because of their habit wreaking havoc on the welfare of families and communities worldwide. While cigarettes remain the main tobacco killer worldwide, for many youth...
journal_title:Cancer epidemiology
pub_type: 杂志文章,评审
doi:10.1016/j.canep.2012.10.013
更新日期:2013-02-01 00:00:00
abstract::Oral cancers are the 11th most common malignancy reported worldwide, accounting for 3% of all newly diagnosed cancer cases, and one with high mortality ratios among all malignancies. The objectives of this study were therefore to study the electrical properties of cancerous tongue tissue and normal tongue tissue, as w...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2009.12.017
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:New therapeutic options have led to substantial increases in survival expectations of patients with non-Hodgkin lymphoma (NHL) in recent years. In contrast to many malignancies, survival in older patients has improved in NHL at a rate similar to that in younger patients. In the past, the impact of innovation...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.08.006
更新日期:2012-02-01 00:00:00
abstract::DNA repair plays a pivotal role in maintaining genomic integrity with over 130 genes involved in various repair pathways that include base excision repair, nucleotide excision repair, double strand break repair and DNA mismatch repair. Polymorphisms within genes that are involved in these processes have been widely re...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.09.003
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The objective of this study is to estimate the gap between smoking prevalence and lung cancer mortality and provide predictions of lung cancer mortality based on previous smoking prevalence. MATERIALS AND METHODS:We used data from the Spanish National Health Surveys (2003, 2006 and 2011) to obtain informati...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2017.04.012
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The aim of this study was to analyze the properties of the immune cell microenvironment of regional lymph nodes (LNs) positive for lung cancer. METHODS:Twenty-four patients operated on for stages T1 and T2 of the NSCLC, were enrolled in the study. Peripheral blood and LN tissue were obtained from different ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2009.10.011
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:DNA repair gene polymorphisms can contribute to susceptibility of human cancer, including gastric cancer. Three single nucleotide polymorphisms (SNPs) of xeroderma pigmentosum group D (XPD) and X-ray repair cross complement 1 (XRCC1) genes were genotyped in gastric cancer and control subjects in a population...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.08.008
更新日期:2011-04-01 00:00:00
abstract::The complement system is an important immunosurveillance mechanism against tumors, and complement factor H (CFH) is a key regulator for activation of the complement system. Expression of complement factor H has been demonstrated in cell lines from several malignancies. In this study we examined the contribution of the...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.11.004
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Esophageal cancer is one of the most commonly diagnosed malignant tumors in China. The aim of this study was to provide the representative and comprehensive informations about the long-term mortality trends of this disease in China between 1987 and 2009, using joinpoint regression and generalized additive mo...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.12.003
更新日期:2012-04-01 00:00:00
abstract::CDKN2A is the most common, most penetrant gene whom germline mutations predisposing to cutaneous familial melanoma (FAM). Multiple primary melanoma (MPM), early age at onset, >2 affected members and pancreatic cancer are consistent features predicting positive test. However, the impact that cumulative clinical feature...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.07.007
更新日期:2011-12-01 00:00:00
abstract::Recent studies have identified the important role of cancer stem cells (CSCs) in carcinogenesis and relapse. However, with respect to multistage cancer metastasis, the role of CSCs has not been well-defined. In several human cancers, data showed that some phenotypic subsets of CSCs were responsible for cancer metastas...
journal_title:Cancer epidemiology
pub_type: 杂志文章,评审
doi:10.1016/j.canep.2012.07.007
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to describe survival of lymphoid neoplasms (LNs) in the Girona province (Spain) during 1996-2015. METHODS:Data were extracted from the Girona cancer registry. LN incident cases were registered using the ICD-O-3, following the 2008 WHO classification scheme and HAEMACARE grouping. F...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101841
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:In the last ten to twenty years, a stabilization or decline in colorectal cancer (CRC) incidence has been observed in some countries across the world but not in Spain. Our objective here is to assess the gender-specific CRC spatio-temporal pattern in the health areas of Navarre, a Spanish province, during ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.10.004
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Consumption of fruit and vegetables has been inversely related to gastric cancer. Two studies found that dietary antioxidant capacity has some role in explaining this association. We investigated the overall antioxidant effect from diet on gastric cancer using three measures of non-enzymatic antioxidant capa...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2015.04.003
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The incidence trends of biliary tract cancer need to be established. This study investigated the incidence and mortality of biliary tract cancer in Sweden in 1970-2010. METHODS:Sex-specific biliary tract cancer incidence and mortality rates were evaluated using data from the Swedish Cancer Register, Patient...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.06.004
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Uruguay, a country with one of the highest lung cancer rates worldwide, initiated a series of comprehensive anti-smoking measures in 2005. We assess the tobacco control policies in the context of cohort-driven lung cancer incidence trends over a 25-year period, providing baseline predictions to 2035. METHOD...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.04.012
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the prognostic role of diagnostic delay and clinical presentation (regarding pain, jaundice, and weight loss) in pancreatic carcinoma. METHODS:One hundred and seventy patients with pancreatic cancer were diagnosed and treated in the decade 2001-2010 (100 males and 70...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2012.12.002
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:We developed a novel method of methylation-specific PCR (MSP) using immunoprecipitation with anti-histone antibody (IP-MSP) to efficiently detect serum methylated DNA tightly bound to de-acetylated histones. MATERIALS AND METHODS:The detection limit of IP-MSP for p16 methylation was determined with a standa...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.01.004
更新日期:2010-04-01 00:00:00
abstract::Esophageal cancer is a relatively rare form of cancer, but some world areas have a markedly higher incidence than others: China, Iceland, India, Japan and United Kingdom, appear to have a higher incidence, as well as the region around the Caspian Sea. In India the incidence rates vary across the country. Despite highe...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2009.09.002
更新日期:2009-12-01 00:00:00
abstract::Down syndrome (DS) is a common congenital anomaly, and children with DS have a substantially higher risk of leukemia. Although understanding of genetic and epigenetic changes of childhood leukemia has improved, the causes of childhood leukemia and the potential role of environmental exposures in leukemogenesis remain ...
journal_title:Cancer epidemiology
pub_type: 杂志文章,评审
doi:10.1016/j.canep.2014.07.006
更新日期:2014-10-01 00:00:00
abstract:AIM:We have reported the in vitro and in vivo anticancer activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) derived from a Japanese spice, wasabi. In order to obtain some clues about the mechanism of the anticancer activity, we have studied the effect of alkyl isothiocyanates (MITCs) on protein kinase activi...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2009.08.009
更新日期:2009-10-01 00:00:00