Abstract：
:Several risk factors for colorectal cancer (CRC) have been identified. If individuals with risk factors are more likely to harbor cancer or it precursors screening programs should be targeted toward this population. We evaluated the predictive value of colorectal cancer risk factors for the detection of advanced colorectal adenoma in a population based CRC colonoscopy screening program. Data were collected in a multicenter trial conducted in the Netherlands, in which 6600 asymptomatic men and women between 50 and 75 years were randomly selected from a population registry. They were invited to undergo a screening colonoscopy. Based on a review of the literature CRC risk factors were selected. Information on risk factors was obtained from screening attendees through a questionnaire. For each CRC risk factor, we estimated its odds ratio (OR) relative to the presence of advanced neoplasia as detected at colonoscopy. Of the 1426 screening participants who underwent a colonoscopy, 1236 (86%) completed the risk questionnaire. 110 participants (8.9%) had advanced neoplasia. The following risk factors were significantly associated with advanced neoplasia detected by colonoscopy: age (OR: 1.06 per year; 95% CI: 1.03-1.10), calcium intake (OR: 0.99 per mg; 95% CI: 0.99-1.00), positive CRC family history (OR: 1.55 per first degree family member; 95%CI: 1.11-2.16) and smoking (OR: 1.75; 95%CI: 1.09-2.82). Elderly screening participants, participants with lower calcium intake, a CRC family history, and smokers are at increased risk of harboring detectable advanced colorectal neoplasia at screening colonoscopy.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Stegeman I,de Wijkerslooth TR,Stoop EM,van Leerdam ME,Dekker E,van Ballegooijen M,Kuipers EJ,Fockens P,Kraaijenhagen RA,Bossuyt PMdoi
10.1016/j.canep.2013.02.004subject
Has Abstractpub_date
2013-06-01 00:00:00pages
278-83issue
3eissn
1877-7821issn
1877-783Xpii
S1877-7821(13)00027-1journal_volume
37pub_type
杂志文章abstract：INTRODUCTION:Antigenic stimulation is a proposed aetiologic mechanism for many haematological malignancies. Limited evidence suggests that community-acquired infections may increase the risk of acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). However, associations with other myeloid malignancies includ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.10.009
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:This paper aims to determine whether racial disparities exist in hospitalization outcomes among African-American and White hospitalized prostate cancer patients in the United States. We evaluated racial differences among matched groups of patients in post-operative complications, hospital length of stay and ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.12.001
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:There is a strong evidence for a protective role of physical activity (PA) on cancers of the colon, breast (postmenopausal) and endometrium, but data are less consistent or scarce for other cancer types. This study assessed the relationship between occupational and recreational PA and cancer risk among men i...
journal_title：Cancer epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.canep.2010.09.004
更新日期：2011-04-01 00:00:00
abstract：:The complement system is an important immunosurveillance mechanism against tumors, and complement factor H (CFH) is a key regulator for activation of the complement system. Expression of complement factor H has been demonstrated in cell lines from several malignancies. In this study we examined the contribution of the...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.11.004
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:A new cancer patient pathway for patients presenting with non-specific signs and symptoms (NSSC-CPP) was implemented nationally in Denmark in 2012. This study aims to describe, on a national level, the characteristics of patients referred to the Danish NSSC-CPP, and to estimate the prevalence and distributio...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.08.003
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Chewing areca (betel) nut has been deemed carcinogenic. The practice has become a public health concern in Micronesia. The Children's Healthy Living (CHL) Program included an areca (betel) nut questionnaire in a survey of household characteristics in the Freely Associated States (FAS). This paper describes a...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.07.009
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVES:A prospective study to estimate benefits due to fecal occult blood tests for colorectal cancer are carried out for both males and females, under different screening frequencies. METHODS:We apply the statistical method developed by Wu et al. (2007) [1] using the Minnesota colorectal cancer study group data, ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.08.001
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Corpus uteri cancer has become the fourth most common female cancer in Europe. In Estonia, the prevalence of obesity is increasing, and corpus uteri cancer survival has been relatively low. The aim of the study was to evaluate incidence, mortality and survival trends of corpus uteri cancer in Estonia by age,...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.101566
更新日期：2019-10-01 00:00:00
abstract：:Here we discuss the impact of Beral et al's 1990 paper "Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection?" Not only did this paper galvanise research into the underlying infectious cause of Kaposi's sarcoma, it also demonstrated the power of observational epidemiology in pointing the way towa...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2016.07.014
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Survival of children with cancer in resource-limited regions is very poor compared to better-resourced regions. Retinoblastoma (RB) is a childhood cancer that is commonly reported in many regions of Africa. RB may be safely and effectively treated by non-specialists, which could facilitate more widespread av...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101777
更新日期：2020-07-10 00:00:00
abstract：BACKGROUND:Despite the progress made in recent years, multiple myeloma is still considered an incurable disease. Most survival data come from clinical trials. Little is known about the outcome in unselected real-life patients. METHODS:Overall survival was analyzed in a cohort of newly diagnosed symptomatic multiple my...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.08.002
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Asian studies on soft tissue sarcoma (STS) incidence, irrespective of the primary site, are scant. METHODS:STS data were acquired from the population-based 2007-2013 Taiwan Cancer Registry of the Health and Welfare Data Science Center, Taiwan. Histological subtype-, site-, sex-, and age-specific STS inciden...
journal_title：Cancer epidemiology
pub_type： 历史文章,杂志文章
doi：10.1016/j.canep.2019.04.007
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:Although the risk of oxaliplatin-induced neuropathy depends on cumulative oxaliplatin dose, susceptibility to this adverse event differs greatly among patients. In this study, we investigated the associations between oxaliplatin-induced neuropathy and the following polymorphisms: glutathione S-transferase pi (G...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.02.008
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:DNA repair gene polymorphisms can contribute to susceptibility of human cancer, including gastric cancer. Three single nucleotide polymorphisms (SNPs) of xeroderma pigmentosum group D (XPD) and X-ray repair cross complement 1 (XRCC1) genes were genotyped in gastric cancer and control subjects in a population...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.08.008
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:To develop a prediction model to quantify the cumulative risk of Second Primary Cancer (SPC) among cancer patients given that they survive their disease. METHODS:A cohort of 293,435 patients based on data from twelve French cancer registries was analyzed. For five first cancer sites, SPC incidence rates wer...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.01.001
更新日期：2017-04-01 00:00:00
abstract：AIM:Several studies indicate that use of hormone replacement therapy (HRT) is associated with an increased risk of intracranial meningioma, while associations between HRT use and risk of other brain tumors have been less explored. We investigated the influence of HRT use on the risk of glioma in a nationwide setting. ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.09.017
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Chronic myelomonocytic leukemia (CMML) is a rare hematopoietic malignancy. Treatment with hypomethylating agents (HMA) was introduced between 2004 and 2006 but its impact on population-based survival remains controversial. The aim of this study was to investigate epidemiological characteristics and survival ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.01.003
更新日期：2019-04-01 00:00:00
abstract：:We examined the prevalence of HR- and LR-HPV by Linear Array genotyping test in 299 women aged 18-63 years who consecutively visited Molise Region main hospitals for routine Pap smear between February and August 2008. Ninety women were positive for any HPV (30.1%), and 66 for any HR-HPV (22.1%). The most prevalent HR-...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.12.010
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Uruguay, a country with one of the highest lung cancer rates worldwide, initiated a series of comprehensive anti-smoking measures in 2005. We assess the tobacco control policies in the context of cohort-driven lung cancer incidence trends over a 25-year period, providing baseline predictions to 2035. METHOD...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.04.012
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Melanoma is one of the highest metastatic cancers and its incidence is rapidly increasing. A great effort has been devoted to determine gene mutations and expression profiles in melanoma cells, but less attention has been given to the possible influence of melanin synthesis in melanocytes on melanomagenesis....
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.101582
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Barrett's Esophagus (BE), particularly long-segment Barrett's Esophagus, and the age of onset of Barrett's Esophagus are risk factors for esophageal adenocarcinoma. However, it is unknown if lifestyle factors such as alcohol abuse, tobacco use, weight gains that increase the risk of developing BE and esophag...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.10.013
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The cancer research groups of the National Cancer Institute's National Clinical Trials Network have a history of successful conduct of large randomized phase III trials of chemoprevention for cancer. An important question for funding agencies is whether the conduct of large chemoprevention trials provides st...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.06.005
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Despite evidence of a decline in both incidence and prevalence of colorectal cancer nationwide, it remains the second most commonly diagnosed cancer and the third highest cause of mortality among Asian Americans, including Korean Americans. This community-based and theoretically guided study evaluated a cult...
journal_title：Cancer epidemiology
pub_type： 临床试验,杂志文章
doi：10.1016/j.canep.2009.10.001
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Diabetes and metabolic syndrome have been found to increase the risk of various cancers. Previous studies indicated that diabetes may increase the risk of head and neck squamous cell carcinoma (HNSCC). Metabolic syndrome has not been investigated as a risk factor. We tested whether type II diabetes or metabo...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.03.006
更新日期：2013-08-01 00:00:00
abstract：RATIONALE AND OBJECTIVE:Cancer burden is increasing in Central and South America (CSA). We describe the current burden of cancer in CSA. METHODS:We obtained regional and national-level cancer incidence data from 48 population-based registries (13 countries) and nation-wide cancer mortality data from the WHO (18 countr...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.07.013
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Upper-tract urothelial cancer (UTUC), which includes renal pelvic cancer and ureter cancer, is a rare cancer and its prognosis is poor. Smoking and high-risk occupations (e.g., printing and dyestuff working which involves exposure to aniline dyes) are well-known risk factors for UTUC. However, the risk of al...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:It is estimated that over half the population of the European Union (EU) is overweight or obese due to an imbalance between energy expenditure and energy intake; this is related to an obesogenic environment of sociocultural, economic and marketing challenges to the control of body weight. Excess body fat is associated...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.01.017
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited number of studies have investigated SES differences in tumour stage at...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.canep.2016.01.012
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND AND AIM:SOX6, a member of the D subfamily of sex determining region y-related transcription factors, plays critical roles in cell fate determination, differentiation and proliferation. It has been identified as a tumor suppressor or an oncogene in different human cancers. However, the role of SOX6 in the dev...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.05.002
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Telomeres help maintain chromosomal structure and may influence tumorigenesis. We examined the association between telomere length and skin cancer in a clinic-based case-control study of 198 melanoma cases, 136 squamous cell carcinoma (SCC) cases, 185 basal cell carcinoma (BCC) cases, and 372 healthy control...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.02.010
更新日期：2013-08-01 00:00:00
